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MdbHLH162 connects the gibberellin and jasmonic acid signals to regulate anthocyanin biosynthesis in apple

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Journal of Integrative Plant Biology 2024年第2期66卷 265-284页

作者： Jian-Ping An Rui-Rui Xu Xiao-Na Wang Xiao-Wei Zhang Chun-Xiang you Yuepeng Han Apple technology innovation center of Shandong Province College of Horticulture Science and EngineeringShandong Agricultural UniversityTai-An 271018China CAS Key Laboratory of Plant Germplasm enhancement and Specialty Agriculture Wuhan Botanical GardenHubei Hongshan LaboratoryThe Innovative Academy of Seed Design of Chinese Academy of SciencesWuhan 430074China College of Biology and Oceanography Weifang UniversityWeifang 261061China

Anthocyanins are secondary metabolites induced by environmental stimuli and developmental *** positive regulators of anthocyanin biosynthesis have been reported,whereas the anthocyanin repressors have been *** the signal transduction pathways of gibberellin(GA)and jasmonic acid(ja)and their regulation of anthocyanin biosynthesis have been investigated,the cross-talk between GA and ja and the antagonistic mechanism of regulating anthocyanin biosynthesis remain to be *** this study,we identified the anthocyanin repressor MdbHLH162 in apple and revealed its molecular mechanism of regulating anthocyanin biosynthesis by integrating the GA and ja ***162 exerted passive repression by interacting with MdbHLH3 and MdbHLH33,which are two recognized positive regulators of anthocyanin ***162 negatively regulated anthocyanin biosynthesis by disrupting the formation of the anthocyanin-activated MdMYB1-MdbHLH3/33complexes and weakening transcriptional activation of the anthocyanin biosynthetic genes MdDFR and MdUF3GT by MdbHLH3 and *** GA repressor MdRGL2a antagonized MdbHLH162-mediated inhibition of anthocyanins by sequestering MdbHLH162 from the MdbHLH162-MdbHLH3/33 *** ja repressors MdjaZ1 and MdjaZ2 interfered with the antagonistic regulation of MdbHLH162 by MdRGL2a by titrating the formation of the MdRGL2a-MdbHLH162 *** findings reveal that MdbHLH162 integrates the GA and ja signals to negatively regulate anthocyanin *** study provides new information for discovering more anthocyanin biosynthesis repressors and explores the cross-talk between hormone signals.

关键词： anthocyanin biosynthesis bHLH transcription factor gibberellin jasmonic acid regulatory network transcriptional regulation

Matched pair analysis of the effect of longer hypothermic machine perfusion time on kidney transplant outcomes

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World Journal of Transplantation 2024年第3期14卷 95-101页

作者： Carlos Verdiales Luke Baxter Hyun ja Lim Gavin Beck Michael A Moser Department of Surgery University of SaskatchewanSaskatoonSaskatchewan S7N 0W8Canada College of Medicine University of SaskatchewanSaskatoonSaskatchewan S7N 0W8Canada Canada and Northern Ontario School of Medicine Thunder BayOntario P7B 5E1Canada Department of Community Health and epidemiology University of SaskatchewanSaskatoonSaskatchewan S7N 0W8Canada

BACKGROUND Hypothermic machine perfusion(HMP)has demonstrated benefits in terms of early kidney transplant function compared to static cold *** longer preservation times have shown detrimental effects,a previous paired study indicated that longer pump times(the second kidney in a pair)might lead to improved *** To revisit the prior paired study's somewhat unexpected results by reviewing our program's *** A total of 61 pairs of transplant recipients who received kidneys from the same donor(2012-2021)were *** were divided into two groups depending on whether they were transplanted first(K1)or second(K2).Therefore,the patients in each pair had identical donor characteristics,except for time on the *** analyses included Kaplan-Meyer analysis and paired tests,including McNemar's test,student's paired t-test,or Wilcoxon's test,as *** The two groups of recipients had similar demographics(age,body mass index,diabetes,time on dialysis,sensit-ization and retransplants).Cold ischemic times for K1 and K2 were 8.9(95%CI:7.9,9.8)and 14.7 hours(13.7,15.8)(Per rate of freedom from biopsy-proven acute rejection at 1 year(P=0.015).Delayed graft function was less common in K2,12/61(20%)than in K1,20/61(33%)(P=0.046).Finally,K2 showed a higher graft survival than K1(P=0.023).CONCLUSION Our results agree with a previous study that suggested possible advantages to longer pump *** studies should encourage further research into HMP's potential anti-inflammatory effect.

关键词： Hypothermic machine perfusion Paired kidney study early acute rejection

Measurement　of　excursion　of　Finger　Flexor　Tendons　Produced　by　a　Continuous　Passive　Motion　Machine

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中华骨科杂志 1995年第2期15卷 76-83页

作者： Yoshida e Dent ja Rowley JI University of Dundee 苏格兰

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ＭｅａｓｕｒｅｍｅｎｔｏｆＥｘｃｕｒｓｉｏｎｏｆＦｉｎｇｅｒＦｌｅｘｏｒＴｅｎｄｏｎｓＰｒｏｄｕｃｅｄｂｙａＣｏｎｔｉｎｕｏｕｓＰａｓｓｉｖｅＭｏｔｉｏｎＭａｃｈｉｎｅＹｏｓｈｉｄａＥ；ＤｅｎｔＪＡ；ＲｏｗｌｅｙＪＩＲｅｃｅｉｖｅｄ９Ａｕｇｔｔｓｔ１...

关键词：掌指关节指尖手指指间关节指关节 Continuous excursion Finger Flexor Machine Measurement Motion Passive Produced Tendons

Association between Tropical Convection and Boreal Wintertime extratropical Circulation in 1982/83 and 1988/89

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Advances in Atmospheric Sciences 2003年第4期20卷 593-603页

作者： ja-Yeon MOON Kyung-ja HA Climate Research Laboratory Meteorological Research InstituteSeoul156-720KoreaDepartment of Atmospheric SciencesPusan National UniversityPusan609-735Korea

Boreal wintertime extratropical circulation is studied in relation to the tropical convection during the 1982/83 el Niño and 1988/89 La Niña. The anomaly structure of 1982/83 and 1988/89 over the extratropics reveals remarkably different features as the longitudinal tropical forcing region changes. The Rossby wave source (Positive) shows the largest maximum over east Asia in both years due to the persistent heating from the western Pacific warm pool area. However, the sink term shows contrasting features over the subtropics and extratropics between the two years. In the el Niño year, enhanced tropical convection over the eastern Pacific produces the Rossby wave sink at 10°N and shifted eastward over the North Pacific, while in the La Niña year, the sink area is shifted westward over the North Pacific. The contrasting features between the two events in mean-eddy interaction appears especially over the downstream area of the east Asian Jet. The extension (retraction) of the meanflow eastward (westward) to the east (west) of the dateline is related with the effect of the westward (eastward) e-vector and the strengthening (weakening) of the negative anomalies of the barotropic growth of kinetic energy. Hence, almost opposite characteristics between the two events can explain the close relationship of tropical convection and the extratropical internal variability.

关键词： tropical convection extratropical circulation rossby wave source mean-eddy interaction

Genome-wide markers for seed yield and disease resistance in perennial ryegrass

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The Crop Journal 2022年第2期10卷 508-514页

作者： Kristina jaškune Vilma Kemešyte Andrius Aleliūnas Grazina Statkeviciute Institute of Agriculture Lithuanian Research Centre for Agriculture and Forestry(LAMMC)Instituto av.1Akademija LT-58344Lithuania

The market success of perennial ryegrass(Lolium perenne L.) cultivars depends on sufficient seed production, as they are propagated by seed. However, breeding for high quality forage production reduces seed yield, and breaking the negative correlation would help to overcome the problem. The foliar disease crown rust is another factor affecting reproductive capacity and thereby seed yield. We evaluated seed yield-related traits and resistance to crown rust in a collection of commercial cultivars and ecotypes of perennial ryegrass and identified genome-wide markers associated with the traits. The study revealed high variation between the ecotype and cultivar groups as well as between years. A genome-wide association study identified 17 DNA single-nucleotide polymorphisms(SNPs) of which eight were associated with crown rust and nine with flag-leaf length. The SNP markers were located within or near predicted genes functioning in defense against pathogens. The identified genes are strong candidates for a further in-depth functional study to continue unravel determination of leaf architecture and crown rust resistance in perennial ryegrass.

关键词： Crown rust Puccinia coronata f.sp.lolli Flag-leaf length Genome-wide association study(GWAS) Seed yield Lolium perenne L.

Male masturbation device for the treatment of delayed ejaculation: A case report

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Asian pacific Journal of Reproduction 2017年第4期6卷 191-192页

作者： Rodríguez Je Picazo ja López e Research Department of Instituto Sexológico Murciano C/Periodista Encarna Sánchez22030007 MurciaSpain

Delayed ejaculation is a rare condition with different etiologies. Majority of cases of delayed ejaculation have a strong psychological/behavior component. A 48-year-old male with a diagnostic of delayed ejaculation acquired was encouraged to make an exercise protocol using a masturbation device for 8 wk, the percentage of intercourse successful a month after finish protocol exercise was 81%.

关键词： Delayed ejaculation Male Device Treatment ejaculation disorders

An accelerated K-means clustering algorithm using selection and erasure rules

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Journal of Zhejiang University-Science C(Computers and electronics) 2012年第10期13卷 761-768页

作者： Suiang-Shyan Lee ja-Chen LIN Department of Computer Science National Chiao Tung University

The K-means method is a well-known clustering algorithm with an extensive range of applications,such as biological classification,disease analysis,data mining,and image ***,the plain K-means method is not fast when the number of clusters or the number of data points becomes large.A modified K-means algorithm was presented by Fahim et al.(2006).The modified algorithm produced clusters whose mean square error was very similar to that of the plain K-means,but the execution time was *** this study,we try to further increase its *** are two rules in our method:a selection rule,used to acquire a good candidate as the initial center to be checked,and an erasure rule,used to delete one or many unqualified centers each time a specified condition is *** clustering results are identical to those of Fahim et al.(2006).However,our method further cuts computation time when the number of clusters *** mathematical reasoning used in our design is included.

关键词： K-means clustering Acceleration Vector quantization Selection erasure

山楂叶总黄酮通过miR-21a-5p对血管紧张素Ⅱ诱导的心肌细胞肥大的影响

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中国临床药理学杂志 2024年第15期40卷 2182-2186页

作者：田林燕朱冉代聚平王佳佳张斌南阳医学高等专科学校内科教研室河南南阳473000 南阳医学高等专科学校临床实训室河南南阳473000 南阳医学高等专科学校第一附属医院心血管内科河南南阳473000 南阳医学高等专科学校第一附属医院病理科河南南阳473000

目的探讨山楂叶总黄酮对血管紧张素Ⅱ(AngⅡ)诱导的心肌肥大的影响,及其可能作用机制。方法将H9c2细胞分为对照组(正常培养),模型组(100 nmol·L^(-1)AngⅡ处理24 h),低、中、高剂量实验组(先给予100 nmol·L^(-1)AngⅡ处理24 h后,再分... 详细信息

目的探讨山楂叶总黄酮对血管紧张素Ⅱ(AngⅡ)诱导的心肌肥大的影响,及其可能作用机制。方法将H9c2细胞分为对照组(正常培养),模型组(100 nmol·L^(-1)AngⅡ处理24 h),低、中、高剂量实验组(先给予100 nmol·L^(-1)AngⅡ处理24 h后,再分别给予25、50、100 mg·L^(-1)的山楂叶总黄酮处理24 h),anti-miR-NC、anti-miR-21a-5p组(分别转染anti-miR-NC、anti-miR-21a-5p后,给予100 nmol·L^(-1)AngⅡ处理24 h),miR-NC+高剂量组和miR-21a-5p+高剂量组(分别转染miR-NC、miR-21a-5p mimics,再给予100 nmol·L^(-1)AngⅡ+100 mg·L^(-1)山楂叶总黄酮各处理24 h)。用CCK-8法和流式细胞术检测细胞活力和凋亡情况,用实时荧光定量聚合酶链反应法检测miR-21a-5p的表达水平,用蛋白质印迹法检测环氧化酶-2(COX2)/前列腺素e2(PGe2)的表达水平。结果对照组、模型组和高剂量实验组的细胞活力分别为1.03±0.09、0.51±0.05和0.93±0.08,凋亡率分别为(7.69±0.61)%、(23.04±1.82)%和(9.43±0.71)%,miR-21a-5p表达水平分别为1.00±0.09、2.43±0.18和1.09±0.08,COX2蛋白相对表达水平分别为0.42±0.03、0.85±0.08和0.40±0.04,PGe2蛋白相对表达水平分别为0.34±0.03、0.75±0.07和0.35±0.03,模型组的上述指标与高剂量实验组和对照组相比,在统计学上差异均有统计学意义(均Pe2蛋白相对表达水平分别为0.74±0.06、0.38±0.07、0.36±0.02、0.71±0.05,anti-miR-21a-5p组的上述指标与anti-miR-NC组比较,miR-21a-5p+高剂量组的上述指标与miR-NC+高剂量组比较,在统计学上差异均有统计学意义(均Pe2通路的表达,从而抑制AngⅡ诱导的心肌肥大。

关键词：山楂叶总黄酮心肌肥大血管紧张素Ⅱ 细胞增殖凋亡

CONJUGATe FLOWS OVeR A STeP IN A THRee-LAYeR FLUID

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Journal of Hydrodynamics 2002年第4期14卷 15-23页

作者： Wei, Gang Le, ja-Chun Dai, Shi-Qiang Inst. of Appl. Math. and Mech. Shanghai Univ. Shanghai 200072 China Sch. of Sci. P.L.A Univ. of Sci. and Eng. Nanjing 211101 China

The conjugate flows over a step with the height h_0, which might be positive or negative, was studied in a three-layer fluid and the coupled nonlinear equations were derived, with which the effects of varying height h_0 on the existence and evolution of conjugate flows were examined. It is concluded that the conjugate flow is sharply sensitive to the thickness of fluid layers and its characteristics alters remarkably due to the existence of the step. As the flow climbs up a step (h_0>0), the conjugate flow with a convex lower interface and a concave upper interface is allowed to appear, while the flow with the concave lower interface or the simultaneous concave interfaces will be depressed. As the flow goes down a step (i.e., h_0e kind of conjugate flow could exist, which prossesses the form with the simultaneous convex interfaces and will disappear rapidly with the increase of the step depth.

关键词： conjugate flow flat solitary wave stratified flow step topography three-layer fluid