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Spider angiomas in patients with liver cirrhosis: Role of vascular endothelial growth factor and basic fibroblast growth factor

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World Journal of Gastroenterology 2003年第12期9卷 2832-2835页

作者： Chun-Pin Li Fa-Yauh Lee Shinn-Jang Hwang Rei-Hwa Lu Wei-Ping Lee Yee Chao Sung-Sang Wang Full-Young Chang jacqueline whang-peng Shou-Dong Lee Division of Gastroenterology Department of MedicineTaipei Veterans General Hospital and Institute of Clinical MedicineNational Yang-Ming University School of MedicineTaipeiTaiwanChina Cancer Center Taipei Veterans General Hospital and National Yang-Ming University School of MedicineTaipeiTaiwanChina Cancer Research Division National Health Research Institutes and Institute of Clinical MedicineNational Yang-Ming University School of MedicineTaipeiTaiwanChina

AIM: To investigate whether vascular endothelial growth factor (VEGF) and basic fibroblastic growth factor (bFGF) are associated wibh spider angiomas in patients wibh liver cirrhosis. METHODS: Eighty-six patients with liver cirrhosis were enrolled and the number and size of the spider angiomas were recorded. Fifty-three healthy subjects were selected as controls. Plasma levels of VEGF and bFGF were measured in both the cirrhotics and the controls. RESULTS: Plasma VEGF and bFGF were increased in cirrhotics compared with controls (122±13 vs. 71±11 pg/mL, P=0.003 for VEGF; 5.1±0.5 vs. 3.4±0.5 pg/mL, P=0.022 for bFGF). In cirrhotics, plasma VEGF and bFGF were also higher in patients with spider angiomas compared with patients without spider angiomas (185±28 vs. 90±10 pg/mL, P=-0.003 for VEGF; 6.8±1.0 vs. 4.1±0.5 pg/mL, P=0.017 for bFGF). Multivariate logistic regression showed that young age and increased plasma levels of VEGF and bFGF were the most significant predictors for the presence of spider angiomas in cirrhotic patients (odds ratio [OR]=6.64, 95% confidence interval[CI]=2.02-21.79, P=0.002; OR=4.35, 95% CI=1.35-14.01,P=0.014; OR=5.66, 95% CI=1.72-18.63, P=0.004, respectively). CONCLUSION: Plasma VEGF and bFGF are elevated inpatients with liver cirrhosis. Age as well as plasma levels of VEGF and bFGF are significant predictors for spider angiomas in cirrhotic patients.

关键词：血管内皮生长因子基质纤维原细胞生长因子肝硬化蛛形血管瘤作用机制

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Long-term hepatic consequences of chemotherapy-related HBV reactivation in lymphoma patients

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World Journal of Gastroenterology 2005年第34期11卷 5283-5288页

作者： Chi-Chung Wen Chao A.Hsiung Ih-Jen Su Ann-Lii Cheng Ming-Chih Chang Chao-Jung Tsao Woei-Yao Kao Wu-Ching Uen Chiun Hsu Chih-Hung Hsu Yen-Shen Lu Hwei-Fan Tien Tsu-Yi Chao Li-Tzong Chen jacqueline whang-peng Pei-Jer Chen Division of Biostatics and Bioinformatics National Health Research Institutes Taipei Taiwan China Division of Clinical Research National Health Research Institutes Taipei Taiwan China Department of Oncology National Taiwan University Hospital Taipei Taiwan China Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan China Department of Internal Medicine Mackay Memorial Hospital Taipei Taiwan China Department of Internal Medicine Chi-Mei Hospital Tainan Taiwan China Department of Internal Medicine Tri-Service General Hospital Taipei Taiwan China Department of Internal Medicine Shin Kong Memorial Hospital Taipei Taiwan China Department of Oncology National Taiwan University Hospital Taipei Taiwan China Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan China Division of Cancer Research National Health Research Institutes Taipei Taiwan China

AIM: To investigate the long-term consequences of chemotherapy-related HBV reactivation in patients with ***: This study was based on the database of published prospective study evaluating HBV reactivation in HBV lymphoma patients during *** liver reserve (DLR) was defined as development of either one of the following conditions during follow-up: (1) newly onset parenchyma liver disease, splenomegaly or ascites without evidence of lymphoma involvement; (2) decrease of the ratio (albumin/globulin ratio) to less than 0.8 or increase of the ratio of INR of prothrombin time to larger than 1.2 without evidence of malnutrition or infection. Liver cirrhosis was diagnosed by imaging ***: A total of 49 patients were included. The median follow-up was 6.2 years (range, 3.9-8.1 years).There were 31 patients with and 18 patients without HBV reactivation. Although there was no difference of overall survival (OS) and chemotherapy response rate between the two groups, DLR developed more frequently in patients with HBV reactivation (48.4% vs 16.7%; P= 0.0342). Among the HBV reactivators, HBV genotype C was associated with a higher risk of developing DLR (P = 0.0768) and liver cirrhosis (P = 0.003). Four of five patients with sustained high titer of HBV DNA and two of three patients with multiple HBV reactivation developed DLR. Further, patients with a sustained high titer of HBV DNA had the shortest OS among the HBV reactivators (P= 0.0000). No patients in the non-HBV reactivation group developed hepatic failure or liver ***: Chemotherapy-related HBV reactivation is associated with the long-term effect of deterioration of hepatic function.

关键词： HBV reactivation Liver function Non-HodgkJn'slymphoma, Chemotherapy

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Investigation of the genetic etiology in male infertility with apparently balanced chromosomal structural rearrangements by genome sequencing

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Asian Journal of Andrology 2022年第3期24卷 248-254页

作者： Matthew Hoi Kin Chau Ying Li peng Dai Mengmeng Shi Xiaofan Zhu jacqueline Pui Wah Chung Yvonne K Kwok Kwong Wai Choy Xiangdong Kong Zirui Dong Department of Obstetrics and Gynaecology The Chinese University of Hong KongHong KongChina Shenzhen Research Institute The Chinese University of Hong KongShenzhen 518057China Hong Kong Hub of Paediatric Excellence The Chinese University of Hong KongHong KongChina Genetics and Prenatal Diagnosis Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China The Chinese University of Hong Kong-Baylor College of Medicine Joint Center for Medical Genetics Hong KongChina

Apparently balanced chromosomal structural rearrangements are known to cause male infertility and account for approximately 1%of azoospermia or severe ***,the underlying mechanisms of pathogenesis and etiologies are still largely ***,we investigated apparently balanced interchromosomal structural rearrangements in six cases with azoospermia/severe oligospermia to comprehensively identify and delineate cryptic structural rearrangements and the related copy number *** addition,high read-depth genome sequencing(GS)(30-fold)was performed to investigate point mutations causative of male ***-pair GS(4-fold)revealed additional structural rearrangements and/or copy number changes in 5 of 6 cases and detected a total of 48 ***,the breakpoints caused truncations of 30 RefSeq genes,five of which were associated with ***,the breakpoints disrupted 43 topological-associated *** disruptions or potential dysregulations of genes,which play potential roles in male germ cell development,apoptosis,and spermatogenesis,were found in all cases(n=6).In addition,high read-depth GS detected dual molecular findings in case MI6,involving a complex rearrangement and two point mutations in the gene ***,our study provided the molecular characteristics of apparently balanced interchromosomal structural rearrangements in patients with male *** demonstrated the complexity of chromosomal structural rearrangements,potential gene disruptions/dysregulation and single-gene mutations could be the contributing mechanisms underlie male infertility.

关键词： azoospermia balanced structural rearrangements genome sequencing male infertility severe oligospermia

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黄河口国家公园生态保护补偿机制探究

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湿地科学与管理 2024年第2期20卷 89-92,96页

作者：朱梦洵王爽朱岩芳何洪兵吴裕鹏张俊王立东王忠敏中咨集团生态技术研究所(北京)有限公司北京100037 东营市湿地保护中心山东东营257091 黄河口国家公园山东东营257000

为健全黄河口国家公园生态保护补偿机制,探索多元补偿方式及科学合理的补偿标准。通过文献资料搜集、内容分析、关键人物访谈和问卷调研等方法,梳理黄河口国家公园的自然地理概况、资源禀赋特征和社区生产生活等基本情况,分析国家公园... 详细信息

为健全黄河口国家公园生态保护补偿机制,探索多元补偿方式及科学合理的补偿标准。通过文献资料搜集、内容分析、关键人物访谈和问卷调研等方法,梳理黄河口国家公园的自然地理概况、资源禀赋特征和社区生产生活等基本情况,分析国家公园不同利益群体的生态保护补偿需求,并从野生动物补偿、原住民生产居住补偿、横向补偿、市场补偿4个维度提出了补偿方式及补偿标准测算方法,为完善以国家公园为主体的自然保护地生态保护补偿机制提供参考依据。

关键词：生态保护补偿黄河口国家公园生态保护补偿对象生态保护补偿标准

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一种基于MapReduce高效K-means并行算法

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辽宁工程技术大学学报（自然科学版） 2017年第11期36卷 1204-1211页

作者：王永贵崔鹏辽宁工程技术大学软件学院辽宁葫芦岛125105

针对K-means算法对初值选取的依赖,收敛速度慢,聚类精度低,以及对海量数据的处理存在内存瓶颈的问题,提出一种基于MapReduce的高效K-means并行算法.该算法在MapReduce框架基础上,结合K选择排序算法进行并行采样,提高采样效率;采用基于... 详细信息

针对K-means算法对初值选取的依赖,收敛速度慢,聚类精度低,以及对海量数据的处理存在内存瓶颈的问题,提出一种基于MapReduce的高效K-means并行算法.该算法在MapReduce框架基础上,结合K选择排序算法进行并行采样,提高采样效率;采用基于样本预处理策略获取初始中心点;使用权值替换策略对迭代中心进行更新;此外,通过调整Hadoop集群,对算法的运行效率作出进一步提升.实验结果表明,该算法不仅具有良好的收敛性、准确率、加速比,算法性能也得到进一步改善.

关键词： K-means MapReduce Hadoop 并行采样 K选择排序

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卵巢癌的细胞遗传学研究

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国际妇产科学杂志 1984年第5期 278-281页

作者： whang-peng J 戴德林

卵巢癌是美国妇科癌死亡中的主要原因之一。在卵巢癌的细胞遗传学研究中,多数类型为卵巢上皮细胞癌,占卵巢癌的80～90%。自从产生显带技术以来,已证实卵巢癌伴有许多染色体结构变化,其中一些研究发现非特异的染色体标记。然而,Trent和Sa... 详细信息

卵巢癌是美国妇科癌死亡中的主要原因之一。在卵巢癌的细胞遗传学研究中,多数类型为卵巢上皮细胞癌,占卵巢癌的80～90%。自从产生显带技术以来,已证实卵巢癌伴有许多染色体结构变化,其中一些研究发现非特异的染色体标记。然而,Trent和Salmon报导,卵巢癌病人使用琼脂集落系统进行研究,发现一种特异的非随机染色体异常,即6号染色体长臂缺失(6q-)。一年以后,Wake等人报导,在卵巢乳头状浆液腺癌中发现同样的染色体标记,并增加涉及14号染色体的附加特异标记。在1976年至1981年的五年期间,作者研究了72例卵巢癌

关键词：标记染色体病人中值染色体异常标志染色体卵巢癌卵巢恶性肿瘤卵巢肿瘤染色体结构异常染色体结构畸变细胞遗传学

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A cryptic mitochondrial DNA link between North European and West African dogs

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Journal of Genetics and Genomics 2017年第3期44卷 163-170页

作者： Adeniyi C.Adeola Sheila C.Ommeh Jiao-Jiao Song S.Charles Olaogun Oscar J.Sanke Ting-Ting Yin Guo-Dong Wang Shi-Fang Wu Zhong-Yin Zhou jacqueline K.Lichoti Bernard R.Agwanda Philip M.Dawuda Robert W.Murphy Min-Sheng peng Ya-Ping Zhang State Key Laboratory for Conservation and Utilization of Bio-Resources Yunnan University Kunming 650091 China

Domestic dogs have an ancient origin and a long history in Africa. Nevertheless, the timing and sources of their introduction into Africa remain enigmatic. Herein, we analyse variation in mitochondrial DNA（mt DNA） D-loop sequences from 345 Nigerian and 37 Kenyan village dogs plus 1530 published sequences of dogs from other parts of Africa, Europe and West Asia. All Kenyan dogs can be assigned to one of three haplogroups（matrilines; clades）： A, B, and C, while Nigerian dogs can be assigned to one of four haplogroups A, B, C, and D. None of the African dogs exhibits a matrilineal contribution from the African wolf（Canis lupus lupaster）. The genetic signal of a recent demographic expansion is detected in Nigerian dogs from West Africa. The analyses of mitochondrial genomes reveal a maternal genetic link between modern West African and North European dogs indicated by sub-haplogroup D1（but not the entire haplogroup D） coalescing around 12,000 years ago. Incorporating molecular anthropological evidence,we propose that sub-haplogroup D1 in West African dogs could be traced back to the late-glacial dispersals, potentially associated with human hunter-gatherer migration from southwestern Europe.

关键词： Dog Mitochondrial DNA Africa Haplogroup D Late-glacial dispersal Hybridization

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Fourteen Actions and Six Proposals for Science and Technology-Based Disaster Risk Reduction in Asia Second Asian Science and Technology Conference for Disaster Risk Reduction:SciencePolicy Dialogue for Implementation of the Sendai Framework,April 2018

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International Journal of Disaster Risk Science 2018年第2期9卷 275-279页

作者： Peijun Shi Rajib Shaw Ali Ardalan Emily Ying Yang Chan Jamilur Reza Choudhury peng Cui Bojie Fu Guoyi Han Qunli Han Takako Izumi Fumiko Kasuga Antonia Yulo Loyzaga Joy jacqueline PereiraShirish Kumar Ravan David Sanderson Vinod Kumar Sharma Frank Thomalla Sugeng Triutomo Siquan Yang Qian Ye Ming Wang Yaqiao Wu Renhe Zhang Wenjian Zhang Ying Li Saini Yang State Key Laboratory of Earth Surface Processes and Resource Ecology Faculty of Geographical ScienceBeijing Normal UniversityBeijing 100875China Academy of Disaster Reduction and Emergency Management Faculty of Geographical ScienceBeijing Normal UniversityBeijing 100875China Graduate School of Media and Governance Keio UniversityShonan Fujisawa Campus(SFC)FujisawaKanagawa 252-0882Japan Department of Disaster and Emergency Health Tehran University of Medical SciencesTehranIran Faculty of Medicine The Chinese University of Hong KongHong KongChina University of Asia Pacific DhakaBangladesh The Institute of Mountain Hazards and Environment(IMHE) Chinese Academy of SciencesChengduChina Faculty of Geographical Science Beijing Normal UniversityBeijingChina Stockholm Environment Institute StockholmSweden Integrated Research on Disaster Risk BeijingChina International Research Institute of Disaster Science(IRIDeS) Tohoku UniversitySendaiJapan Future Earth TokyoJapan Manila Observatory Quezon CityPhilippines Southeast Asia Disaster Prevention Research Initiative(SEADPRI-UKM) Universiti Kebangsaan MalaysiaBangiMalaysia United Nations Office for Outer Space Affairs(UNOOSA) ViennaAustria The University of New South Wales Sydney SydneyAustralia Disaster Management/Consultant at Indian Institute of Public Administration New DelhiIndia Stockholm Environment Institute BangkokThailand Disaster Risk Reduction Foundation Daerah Khusus IbukotaIndonesia National Disaster Reduction Center of China Ministry of Emergency ManagementBeijingChina Integrated Risk Governance Program Academy of Disaster Reduction and Emergency ManagementFaculty of Geographical ScienceBeijing Normal UniversityBeijingChina Fudan University ShanghaiChina World Meteorological Organization GenevaSwitzerland

1 Introduction The Sendai Framework for Disaster Risk Reduction 2015–2030 shifts the focus from managing disasters to reducing *** a shift requires a better understanding of risk in all its dimensions of environment,... 详细信息

关键词： disaster Actions Reduction governance dimensions managing vulnerability technological innovative urgent

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化学气相沉积TaC涂层的微观形貌及晶粒择优生长

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中国有色金属学报 2008年第8期18卷 1377-1382页

作者：陈招科熊翔李国栋肖鹏张红波王雅雷黄伯云中南大学粉末冶金国家重点实验室长沙410083

利用TaCl5-Ar-C3H6体系，采用X射线衍射技术和扫描电镜研究不同温度下化学气相沉积Tac涂层微观形貌及晶粒择优生长。结果表明：在800～1200℃时，随沉积温度升高，TaC颗粒从网球形逐渐转变为多角形以及金字塔形多面体，而其晶体择优取... 详细信息

利用TaCl5-Ar-C3H6体系，采用X射线衍射技术和扫描电镜研究不同温度下化学气相沉积Tac涂层微观形貌及晶粒择优生长。结果表明：在800～1200℃时，随沉积温度升高，TaC颗粒从网球形逐渐转变为多角形以及金字塔形多面体，而其晶体择优取向依次从无明显择优取向向〈220〉和H〈200〉转变；利用牛长参数α和VAN DER DRIFT,MEAKIN的纳米级晶粒选择生长模型可较好地解释不同形貌的生长机制。当a=3时，薄膜会优先生长成〈200〉择优取向的金字塔品粒；当a=1．5时，则容易生长成〈220〉取向的多角形品粒。

关键词： TaC涂层化学气相沉积择优取向微观形貌

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Genetic Evidence of Middle East Respiratory Syndrome Coronavirus(MERS-Cov) and Widespread Seroprevalence among Camels in Kenya

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Virologica Sinica 2018年第6期33卷 484-492页

作者： Sheila Ommeh Wei Zhang Ali Zohaib Jing Chen Huajun Zhang Ben Hu Xing-Yi Ge Xing-Lou Yang Moses Masika Vincent Obanda Yun Luo Shan Li Cecilia Waruhiu Bei Li Yan Zhu Desterio Ouma Vincent Odendo Lin-Fa Wang Danielle E.Anderson jacqueline Lichoti Erick Mungube Francis Gakuya peng Zhou Kisa-Juma Ngeiywa Bing Yan Bernard Agwanda Zheng-Li Shi Institute for Biotechnology Research Jomo Kenyatta University of Agriculture and TechnologyNairobi 62000-00200Kenya CAS Key Laboratory for Special Pathogens and Biosafety Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China College of Biology Hunan University410006China Department of Medical Microbiology University of NairobiNairobi 30197-00100Kenya Veterinary Services Department Kenya Wildlife ServiceNairobi 40241-00100Kenya Veterinary Research Institute Kenya Agriculture and Livestock Research OrganizationNairobi 57811-00200Kenya Veterinary Services Programme in Emerging Infectious Diseases Duke-NUS Medical SchoolSingapore 169857Singapore Directorate of Veterinary Services State Department of LivestockMinistry of AgricultureLivestock Fisheries and IrrigationNairobi 34188-00100Kenya Kenya Camel Association Nairobi 30095-00100Kenya Department of Zoology National Museums of KenyaNairobi 40658-00100Kenya

We describe the first genome isolation of Middle East respiratory syndrome coronavirus(MERS-CoV) in Kenya. This fatal zoonotic pathogen was first described in the Kingdom of Saudi Arabia in 2012. Epidemiological and molecular evidence revealed zoonotic transmission from camels to humans and between humans. Currently, MERS-CoV is classified by the WHO as having high pandemic potential requiring greater surveillance. Previous studies of MERS-CoV in Kenya mainly focused on site-specific and archived camel and human serum samples for antibodies. We conducted active nationwide cross-sectional surveillance of camels and humans in Kenya, targeting both nasal swabs and plasma samples from 1,163 camels and 486 humans collected from January 2016 to June 2018. A total of 792 camel plasma samples were positive by ELISA. Seroprevalence increased with age, and the highest prevalence was observed in adult camels(82.37%, 95%confidence interval(CI) 79.50–84.91). More female camels were significantly seropositive(74.28%, 95% CI 71.14–77.19)than male camels(P \ 0.001)(53.74%, 95% CI 48.48–58.90). Only 11 camel nasal swabs were positive for MERS-CoV by reverse transcription-quantitative PCR. Phylogenetic analysis of whole genome sequences showed that Kenyan MERSCoV clustered within sub-clade C2, which is associated with the African clade, but did not contain signature deletions of orf4 b in African viruses. None of the human plasma screened contained neutralizing antibodies against MERS-CoV. This study confirms the geographically widespread occurrence of MERS-CoV in Kenyan camels. Further one-health surveillance approaches in camels, wildlife, and human populations are needed.

关键词： Middle East respiratory syndrome coronavirus(MERS-CoV) One-health Public health Zoonosis Kenya

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