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Remote induction of in situ hydrogelation in a deep tissue,using an alternating magnetic field and superparamagnetic nanoparticles

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Nano Research 2018年第11期11卷 5997-6009页

作者： Hwangjae lee Guru Karthikeyan Thirunavukkarasu Semin Kim jae young lee School of Materials Science and Engineering Gwangju Institute of Science and Technology Gwongju 51005 Republic of Korea Department of Biomedical Science and Engineering Gwangju Institute of Science and Technology Gwangju 61005 Repubfic of Korea

In situ hydrogelation systems, such as transdermal polymerization, allow for external control over the gelation processes in a minimally invasive way. Recently, a novel system consisting of near-infrared (NIR) light and plasmonic nanomaterials was demonstrated to cause in vivo transdermal gelation. However, NIR light is not sufficient for gelation induction in deep tissues owing to its limited penetration into tissues. To overcome this problem, here we developed an alternating magnetic field (AMF)-inducible hydrogelation system with superparamagnetic iron oxide nanoparticles (SPIONs), by which a deep-tissue–penetrating AMF can induce heat generation in the SPIONs and temperature elevation (≥ 43 °C), leading to initiation of thermal polymerization of poly(ethylene glycol) diacrylate. The feasibility of our AMF-inducible hydrogelation was successfully demonstrated using thick porcine muscle tissues (> 2 cm), whereas the NIR light–based hydrogelation system could induce gelation only in tissues thinner than several millimeters. Cell viability assays indicated cytocompatibility of the AMF-inducible hydrogelation for cell encapsulation and delivery. In vivo hydrogelation in rat muscle tissues further validated in situ hydrogelation in deep muscle tissues of a living animal. This AMF-inducible hydrogelation system may overcome the conventional problems of depth limitation and should extend the applicable area of on-demand injectable hydrogel systems for tissue engineering and drug delivery applications.

关键词： hydrogelation alternating magnetic field superparamagnetic nanoparticles hydrogel tissue engineering cell delivery

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Wolf phase tomography(WPT) of transparent structures using partially coherent illumination

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Light(Science & Applications) 2020年第1期9卷 656-664页

作者： Xi Chen Mikhail E.Kandel Chenfei Hu young jae lee Gabriel Popescu Quantitative Light Imaging Laboratory Beckman Institute for Advanced Science and TechnologyDepartment of Electrical and Computer EngineeringUniversity of Illinois at Urbana-ChampaignUrbanaIL 61801USA

In 1969,Emil Wolf proposed diffraction tomography using coherent holographic imaging to extract 3D information from transparent,inhomogeneous *** the same era,the Wolf equations were first used to describe the propagation correlations associated with partially coherent *** these two concepts,we present Wolf phase tomography(WPT),which is a method for performing diffraction tomography using partially coherent *** reconstruction works directly in the space-time domain,without the need for Fourier transformation,and decouples the refractive index(RI)distribution from the thickness of the *** demonstrate the WPT principle using the data acquired by a quantitative-phase-imaging method that upgrades an existing phase-contrast microscope by introducing controlled phase shifts between the incident and scattered *** illumination field in WPT is partially spatially coherent(emerging from a ring-shaped pupil function)and of low temporal coherence(white light),and as such,it is well suited for the Wolf *** three intensity measurements corresponding to different phase-contrast frames,the 3D RI distribution is obtained immediately by computing the Laplacian and second time derivative of the measured complex correlation *** validate WPT with measurements of standard samples(microbeads),spermatozoa,and live neural *** high throughput and simplicity of this method enables the study of 3D,dynamic events in living cells across the entire multiwell plate,with an RI sensitivity on the order of 10^(−5).

关键词： WPT coherent illumination

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Tamsulosin-induced life-threatening hypotension in a patient with spinal cord injury:A case report

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World Journal of Clinical Cases 2022年第25期10卷 9142-9147页

作者： jae young lee Ho Seok lee Si-Bog Park Kyu Hoon lee Rehabilitation Medicine Hanyang University HospitalSeoul 04763South Korea

BACKGROUND Tamsulosin,a selectiveα1-adrenergic receptor antagonist,is commonly used for treating neurogenic bladder in patients with spinal cord injury(SCI).No severe adverse events have been described with such tamsulosin *** our knowledge,we report the first case of severe life-threatening hypotension as an adverse effect of tamsulosin in a person with ***,we report this case to inform that this severe adverse effect of tamsulosin can occur when treating patients with *** SUMMARY A 59-year-old woman was diagnosed with cervical spinal cord myelopathy and was classified as American Spinal Injury Association Impairment Scale D,neurological level of injury *** she suffered from voiding difficulty due to neurogenic bladder,we prescribed *** vital signs remained stable,but occasional hypotensive symptoms followed *** reduced the dose of tamsulosin,but after administering tamsulosin for 9 d,she experienced lifethreatening hypotension with no evidence of hypovolemic shock,neurogenic shock,cardiogenic shock,or septic shock.A hypotensive condition induced by tamsulosin was the suspected cause,and her symptoms could be associated with adverse effects of *** symptoms resolved after stopping tamsulosin,and no other reason was found,we concluded that tamsulosin was the cause of her *** Caution for severe hypotension is needed when administering tamsulosin for neurogenic bladder in a patient with SCI.

关键词： Tamsulosin Neurogenic bladder Spinal cord injury Hypotension Vasovagal symptoms Case report

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Bilateral musculocutaneous neuropathy:A case report

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World Journal of Clinical Cases 2021年第5期9卷 1237-1246页

作者： Ji Won Jung Yu Chan Park jae young lee jae Hyeon Park Seong Ho Jang Department of Rehabilitation Medicine Hanyang University HospitalSeoul 04763South Korea Department of Rehabilitation Medicine Hanyang University Guri HospitalGuri 11923South Korea

BACKGROUND Isolated musculocutaneous nerve injury is a rare ***,we report the first case of bilateral musculocutaneous neuropathy after vigorous stretching of both upper extremities with normal results of sensory nerve action *** should be aware of this rare condition that can appear *** addition,the interpretation of the aberrant electrodiagnostic study results of this case was *** SUMMARY A 29-year-old male complaining of bilateral forearm tingling and upper extremity weakness visited the outpatient *** symptoms began 6 mo prior,and he visited another hospital before visiting our *** diagnosis was not made even after cervical spine magnetic resonance imaging,electrodiagnostic study,brain magnetic resonance imaging,and arteriography were *** patient performed unique exercises that stretched the pectoralis minor and coracobrachialis *** the follow-up electrodiagnostic study,abnormal spontaneous activities in the bilateral biceps and brachialis muscles were *** patient was diagnosed with bilateral musculocutaneous *** pulse therapy was administered for approximately 6 *** treatment,his muscle strength returned to the predisease *** Clinicians should be aware of this condition,have adequate understanding of anatomy,and advise to correct inappropriate exercises.

关键词： Musculocutaneous nerve Peripheral neuropathy Electrodiagnosis Exercise Diagnosis Case report

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Wet tissue adhesive polymeric powder hydrogels for skeletal muscle regeneration

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Bioactive Materials 2024年第10期40卷 334-344页

作者： Mingyu lee Daun Seo Junggeon Park Sun Hong lee Jin Jeon Woochan Kim Jangho Kim Hee Seok Yang jae young lee School of Materials Science and Engineering Gwangju Institute of Science and TechnologyGwangju61005Republic of Korea Department of Nanobiomedical Science&BK21 FOUR NBM Global Research Center for Regenerative Medicine Dankook UniversityCheonan31116Republic of Korea Department of Convergence Biosystems Engineering Chonnam National UniversityGwangju61186Republic of Korea Department of Rural and Biosystems Engineering Chonnam National UniversityGwangjuRepublic of Korea Interdisciplinary Program in IT-Bio Convergence System Chonnam National UniversityGwangju61186Republic of Korea

Volumetric muscle loss(VML)frequently results from traumatic incidents and can lead to severe functional *** have been widely employed for VML tissue regeneration,which are unfortunately ineffective because of the lack of intimate contact with injured tissue for structural and mechanical *** hydrogels allow for strong tissue connections for wound ***,conventional adhesive hydrogels exhibit poor tissue adhesion in moist,bleeding wounds due to the hydration layer at the tissue–hydrogel interfaces,resulting in insufficient *** this study,we developed a novel,biocompatible,wet tissue adhesive powder hydrogel consisting of dextran-aldehyde(dex-ald)and gelatin for the regeneration of *** powder absorbs the interfacial tissue fluid and buffer solution on the tissue,spontaneously forms a hydrogel,and strongly adheres to the tissue via various molecular interactions,including the Schiff base *** particular,the powder composition with a 1:4 ratio of dex-ald to gelatin exhibited optimal characteristics with an appropriate gelation time(258 s),strong tissue adhesion(14.5 kPa),and ***-ald/gelatin powder hydrogels presented strong adhesion to various organs and excellent hemostasis compared to other wet hydrogels and fibrin glue.A mouse VML injury model revealed that the dex-ald/gelatin powder hydrogel significantly improved muscle regeneration,reduced fibrosis,enhanced vascularization,and decreased ***,our wet-adhesive powder hydrogel can serve as an effective platform for repairing various tissues,including the heart,muscle,and nerve tissues.

关键词： Powder Hydrogel Wet-adhesive Skeletal muscle regeneration

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Sprinkle formulations——A review of commercially available products

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Asian Journal of Pharmaceutical Sciences 2020年第3期15卷 292-310页

作者： Han Sol lee Jeong-Jun lee Myeong-Gyu Kim Ki-Taek Kim Cheong-Weon Cho Dae-Duk Kim jae-young lee College of Pharmacy Chungnam National UniversityDaejeon 34134Republic of Korea Graduate School of Clinical Pharmacy CHA UniversityPocheon 11160Republic of Korea College of Pharmacy and Natural Medicine Research Institute Mokpo National UniversityJeonnam 58554Republic of Korea College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National UniversitySeoul 08826Republic of Korea

Currently, sixty-five original sprinkle drug products are available in various dosage forms including tablets, powders, granules, immediate-release capsules, extended-release capsules, delayed-release capsules, and multiparticulate drug delivery systems. By sprinkling on soft food vehicles, these products provide dosing flexibility and convenience of administration, which potentially improve the compliance of patients with *** to these advantages, the growth of sprinkle products picked up since the 1990s, and several regulatory issues regarding this dosage form have been raised and *** this article, the types of sprinkle formulations were discussed by dividing them into seven categories, and the commercial products were summarized in terms of the drug substance, pharmaceutical excipients, storage conditions and administration methods. In addition, several US Food and Drug Administration guidelines related to the regulatory issues of sprinkle formulations were reviewed, which led to the conclusion that the future development of this promising dosage form demands integrated guidance for industry rather than scattered information in various documents.

关键词： Sprinkle formulation Soft food Geriatric Pediatric Dysphagia Guidance for industry

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Is mannitol combined with furosemide a new treatment for refractory lymphedema?A case report

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World Journal of Clinical Cases 2021年第29期9卷 8804-8811页

作者： Hyeon Seong Kim jae young lee Ji Won Jung Kyu Hoon lee Mi Jung Kim Si-Bog Park Department of Rehabilitation Medicine Hanyang University HospitalSeoul 04763South Korea

BACKGROUND Mannitol is a hyperosmolar agent and the combination of mannitol and furosemide is a widely used treatment for intracranial pressure *** the hypertonic properties of mannitol to move water out of intracellular spaces,we hypothesized that mannitol combined with furosemide could relieve focal tissue swelling in refractory *** SUMMARY A 90-year-old female had been diagnosed with intracranial hemorrhage and received a combination of mannitol and furosemide for intracranial pressure *** of the intracranial hemorrhage,she had refractory lymphedema of the left lower extremity since ***,after receiving the mannitol and furosemide,the patient’s lower extremity lymphedema improved *** the mannitol and furosemide were discontinued,the lymphedema worsened in spite of complete decongestive therapy(CDT)and intermittent pneumatic compression treatment(IPC).To identify the presumed effect of mannitol and furosemide on the lymphedema,these agents were resumed,and the lymphedema improved *** The present case raises the possibility that a combination of mannitol and furosemide might be considered another effective therapeutic option for refractory lymphedema when CDT and IPC are ineffective.

关键词： Lymphedema Mannitol Furosemide Rehabilitation Intermittent pneumatic compression Case report

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Gastric angiodysplasia in a hereditary hemorrhagic telangiectasia type 2 patient

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World Journal of Gastroenterology 2012年第15期18卷 1840-1844页

作者： Minsu Ha Yoon jae Kim Kwang An Kwon Ki Baik Hahm Mi-Jung Kim Dong Kyu Kim young jae lee S Paul Oh Department of Gastroenterology Gachon University Gil Medical CenterIncheon 402-751South Korea World Class University program Lee Gil Ya Cancer and Diabetes InstituteGachon University of Medicine and ScienceIncheon 402-751South Korea lee Gil Ya Cancer and Diabetes Institute Gachon University of Medicine and ScienceIncheon 402-751South Korea

Hereditary hemorrhagic telangiectasia(HHT)is a rare autosomal-dominantly inherited disease that occurs in approximately one in 5000 to 8000 *** diagnosis of HHT is made when a person presents three of the following four criteria:family history,recurrent nosebleeds,mucocutaneous telangiectasis,and arteriovenous malformations(AVM)in the brain,lung,liver and gastrointestinal(GI)*** epistaxis is themost common presenting symptom,AVMs affecting the lungs,brain and GI tract provoke a more serious *** mutations in endoglin,activin receptor-like kinase 1(ACVRL1;ALK1),and SMAD4,the genes involved in the transforming growth factor-βfamily signaling cascade,cause *** report here the case of a 63 year-old male patient who presented melena and GI bleeding episodes,proven to be caused by bleeding from multiple gastric *** revealed multiple angiodysplasia throughout the *** argon plasma coagulation was performed to control bleeding from a gastric *** patient has been admitted several times with episodes of hemoptysis and *** year ago,the patient was hospitalized due to right-sided weakness,which was caused by left basal ganglia hemorrhage as the part of HHT *** family history,the patient's mother and elder sister had died,due to intracranial hemorrhage,and his eldest son has been suffered from recurrent epistaxis for 20 years.A genetic study revealed a mutation in exon 3 of ALK1(c.199C>T;***67Trp)in the proband and his eldest son presenting epistaxis.

关键词： Hereditary hemorrhagic telangiectasia Angiodysplasia Intracranial hemorrhage Epistaxis Activin receptor-like kinase 1

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A paintable and adhesive hydrogel cardiac patch with sustained release of ANGPTL4 for infarcted heart repair

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Bioactive Materials 2024年第1期31卷 395-407页

作者： Mingyu lee Yong Sook Kim Junggeon Park Goeun Choe Sanghun lee Bo Gyeong Kang Ju Hee Jun Yoonmin Shin Minchul Kim youngkeun Ahn jae young lee School of Materials Science and Engineering Gwangju Institute of Science and TechnologyGwangju61005Republic of Korea Cell Regeneration Research Center Chonnam National UniversityGwangjuRepublic of Korea Biomedical Research Institute Chonnam National University HospitalGwangjuRepublic of Korea Department of Cardiology Chonnam National University HospitalGwangjuRepublic of Korea Chonnam National University Medical School GwangjuRepublic of Korea

The infarcted heart undergoes irreversible pathological remodeling after reperfusion involving left ventricle dilation and excessive inflammatory reactions in the infarcted heart,frequently leading to fatal functional *** attempts have been made to attenuate pathological remodeling in infarcted hearts using cardiac patches and anti-inflammatory drug *** this study,we developed a paintable and adhesive hydrogel patch using dextran-aldehyde(dex-ald)and gelatin,incorporating the anti-inflammatory protein,ANGPTL4,into the hydrogel for sustained release directly to the infarcted heart to alleviate *** optimized the material composition,including polymer concentration and molecular weight,to achieve a paintable,adhesive hydrogel using 10%gelatin and 5%dex-ald,which displayed in-situ gel formation within 135 s,cardiac tissue-like modulus(40.5 kPa),suitable tissue adhesiveness(4.3 kPa),and excellent mechanical ***4 was continuously released from the gelatin/dex-ald hydrogel without substantial burst *** gelatin/dex-ald hydrogel could be conveniently painted onto the beating heart and degraded in ***,in vivo studies using animal models of acute myocardial infarction revealed that our hydrogel cardiac patch containing ANGPTL4 significantly improved heart tissue repair,evaluated by echocardiography and histological *** heart tissues treated with ANGPTL4-loaded hydrogel patches exhibited increased vascularization,reduced inflammatory macrophages,and structural maturation of cardiac *** novel hydrogel system,which allows for facile paintability,appropriate tissue adhesiveness,and sustained release of anti-inflammatory drugs,will serve as an effective platform for the repair of various tissues,including heart,muscle,and cartilage.

关键词： Cardiac patch Hydrogel Angiopoietin-like 4 Myocardial infarction

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Nogo receptor expression in microglia/macrophages during experimental autoimmune encephalomyelitis progression

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Neural Regeneration Research 2018年第5期13卷 896-907页

作者： Amani A.Alrehaili jae young lee Maha M.Bakhuraysah Min Joung Kim Pei-Mun Aui Kylie A.Magee Steven Petratos Department of Neuroscience Central Clinical School Monash University Department of Clinical Laboratories College of Applied Medical Sciences Taif University Toolgen Inc. Gasan Digital-Ro

Myelin-associated inhibitory factors within the central nervous system（CNS） are considered to be one of the main obstacles for axonal regeneration following disease or injury. The nogo receptor 1（NgR1） has been well documented to play a key role in limiting axonal regrowth in the injured and diseased mammalian CNS. However, the role of nogo receptor in immune cell activation during CNS inflammation is yet to be mechanistically elucidated. Microglia/macrophages are immune cells that are regarded as pathogenic contributors to inflammatory demyelinating lesions in multiple sclerosis（MS）. In this study, the animal model of MS, experimental autoimmune encephalomyelitis（EAE） was induced in ngr1^＋/＋ and ngr1^–/– female mice following injection with the myelin oligodendrocyte glycoprotein（MOG_（35–55）） peptide. A fatemap analysis of microglia/macrophages was performed throughout spinal cord sections of EAE-induced mice at clinical scores of 0, 1, 2 and 3, respectively（increasing locomotor disability） from both genotypes, using the CD11 b and Iba1 cell markers. Western immunoblotting using lysates from isolated spinal cord microglia/macrophages, along with immunohistochemistry and flow cytometric analysis, was performed to demonstrate the expression of nogo receptor and its two homologs during EAE progression. Myelin protein engulfment during EAE progression in ngr1^＋/＋ and ngr1^–/– mice was demonstrated by western immunblotting of lysates from isolated spinal cord microglia/macrophages, detecting levels of Nogo-A and MOG. The numbers of M1 and M2 microglia/macrophage phenotypes present in the spinal cords of EAE-induced ngr1^＋/＋ and ngr1^–/– mice, were assessed by flow cytometric analysis using CD38 and Erg-2 markers. A significant difference in microglia/macrophage numbers between ngr1^＋/＋ and ngr1^–/– mice was identified during the progression of the clinical symptoms of EAE, in the white versus gray matter regions of the spinal cord. This difference was unrelated to the e

关键词： microglia experimental autoimmune encephalomyelitis nogo receptor myelin-associated inhibitory factors (MAIFs) Nogo A neural regeneration

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