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Hot Deformation Behavior and Microstructural Characteristics of Ti–46Al–8Nb Alloy

Acta Metallurgica Sinica(English Letters) 2018年第9期31卷 933-944页

作者： Tian-Rui Li Guo-Huai Liu Mang Xu Tian-Liang Fu Yong Tian ra-ja Devesh Kumar Misra Zhao-DongWang State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China Laboratory for Excellence in Advanced Steel Research Department of MetallurgicalMaterials and BiomedicalEngineeringUniversity of Texas at E1 PasoE1 PasoTX 79968-0521USA

Hot deformation behavior, microstructural evolution and flow softening mechanism were investigated in Ti-46A1-8Nb alloy via isothermal compression approach. The true stress-strain curves exhibited typical work hardening and flow softening, in which the dependence of the peak stress on temperature and strain rate was obtained by hyperbolic sine equation with Zener-Hollomon （Z） parameter, and the activation energy was calculated to be 446.9 kJ/mol. The microstructural analysis shows that the alternate dark and light deformed ribbons of Al-rich and Nb-rich regions appeared and were associated with local flow involving solute segregation. The Al segregation promoted flow softening mainly arising from the recrystaUization of V phase with low stacking fault energy. The coarse recrystallized 7 and several massive phase were observed at grain boundaries. While in the case of Nb segregation, t/B2 phase harmonized bending of lamellae, combined with the growth of recrystallized γ grains and α ＋ β ＋ γ→α＋ γ transition under conditions of temperature and stress, leading to the breakdown of α2/γ lamellar colony. During the hot compression process, gliding and dissociation of dislocations occurred in γ phase that acted as the main softening mechanism, leading to extensive γ twins and cross twins in α/γ lamellae and at grain boundaries. in general, homogeneous microstructure during the hot defor- mation process can be obtained in TiAl alloy with high Nb addition and low Al segregation. The deformation substructures intrinsically promote the formability of Ti--46Al-8Nb alloy.

关键词： Titanium aluminides Deformation behavior Activation energy Dynamic recrystallization Local flow softening

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Effect of dexamethasone injection into Zusanli(ST 36) acupoint on ovalbumin-induced allergic rhinitis

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Journal of Traditional Chinese Medicine 2019年第3期39卷 307-314页

作者： Na-ra Han Seung-Jun Han Phil-Dong Moon Sungwei Hong Hyeongjin Kim Yanhua Li Hyung-Min Kim Hyun-ja Jeong Department of Pharmacology College of Korean Medicine Kyung Hee University Seoul 02447 Republic of Korea Department of Korean Medicine Graduate School of Wonkwang University Iksan 54538 Republic of Korea Department of Pharmacology Graduate School Kyung Hee University Seoul 02447Republic of Korea Department of Clinical Korean Medicine Graduate School Kyung Hee University Seoul 02447 Republic of Korea Department of Food Science & Technology and Research institute for Basic Science Hoseo UniversityChungnam 31499 Republic of Korea

OBJECTiVE:To investigate the effects of acupunc ture with dexamethasone(***)on allergic rhini tis(AR)by injecting dexamethasone into the Zusan li(ST 36)***:Thirty 6-week-old female BALB/c mice were sensitized on days 1,5,and 14 by intraperitoneal injection of 100 pg of ovalbumin(OVA).The mice were then randomly divided into six groups(n =5 in each group).Five groups were sensitized intranasally with 2μL of 1.5 mg of OVA for 10 consecutive days,while one group was sensitized intranasally with PBS in a similar manner as a negative control *** hour before each administration of intranasal OVA,two groups were orally administered either a control vehicle(distilled water;AR control group)or 200 pg/kg Dex(*** group),while three groups received *** at Zusanli(ST36)with Dex concentrations of 2,20,and 200μg/kg for each group,*** symptoms were evaluated by measuring the rubbing score,which comprised the number of nose,ear,and eye rubs that occurred in the initial 10 min after OVA intranasal provocation on the 10 th *** isolated spleen,serum,and nasal mucosal tissue after measuring the rubbing *** weight was measured using an electronic *** levels of igE,thymic stromal lymphopoietin,tumor necrosis factor-a,intercellular adhesion molecule-1,and macrophage-inflammatory protein-2 in serum or nasal mucosal tissue were measured using enzyme-linked immunosorbent *** serum histamine levels of OVA-sensitized AR mice were measured using O-phthaldialdehyde *** blot analysis was performed on nasal mucosal tissue ***:*** significantly reduced the rubbing score,spleen weight,serum igE,and serum histamine in OVA-sensitized *** significantly decreased the serum levels of inflammatory cytokines(thymic stromal lymphopoietin and tumor necrosis factor-a)in OVA-sensitized *** significantly reduced the nasal mucosal levels of inflammatory markers(intercellular adhesion molecule-l

关键词： Dexamethasone Point ST36 (Zusanli) Pharmaceutical research Acupuncture Rhinitis,allergic Ovalbumin Thymic stromal lymphopoietin

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Does climate change alter the nutrient trends of Cedrela fissilis Vell. trees in the southern Brazilian Amazon?

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Ecological Processes 2023年第4期12卷 164-185页

作者： Daigard R.Ortega Rodriguez raúl Sánchez-Salguero Andrea Hevia Renata C.Bovi Marciel J.Ferreira james H.Speer Fidel A.Roig Mario Tomazello-Filho Escola Superior de Agricultura Luiz de Queiroz Departamento de Ciências Florestais Universidade de S?o Paulo Dendr Olavide-Department Sistemas Físicos Químicos y Naturales Universidad Pablo de Olavide Department of Ecology Universidad de Jaén Campus Las Lagunillas s/n. Departamento de Ciência Florestal Solos e AmbienteUniversidade Estadual Paulista Laboratory of Silviculture Universidade Federal do Amazonas Department of Earth and Environmental Systems Indiana State University Argentine institute of Nivology Glaciology and Environmental Sciences(IANIGLA CONICET Universidad Nacional de Cuyo) Hémera Centro de Observación de la Tierra Escuela de Ingeniería Forestal Facultad de CienciasUniversidad Mayor

Background The increase in the frequency and intensity of droughts is pointed out as one of the main factors altering biogeochemical cycles in the Amazon basin. An eco-nutritional approach using X-ray fluorescence micro-analysis(μXRF) is proposed to verify the long-and short-term effects of droughts on the growth and xylem nutrient concentrations of Cedrela fissilis *** Fourteen radii were selected from a tree-ring width chronology and X-rayed by itrax Multiscanner. Profiles of ring width, wood density, and concentrations of aluminum(Al), phosphorus(P), sulfur(S), calcium(Ca), potassium(K), manganese(Mn), iron(Fe) and strontium(Sr) together with Al/Ca, Ca/Mn, K/Ca, Sr/Ca and Mn/S ratios were constructed and correlated with precipitation, temperature, the difference between precipitation and potential evapotranspiration(P-PET) and standardized precipitation–evapotranspiration index(SPEi).Results During dry years, C. fissilis showed narrower, less dense rings, lower Al, P, S and Ca, and higher K and Fe concentrations(the opposite was found in wet years). Ring width decreased(together with Al, P, S, K, Ca, Mn, Fe, Sr, Al/Ca, K/Ca and Sr/Ca) and wood density increased(together with Ca/Mn and Mn/S), which was associated with an increase in evapotranspiration and temperature over time, mainly since 1990. Cedrela fissilis showed a tendency to increase its capacity for resistance, and a recovery and resilience in growth over time associated with responses in Al, Ca, P and S. However, it showed a risk in the capacity for recovery of the pre-drought density values, associated with unsatisfactory responses in Al, Ca, K, Fe and *** This study is the first attempt to analyze tree-ring nutritional evidences of C. fissilis trees to climate sensitivity and resilience to drought, based on long-term data from seasonal moist tropical forests of the Amazon. Our data suggested that C. fissilis is undergoing alterations in the concentration, use and redistribution of n

关键词： Dendrochemistry µXRF Drought Tropical tree Eco-chemical indicator Resilience Resistance Recovery

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Does climate change alter the nutrient trends of Cedrela fissilis Vell. trees in the southern Brazilian Amazon?

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Ecological Processes 2023年 806-827页

作者： Daigard R.Ortega Rodriguez raúl Sánchez-Salguero Andrea Hevia Renata C.Bovi Marciel J.Ferreira james H.Speer Fidel A.Roig Mario Tomazello-Filho Escola Superior de Agricultura Luiz de Queiroz Departamento de Ciências Florestais Universidade de S?o Paulo Dendr Olavide-Department Sistemas Físicos Químicos y Naturales Universidad Pablo de Olavide Department of Ecology Universidad de JaénCampus Las Lagunillas s/n. Departamento de Ciência Florestal Solos e Ambiente Universidade Estadual Paulista Laboratory of Silviculture Universidade Federal do Amazonas Department of Earth and Environmental Systems Indiana State University Argentine institute of Nivology Glaciology and Environmental Sciences (IANIGLA CONICET Universidad Nacional de Cuyo) Hémera Centro de Observación de la Tierra Escuela de Ingeniería Forestal Facultad de CienciasUniversidad Mayor

Background The increase in the frequency and intensity of droughts is pointed out as one of the main factors altering biogeochemical cycles in the Amazon basin. An eco-nutritional approach using X-ray fluorescence micro-analysis(μXRF) is proposed to verify the long-and short-term effects of droughts on the growth and xylem nutrient concentrations of Cedrela fissilis *** Fourteen radii were selected from a tree-ring width chronology and X-rayed by itrax Multiscanner. Profiles of ring width, wood density, and concentrations of aluminum(Al), phosphorus(P), sulfur(S), calcium(Ca), potassium(K), manganese(Mn), iron(Fe) and strontium(Sr) together with Al/Ca, Ca/Mn, K/Ca, Sr/Ca and Mn/S ratios were constructed and correlated with precipitation, temperature, the difference between precipitation and potential evapotranspiration(P-PET) and standardized precipitation–evapotranspiration index(SPEi).Results During dry years, C. fissilis showed narrower, less dense rings, lower Al, P, S and Ca, and higher K and Fe concentrations(the opposite was found in wet years). Ring width decreased(together with Al, P, S, K, Ca, Mn, Fe, Sr, Al/Ca,K/Ca and Sr/Ca) and wood density increased(together with Ca/Mn and Mn/S), which was associated with an increase in evapotranspiration and temperature over time, mainly since 1990. Cedrela fissilis showed a tendency to increase its capacity for resistance, and a recovery and resilience in growth over time associated with responses in Al, Ca, P and ***, it showed a risk in the capacity for recovery of the pre-drought density values, associated with unsatisfactory responses in Al, Ca, K, Fe and *** This study is the first attempt to analyze tree-ring nutritional evidences of C. fissilis trees to climate sensitivity and resilience to drought, based on long-term data from seasonal moist tropical forests of the *** data suggested that C. fissilis is undergoing alterations in the concentration, use and redistribution of nutr

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脉搏波反射幅度对死亡率的预测作用:动脉粥样硬化多种族研究

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中华高血压杂志 2014年第11期22卷 1042-1042页

作者：刘莉叶鹏 Zamani P jacobs DR Jr Segers P Duprez DA Brumback L Kronmal ra Lilly SM Townsend RR Budoff M Lima ja Hannan P Chirinos ja

研究表明,纯亚裔人群中脉搏波反射与死亡率相关。但是,多种族人群中是否存在这样的关系,以及其是否独立于亚临床动脉粥样硬化,尚未确定。该研究人员假设,以社区为基础的多种族成人样本中,脉搏波反射幅度（定义为后向波振幅Pb与前向波振... 详细信息

研究表明,纯亚裔人群中脉搏波反射与死亡率相关。但是,多种族人群中是否存在这样的关系,以及其是否独立于亚临床动脉粥样硬化,尚未确定。该研究人员假设,以社区为基础的多种族成人样本中,脉搏波反射幅度（定义为后向波振幅Pb与前向波振幅Pf的比值）与全因死亡率相关。方法与结果：纳入多种族动脉粥样硬化研究中,行动脉张力波形分析的5984名受试者作为研究对象。

关键词：亚临床动脉粥样硬化全因死亡率种族人群波反射预测作用脉搏社区为基础研究人员

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婴幼儿血管瘤中促卵泡激素受体分析

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中国口腔颌面外科杂志 2018年第3期 274-274页

作者： Maclellan ra Konczyk DJ Goss ja 赵泽亮

简介:婴幼儿血管瘤(iH)的生命周期和促卵泡激素(FSH)的分泌是相同的。我们之前已经证明了iH中包含FSH受体(FSHR),本研究旨在确定iH中哪类细胞表达FSHR。方法:获取临床上有手术指征患儿的增殖期血管瘤组织。在石蜡切片和分离的细胞群(内... 详细信息

简介:婴幼儿血管瘤(iH)的生命周期和促卵泡激素(FSH)的分泌是相同的。我们之前已经证明了iH中包含FSH受体(FSHR),本研究旨在确定iH中哪类细胞表达FSHR。方法:获取临床上有手术指征患儿的增殖期血管瘤组织。在石蜡切片和分离的细胞群(内皮细胞、周细胞、干细胞)中进行免疫荧光以检测FSHR,组织中包含DAPi、抗-α平滑肌肌动蛋白或生物素化的Ulex Europaeus凝集素Ⅰ,以分别确

关键词：婴幼儿血管瘤促卵泡激素

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室内氡与肺癌关系研究

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中华放射医学与防护杂志 2002年第3期22卷 209-214页

作者：王作元 Lubin JH 王陇德张守志 Boice JD Jr 崔宏星张淑蓉 Conrath SC 夏英尚兵 Brenner A 雷苏文 Metayer KC 曹吉生 Chen KW 雷淑杰 Kleinerman ra 卫生部工业卫生实验所 100088 美国国立癌症研究所卫生部美国国际流行病研究所美国环境保护局

目的　直接调查居室水平氡浓度对居民肺癌危险度的影响 ,并与由矿工受照结果推导的结论相比较。方法　在甘肃省平凉、庆阳两地区进行病例对照研究。该地区居民稳定而室内氡水平较高。肺癌病例必须是在 1994年 1月至 1998年 4月期间诊... 详细信息

目的　直接调查居室水平氡浓度对居民肺癌危险度的影响 ,并与由矿工受照结果推导的结论相比较。方法　在甘肃省平凉、庆阳两地区进行病例对照研究。该地区居民稳定而室内氡水平较高。肺癌病例必须是在 1994年 1月至 1998年 4月期间诊断 ,年龄在 30～ 75岁之间 ,居住在平凉和庆阳两地区的居民。根据人口调查资料随机选取对照 ,对照要在年龄、性别、地区方面与病例相匹配。在过去 5～ 30年期间 ,凡住过两年以上的房间都布放了氡探测器。氡测量涵盖了 77%的照射周期。结果　病例居室的平均氡浓度为 2 30 4Bq m3 (n =76 8) ,对照为 2 2 2 2Bq m3 (n =16 5 9)。居民肺癌危险度随室内氡水平的增高有所上升 (P i:0 0 5 ,0 47)。对测量涵盖了 10 0 %照射周期的个体 ,为 0 31(95 %Ci:0 10 ,0 81)。在对照射的不确定度进行调整后 ,估算值可增加70 %。结论　研究结果证明室内水平氡照射会增加肺癌危险度。

关键词：危险度室内氡肺癌关系研究

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Heterogeneity of Glycoconjugates within Secretory Granules of Rhesus Monkey Tracheal Mucous Goblet Cells

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解剖学报 1987年第2期 198-198页

作者： Wang Shiping Plopper CO St George ja Department of Animal Husbandry and Veterinary Medicine Huazhong AgriculturalUniversity Wuhan Department of Anatomy School of Veterinary MedicineUniversity of California at DavisUSA

Tracheas fromthree rhesus monkeys(Macaca mulatta)were *** the animalswere killed by pentobarbital anesthesia fo1lowedby exsanguination,the trachea and lungs wereremoved by thoracotomy and fixed by airwayinfusion at 30 cm of water pressure with gluta-ra1dehyde(0.9%)/paraformaldehyde(0.7%)fixative in sodium cacodylate buffer(400 mOsmand pH7.4).

关键词： removed anesthesia killed

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表达D型流感病毒HEF蛋白重组新城疫病毒的拯救及其免疫原性研究

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中国兽医科学 2021年第9期51卷 1082-1089页

作者：张鑫张进进贾艳娥罗建勋吉艳红中国农业科学院兰州兽医研究所家畜疫病病原生物学国家重点实验室甘肃兰州730046

D型流感病毒是近年来新发现的一种流感病毒,宿主范围、地域分布广泛,可与其它呼吸道病毒一起引起严重的牛呼吸道疾病,给家畜养殖业造成了威胁,并存在跨越种间屏障向人类传播的风险。国外的D型流感疫苗研究结果虽然并不理想,但已经在灭... 详细信息

D型流感病毒是近年来新发现的一种流感病毒,宿主范围、地域分布广泛,可与其它呼吸道病毒一起引起严重的牛呼吸道疾病,给家畜养殖业造成了威胁,并存在跨越种间屏障向人类传播的风险。国外的D型流感疫苗研究结果虽然并不理想,但已经在灭活苗和DNA疫苗两个方向都有所涉及,而国内对于D型流感疫苗的研究尚未有报道。D型流感病毒基因组由7个RNA片段组成,共编码9种蛋白。血凝素酯酶融合蛋白(hemagglutinin-esterase-fusion,HEF)是D型流感病毒唯一的糖蛋白,具有A型流感病毒血凝素(hemagglutinin,HA)和神经氨酸酶(neuraminidase,NA)蛋白的功能,同时有较强的免疫原性,是开发预防性疫苗的关键免疫原。本研究采用反向遗传学技术拯救了表达HEF蛋白的重组新城疫病毒,命名为rNDV-F-HEF(NDV97 F裂解位点替换为Lasota裂解位点的突变病毒);传代测序验证重组病毒的遗传稳定性,结果显示HEF基因在重组新城病毒rNDV-F-HEF中可以稳定遗传;Western-blot试验和间接免疫荧光试验表明rNDV-F-HEF能成功表达外源蛋白HEF;rNDV-F-HEF在鸡胚和雏鸡体内的毒力和生长能力与其亲本毒株NDV-F基本一致;rNDV-F-HEF肌肉注射免疫BALB/c小鼠的血清中含有HEF特异性ig G抗体,其含量在三免后的第7天既能达到较高水平(约1800 ng/m L),说明rNDV-F-HEF具有防控iDV的潜质。重组病毒株rNDV-F-HEF可以用于iDV的预防性疫苗研发。

关键词： D型流感病毒 HEF蛋白新城疫病毒反向遗传学免疫原性

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卒中介入治疗培训指南：国际多学会共识文件

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国际脑血管病杂志 2017年第5期25卷 396-399页

作者： Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch ja Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ jansen O Muto M Szikora i Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T iihara K ishii A Higashi T Hirohata M Hyodo A ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata i Nakahara i Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart ra Meyers PM Mocco J Prestigiacomo CA Pride GL rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante i Yavagal D Liebeskind D Novakovic R Pongpech S 许岩孙瑞郭芮兵 From the American Association of Neurological Surgeons/Congress of Neurological Surgeons (AANS/CNS) Rolling Meadows IL USA American Society of Neuroradiology (ASNR) Oak Brook IL USA Asian Australasian Federation of lnterventional and Therapeutic Neuroradiology (AAFiTN) Bali Indonesia Australian and New Zealand Society of Neuroradiobgy-Conjomt Committee for Recognition of Training in interventional Neuroradiology (CCiNR) representing the raNZCR (ANZSNR) ANZAN and NSA Sydney Australia Canadian interventional Neuro Group (CiNG) Edmonton AB Canada World Federation of interventional and Therapeutic Neuroradiology (WFiTN) Gold Coast Australia European Society of Neuroradiology (ESNR) Milan Italy European Society of Minimally invasive Neurologic Therapy (ESMiNT) Nice France japanese Society for Neuroendovascular therapy (JSNET) Okayama Japan Sociedad ibero Latino Americana de Neuroradiologica (SiLAN) Cartagena Colombia Society of Neurolnterventional Surgery (SNiS) Washington DC USA Society of Vascular and interventional Neurology (SViN) Brooklyn NY USA 南京大学医学院附属金陵医院(南京军区南京总医院)神经内科 210002 解放军第一0一医院(无锡太湖医院)神经内科无锡214004

1背景缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞（emergent large vesselocclusion，ELVO）患者都会遗留长期残疾。事实上，这些颅内大动脉闭塞经常会导致大面积脑损伤，进而造成患者死亡或严重致残。

关键词：缺血性卒中培训指南介入治疗文件学会国际血管闭塞动脉闭塞

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