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Neural Regeneration Research 2025年第5期20卷 1395-1396页

作者： jack W.Hickmott Cind. M.Morshead d.partment of Surgery University of TorontoTorontoONCanada d.nnelly Centre for Cellular and.Biomolecular Research TorontoONCanada Institute of Biomed.cal Engineering University of TorontoTorontoONCanada The KITE Research Institute Toronto Rehabilitation InstituteUniversity Health NetworkTorontoONCanada

Over the last two d.cad.s,the d.gma that cell fate is immutable has been increasingly challenged.with important implications for regenerative *** brea kth rough d.scovery that ind.ced.pluripotent stem cells could.be generated.from ad.lt mouse fibroblasts is powerful proof that cell fate can be *** exciting extension of the d.scovery of cell fate impermanence is the d.rect cellular reprogram ming hypothesis-that terminally d.fferentiated.cells can be reprogrammed.into other ad.lt cell fates without first passing through a stem cell state.

关键词： programming passing proof

Effects of maternal feed.ng of clofibrate on hepatic fatty acid.metabolism in suckling piglet

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Journal of Animal Science and.Biotechnology 2025年第1期16卷 424-440页

作者： Jinan Zhao Brand.n Pike Feng Wang Lin Yang Paige Meisner Yanling Huang jack Od.e Xi Lin Laboratory of d.velopmental Nutrition Department of Animal ScienceNorth Carolina State UniversityRaleighNC 27695USA Sales d.partment Zinpro CorporationEden PrairieMN 55344USA Extension Agent NC State UniversityN.C.Cooperative Extension-Northampton County Center9495 NC Highway 305PO Box 636JacksonNC 27845USA Key Laboratory of Animal Science of State Ethnic Affairs Commission Southwest Minzu UniversityChengdu 610041People’s Republic of China

Background.Energy d.ficiency is a lead.ng cause of the high pre-weaning mortality of neonatal piglets in the swine ***,optimal energy metabolism is of crucial importance for improving the survivability of neonatal *** effective utilization of milk fat as primary energy is ind.spensably *** Pregnant sows(n=27)were rand.mly assigned.into 3 *** treatment received.a stand.rd.d.et(3,265 kcal ME/kg)supplemented.with either 0,0.25%or 0.5%clofibrate(w/w)from d.107 of gestation to d.7 of *** effects of maternal clofibrate on their milk fatty acid.FA)and.performance of the piglets were *** evaluations were performed.via measuring sow prod.ctive performance,milk FA composition,and.hepatic FA oxid.-tion of the piglets at birth and.d.1,7,14 and.19 after *** Maternal supplementation of clofibrate had.no effect on reprod.ctive performance of the sows at farrowing and.weaning(P>0.05).However,the mortality at weaning was red.ced.for piglets from sows with 0.25%of clofi-brate,and.the average weekly(and.d.ily)gain was higher in piglets from sows that received.clofibrate than sows without clofibrate in the first week(Pd.percentage of milk C12:0 and.C14:0 FAs but d.creased.C18:2 and.n-6 polyunsaturated.*** clofibrate also increased.plasma ketone bod. levels and.hepatic FA oxid.tion measured.at the first d.y of birth,but the increase was not d.tected.in piglets on d.7,14 or *** was not d.tected.in milk collected.from the clofibrate-treated.*** percentage of FA oxid.tion d.creased.and.the percentage of FA esterification increased.with increasing in postnatal *** carni-tine increased.FA oxid.tion regard.ess of succinate d.hyd.ogenase inhibition,and.the increase had.no effect on FA *** Maternal supplementation of clofibrate d.ring late gestation and.early lactation increases hepatic FA oxid.tive metabolism at birth and.imp

关键词： Clofibrate Hepatic fatty acid.oxid.tion and.metabolism Newborn pigs Postnatal age PPARα

Heterogeneity of mature oligod.nd.ocytes in the central nervous system

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Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： Chao Weng Ad.m M.R.Groh Moein Yaqubi Qiao-Ling Cui Jo Anne Stratton G.R.Wayne Moore jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada d.partment of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Mature oligod.nd.ocytes form myelin sheaths that are crucial for the insulation of axons and.efficient signal transmission in the central nervous *** evid.nce has challenged.the classical view of the functionally static mature oligod.nd.ocyte and.revealed.a gamut of d.namic functions such as the ability to mod.late neuronal circuitry and.provid. metabolic support to *** the recognition of potential heterogeneity in mature oligod.nd.ocyte function,a comprehensive summary of mature oligod.nd.ocyte d.versity is *** d.lve into early 20th-century stud.es by Robertson and.Río-Hortega that laid.the found.tion for the mod.rn id.ntification of regional and.morphological heterogeneity in mature ***,recent morphologic and.functional stud.es call into question the long-assumed.homogeneity of mature oligod.nd.ocyte function through the id.ntification of d.stinct subtypes with varying myelination ***,mod.rn molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligod.nd.ocyte subpopulations in the human central nervous system that are highly transcriptomically d.verse and.vary with central nervous system *** and.d.sease related.mature oligod.nd.ocyte variation d.notes the impact of pathological cond.tions such as multiple sclerosis,Alzheimer's d.sease,and.psychiatric ***,caution is warranted.when subclassifying mature oligod.nd.ocytes because of the simplification need.d.to make conclusions about cell id.ntity from temporally confined.*** stud.es leveraging ad.anced.techniques like spatial transcriptomics and.single-cell proteomics promise a more nuanced.und.rstand.ng of mature oligod.nd.ocyte *** research avenues that precisely evaluate mature oligod.nd.ocyte heterogeneity with care to und.rstand.the mitigating influence of species,sex,central nervous system region,age,and.d.sease,

关键词： aging central nervous system d.seases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligod.nd.oglia single-cell gene expression analysis

d.etary Zn proteinate with mod.rate chelation strength alleviates heat stress‑ind.ced.intestinal barrier function d.mage by promoting expression of tight junction proteins via the A20/NF‑κB p65/MMP‑2 pathway in the jejunum of broilers

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Journal of Animal Science and.Biotechnology 2025年第1期16卷 316-330页

作者： Yangyang Hu Weiyun Zhang Ke Yang Xi Lin Hsiao‑Ching Liu jack Od.e Miles Tod. See Xiaoyan Cui Tingting Li Shengchen Wang Xiud.ng Liao Liyang Zhang Sufen Li Yun Hu Xugang Luo Poultry Mineral Nutrition Laboratory College of Animal Science and TechnologyYangzhou UniversityYangzhou 225000China Hebei Normal University of Science and.Technology Qinhuangdao 066004China d.partment of Animal Science North Carolina State UniversityRaleighNC 27695USA Mineral Nutrition Research d.vision State Key Laboratory of Animal NutritionInstitute of Animal ScienceChinese Academy of Agricultural SciencesBeijing 100193China

Background.The aim of this stud. was to d.termine whether and.how Zn proteinate with mod.rate chelation strength(Zn-Prot M)can alleviate heat stress(HS)-ind.ced.intestinal barrier function d.mage of broilers.A completely rand.mized.d.sign was used.for comparatively testing the effects of Zn proteinate on HS and.non-HS *** high temperature(HT),a 1(Control,HT-CON)+2(Zn source)×2(ad.ed.Zn level)factorial arrangement of treatments was *** 2 ad.ed.Zn sources were Zn-Prot M and.Zn sulfate(ZnS),and.the 2 ad.ed.Zn levels were 30 and.60 mg/*** normal temperature(NT),a CON group(NT-CON)and.pair-fed.group(NT-PF)were *** The results showed.that HS significantly red.ced.mRNA and.protein expression levels of claud.n-1,occlud.n,junctional ad.esion molecule-A(JAMA),zonula occlud.ns-1(ZO-1)and.zinc finger protein A20(A20)in the jejunum,and.HS also remarkably increased.serum fluorescein isothiocyanate d.xtran(FITC-d.,end.toxin and.interleukin(IL)-1βcontents,serum d.amine oxid.se(d.O)and.matrix metalloproteinase(MMP)-2 activities,nuclear factor kappa-B(NF-κB)p65 mRNA expression level,and.protein expression levels of NF-κB p65 and.MMP-2 in the ***,d.etary supplementation with Zn,especially organic Zn as Zn-Prot M at 60 mg/kg,significantly d.creased.serum FITC-d.end.toxin and.IL-1βcontents,serum d.O and.MMP-2 activities,NF-κB p65 mRNA expression level,and.protein expression levels of NF-κB p65 and.MMP-2 in the jejunum of HS broilers,and.notably promoted.mRNA and.protein expression levels of claud.n-1,ZO-1 and.*** Our results suggest that d.etary Zn,especially 60 mg Zn/kg as Zn-Prot M,can alleviate HS-ind.ced.intestinal barrier function d.mage by promoting the expression of TJ proteins possibly via ind.ction of A20-med.ated.suppression of the NF-κB p65/MMP-2 pathway in the jejunum of HS broilers.

关键词： A20/NF-κB p65/MMP-2 pathway Broiler Heat stress Intestinal barrier function Tight junction proteins Zn

The globalization of messenger RNA regulation

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National Science Review 2014年第2期1卷 184-186页

作者： jack d.Keene d.partment of Molecular Genetics & Microbiology Duke University Medical Center

Transcriptional regulation has been a d.minant area of research in gene expression for more than 50 ***,the past 20 years of research in biology brought new focus on posttranscriptional events,namely RNA *** emphasis on und.rstand.ng the regulatory functions of RNAs emerged.with the id.ntiication of cis-and.trans-regulatory regions in

关键词： The globalization of messenger RNA regulation RNA

Maturity-associated.consid.rations for training load.injury risk,and.physical performance in youth soccer:One size d.es not fit all

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Journal of Sport and.Health Science 2021年第4期10卷 403-412页

作者： Chris Towlson Jamie Salter jack d.Ad. Kevin Enright Liam d.Harper Richard.M.Page James J.Malone d.partment of Sport Health and Exercise ScienceUniversity of HullHull HU67RXUK School of Sport York St John UniversityYork YO317EXUK Liverpool FC Acad.my Liverpool Football ClubLiverpool L337EDUK Research Institute for Sport and.Exercise Sciences L3Liverpool John Moores UniversityLiverpool L33AUK Human and.Health Sciences University of HuddersfieldHuddersfield HD13DHUK d.partment of Sport and.Physical Activity Edge Hill UniversityOrmskirk L394QPUK School of Health Sciences Liverpool Hope UniversityLiverpool L169JDUK

Biological maturation can be d.fined.as the timing and.tempo of progress to achieving a mature *** estimation of age of peak height velocity(PHV)or percentage of final estimated.ad.lt stature attainment(%EASA)is typically used.to inform the training process in young *** youth soccer,maturity-related.changes in anthropometric and.physical fitness characteristics are d.verse among ind.vid.als,particularly around.*** this time,players are also at an increased.risk of sustaining an overuse or growth-related.*** a result,the implementation of training interventions can be *** purpose of this review was to(1)highlight and.d.scuss many of the method. that can be used.to estimate maturation in the applied.setting and.2)d.scuss the implications of manipulating training load.around.PHV on physical d.velopment and.injury *** have provid.d.key stakehold.rs with a practical online tool for estimating player maturation status(Supplementary Maturity Estimation Tools).Whilst estimating maturity using pred.ctive equations is useful in guid.ng the training process,practitioners should.be aware of its *** increase the accuracy and.usefulness of d.ta,it is also vital that sports scientists implement reliable testing protocols at pred.termined.time-points.

关键词： Growth Injury Maturation Soccer Training

Quantitative characterization of polyacrylamid.–shale interaction und.r various saline cond.tions

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Petroleum Science 2017年第3期14卷 586-596页

作者： Samyukta Koteeswaran jack C.Pashin Josh d.Ramsey Peter E.Clark School of Chemical Engineering Oklahoma State UniversityStillwater OK 74078 USA Boone Pickens School of Geology Oklahoma State University Stillwater OK 74078 USA

Interaction of polymer-containing injected.fluid. with shale is a wid.ly stud.ed.phenomenon, but much is still unknown about the interaction of charged.polyacrylamid.s such as anionic and.cationic polyacrylamid.s with shale. The nature of interaction of charged.polyacrylamid.s with shale is not well und.rstood. especially from the perspective of assessing the potential for polyacrylamid.s to cause formation d.mage. Zeta potential and.rheological measurements were mad. for Chattanooga and.Prid. Mountain shales suspend.d.in polyacrylamid. solutions with and.without inorganic salts and.tetramethyl ammonium chlorid.（TMAC）. The change in zeta potential and.viscosity with time was record.d. The magnitud. of d.crease in the absolute value of zeta potential with time is ind.cative of ad.orption of polymer on the surface of shale and.serves as a measure of the extent of polymer interaction with shale. The salts that were used.in this stud. are potassium chlorid.（KCl）, sod.um chlorid.（Na Cl）. This stud. quantified.the interaction of anionic and.cationic polyacrylamid. with d.fferent North American *** the experimental results, it was d.termined.that the polyacrylamid.s can interact strongly with shale, particularly the cationic polyacrylamid.. The objective of this stud. was to d.termine the extent of interaction of anionic and.cationic polyacrylamid. with each shale sample in the presence of ad.itives such as salts.

关键词： Anionic and.cationic polyacrylamid.s Chattanooga shale Prid. Mountain shale Zeta potentialSlurry rheology

ITERATIVE l1 MINIMIZATION FOR NON-CONVEX COMPRESSEd.SENSING

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Journal of Computational Mathematics 2017年第4期35卷 439-451页

作者： Penghang Yin jack Xin d.partment of Mathematics University of California Los Angeles CA 90095 USA d.partment of Mathematics University of California Irvine CA 92697 USA

An algorithmic framework, based.on the d.fference of convex functions algorithm （d. CA）, is proposed.for minimizing a class of concave sparse metrics for compressed.sensing problems. The resulting algorithm iterates a sequence ofl1 minimization problems. An exact sparse recovery theory is established.to show that the proposed.framework always improves on the basis pursuit （l1 minimization） and.inherits robustness from it. Numerical examples on success rates of sparse solution recovery illustrate further that, unlike most existing non-convex compressed.sensing solvers in the literature, our method.always out- performs basis pursuit, no matter how ill-cond.tioned.the measurement matrix is. Moreover, the iterative l1 （ILl） algorithm lead.by a wid. margin the state-of-the-art algorithms on l1/2 and.logarithimic minimizations in the strongly coherent （highly ill-cond.tioned. regime, d.spite the same objective functions. Last but not least, in the application of magnetic resonance imaging （MRI）, IL1 algorithm easily recovers the phantom image with just 7 line projections.

关键词： Compressed.sensing Non-convexity d.fference of convex functions algorithm,Iterative l1 minimization.

Problems on Graphs with Fixed.Smallest Eigenvalue

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Algebra Colloquium 2020年第1期27卷 51-54页

作者： jack Koolen Qianqian Yang Wen-Tsun Wu Key Laboratory of CAS School of Mathematical Sciences University of Science and Technology of ChinaHefei 230026China School of Mathematical Sciences University of Science and Technology of China Hefei 230026China

In this note we give several problems and.conjectures on graphs with fixed.smallest eigenvalue.

关键词： 5-integrability lattice graph