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Subpopulations of regulatory T cells are associated with subclinical atherosclerotic plaques,levels of LDL,and cardiorespiratory fitness in the elderly

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Journal of Sport and Health Science 2024年第3期13卷 288-296,I0002页

作者： Tim Böttrich Pascal Bauer Vincent Gröβer Magdalena Huber Hartmann Raifer Torsten Frech Svenja Nolte Theresa dombrowski Franz Cemic Natascha Sommer Robert Ringseis Klaus Eder Karsten Krüger Christopher Weyh Department of Exercise Physiology and Sports Therapy Institute of Sports ScienceJustus-Liebig-UniversityGiessen 35394Germany Department of Cardiology and Angiology Justus-Liebig-University GiessenGiessen 35392Germany Institute for Systems Immunology Center for Tumor und ImmunologyMarburg 35032Germany TH Mittelhessen Department of Computer ScienceUniversity of Applied Sciences GiessenGiessen 35390Germany Department of Internal Medicine Universities of Giessen and Marburg Lung Center(UGMLC)Member of the German Center for Lung Research(DZL)Giessen 35394Germany Excellence Cluster Cardio-Pulmonary Institute(CPI) Justus-Liebig UniversityGiessen 35394Germany Institute of Animal Nutrition and Nutrition Physiology Justus-Liebig-University GiessenGiessen 35390Germany

Background:Atherosclerosis forms the pathological basis for the development of cardiovascular *** pathological processes initially develop without clinically relevant symptoms,the identification of early markers in the subclinical stage plays an important role for initiating early *** is evidence that regulatory T cells(Tregs)are involved in the development of ***,the present study aimed to identify and investigate associations with Tregs and their subsets in a cohort of healthy elderly individuals with and without subclinical atherosclerotic plaques(SAP).In addition,various lifestyle and risk factors,such as cardiorespiratory fitness,were investigated as associated ***:A cross-sectional study was performed in 79 participants(male:n=50;age=63.6±3.7 years;body mass index=24.9±3.1 kg/m2;mean±SD)who had no previous diagnosis of chronic disease and were not taking *** of the carotids to identify SAP,cardiovascular function measurement for vascular assessment and a cardiorespiratory fitness test to determine peak oxygen uptake were ***,tests were conducted to assess blood lipids and determine glucose *** of Tregs and their subtypes(resting(rTregs)and effector/memory(mTregs))was performed by 8-chanel flow *** were categorized according to atherosclerotic plaque *** and logistic regression models were used to analyze associations between ***:SAP was detected in a total of 29 *** participants with plaque were older(64.8±3.6 years vs.62.9±3.5 years)and had higher peripheral systolic blood pressure(133.8±14.7 mmHg vs.125.8±10.9 mmHg).The participants with SAP were characterized by a lower percentage of rTregs(28.8%±10.7%vs.34.6%±10.7%)and a higher percentage of mTregs(40.3%±14.7%vs.30.0%±11.9%).Multiple logistic regression identified age(odds ratio(OR)=1.20(95%confidence interval(95%CI):1.011.42))and

关键词： Cardiorespiratory fitness Elderly Regulatory T cells Subclinical atherosclerosis

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Role of natural killer (NK) cells during pregnancy: A review

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Open Journal of Animal Sciences 2013年第2期3卷 138-144页

作者： Marcio Nogueira Rodrigues Phelipe Oliveira Favaron ja.ille gregório dombrowski Rodrigo Medeiros de Souza Maria Angelica Miglino Federal University of Acre Cruzeiro do Sul Brazil Institute of Biomedical Science University of Sao Paulo Sao Paulo Brazil School of Veterinary Medicine and Animal Science University of Sao Paulo Sao Paulo Brazil

The homeostasis is maintained by the immune system which is constituted a network of organs, cells and molecules that act to combating the assaults affecting the body. The immune function has been conceptually divided into innate immunity and acquired immunity. Among the effector cells of innate immunity are the natural killer cells (NK), they play an important role in the reproductive immunology in the establishment and maintenance of pregnancy and fetus. The study of the biological mechanisms involved in the maintenance of pregnancy contributes to increase knowledge about immune tolerance. The way in which the immune system is modulated, and the study of the recognition systems maternal innate and adaptive occurring during pregnancy, allow to understand the survival of the fetus. The aim of this review was to present the main functions of NK cells and describe their role in the process of trophoblastic invasion in the deployment process, in the maternal-fetal interaction and development of the fetus. The knowledge of the precise role of NK cells is necessary, because these cells may be responsible for reactions which lead to embryonic and fetal loss during the organogenesis process.

关键词： Reproduction Natural Killer Pregnancy Imunne System

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The innate immune receptor NLRP12 maintains intestinal homeostasis by regulating microbiome diversity

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Cellular & Molecular Immunology 2018年第3期15卷 193-195页

作者： Jenny Moi-Fong Lau Yvonne dombrowski Centre for Experimental Medicine Wellcome-Wolfson Institute for Experimental MedicineQueen’s University BelfastBelfastBT97BLUK

Inflammatory bowel disease(IBD)is on the rise in the western world.1 The dynamic interplay between genetic susceptibility,the gut microbiome and host inflammatory reactions underlying IBD are still *** light onto these complex interactions in IBD,Chen et al.2 identified a key role for the negative immune regulator NLRP12 in shaping the composition of the gut microbiome and maintaining intestinal *** finding,published in the most recent issue of Nature Immunology,2 can advance the development of much needed microbiome-based therapies for IBD patients.

关键词： homeostasis Immunology maintain

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Successful Treatment with ¹⁷⁷Lutetium-Dotatate and Maintenance Octreotide in a Patient with Esthesioneuroblastoma with Central Nervous System Invasion: Case Report and Review of the Literature

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International Journal of Otolaryngology and Head & Neck Surgery 2023年第1期12卷 8-20页

作者： Gabriela dombrowski Laura Fernandes Ferreira Dalcin Francisco Assis Coelho Patricia Massucheto Ledesma Daniel Herchenhorn Department of Clinical Oncology Instituto D’Or de Pesquisa e Ensino Rio de Janeiro Brazil Clínica de Diagnóstico por Imagem CDPI DASA Instituto D’Or de Pesquisa e Ensino Rio de Janeiro Brazil Clínica de Medicina Nuclear Villela Pedras Clínica de Diagnóstico por Imagem CDPI DASA Rio de Janeiro Brazil

This article presents a case of a patient with relapsed esthesioneuroblastoma (ENB), an aggressive rare tumor that arises from the specialized sensory epithelial olfactory cells in the skull base area, which was initially treated with endoscopic surgery, followed by adjuvant radiotherapy. After local relapse, new surgical approaches and subsequent lines of platin-based chemotherapy were performed. A PET-CT with 68GALIUM DOTATATOC (PET-DOTATOC) showed intense uptake of disease, compatible with the presence of somatostatin receptors, in the face, nodes, liver, bones, and meningeal area. Treatment with 4 cycles of 177Lutetium-Dotatate was performed, followed by maintenance octreotide, with a major radiological and clinical response that is lasting more than 1 year after treatment. This article describes a rare case of a skull-base tumor, with multiple recurrences, in which disease control was achieved with a targeted Peptide Receptor Radionuclide Therapy (PRRT) with 177Lutetium-Dotatate, and discusses factors that could influence the incorporation of this form of therapy. Previous case reports proved the potential efficacy of this therapy usually given for low-grade neuroendocrine tumors and will be carefully reviewed.

关键词： Esthesioneuroblastoma Olfactory Neuroblastoma Peptide Receptor Radionuclide Therapy PRRT 177Lutetium

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Study of the Corrosion of High Alumina Refractories by Al_2O_3-CaO Slag as a Reactive Impregnation Mechanism

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China's Refractories 2015年第1期24卷 7-10页

作者： Emmanuel DE BILBAO Mathieu dombrowski jacques POIRIER CNRS CEMHTI UPR 30791D avenue de la Recherche Scientifique

The corrosion of refractories results from reactive transport,namely,transport of agents and chemical reactions of these agents with impregnated medium. On one hand,the transport involves either diffusion or impregnation depending on the state of the corrosive agents and the microstructure of the host media. On the other hand,chemical reactions may be very numerous and *** study focused on the reactive impregnation of Al2O3- CaO slag into porous high alumina refractory. The transport properties of the refractory material were identified by means of a dedicated capillary rising test. Chemical reactions between the solid high alumina skeleton and Al2O3- CaO slag involve successive dissolution / precipitation mechanisms forming aluminates of lime. Contrary to the thermodynamic properties of the binary system,the kinetics of these solid / liquid reactions is not well *** tests associated with the quenching method,XRD analyses were performed for a better understanding of the kinetics. The results of this study open up a coupling approach for predicting the corrosion wear of refractory.

关键词： high alumina refractory corrosion by slag reactive impregnation kinetics

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超越感觉:溴系阻燃剂

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纺织导报 2006年第12期 34-34,36页

作者： Ronald dombrowski TechTex Solutions公司

近年来,人们对环保和健康要求的提高,给溴系阻燃剂的发展造成了很大影响。虽然欧盟RoHS禁令明确禁用多溴联苯和多溴联苯醚类阻燃剂后,又豁免了十溴联苯醚(DECA),但它的危害性仍然受到人们的普遍质疑。文章对这种卤化阻燃剂的安全使用性... 详细信息

近年来,人们对环保和健康要求的提高,给溴系阻燃剂的发展造成了很大影响。虽然欧盟RoHS禁令明确禁用多溴联苯和多溴联苯醚类阻燃剂后,又豁免了十溴联苯醚(DECA),但它的危害性仍然受到人们的普遍质疑。文章对这种卤化阻燃剂的安全使用性进行了讨论。

关键词：十溴联苯醚毒性阻燃剂溴系阻燃剂

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Evaluation of nutrient stoichiometric relationships among ecosystem compartments of a subtropical treatment wetland. Do we have “Redfield wetlands”?

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Ecological Processes 2019年第1期8卷 267-287页

作者： Paul Julian II Stefan Gerber Rupesh K.Bhomia Jill King Todd Z.Osborne Alan L.Wright Matthew Powers jacob dombrowski Soil and Water Sciences Department University of FloridaFt.PierceFL34945USA Soil and Water Sciences Department University of FloridaGainesvilleFL 32611USA South Florida Water Management District Water Quality Treatment TechnologiesWest Palm BeachFL 33406USA Whitney Laboratory for Marine Bioscience University of FloridaSt AugustineFL 32080USA.

Background:Evaluation of carbon(C),nitrogen(N),and phosphorus(P)ratios in aquatic and terrestrial ecosystems can advance our understanding of biological processes,nutrient cycling,and the fate of organic matter(OM)in these *** of aquatic ecosystems can change the accumulation and decomposition of OM which can alter biogeochemical cycling and alter the base of the aquatic food *** study investigated nutrient stoichiometry within and among wetland ecosystem compartments(i.e.,water column,flocculent,soil,and aboveground vegetation biomass)of two subtropical treatment wetlands with distinct vegetation *** flow-ways(FWs)within the network of Everglades Stormwater Treatment Areas in south Florida(USA)were selected for this *** evaluated nutrient stoichiometry of these to understand biogeochemical cycling and controls of nutrient removal in a treatment wetland within an ecological stoichiometry ***:This study demonstrates that C,N,and P stoichiometry can be highly variable among ecosystem compartments and between *** law slopes of C,N,and P within surface water floc,soil,and vegetation were significantly different between and along ***:Assessment of wetland nutrient stoichiometry between and within ecosystem compartments suggests unconstrained stoichiometry related to P that conforms with the notion of P limitation in the *** in N:P ratios between floc and soil suggest different pathways of organic nutrient accumulation and retention between *** nutrient stoichiometry was highly variable and decoupled(or close to decoupled as indicated by<25%explained variation between parameters),in particular with respect to *** hypothesize that decoupling may be the imprint of variability in inflow nutrient ***,despite active biogeochemical cycles that could act to restore nutrient stoichiometry along the FW,there was little evidence that such balancing occurred,as the

关键词： Decomposition Mineralization Everglades Treatment wetlands

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Newer developments in viral hepatitis:Looking beyond hepatotropic viruses

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World Journal of Meta-Analysis 2021年第6期9卷 522-542页

作者： Manasvi Gupta Gaurav Manek Kaitlyn dombrowski Rakhi Maiwall Department of Internal Medicine University of ConnecticutFarmingtonCT 06030United States Department of Pulmonology and Critical Care Cleveland ClinicClevelandOH 44195United States Department of Hepatology Institute of Liver and Biliary SciencesNew Delhi 110070India

Viral hepatitis in the entirety of its clinical spectrum is vast and most discussion are often restricted to hepatotropic viral infections,including hepatitis virus(A to E).With the advent of more advanced diagnostic techniques,it has now become possible to diagnose patients with non-hepatotropic viral infection in patients with *** of these viruses belong to the Herpes family,with characteristic feature of *** the increase in the rate of liver transplantation globally,especially for the indication of acute hepatitis,it becomes even more relevant to identify non hepatotropic viral infection as the primary hepatic *** post-transplant is an established cause of reactivation of a number of viral infections that could then indirectly cause hepatic *** agents may be utilized for treatment of most of these infections,although data supporting their role is derived primarily from case *** are no current guidelines to manage patients suspected to have viral hepatitis secondary to non-hepatotropic viral infection,a gap that needs to be *** this review article,the authors analyze the common non hepatotropic viral infections contributing to viral hepatitis,with emphasis on recent advances on diagnosis,management and role of liver transplantation.

关键词： Hepatitis Non hepatotropic viruses Cytomegalovirus Herpes simplex virus Coronavirus-2019 Liver transplant

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Isolation and Identification of Fungal Endophytes from Grasses along the Oregon Coast

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American Journal of Plant Sciences 2015年第19期6卷 3216-3230页

作者： Ruth C. Martin james E. dombrowski USDA ARS Forage Seed and Cereal Research Unit Corvallis USA

Fungal endophytes have been shown to improve abiotic and biotic stress response in plants. Grasses growing along the Oregon coast are exposed to harsh conditions and may harbor endophytes that enable them to survive and grow under these conditions. Endophytic fungi were isolated from thirty-four grass plants representing eight different grass species at four different locations along the Oregon coast. The ITS-1, 5.8S, and ITS-2 regions of each isolate were amplified, sequenced, and used to perform a BLAST search against the nucleotide database collection at National Center for Biotechnology Information. One-hundred-eleven different fungal isolates were classified into thirtynine genera with two isolates that did not show a match greater than 95%. These endophytes will be investigated to determine their potential for improving the adaptability of grasses and other crop plants to grow in diverse environments where they are subjected to multiple biotic and abiotic stresses.

关键词： Fungi Endophytes Abiotic Stress Grass Biotic Stress Salt Stress

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Topological and Historical Considerations for Infectious Disease Transmission among Injecting Drug Users in Bushwick, Brooklyn (USA)

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World Journal of AIDS 2013年第1期3卷 1-9页

作者： Kirk dombrowski Richard Curtis Samuel Friedman Bilal Khan National Development Research Institute New York USA. Social Networks Research Group John Jay College CUNY New York USA

Recent interest by physicists in social networks and disease transmission factors has prompted debate over the topology of degree distributions in sexual networks. Social network researchers have been critical of “scale-free” Barabasi-Albert approaches, and largely rejected the preferential attachment, “rich-get-richer” assumptions that underlie that model. Instead, research on sexual networks has pointed to the importance of homophily and local sexual norms in dictating degree distributions, and thus disease transmission thresholds. Injecting Drug User (IDU) network topologies may differ from the emerging models of sexual networks, however. Degree distribution analysis of a Brooklyn, NY, IDU network indicates a different topology than the spanning tree configurations discussed for sexual networks, instead featuring comparatively short cycles and high concurrency. Our findings suggest that IDU networks do in some ways conform to a “scale-free” topology, and thus may represent “reservoirs” of potential infection despite seemingly low transmission thresholds.

关键词： Social Network Analysis Injecting Drug Users Scale-Free Networks

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