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Is.lated unilateral chorea:a diagnos.ic challenge

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Neuroimmunology and Neuroinf.ammation 2016年第1期3卷 260-261页

作者： Marta lopes Eva Brandão Department of.Neurology Hospital São SebastiãoEntre Douro e Vouga Hospital Centre4720-411 Santa Maria da FeiraPortugal

Movement dis.rders.of.paraneoplas.ic etiology are very rare,repres.nting s.lely about 1%of.all paraneoplas.ic neurological s.ndromes.^([1])The mos. f.equently as.ociated carcinoma is.s.all-cell lung cancer,although s.veral others.are reported s.ch as.hematologic,bowel,breas.,pros.ate and *** was.reported an as.ociation with CV2/CRMP5,Anti-Hu/ANNA,CAs.R2 and Yo antibodies.which are detectable in s.rum in mos. cas.s.is.lated or in as.ociation.^([1-4])However,in a minority of.cas.s.an autoantibody cannot be detected.^([1])The antibody mos. f.equently as.ociated with paraneoplas.ic chorea is.CV2/CRMP5,f.llowed by Anti-Hu/ANNA.

关键词： bladder neoplas.ic lung

＂My News.as.＂ Is.No Longer Ours

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Journalis. and Mas. Communication 2011年第3期1卷 201-212页

作者： f.lis.ela lopes Luis.M. Loureiro Univers.ty of.Minho Braga Portugal

With this.article we aim to propos. an analytical alternative to what we could call the s.bs.itution and condemnation of.the s.ectator as.an element of.the new technological apparatus.s. Actually, what we s.e in many of.the current ref.ections.on new media is.that while the s.ectator is.being accus.d of.ultimate pas.ivity, he is.als. being mobilized to emancipated action as.an empowered us.r. Through the critique of.an online application available on Portugues. Radio Televis.on （RTP）＇s.webs.te, the s.ate-owned televis.on network, called 0 Meu Telejornal1, we will try to demons.rate that we actually need to develop a s.ectator theory to critically unders.and the political pos.tion of.the citizen within our changing contemporary media environment.

关键词： TV news.as. online news s.ectators.ip citizens.ip technological determinis.

Es.phageal s.uamous.cell carcinoma-precurs.r les.ons.and early diagnos.s

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World Journal of.Gas.rointes.inal Endos.opy 2012年第1期4卷 9-16页

作者： Antonio Barros.lopes Renato Borges.f.gundes Pos.-Graduate Program: s.iences.in Gas.roenterology and Hepatology-Univers.dade f.deral do Rio Grande do s.l Rio Grande do Sul 90035-003 Brazil Departamento de Clínica Médica-Univers.dade f.deral de s.nta Maria Rio Grande do Sul 97119-900 Brazil

s.uamous.cell carcinoma of.the es.phagus.(s.CE) carries.a poor prognos.s.due to late *** detection is.highly des.rable,s.nce s.rgical and endos.opic res.ction of.ers.the only pos.ible cure f.r es.phageal *** s.reening s.ould be undertaken in high ris. areas.and in low or moderate ris. areas.f.r people with ris. f.ctors.(alcoholics.s.okers.mate drinkers.his.ory of.head and neck cancer,achalas.a and lye s.ricture of.the es.phagus..Es.phageal balloon cytology is.an eas. and inexpens.ve s.mpling technique,but the current methods.are ins.f.icient f.r primary s.reening due to s.mpling *** endos.opy with biops. remains.the s.andard procedure f.r the identif.cation of.pre-malignant and early malignant changes.in es.phageal mucos. and endos.opic *** may be enhanced by s.veral techniques.s.ch as.dye and optic chromoendos.opy,magnif.ing endos.opy,and optical-bas.d s.ectros.opic and imaging *** more than 80% of.s.CE deaths.occur in developing countries.where expens.ve techniques.s.ch as.narrow band imaging (NBI) and autof.uores.ence imaging are unavailable,the mos. cos.-ef.ective tool f.r targeting biops.es.may be Lugol dye chromoendos.opy,s.nce it is.eas.,accurate,inexpens.ve and available *** ideal conditions.or in developed countries.is.it reas.nable to think that optimal detection will require a combination of.techniques.s.ch as.the combination of.Lugol’s.chromoendos.opy and NBI to identif. es.phageal areas.that require f.rther characterization by a high res.lution *** ef.icacy and cos.-ef.ectivenes. will determine whether thes. modalities.will become part of.s.andard endos.opy practice.

关键词： Autof.uores.ence endos.opy Early diagnos.s Es.phageal cancer Es.phageal s.uamous cell carcinoma Lugol’s s.lution Narrow-band imaging endos.opy

Unintended changes.in ocular biometric parameters.during a 6-month f.llow-up period af.er f.-LAs.K and s.ILE

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Eye and Vis.on 2021年第1期8卷 75-82页

作者： Junjie Wang Bernardo T.lopes Hechen Li Riccardo Vinciguerra s. Cao s.ngan Wu Rong Zhu Qinmei Wang Xiaobo Zheng f.ngjun Bao Ahmed Els.eikh Eye Hos.ital Wenzhou Medical UniversityWenzhou 325027ZhejiangChina The Ins.itution of.Ocular Biomechanics Wenzhou Medical UniversityWenzhou 325027ZhejiangChina s.hool of.Engineering University of LiverpoolLiverpool L693GHUK Humanitas.s.n Pio X Hos.ital MilanItaly National Ins.itute f.r Health Res.arch(NIHR)Biomedical Res.arch Centre f.r Ophthalmology Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of OphthalmologyLondonUK Beijing Advanced Innovation Center f.r Biomedical Engineering Beihang UniversityBeijingChina

Background:Corneal ref.active s.rgery has.become reliable f.r correcting ref.active errors.but it can induce unintended ocular changes.that alter ref.active *** s.udy is.to evaluate the unintended changes.in ocular biometric parameters.over a 6-month f.llow-up period af.er f.mtos.cond las.r-as.is.ed las.r in s.tu keratomileus.s.f.-LAs.K)and s.all incis.on lenticule extraction(s.ILE).Methods.156 cons.cutive myopic patients.s.heduled f.r f.-LAs.K and s.ILE were included in this.*** corneal thicknes.(CCT),mean curvature of.the corneal pos.erior s.rf.ce(K_(pm)),internal anterior chamber depth(IACD)and the length f.om corneal endothelium to retina(ER)were evaluated bef.re and af.er s.rgery over a 6-month ***:Both the f.-LAs.K and s.ILE groups.clos.ly matched at the pre-s.rgery s.age)experienced f.atter Kpm,s.allower IACD and decreas.d ER 1 week pos.-s.rgery(Ps. changes.were larger in f.-LAs.K than in s.ILE *** the 1 week to 6 months.f.llow up period,K_(pm),IACD and ER remained s.able unlike CCT which increas.d s.gnif.cantly(Pf.-LAs.K ***:During the f.llow up,the pos.erior corneal s.rf.ce became f.atter and s.if.ed pos.eriorly,the anterior chamber depth and the length f.om the corneal endothelium to retina decreas.d s.gnif.cantly compared with the pre-s.rgery *** unintended changes.in ocular biometric parameters.were greater in patients.undergoing f.-LAs.K than *** changes.pres.nt clear challenges.f.r IOL power calculations.and s.ould be cons.dered to avoid af.ecting the outcome of.cataract s.rgery.

关键词： Pos.erior corneal s.rf.ce Internal anterior chamber depth The length f.om corneal endothelium to retina f.-LAs.K s.ILE

s.mple General Purpos. Ion Beam Deceleration s.s.em Us.ng a s.ngle Electrode Lens

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World Journal of.Engineering and Technology 2015年第3期3卷 127-133页

作者： J. lopes J. Rocha Ins.ituto s.perior de Engenharia de Lis.oa Rua Conselheiro Emídio Navarro Lisbon Portugal Ins.ituto de Plas.as.e f.s.atilde o Nuclear Campus Tecnológico e Nuclear Instituto Superior Técnico Lisboa Portugal

Ion beam deceleration properties.of.a newly developed low-energy ion beam implantation s.s.em were s.udied. The objective of.this.s.s.em was.to produce general purpos. low-energy (5 to 15 keV) implantations.with high current beam of.hundreds.of.μA level, providing the mos. wide implantation area pos.ible and allowing continuous.y magnetic s.anning of.the beam over the s.mple(s.. This.paper des.ribes.the developed s.s.em ins.alled in the high-current ion implanter at the Laboratory of.Accelerators.and Radiation Technologies.of.the Nuclear and Technological Cam-pus. s.cavém, Portugal (CTN).

关键词： Deceleration Low Energy Pos.tive Ion Beam

Development of.a Xeno-f.ee and s.rum-f.ee Replacement f.r T and NK Cell Culture

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Development of a Xeno-Free and Serum-Free Replacement for T ...

Gas.ric cancer in a Caucas.an population: Role of.peps.nogen C genetic variants

第十四届全国免疫学学术大会

作者： Xiaodan He Vanda s.lopes Hannah s.rraceno Yuns.i Zhou Jes.ie Ni BioLegend

Cancer immunotherapy has.become one of.the mos. promis.ng f.elds.in the treatment of.oncologic related dis.rders. It takes.advantage of.the body’s.own immune def.ns.s. by harnes.ing the power of.T and NK cells. Expans.on and/or dif.erentiation of.cells.with the right therapeutic prof.les. in a cons.s.ent and s.f. manner, requires.the us. of.def.ned cell culture reagents. One major caus. of.variability is.s.rum, with its.undef.ned compos.tion. While we tend to look at s.rum as.a reagent, it is.in truth a mixture of.hundreds.of.reagents. that vary in concentration with the gender, age, diet, and genetics.of.the donor. The introduction of.s.rum-f.ee reagents.in the culture of.T and NK cell culture allows.f.r a more controlled cell culture proces., and higher reproducibility in res.arch and clinical *** our development s.rategy, we were able to identif. s.veral critical f.ctors.pres.nt in human AB s.rum that impact T cell culture. Here, we characterized the optimization of.key components.in the development of.a novel s.rum s.bs.itute f.r cell culture of.T and NK *** extens.ve development and verif.cation, we were able to develop a f.rmulation that meets.key parameters.in cell therapy: expans.on, viability, and cell population phenotype. Our development proces. dis.ected the roles.and impact of.each critical component. This.know-how will allow us.to modif. the f.rmulation to meet any cus.om criteria f.r divers. cell culture needs.

关键词： s.rum s.bs.itute cell therapy T and NK cell expans.on

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World Journal of.Gas.roenterology 2006年第31期12卷 5033-5036页

作者： Ana L Pinto-Correia Hugo s.us. Maria f.agos. Luís.Moreira-Dias.Carlos.lopes Rui Medeiros.Mário Dinis.Ribeiro Molecular Oncology GroupPortugues. Ins.itute of.Oncology of.Porto Portugal Oncology DepartmentPortugues. Ins.itute of.Oncology of.Porto Portugal Gas.roenterology DepartmentPortugues. Ins.itute of.Oncology of.Porto Portugal and ICBAs Abel Salazar Institute for the Biomedical SciencesPortoPortugal and CINTEs.s.f.culty of.Medicine Univers.ty of.Porto PortoPortugal

AIM： To s.udy the role of.an ins.rtion/deletion polymorphis. in the peps.nogen C （PGC） gene, an ef.ective marker f.r terminal dif.erentiation of.the s.omach mucos., in the s.s.eptibility to the development of.gas.ric les.ons. METHODs. The s.udy was.perf.rmed with 99 s.mples.of.known gas.ric les.ons.and 127 s.mples.without evidence of.neoplas.ic dis.as.. PCR was.employed and the 6 polymorphic alleles.were amplif.ed： Allele 1 （510 bp）, Allele 2 （480 bp）, Allele 3/4 （450/460 bp）, Allele 5 （400 bp） and Allele 6 （310 bp）. REs.LTs. Our res.lts.revealed that Allele 6 carriers.s.emed to have protection agains. the development of.any gas.ric les.on （OR = 0.34; P 〈 0.001）, non-dys.las.ic les.ons.as.ociated with gas.ric adenocarcinoma s.ch as.atrophy or intes.inal metaplas.a （OR = 0.28; P 〈 0.001） or invas.ve GC （OR = 0.39; P = 0.004）. CONCLUs.ON： Our s.udy reveals.that the Allele 6 carrier s.atus.has.a protective role in the development of.gas.ric les.ons. probably due to its.as.ociation with higher expres.ion of.PGC. Moreover, the f.equency of.Allele 6 carriers.in the control group is.f.r higher than that obtained in As.an populations. which might repres.nt a genetic gap between Caucas.an and As.an populations.

关键词： Gas.ric adenocarcinoma Peps.nogen C Polymorphis.

Alkaline hydrolyzable nitrogen and properties.that dictate its.dis.ribution in paddy s.il prof.les

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Pedos.here 2020年第3期30卷 326-335页

作者： Gers.n Laers.n DREs.HER Leandro s.uza DA s.LVA Qamar s.Rf.RAZ Gus.avo DAL MOLIN Laura Brondani MARZARI Augus.o f.rreira lopes Ces.r CELLA Daniela Bas.o f.CCO Rodrigo Knevitz HAMMERs.HMITT Department of.s.il s.ience Federal University of Santa MariaSanta Maria 97105-900Brazil f.deral Univers.ty of.s.nta Maria Campus Cachoeira do SulCachoeira do Sul 96506-310Brazil

Nitrogen(N) is.a key nutrient f.r rice production, and its.bioavailability in paddy s.ils.is.s.rongly coupled to s.il organic matter(s.M) cycling. A better unders.anding of.potentially available N f.rms.in s.il, s.ch as.alkaline hydrolyzable N(AH-N), and their depth dis.ribution will s.pport the development of.bes. management practices.to improve the N us. ef.iciency of.rice while minimizing advers. environmental ef.ects. f.f.een rice(Oryza s.tiva L.) f.elds.f.om s.uthern Brazil were s.lected, and s.ratif.ed s.il s.mples.were taken to a depth of.60 cm bef.re crop es.ablis.ment. s.lected s.il phys.cal and chemical properties.were analyzed to evaluate their relations.ips.with AH-N contents.in the s.il prof.le. The AH-N contents.below 20 cm varied extens.vely(increas.d,reduced, or cons.ant) compared with that above 20 cm. Although clay and clay + s.lt contents.were highly correlated to AH-N f.r s.me s.ils. the major property dictating AH-N dis.ribution by depth was.total N(TN), as.the correlation between TN and AH-N was.mainly by direct ef.ect. The proportion of.TN recovered as.AH-N acros. s.tes.and depths.pres.nted high amplitude, and thus.AH-N was.not a cons.ant N pool acros. depths. indicating that AH-N can be af.ected by s.il management practices.even when TN s.owed no major changes. The dis.inct dis.ribution of.AH-N acros. s.il s.mpling s.tes.and depths.indicates.that depths.greater than 20 cm s.ould be cons.dered when calibrating the AH-N index f.r N f.rtilizer recommendations.f.r f.ooded rice in s.uthern Brazil.

关键词： f.rtilizer recommendation nitrogen availability nutrient management practices organo-mineral interaction Oryza s.tiva L. s.il analys.s s.il organic matter

社会经济因素在巴西心力衰竭患者队列预后中的作用

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世界核心医学期刊文摘（心脏病学分册） 2007年第4期3卷 28-29页

作者： de Campos.lopes C.B. Yamada A.T. Araújo f. 郭俊 Heart Ins.itute University of So Paulo Medical SchoolGeneral Outpatient Clinics UnitSo PauloBrazil

大量证据支持社会经济因素可影响心血管疾病的预后。

关键词：社会经济因素心血管疾病公共卫生系统动脉性人口统计学社会经济特征