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An oxygenating colloidal bioink for the engineering of biomimetic tissue constructs

Bio-Design and Manufacturing 2024年第3期7卷 240-261页

作者： Seol-Ha Jeong ja.no hiemstra.pa.rick v.blokzijl Rebeca Damian-Ferrara Danilo Martins dos Santos Jéssica H.L.da Fonseca Min-Ho Kang Jihyun Kim Dilara Yilmaz-Aykut Mei L.L.Cham-Pérez Jeroen Leijten Su Ryon Shin Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02139USA Leijten Lab Department of Developmental BioEngineeringFaculty of Science and TechnologyTechnical Medical CentreUniversity of TwenteDrienerlolaan 57522 NB EnschedeThe Netherlands Nanotechnology National Laboratory for Agriculture(LNNA) Embrapa InstrumentaçãoSao CarlosSao Paulo 13560-970Brazil Department of Biomedical-Chemical Engineering The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea Department of Biotechnology The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea

Ensuring a sufficient oxygen supply is pivotal for the success of bioprinting applications since it fosters tissue integration and natural *** in oxygen concentration among diverse tissues necessitates the precise recreation of tissue-specific oxygen levels in imprinted constructs to support the survival of targeted *** oxygen-releasing biomaterials,such as oxygen-generating microparticles(OMPs),have shown promise for enhancing the oxygen supply of microenvironments in injured tissues,whether this approach is scalable for large tissues and whether tissue-specific bioinks with varying OMP concentrations remain printable remain *** study addresses this critical gap by introducing an innovative class of engineered oxygenated bioinks that combine colloidal-based microgels with *** report that incorporating nanosized calcium peroxide(nCaO_(2))and manganese oxide nanosheets(nMnO_(2))into hydrophobic polymeric microparticles enables precise modulation of oxygen release while controlling hydrogen peroxide ***,the fabrication of oxygenating and cytocompatible colloidal gels is achieved using an aqueous two-phase *** study thoroughly evaluates the fundamental characteristics of the resulting bioink,including its rheological behaviors,printability,shape fidelity,mechanical properties,and oxygen release ***,this study demonstrates the macroscopic scalability and cytocompatibility of printed constructs produced via cell-laden oxygenating colloidal *** showcasing the effectiveness of extrusion-based bioprinting,this study underscores how it can be used to fabricate biomimetic tissues,indicating its potential for new *** findings presented here advance the bioprinting field by achieving scalability with both high cell viability and the possibility of mimicking specifically oxygenated *** work thereby offers a promising avenue for the development of functional tissues with e

关键词： 3D bioprinting Bioink Colloidal gels Extrusion printing Oxygen-generating microparticle

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Genome-wide Studies Reveal Genetic Risk Factors for Hepatic Fat Content

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Genomics, Proteomics & Bioinformatics 2024年第2期22卷 57-68页

作者： Yanni Li Eline H.van den Berg Alexander Kurilshikov Dasha v.Zhernakova Ranko Gacesa Shixian Hu Esteban A.Lopera-Maya Alexandra Zhernakova Lifelines Cohort Study vincent E.de Meijer Serena Sanna Robin P.F.Dullaart Hans blokzijl Eleonora A.M.Festen Jingyuan Fu Rinse K.Weersma Department of Gastroenterology and Hepatology University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Genetics University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China Laboratory of Genomic Diversity Center for Computer TechnologiesITMO UniversitySaint Petersburg 199034Russia Institute of Precision Medicine the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Surgery Section of Hepatobiliary Surgery and Liver TransplantationUniversity of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Endocrinology University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Pediatrics University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands 不详

Genetic susceptibility to metabolic associated fatty liver disease(MAFLD)is complex and poorly *** characterization of the genetic background of hepatic fat content would provide insights into disease etiology and causality of risk *** performed genome-wide association study(GWAS)on two noninvasive definitions of hepatic fat content:magnetic resonance imaging proton density fat fraction(MRI-PDFF)in 16,050 participants and fatty liver index(FLI)in 388,701 participants from the United Kingdom(UK)Biobank(UKBB).Heritability,genetic overlap,and similarity between hepatic fat content phenotypes were analyzed,and replicated in 10,398 participants from the University Medical Center Groningen(UMCG)Genetics Lifelines Initiative(UGLI).Meta-analysis of GWASs of MRI-PDFF in UKBB revealed five statistically significant loci,including two novel genomic loci harboring CREB3L1(rs72910057-T,P=5.40E−09)and GCM1(rs1491489378-T,P=3.16E−09),respectively,as well as three previously reported loci:PNPLA3,TM6SF2,and *** of FLI in UKBB identified 196 genome-wide significant loci,of which 49 were replicated in UGLI,with top signals in ZPR1(P=3.35E−13)and FTO(P=2.11E−09).Statistically significant genetic correlation(rg)between MRI-PDFF(UKBB)and FLI(UGLI)GWAS results was found(rg=0.5276,P=1.45E−03).Novel MRI-PDFF genetic signals(CREB3L1 and GCM1)were replicated in the FLI *** identified two novel genes for MRI-PDFF and 49 replicable loci for *** a difference in hepatic fat content assessment between MRI-PDFF and FLI,a substantial similar genetic architecture was *** is identified as an easy and reliable approach to study hepatic fat content at the population level.

关键词： Hepatic fat content MAFLD Genome-wide association study Fatty liver index Magnetic resonance imaging proton density fat fraction

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Effect of ultrasound on reverse leakage current of silicon Schottky barrier structure

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Journal of Semiconductors 2016年第12期37卷 5-11页

作者： O.Ya Olikh K.v.voitenko R.M.Burbelo ja M.Olikh Faculty of Physics Taras Shevchenko National University of Kyiv v Lashkaryov Institute of Semiconductor Physics National Academy of Sciences of Ukraine

The influence of ultrasonic loading on reverse current-voltage characteristics of Mo/n-n＋-Si structures has been investigated. The research of leakage current variation has been carried out for various ultrasonic wave frequencies （4.1 and 8.4 MHz）, intensities （up to 0.8 W/cm2） and loading temperatures （130-330 K）. The observed reversible acoustically induced increase in reverse currents was as large as 60%. It has been found that dominant charge transfer mechanisms are the thermionic emission （at high temperature） and the phonon-assisted tunneling （at low temperature）. The ultrasound loading affects both processes due to the decrease of Schottky barrier height and binding energy of the electron on the trap.

关键词： Schottky contact leakage current ultrasound influence

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Deep Unity of Classic and Quantum Physics at the Space Thermostat Presence with Technical Applications

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Journal of Applied Mathematics and Physics 2017年第4期5卷 801-812页

作者： M. ja. Ivanov v. K. Mamaev Guanghua Zheng Gas Turbine Department Central Institute of Aviation Motors Moscow Russia Northwestern Polytechnic University Xian China

The paper demonstrates deep unity of classic and quantum physics at the space thermostat (ST) presence, which fulfilled all space by the temperature T0 = 2.73 K. The ST presents itself the Cosmic Microwave Background (CMB). From the main quantum position we consider the ST/CMB as the wave function carrier (“quantum background”). The paper is devoted to ST/CMB medium the classic conservation laws of mass, momentum and energy. We show the soliton like solutions of our classic model correspond to Schrodinger’s quantum solutions, demonstrate the atom hydrogen specter and other quantum peculiarities. The paper contains typical technical examples classic/ quantum simulation at the ST presence.

关键词： Space Thermostat Conservation Laws Schrodinger’s Solutions Technical Ap-plications

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Effect of pineapple peel extract on total phospholipids and lipid peroxidation in brain tissues of rats

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Asian pacific Journal of Tropical Medicine 2011年第3期4卷 182-184页

作者： Erukainure OL Ajiboye ja Adejobi RO Okafor OY Kosoko SB Owolabi FO Food Technology Division Federal Institute of Industrial ResearchOshodiNigeria College of Natural and Applied Sciences Bells University of TechnologyOtaNigeria

Objective:To investigate the ability of the methanolic extract of pineapple peel to attenuate alcohol-induced changes in total phospholipids and lipid peroxidation in brain tissues. Methods:Oxidative stress was induced by oral administration of ethanol(20%w/v) at a dosage of 5 mL/kg bw in *** 28 days of treatment,the rats were fasted overnight and sacrificed by cervical *** tissues were assayed for total phospholipid(TP) content and malondialdehyde(MDA).Results:Administration of alcohol significantly caused a reduction in TP *** with pineapple peel extract significantly increased the TP content. Significant high levels of MDA was observed in alcohol-fed rats,treatment with pineapple peel extract significantly reduced the MDA ***:Results obtained from this study indicates that pineapple peel extract protects against alcohol-induced changes in total phospholipids and lipid peroxidation in brain tissues.

关键词： Brain Malondialdehyde Total phospholipids Alcohol

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Review of Obstetrics and Perinatal Outcome of Multiple Pregnancies with vanishing and Selective Embryo Reduction in an Oocyte Donation Program

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Journal of Reproduction and Contraception 2005年第2期16卷 73-82页

作者： Rodríguez-González M García-velasco ja Remohí J Pellicer A Serra v Instituto valenciano de Infertilidad of Castellón Spain Instituto valenciano de Infertilidad of Madrid. Instituto valenciano de Infertilidad of valencia Spain Departmen of Pediatrics Obstetrics and Gynaecology Valencia University School of Medicine Spain

To check previous findings of the most common complications among pregnancies with vanishing embryo（vE） in another actual study retropective and in group of patiens with selective embryo reduction （SER） Methods We defined vanishing phenomenon as the spontaneous loss of one or more embryos after visualizing heart activity at the first trimester of pregnancy. Selective embryo reduction was performed between 8th-12th pregnancy week, through vaginal punction and aspiration of embryonic mass. Results vanishing embryo was observed in 86 patients （18.0%）. In 61 patients （70.9%） this phenomenom happened before 9th pregnancy week. The incidence of vE increased with higher number of gestational sacs initially visualized （P〈0.03）. First trimester bleeding was more common among pregnancies with vE than in the control （P〈0.005）. The incidence of pregnancy induced hypertension was lower in pregnancies with vE than in the controls （P〈0.03）. In contrast, preterm spontaneous rupture of membranes was higher, although without statistical significance. Gestational age at delivery, mode of delivery and birth weight was similar in the group of vE and the controls （P=NS）. Conclusion All these informations may be useful in counselling patients on the prognosis and outcome of pregnancies achieved by oocyte donation.

关键词： vanishing embryo spontaneous embryo reduction selective embryo reduction outcome

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Hot Deformation Behavior and Microstructural Characteristics of Ti–46Al–8Nb Alloy

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Acta Metallurgica Sinica(English Letters) 2018年第9期31卷 933-944页

作者： Tian-Rui Li Guo-Huai Liu Mang Xu Tian-Liang Fu Yong Tian Ra-ja Devesh Kumar Misra Zhao-DongWang State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China Laboratory for Excellence in Advanced Steel Research Department of MetallurgicalMaterials and BiomedicalEngineeringUniversity of Texas at E1 PasoE1 PasoTX 79968-0521USA

Hot deformation behavior, microstructural evolution and flow softening mechanism were investigated in Ti-46A1-8Nb alloy via isothermal compression approach. The true stress-strain curves exhibited typical work hardening and flow softening, in which the dependence of the peak stress on temperature and strain rate was obtained by hyperbolic sine equation with Zener-Hollomon （Z） parameter, and the activation energy was calculated to be 446.9 kJ/mol. The microstructural analysis shows that the alternate dark and light deformed ribbons of Al-rich and Nb-rich regions appeared and were associated with local flow involving solute segregation. The Al segregation promoted flow softening mainly arising from the recrystaUization of v phase with low stacking fault energy. The coarse recrystallized 7 and several massive phase were observed at grain boundaries. While in the case of Nb segregation, t/B2 phase harmonized bending of lamellae, combined with the growth of recrystallized γ grains and α ＋ β ＋ γ→α＋ γ transition under conditions of temperature and stress, leading to the breakdown of α2/γ lamellar colony. During the hot compression process, gliding and dissociation of dislocations occurred in γ phase that acted as the main softening mechanism, leading to extensive γ twins and cross twins in α/γ lamellae and at grain boundaries. In general, homogeneous microstructure during the hot defor- mation process can be obtained in TiAl alloy with high Nb addition and low Al segregation. The deformation substructures intrinsically promote the formability of Ti--46Al-8Nb alloy.

关键词： Titanium aluminides Deformation behavior Activation energy Dynamic recrystallization Local flow softening

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Interplay between post-translational cyclooxygenase-2 modifications and the metabolic and proteomic profile in a colorectal cancer cohort

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World Journal of Gastroenterology 2019年第4期25卷 433-446页

作者： patricia Prieto Rafael I jaén Daniel Calle María Gómez-Serrano Estefanía Nú?ez María Fernández-velasco paloma Martín-Sanz Sergio Alonso Jesús vázquez Sebastián Cerdán Miguel ángel Peinado Lisardo Boscá Department of Metabolism and Physiopathology of Inflammatory Diseases Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM) Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (Ciber-Cv) Instituto de Salud Carlos III (ISCIII) Laboratorio de Imagen Médica Hospital Universitario Gregorio Mara?ón Laboratorio de Proteómica Cardiovascular Centro Nacional de Investigaciones Cardiovasculares (CNIC) Instituto de Investigación Sanitaria del Hospital Universitario la paz(Idipaz) Programa de Medicina Predictiva y Personalizada del Cáncer (PMPPC) Fundación Instituto de investigación en ciencias de la salud Germans Trias i PujolCtra Can Ruti

BACKGROUND Colorectal cancer(CRC) is the second most common cause of cancer death worldwide. It is broadly described that cyclooxygenase-2(COX-2) is mainly overexpressed in CRC but less is known regarding post-translational modifications of this enzyme that may regulate its activity, intracellular localization and stability. Since metabolic and proteomic profile analysis is essential for cancer prognosis and diagnosis, our hypothesis is that the analysis of correlations between these specific parameters and COX-2 state in tumors of a high number of CRC patients could be useful for the understanding of the basis of this cancer in *** To analyze COX-2 regulation in colorectal cancer and to perform a detailed analysis of their metabolic and proteomic *** Biopsies from both healthy and pathological colorectal tissues were taken under informed consent from patients during standard colonoscopy procedure in the University Hospital of Bellvitge(Barcelona, Spain) and Germans Trias i Pujol University Hospital(Campus Can Ruti)(Barcelona, Spain). Western blot analysis was used to determine COX-2 levels. Deglycosylation assays were performed in both cells and tumor samples incubating each sample with peptide N-glycosidase F(PNGase F). Prostaglandin E2(PGE2) levels were determined using a specific ELISA. 1 H high resolution magic angle spinning(HRMAS) analysis was performed using a Bruker AvIII 500 MHz spectrometer and proteomic analysis was performed in a nano-liquid chromatography-tandem mass spectrometer(nano LC-MS/MS) using a QExactive HF orbitrap *** Our data show that COX-2 has a differential expression profile in tumor tissue of CRC patients vs the adjacent non-tumor area, which correspond to a glycosylated and less active state of the protein. This fact was associated to a lesser PGE2 production in tumors. These results were corroborated in vitro performing deglycosylation assays in HT29 cell line where COX-2 protein profile was modified after PN

关键词： Colon Carcinoma Cyclooxygenase Prostaglandin Proteomics High resolution magic angle spinning

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Modulatory effect of pineapple peel extract on lipid peroxidation,catalase activity and hepatic biomarker levels in blood plasma of alcoholinduced oxidative stressed rats

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Asian pacific Journal of Tropical Biomedicine 2011年第1期1卷 12-14页

作者： Okafor OY Erukainure OL Ajiboye ja Adejobi RO Owolabi FO Kosoko SB Food Technology Division Federal Institute of Industrial Research College of Natural and Applied Sciences Bells University of Technology

Objective:To investigate the ability of the methanolic extract of pineapple peel to modulate alcohol-induced lipid peroxidation,changes in catalase activities and hepatic biochemical marker levels in blood ***:Oxidative stress was induced by oral administration of ethanol(20%w/v) at a dosage of 5 niL/kg bw in *** 28 days of treatment,the rats were fasted overnight and sacrificed by cervical *** was collected with a 2 mL syringe by cardiac puncture and was centrifuged at 3000 rpm for 10 *** plasma was analyzed to evaluate malondialdehyde(MDA),catalase activity,aspartate aminotransferase(AST),alkaline phosphatase(ALP) and alanine aminotransferase(ALT) ***:Administration of alcohol caused a drastic increase(87.74%) in MDA level compared with the *** peel extract significantly reduced the MDA level by 60.16%at 2.S mL/kg *** fed alcohol only had the highest catalase activity,treatment with pineapple peel extract at 2.5 mL/kg bw however, reduced the *** AST,ALP and ALT activities were observed in rats fed alcohol only respectively,treatment with pineapple peel extract drastically reduced their activities. Conclusions:The positive modulation of lipid peroxidation,catalase activities as well as hepatic biomarker levels of blood plasma by the methanolic extract of pineapple peels under alcoholinduced oxidative stress is an indication of its protective ability in the management of alcoholinduced toxicity.

关键词： Blood plasma Catalase Lipid peroxide Aspartate aminotransferase Alkaline phosphatase Alanine aminotransferase Hepatic biomarker Pineapple peel extract Oxidative stress Lipid peroxidation

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不同碳源条件下草菇内切型纤维素酶基因(eg1)转录表达的分析

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应用与环境生物学报 2005年第4期11卷 419-422页

作者：丁少军宋美静池杏微 BUSWELL ja 南京林业大学化工学院南京210037 香港中文大学

利用Northernblot方法分析了不同碳源条件下草菇切型纤维素酶基因(eg1)的表达.结果发现,在含有纤维素的液体培养基中生长10d,eg1在草菇菌丝中有高效表达;纤维二糖、α-乳糖、β-乳糖,也能诱导eg1的表达,但和纤维素相比,eg1的表达量相... 详细信息

利用Northernblot方法分析了不同碳源条件下草菇切型纤维素酶基因(eg1)的表达.结果发现,在含有纤维素的液体培养基中生长10d,eg1在草菇菌丝中有高效表达;纤维二糖、α-乳糖、β-乳糖,也能诱导eg1的表达,但和纤维素相比,eg1的表达量相对较低,并且它们的诱导效应在加入这类糖12h后迅速减弱;槐糖和龙胆二糖的诱导作用非常弱.在天然稻草为基质的固体栽培料生长时,草菇eg1的表达和草菇菌丝生长与出菇相对应,在菌丝生长期(d8)可见eg1的表达,d12时菌丝已长满,表达减弱,在出菇及菇体的分化及增大期,eg1的表达量逐渐增强,在成熟期达到最高水平;表明在草菇菇体发育中需要更多碳源及能源的补充,eg1在这方面起着非常重要的作用.

关键词：草菇内切型纤维素酶基因转录表达

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