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“机械灌注+”应用于扩大标准供肝移植--肝尽其用

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Engineering 2024年第1期32卷 29-40页

作者： Zhoucheng Wang jack Martin Jiongjie Yu Kai Wang Kourosh Saeb-Parsy Xiao Xu Zhejiang University School of Medicine Hangzhou 310058China Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Hangzhou 310006China Department of Surgery Cambridge University Hospitals&NHS Foundation TrustCambridge CB22QQ UK Department of Surgery University of Cambridge&NIHR Cambridge Biomedical Research CentreCambridge CB22QQUK Institute of Organ Transplantation Zhejiang UniversityHangzhou 310003China

Transplantation represents the most effective treatment for end-stage liver diseases but is limited by the shortage of healthy donor *** criteria donor(EcD)liver grafts are increasingly utilized in clinical practice to mitigate this ***,impaired ischemic tolerance of these grafts jeopardizes organ viability during cold *** perfusion(MP)was designed to improve organ preservation and reduce posttransplant ***,it is increasingly evident that MP alone may not preserve EcD grafts *** emphasis has thus been placed on modified MP strategies,including the use of different perfusates,modified perfusion modalities,and different therapeutic ***,we introduce a novel term,"MP Plus,"denoting these additional strategies that are designed to restore organ function and potentially enable regeneration of EcD *** this review,we summarize the existing and potential modified MP strategies and discuss their advantages in reconditioning different EcD grafts in clinical settings.

关键词： Liver transplantation Extended criteria donor Machine perfusion plus Organ shortage

Application of the Shrinking Particle Model for the Evaluation of Molecular Recyclability of PET versus Semi-Aromatic Polyesters

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Open Journal of Physical chemistry 2024年第2期14卷 21-35页

作者： jack van Schijndel Sanne de Krom Dennis Molendijk Koen van Beurden Amarante Böttger Research Group Biopolymers/Green chemistry Centre of Expertise Safe & Resilient Society Avans University of Applied Science Breda Netherlands New Materials and Their Applications Centre of Expertise Safe & Resilient Society Avans University of Applied Science Breda Netherlands Department of Materials Science and Engineering Delft University of Technology Delft Netherlands

The molecular recyclability of poly (ethylene terephthalate) (PET) and three semi-aromatic polyesters poly (phloretic acid) (poly-H), poly (dihydroferulic acid) (poly-G), and poly (dihydrosinapinic acid) (poly-S) is evaluated in this study. PET is an extensively used aromatic polyester, and poly-H, poly-G, and poly-S can be considered semi-aromatic poly (lactic acid) modifications. All these polyesters have been depolymerized at neutral pH and by acid- and base-catalyzed hydrolysis at two temperatures, i.e., 50˚c and 80˚c. Base-catalyzed depolymerization of virgin PET leads to an isolated yield of 38% after 48 hours of reaction at 80˚c. contrary to these results for PET, almost all the monomers of the semi-aromatic polyesters poly-H, poly-G, and poly-S are recovered with isolated yields larger than 90% at the same temperature after 15 minutes in a facile manner. A shrinking particle model used to determine the global kinetics of the base-catalyzed depolymerization showed that the rate rises with increasing temperature. Using the shrinking particle model, the intrinsic reaction rate constants were determined. It has been demonstrated that the rate coefficients of the depolymerization of the semi-aromatic polyesters poly-H, poly-G, and poly-S are between 2 and 3 orders of magnitude higher than those for PET.

关键词： Depolymerization Molecular Recycling Poly-H Poly-G Poly-S PET circular Polymers

Pleckstrin Homology-Like Domain, Family A, Member 1 (PHLDA1): A Multifaceted cell Survival Factor that Drives Metabolic Disease

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Engineering 2023年第1期20卷 9-18页

作者： Tamana Yousof Jae Hyun Byun jack chen Richard c.Austin Department of Medicine Division of NephrologyMcMaster UniversityThe Research Institute of St.Joe’s Hamilton and the Hamilton Centre for Kidney ResearchHamiltonOntarioL8N 4A6Canada

Pleckstrin homology-like domain, family A, member 1 (PHLDA1) is a multifaceted intracellular protein belonging to the evolutionarily conserved pleckstrin homology-related domain family. Its murine homologue, T-cell death-associated 51 (TDAG51) gene, was initially discovered for its role in activation-induced apoptosis in T-cell hybridomas. In recent years, PHLDA1 has received increased attention due to its association with obesity, fatty liver disease, diabetes, atherosclerosis, and cancer. Accumulating evidence also supports its role in endoplasmic reticulum stress signaling pathways as a crucial mediator of apoptosis, autophagy, and cell proliferation. In this review, the current knowledge of PHLDA1 gene and protein regulation, localization, and function is summarized. This review highlights the pro- and anti-apoptotic roles of PHLDA1 that contribute to vast array of metabolic diseases.

关键词： ER-stress Metabolism Apoptosis cell survival PHLDA1

Physics-based,data-driven approach for predicting natural ventilation of residential high-rise buildings

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Building Simulation 2022年第1期15卷 129-148页

作者： Vincent J.L.Gan Boyu Wang c.M.chan A.U.Weerasuriya jack c.P.cheng Department of Building School of Design and EnvironmentNational University of SingaporeSingapore117566 Department of civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong Kong999077China

Natural ventilation is particularly important for residential high-rise buildings as it maintains indoor human comfort without incurring the energy demands that air-conditioning *** improve a building’s natural ventilation,it is essential to develop models to understand the relationship between wind flow characteristics and the building's *** more effort is still needed for developing such reliable,accurate,and computationally economical models instead of currently the most popular physics-based models such as computational fluid dynamics(cFD)*** paper,therefore,presents a novel model developed based on physics-based modelling and a data-driven approach to evaluate natural ventilation in residential high-rise *** model first uses cFD to simulate wind pressures on the exterior surfaces of a high-rise *** the surface pressures have been obtained,multizone modelling is used to predict the air change per hour(AcH)for different flats in various ***-driven prediction models are then developed using data from the simulation and deep neural networks that are based on mean absolute error,mean absolute percentage error,and a fusion algorithm *** data-driven models are used to predict the AcH of 25 *** results from multizone modelling and data-driven modelling are *** results imply a high accuracy of the data-driven prediction in comparison with physics-based *** fusion algorithm-based neural network performs best,achieving 96%accuracy,which is the highest of all models *** study contributes a more efficient and robust method for predicting wind-induced natural *** findings describe the relationship between building design(e.g.,plan layout),distribution of surface pressure,and the resulting AcH,which serve to improve the practical design of sustainable buildings.

关键词： computational fluid dynamics data-driven prediction machine learning multizone model natural ventilation residential building

Aberrant calcium signalling downstream of mutations in TP53 and the PI3K/AKT pathway genes promotes disease progression and therapy resistance in triple negative breast cancer

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cancer Drug Resistance 2022年第3期5卷 560-576页

作者： Alex J.Eustace Min Jie lee Grace colley jack Roban Tim Downing Paul J.Buchanan DcU cancer Research Dublin City UniversityDublin D9Ireland National Institute cellular Biotechnology Dublin City UniversityDublin D9Ireland School of Biotechnology Dublin City UniversityDublin D9Ireland School of Nursing Psychotherapyand Community HealthDublin City UniversityDublin D9Ireland

Triple-negative breast cancer(TNBc)is characterized as an aggressive form of breast cancer(Bc)associated with poor patient *** the majority of patients,there is a lack of approved targeted ***,chemotherapy remains a key treatment option for these patients,but significant issues around acquired resistance limit its ***,TNBc has an unmet need for new targeted personalized medicine ***(ca^(2+))is a ubiquitous second messenger that is known to control a range of key cellular processes by mediating signalling transduction and gene *** in ca^(2+)through altered calcium channel expression or activity are known to promote tumorigenesis and treatment resistance in a range of cancers including *** evidence shows that this is mediated by ca^(2+)modulation,supporting the function of tumour suppressor genes(TSGs)and *** review provides insight into the underlying alterations in calcium signalling and how itplays a key role in promoting disease progression and therapy resistance in TNBc which harbours mutations intumour protein p53(TP53)and the PI3K/AKT pathway.

关键词： Triple-negative breast cancer TP53 PI3K/AKT pathway calcium

Genetic parameters of drinking and feeding traits of wean-to-finish pigs under a polymicrobial natural disease challenge

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Journal of Animal Science and Biotechnology 2022年第1期13卷 17-35页

作者： Jian cheng Austin M.Putz John c.S.Harding Michael K.Dyck Frederic Fortin Graham S.Plastow Pig Gen canada jack c.M.Dekkers Department of Animal Science Iowa State UniversityAmesIA 50011USA Hendrix Genetics Swine Business UnitBoxmeerThe Netherlands 5831CK Department of Large Animal clinical Science University of SaskatchewanSaskatoonSK S7N 5A2Canada Department of Agriculture Food and Nutritional ScienceUniversity of AlbertaEdmontonAB T6G 2R3Canada centre de Developpement du Porc du Quebec Inc. Quebec City G1V 4M6Canada PigGen canada Research consortium GuelphOntario N1H4G8Canada

Background:The pork industry faces unprecedented challenges from disease,which increases cost of production and use of antibiotics,and reduces production efficiency,carcass quality,and animal *** solution is to improve the overall resilience of pigs to a broad array of common diseases through genetic *** changes in feeding and drinking are usually the very first clinical signs when animals are exposed to stressors such as *** in feeding and drinking behaviors in diseased pigs may reflect the way they cope with the challenge and,thus,could be used as indicator traits to select for disease *** objectives of this study were to estimate genetic parameters of feeding and drinking traits for wean-to-finish pigs in a natural polymicrobial disease challenge model,to estimate genetic correlations of feeding and drinking traits with growth rate and clinical disease traits,and to develop indicator traits to select for disease ***:In general,drinking traits had moderate to high estimates of heritability,especially average daily water dispensed,duration,and number of visits(0.44 to 0.58).Similar estimates were observed for corresponding feeding traits(0.35 to 0.51).Most genetic correlation estimates among drinking traits were moderate to high(0.30 to 0.92)and higher than among feeding traits(0 to 0.11).compared to other drinking traits,water intake duration and number of visits had relatively stronger negative genetic correlation estimates with treatment rate and mortality,especially across the challenge nursery and finisher(−0.39 and−0.45 for treatment rate;−0.20 and−0.19 for mortality).conclusion:Most of the recorded drinking and feeding traits under a severe disease challenge had moderate to high estimates of heritability,especially for feed or water intake duration and number of *** and genetic correlations among the recorded feeding traits under disease were generally low but drinking traits show

关键词： Disease resilience Feeding and drinking behavior Genetic parameters Pigs

Pathway engineering strategies for improved product yield in yeast-based industrial ethanol production

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Synthetic and Systems Biotechnology 2022年第1期7卷 554-566页

作者： Aafke c.A.van Aalsta Sophie c.de Valk Walter M.van Gulik Mickel L.A.Jansen jack T.Pronka Robert Mans Department of Biotechnology Delft University of TechnologyVan der Maasweg 92629HZ Delftthe Netherlands DSM Biotechnology centre Alexander Fleminglaan 12613AX Delftthe Netherlands

Product yield on carbohydrate feedstocks is a key performance indicator for industrial ethanol production with the yeast Saccharomyces *** paper reviews pathway engineering strategies for improving ethanol yield on glucose and/or sucrose in anaerobic cultures of this yeast by altering the ratio of ethanol production,yeast growth and glycerol *** attention is paid to strategies aimed at altering energy coupling of alcoholic fermentation and to strategies for altering redox-cofactor coupling in carbon and nitrogen meta-bolism that aim to reduce or eliminate the role of glycerol formation in anaerobic redox *** addition to providing an overview of scientific advances we discuss context dependency,theoretical impact and potential for industrial application of different proposed and developed strategies.

关键词： Saccharomyces cerevisiae Synthetic biology Metabolic engineering Biofuels Redox metabolism Energy metabolism

MATHEMATIcAL MODEL FOR THE ENTERPRISE cOMPETITIVE ABILITY AND PERFORMANcE THROUGH A PARTIcULAR EMDEN-FOWLER EQUATION u〞-n^(-q-1)u(n)~q=0

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Acta Mathematica Scientia 2018年第4期38卷 1311-1321页

作者： Yue-Loong cHANc Meng-Rong LI c. jack YUE Yong-Shiuan lee Tsung-Jui cHIANG-LIN Department of Phycology National Chengchi University Taipei China Department of Mathematical Sciences National Chengchi University Taipei China Department of Statisitics National Chengchi University Taipei China Graduate Institute of Finance National Taiwan University of Science and Technology Taipei China

In this article, we work with the ordinary equation u″-n-q-1u（n）q=0 and learn some interesting phenomena concerning the blow-up and the blow-up rate of solution to the equation.

关键词： estimate life-span blow-up blow-up rate competitive ability performance

Effects of medium chain triglycerides on hepatic fatty acid oxidation in clofibrate-fed newborn piglets

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Animal Nutrition 2023年第1期12卷 334-344页

作者： Jinan Zhao Brandon Pike Jin Huang Zhihua Feng jack Odle Xi Lin Laboratory of Developmental Nutrition Department of Animal SciencesNorth Carolina State UniversityRaleighNC 27695USA Zinpro corporation Eden PrairieMN 55344USA college of Biological Engineering Henan University of TechnologyZhengzhou450001China college of Animal Science and Technology Agricultural University of HebeiBaoding071001China

To investigate whether increasing tricarboxylic acid(TcA)cycle activity and ketogenic capacity would augment fatty acid(FA)oxidation induced by the peroxisome proliferator-activated receptor-alpha(PPARα)agonist clofibrate,suckling newborn piglets(n=54)were assigned to 8 groups following a 2(±clofibrate)×4(glycerol succinate[SUc],triglycerides of 2-methylpentanoic acid[T2M],valeric acid[Tc5]and hexanoic acid[Tc6])factorial *** group was fed an isocaloric milk formula containing either 0%or 0.35%clofibrate(wt/wt,dry matter basis)with 5%SUc,T2M,Tc5 or Tc6 for 5 *** 6 pigs served as newborn *** acid oxidation was examined in fresh homogenates of liver collected on d 6 using[1-^(14)c]palmitic acid(1 mM)as a substrate(0.265μci/μmol).Measurements were performed in the absence or presence of L-carnitine(1 mM)or inhibitors of 3-hydroxy-3-methylglutaryl-coA synthase(L659699,1.6μM)or acetoacetate-coA deacylase(iodoacetamide,50μM).Without clofibrate stimulation,^(14)c accumulation in cO_(2) was higher from piglets fed diets containing T2M and Tc5 than SUc,but similar to those fed *** clofibrate stimulation,accumulation also was higher in homogenates from piglets fed Tc5 than all other dietary *** between clofibrate and carnitine or the inhibitors were observed(P=0.0004)for acid soluble products(ASP).In vitro addition of carnitine increased^(14)c-ASP(Pclofibrate *** percentage of^(14)c in cO_(2) was higher(P=0.0023)in Tc5 than in the control *** these results we suggest that dietary supplementation of anaplerotic and ketogenic FA could impact FA oxidation and modify the metabolism of acetyl-coA(product ofβ-oxidation)via alteration of TcA cycle activity,but the modification has no significant impact on the hepatic FA oxidative capacity induced by PPARα.In addition,the availability of carnitine is a critical element to maintain FA oxidation during the neonatal perio

关键词： PPARα clofibrate Newborn piglets Medium chain triglyceride(McT) Hepatic fatty acid oxidation