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American Journal of Plant Sciences 2023年第6期14卷 677-690页

作者： balma Patrice Kabore boukare Kiebre Mariam Kiebre Zakaria Sanou jacob bationo/Kando Pauline Laboratoire biosciences Unité de Formation et de Recherche en Sciences de la Vie et de la Terre Université Joseph KI-ZERBO Ouagadougou Burkina Faso Institut de l’Environnement et de Recherches Agricoles/Farako-bñ (INERA/Farako-B&#241) Bobo Dioulasso Burkina Faso

Considered as the oldest cereal, fonio (Digitaria exilis Stapf.) is grown in West Africa for its therapeutic virtues, its nutritional and organoleptic qualities. It plays an important socio-cultural and economic role for the populations of western burkina Faso. However, very few studies on the genetic diversity of fonio have been carried out. This study aims to contribute to a better knowledge of the diversity of Digitaria exilis in burkina Faso using agro-morphological descriptors. Thus, 60 accessions of fonio collected from western burkina Faso were characterized using 21 agro-morphological characters according to an Alpha Latice design with three replications. The study showed morphological variability for most of the qualitative and quantitative characters studied. Principal component analysis (PCA) explained 56.07% of the variability. Hierarchical cluster analysis splits the accessions of the collection into four clusters using seven characters. These characters can constitute basic criteria for differentiating fonio accessions in burkina Faso. The accessions of Group II have a long cycle and high production of grain, while the accessions of Group IV have a short cycle and low production of grain. The groups identified can serve as a starting point for fonio breeding in burkina Faso.

关键词： Digitaria exilis Agro-Morphological Variability Accession burkina Faso

Effects of resveratrol in experimental and clinical non-alcoholic fatty liver disease

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World Journal of Hepatology 2014年第4期6卷 188-198页

作者： Sara Heebll Karen Louise Thomsen Steen b Pedersen Hendrik Vilstrup jacob George Henning Grnbk Department of Hepatology and Gastroenterology Aarhus University Hospital Department of Endocrinology Aarhus University Hospital Storr Liver Unit Westmead Millennium InstituteWestmead Hospital and University of Sydney

The prevalence of obesity and related conditions like non-alcoholic fatty liver disease(NAFLD) is increasing worldwide and therapeutic options are *** treatment options are therefore intensively sought *** interesting candidate is the natural polyphenol resveratrol(RSV) that activates adenosinmonophosphate-activated protein kinase(AMPK) and silent information regulation-2 homolog 1(SIRT1).In addition,RSV has known anti-oxidant and anti-inflammatory ***,we review the current evidence for RSVmediated effects on NAFLD and address the different aspects of NAFLD and non-alcoholic steatohepatitis(NASH) pathogenesis with respect to free fatty acid(FFA) flux from adipose tissue,hepatic de novo lipogenesis,inadequate FFA β-oxidation and additional intra- and extrahepatic inflammatory and oxidant *** review the in vivo evidence from animal studies and clinical *** abundance of animal studies reports a decrease in hepatic triglyceride accumulation,liver weight and a general improvement in histological fatty liver changes,along with a reduction in circulating insulin,glucose and lipid *** studies document AMPK or SIRT1 activation,and modulation of relevant markers of hepatic lipogenesis,inflammation and oxidation ***,AMPK/SIRT1-independent actions are also *** trials are scarce and have primarily been performed with a focus on overweight/obese participants without a focus on NAFLD/NASH and histological liver *** clinical studies with appropriate design are needed to clarify the true impact of RSV treatment in NAFLD/NASH patients.

关键词： Non-alcoholic fatty liver disease Nonalcoholic steatohepatitis Steatosis Resveratrol AMPactivated protein kinase Silent information regulation-2 homolog 1 Anti-oxidants Anti-inflammatory agents Animal studies Clinical trial

MyCTC chip:microfluidic-based drug screen with patient-derived tumour cells from liquid biopsies

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Microsystems & Nanoengineering 2022年第6期8卷 125-135页

作者： Fabienne D.Schwab Manuel C.Scheidmann Lauren L.Ozimski AndréKling Lucas Armbrecht Till Ryser Ilona Krol Karin Strittmatter bich Doan Nguyen-Sträuli Francis jacob AndréFedier Viola Heinzelmann-Schwarz Andreas Wicki Petra S.Dittrich Nicola Aceto Department of biomedicine Cancer Metastasis LaboratoryUniversity of BaselBaselSwitzerland Department of Gynaecologic Oncology University Hospital BaselBaselSwitzerland Department of biology Swiss Federal Institute of Technology Zurich(ETH Zurich)ZurichSwitzerland Department of biosystems Science and Engineering Swiss Federal Institute of Technology Zurich(ETH Zurich)BaselSwitzerland Department of Gynaecology University Hospital Zurich and University of ZurichZurichSwitzerland Department of biomedicine Ovarian Cancer ResearchUniversity Hospital Basel and University of BaselBaselSwitzerland University of Zurich and University Hospital Zurich ZurichSwitzerland

Cancer patients with advanced disease are characterized by intrinsic challenges in predicting drug response patterns,often leading to ineffective *** clinical practice for treatment decision-making is commonly based on primary or secondary tumour biopsies,yet when disease progression accelerates,tissue biopsies are not performed on a regular *** is in this context that liquid biopsies may offer a unique window to uncover key vulnerabilities,providing valuable information about previously underappreciated treatment ***,we present MyCTC chip,a novel microfluidic device enabling the isolation,culture and drug susceptibility testing of cancer cells derived from liquid *** cell capture is achieved through a label-free,antigen-agnostic enrichment method,and it is followed by cultivation in dedicated conditions,allowing on-chip expansion of captured *** growth,cancer cells are then transferred to drug screen chambers located within the same device,where multiple compounds can be tested *** demonstrate MyCTC chip performance by means of spike-in experiments with patientderived breast circulating tumour cells,enabling>95%capture rates,as well as prospective processing of blood from breast cancer patients and ascites fluid from patients with ovarian,tubal and endometrial cancer,where sensitivity to specific chemotherapeutic agents was ***,we provide evidence that MyCTC chip may be used to identify personalized drug response patterns in patients with advanced metastatic disease and with limited treatment opportunities.

关键词： fluid transferred Together

Novel data-driven subtypes and stages of brain atrophy in the ALS-FTD spectrum

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Translational Neurodegeneration 2023年第1期12卷 50-69页

作者： Ting Shen jacob W.Vogel Jeffrey Duda Jeffrey S.Phillips Philip ACook James Gee Lauren Elman Colin Quinn Defne A.Amado Michael baer Lauren Massimo Murray Grossman David J.Irwin Corey T.McMillan Penn Frontotemporal Degeneration Center Department of NeurologyPerelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Department of Clinical Sciences SciLifeLabLund University22242 LundSweden Penn Image Computing and Science Lab(PICSL) Department of RadiologyPerelman School of MedicineUniversity of Penn-sylvaniaPhiladelphiaPA 19104USA Department of Neurology Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Digital Neuropathology Laboratory Department of NeurologyPerelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA.

background TDP-43 proteinopathies represent a spectrum of neurological disorders,anchored clinically on either end by amyotrophic lateral sclerosis(ALS)and frontotemporal degeneration(FTD).The ALS-FTD spectrum exhibits a diverse range of clinical presentations with overlapping phenotypes,highlighting its *** study was aimed to use disease progression modeling to identify novel data-driven spatial and temporal subtypes of brain atrophy and its progression in the ALS-FTD *** We used a data-driven procedure to identify 13 anatomic clusters of brain volume for 57 behavioral variant FTD(bvFTD;with either autopsy-confirmed TDP-43 or TDP-43 proteinopathy-associated genetic variants),103 ALS,and 47 ALS-FTD patients with likely TDP-43.A Subtype and Stage Inference(SuStaIn)model was trained to identify subtypes of individuals along the ALS-FTD spectrum with distinct brain atrophy patterns,and we related subtypes and stages to clinical,genetic,and neuropathological features of *** SuStaIn identified three novel subtypes:two disease subtypes with predominant brain atrophy in either prefrontal/somatomotor regions or limbic-related regions,and a normal-appearing group without obvious brain *** limbic-predominant subtype tended to present with more impaired cognition,higher frequencies of pathogenic variants in TbK1 and TARDbP genes,and a higher proportion of TDP-43 types b,E and *** contrast,the prefrontal/somatomotor-predominant subtype had higher frequencies of pathogenic variants in C9orf72 and GRN genes and higher proportion of TDP-43 type *** normal-appearing brain group showed higher frequency of ALS relative to ALS-FTD and bvFTD patients,higher cognitive capacity,higher proportion of lower motor neuron onset,milder motor symptoms,and lower frequencies of genetic pathogenic *** overall SuStaIn stages also correlated with evidence for clinical progression including longer disease duration,higher King’s stage,and cog

关键词： Amyotrophic lateral sclerosis Frontotemporal degeneration Disease heterogeneity SuStaIn model

Helicobacter pylori : Friend or foe?

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World Journal of Gastroenterology 2014年第27期20卷 8979-8985页

作者： Stephen David Howard Malnick Ehud Melzer Malka Attali Gabriel Duek jacob Yahav Department of Internal Medicine C Kaplan Medical Center Gastroenterology Institute Kaplan Medical Center Department of Internal Medicine b Kaplan Medical Center Kaplan Medical Center Affiliated to the Hebrew University

Helicobacter pylori(H. pylori) is a Gram-negative spiral bacterium that is present in nearly half the world's population. It is the major cause of peptic ulcer disease and a recognized cause of gastric carcinoma. In addition, it is linked to non-ulcer dyspepsia, vitamin b12 deficiency, iron-deficient anemia and immune thrombocytopenic purpura. These conditions are indications for testing and treatment according to current guidelines. An additional indication according to the guidelines is "anyone with a fear of gastric cancer" which results in nearly every infected person being eligible for eradication treatment. There may be beneficial effects of H. pylori in humans, including protection from gastroesophageal reflux disease and esophageal adenocarcinoma. In addition, universal treatment will be extremely expensive(more than $32 billion in the United States), may expose the patients to adverse effects such as anaphylaxis and Clostridium difficile infection, as well as contributing to antibiotic resistance. There may also be an as yet uncertain effect on the fecal microbiome. There is a need for robust clinical data to assist in decision-making regarding treatment of H. pylori infection.

关键词： Helicobacter pylori Treatment Cost benefit Cancer

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北卡州图书馆

设计 2013年第10期26卷 52-53页

作者： jacob Snohetta

亨特图书馆是美国北卡罗莱纳州立大学的第二个图书馆，也是学校的核心建筑，图书馆的名字以北卡罗菜纳州前州长詹姆斯·b·亨特的名字命名。建筑充分采用了各种交互系统和智能借还书装置。交互式高清屏幕为用户提供各种实时数据i游戏试... 详细信息

亨特图书馆是美国北卡罗莱纳州立大学的第二个图书馆，也是学校的核心建筑，图书馆的名字以北卡罗菜纳州前州长詹姆斯·b·亨特的名字命名。建筑充分采用了各种交互系统和智能借还书装置。交互式高清屏幕为用户提供各种实时数据i游戏试验区能玩视频游戏和对其进行开发，为学生提供了一个有趣的学习休息区；高科技展柜可以让用户使用最新的电子设备尝试最新的技术。办公区集中在一层而非分散在每一层。图书馆还使用了自动化图书配送体系。这个系统高效存储了200万实体藏书，节省了超过2万平方米的面积，节约出更多的空间用以技术研究和用作学习空间。建筑外表皮铝合金结构的低温玻璃熔块在保证图书馆充足视线和自然光的同时，有效地降低了热量。

关键词：图书馆学习空间交互系统视频游戏铝合金结构州立大学实时数据电子设备

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冰雪之屋

设计 2014年第8期27卷 51-52页

作者： jacob Rafael Pinho

提起冰岛，人们的印象总是冰天雪地与白雪皑皑，在这个冰与火交融的国度里，人们住宅的设计也受到了环境的影响。这栋位于冰岛的别墅采用了大量纯白的设计，就像是用冰雪堆砌而成。

关键词：冰雪冰岛设计

纳米压印光刻技术——下一代批量生产的光刻技术(英文)

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电子工业专用设备 2004年第7期33卷 3-9页

作者： R.Pelzer P.Lindner T.Glinsner b.Vratzov C.Gourgon S.landis P.Kettner C.Schaefer EV Group DI Erich Thallner Strasse 1 A-4780 SchaerdingEV Group DI Erich Thallner Strasse 1 A-4780 SchaerdingEV Group DI Erich Thallner Strasse 1 A-4780 SchaerdingAMICA AMO GmbH Huysensweg 25 D-52074 AachenLaboratoire des Technologies de la Microelectronique-CNRS 17 R. des MartyrsF-38054 Grenoble CedexCEA-LETI17 R.des Martyrs F-38054 Grenoble CedexEV Group DI Erich Thallner Strasse 1 A-4780 SchaerdingEV Group DI Erich Thallner Strasse 1 A-4780 Schaerding

纳米压印光刻技术已被证实是纳米尺寸大面积结构复制的最有前途的下一代技术之一。这种速度快、成本低的方法成为生物化学、μ级流化学、μ-TAS和通信器件制造以及纳米尺寸范围内广泛应用的一种日渐重要的方法,如生物医学、纳米流体学... 详细信息

纳米压印光刻技术已被证实是纳米尺寸大面积结构复制的最有前途的下一代技术之一。这种速度快、成本低的方法成为生物化学、μ级流化学、μ-TAS和通信器件制造以及纳米尺寸范围内广泛应用的一种日渐重要的方法,如生物医学、纳米流体学、纳米光学应用、数据存储等领域。由于标准光刻系统的波长限制、巨大的开发工作量、以及高昂的工艺和设备成本,纳米压印光刻技术可能成为主流IC产业中一种真正富有竞争性方法。对细小到亚10nm范围内的极小复制结构,纳米压印技术没有物理极限。从几种纳米压印光刻技术中选择两种前景广阔的方法——热压印光刻(HEL)和紫外压印光刻(UV-NIL)技术给予介绍。两种技术对各种各样的材料以及全部作图的衬底大批量生产提供了快速印制。重点介绍了HEL和UV-NIL两种技术的结果。全片压印尺寸达200mm直径,图形分辨力高,拓展到纳米尺寸范围。

关键词：纳米压印技术热压印紫外压印电铸光刻

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唯一不变就是改变

设计 2013年第10期26卷 128-135页

作者： Emma jacob Jensen Design

可能是起居室中的那套b＆O音响，可能是一个GAGGENAU炉子，或是厨房里的一个玛格丽特皇家搅拌碗，一个天气预报站，一台NILFSK吸尘器，一部电话，又或是工场中的JOJO电缆盘，你坐着的LAbOFA办公椅，你腕上的手表，你刚经过的风车…从195... 详细信息

可能是起居室中的那套b＆O音响，可能是一个GAGGENAU炉子，或是厨房里的一个玛格丽特皇家搅拌碗，一个天气预报站，一台NILFSK吸尘器，一部电话，又或是工场中的JOJO电缆盘，你坐着的LAbOFA办公椅，你腕上的手表，你刚经过的风车…从1950年代创立以来，雅各布·延森工作室已经设计出品了700余件产品，雅各布·延森则可能是丹麦设计中最具代表性的设计师。

关键词：天气预报经设计起居室吸尘器电缆盘办公椅工作室设计师

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肌肉减少症:早期预防还是过度诊断?

英国医学杂志中文版 2022年第5期25卷 250-255页

作者： Christoffer bjerre Haase John brandt brodersen jacob bülow 汪奕名(译) 宋奇繁(译) Centre of General Practice Department of Public HealthUniversity of CopenhagenDenmark Primary Health Care Research Unit Region ZealandDenmark Institute of Sports Medicine Bispebjerg HospitalCopenhagenDenmark 重庆医药高等专科学校

临床定义:肌肉减少症是指由衰老引起的骨骼肌体量流失和功能下降,与发病率和死亡率的升高相关。随着人口老龄化进程加深,人们对该疾病的现状和治疗方案的研究热度也有所增加。诊断演进:肌肉减少症于1989年首次被描述为随着年龄增长,人... 详细信息

临床定义:肌肉减少症是指由衰老引起的骨骼肌体量流失和功能下降,与发病率和死亡率的升高相关。随着人口老龄化进程加深,人们对该疾病的现状和治疗方案的研究热度也有所增加。诊断演进:肌肉减少症于1989年首次被描述为随着年龄增长,人们会出现消瘦、体重减少的现象。直到1997年,肌肉减少症才被当做一种疾病得以提出。2010—2014年,6个共识性定义将该疾病的诊断重点转移到了肌肉功能的评估上。2016年,肌肉减少症被分配指定代码M62.84,列入国际疾病分类名录(ICD-10-CM)。诊断依据:研究肌肉减少症的专家小组认为,将该疾病编入ICD-10诊断代码或许可以提高人们对该疾病的识别和认知,进而吸引资助者和赞助商提供更多的研究资源,为该疾病的治疗方案研发提供支持。有效尝试:早发现、早治疗可以降低肌肉减少症的发病率和死亡率,提高患者的生活质量。流行状况:肌肉减少症在60~70岁人群中的患病率估计为5%~13%,80岁以上人群的患病率为11%~50%。到2050年,肌肉减少症的全球患病人数可能会多达20亿。过度诊断的依据:最近关于肌肉减少症筛查和诊断的研究还没有涉及对该疾病过度诊断风险评估的内容。就目前来看,对该疾病的过度诊断是很难避免的,因为目前对该疾病的治疗效果与对患者进行健康相关行为指导的效果没有差异。过度诊断的危害:目前尚无关于肌肉减少症过度诊断危害的调查研究,但有间接证据表明,给人们贴上疾病的标签,提示他们发病和死亡风险提升,会给人们带来心理负担。证据的局限性:对肌肉减少症的诊断尚未显示出改善疾病预后的作用。目前还没有证据表明,治疗肌肉减少症的效果会优于体育锻炼和饮食调节等常规医学建议。此外,基于性别和区域差异的诊断临界值确定是随意且未经验证的。诊断结果无法将病理性肌肉损失与年龄增长导致的正常肌肉萎缩加以区分。

关键词：肌肉减少症国际疾病分类过度诊断专家小组肌肉功能间接证据健康相关行为死亡风险