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Re.chability-Base. Confide.ce.Aware.Probabilistic Collision De.e.tion in Highway Driving

e.gine.ring 2024年第2期33卷 90-107页

作者： Xinwe. Wang Zirui Li Javie. alonso-Mora Me.g Wang School of e.gine.ring and Mate.ials Scie.ce Queen Mary University of LondonLondon E14NSUK De.artme.t of Cognitive.Robotics Delft University of TechnologyDelft 2628 CDNetherlands School of Me.hanical e.gine.ring Beijing Institute of TechnologyBeijing 100081China Chair of Traffic Proce.s Automation “Friedrich List”Faculty of Transport and Traffic SciencesTU DresdenDresden 01069Germany

Risk asse.sme.t is a crucial compone.t of collision warning and avoidance.syste.s for inte.lige.t ***-base. formal approache. have.be.n de.e.ope. to e.sure.driving safe.y to accurate.y de.e.t pote.tial ve.icle.***,the. suffe. from ove.-conse.vatism,pote.tially re.ulting in false.positive.risk e.e.ts in complicate. re.l-world *** this pape.,we.combine.two re.chability analysis te.hnique.,a backward re.chable.se.(BRS)and a stochastic forward re.chable.se.(FRS),and propose.an inte.rate. probabilistic collision–de.e.tion frame.ork for highway *** this frame.ork,we.can first use.a BRS to formally che.k whe.he. a two-ve.icle.inte.action is safe.othe.wise.a pre.iction-base. stochastic FRS is e.ploye. to e.timate.the.collision probability at e.ch future.time.***,the.frame.ork can not only ide.tify non-risky e.e.ts with guarante.d safe.y but also provide.accurate.collision risk e.timation in safe.y-critical *** construct the.stochastic FRS,we.de.e.op a ne.ral ne.work-base. acce.e.ation mode. for surrounding ve.icle. and furthe. incorporate.a confide.ce.aware.dynamic be.ie. to improve.the.pre.iction *** e.pe.ime.ts we.e.conducte. to validate.the.pe.formance.of the.acce.e.ation pre.iction mode. base. on naturalistic highway driving *** e.ficie.cy and e.fe.tive.e.s of the.frame.ork with infuse. confide.ce.be.ie.s we.e.te.te. in both naturalistic and simulate. highway *** propose. risk asse.sme.t frame.ork is promising for re.l-world applications.

关键词： Probabilistic collision de.e.tion Confide.ce.aware.e.s Probabilistic acce.e.ation pre.iction Re.chability analysis Risk asse.sme.t

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Low-Cost and Biode.radable.The.moe.e.tric De.ice. Base. on van de. Waals Se.iconductors on Pape. Substrate.

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e.e.gy & e.vironme.tal Mate.ials 2024年第1期7卷 201-206页

作者： Gulsum e.su Carme. Munue.a Fe.e.ico J.Mompe.n Danie. Vaque.o jorge Que.e.a João e.ias F.S.Rodrigue. Jose.A.alonso e.uardo Flore. Jose.R.Are. Isabe. J.Fe.re. Abdullah M.Al-e.izi Ayman Nafady Sruthi Kuriakose.Joshua O.Island Andre. Caste.lanos-Gome. Mate.ials Scie.ce.Factory Instituto de Ciencia de Materiales de Madrid(ICMM-CSIC)Madrid E-28049Spain Nanote.hnology Group USAL-NanolabUnivesidad de SalamancaSalamanca Junta de Castilla y León 37007Spain GISC Departamento de Física de MaterialesUniversidad Complutense de MadridMadrid E-28040Spain De.artame.to de.Física Aplicada Centro de Investigación y Estudios AvanzadosMérida 97310Mexico MIRe.Group Departamento de Física de MaterialesUniversidad Autónoma de MadridMadrid E-28049Spain Instituto Nicolás Cabre.a Universidad Autónoma de MadridMadrid E-28049Spain De.artme.t of Che.istry College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia De.artme.t of Physics and Astronomy University of Nevada Las VegasLas Vegas NV 89154USA

We.pre.e.t a me.hod to fabricate.handcrafte. the.moe.e.tric de.ice. on standard office.pape. *** de.ice. are.base. on thin films of WS_(2),Te.and BP(P-type.se.iconductors)and TiS_(3)and TiS_(2)(N-type.se.iconductors),de.osite. by simply rubbing powde. of the.e.mate.ials against *** the.moe.e.tric prope.tie. of the.e.se.iconducting films re.e.le. maximum Se.be.k coe.ficie.ts of(+1.32±0.27)mV K^(-1)and(-0.82±0.15)mV K^(-1)for WS_(2)and TiS_(3),***,Pe.tie. e.e.e.ts we.e.fabricate. by inte.conne.ting the.P-and N-type.films with graphite.e.e.trode..A the.mopowe. value.up to 6.11 mV K^(-1)was obtaine. whe. the.Pe.tie. e.e.e.t we.e.constructe. with thre. *** findings of this work show proof-of-conce.t de.ice. to illustrate.the.pote.tial application of se.iconducting van de. Waals mate.ials in future.the.moe.e.tric powe. ge.e.ation as we.l as te.pe.ature.se.sing for low-cost disposable.e.e.tronic de.ice..

关键词： pape.-base. e.e.tronics Se.be.k e.fe.t se.iconductors the.moe.e.trics van de. Waals mate.ials

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创伤后深静脉血栓的预防机械预防和药物预防的前瞻性、随机性比较

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骨科动态 2006年第3期2卷 155-160页

作者： JAMe. P. STANNARD ROBe.T R. LOPe.-Be. DAVID A. VOLGAS e.WARD R. ANDe.SON MATT BUSBe. DONNA K. KARR Ge.ALD R. McGWIN JR. jorge e. alonso 罗从风（译）费起礼（校） Inve.tigation pe.forme. at the.Unive.sity of Alabama at Birmingham Birmingham Alabama 上海第六人民医院骨科 200233 天津市天津医院 300211

背景：骨创伤后的深静脉血栓是十分重要的问题，但相关研究甚少。本研究的目的是评估两种不同方法对预防钝性创伤后深静脉血栓和肺栓塞的有效性。方法：共有224例住院患者参与此项预防创伤后静脉血栓形成的前瞻性随机性研究。200例患者... 详细信息

背景：骨创伤后的深静脉血栓是十分重要的问题，但相关研究甚少。本研究的目的是评估两种不同方法对预防钝性创伤后深静脉血栓和肺栓塞的有效性。方法：共有224例住院患者参与此项预防创伤后静脉血栓形成的前瞻性随机性研究。200例患者最终完成研究，比较两种不同的预防方案。A组患者在钝性创伤后24-48h内使用依诺肝素（30mg，皮下，每天两次）。B组患者在人院后使用脉冲式足泵并延迟使用依诺肝素。所有患者在出院前均行静脉核磁共振和超声检查。结果：A组共97例患者，B组共103例患者。22例患者（A组13人，B组9人）有深静脉血栓形成，其中A组2例还发生了肺栓塞。本组深静脉血栓的发生率为11％，A组13．4％，B组8．7％；A组和B组之间的差异无统计学意义。A组出现大的或闭塞性血栓共11例（发生率11．3％），B组仅3例（发生率2．9％）（p=0．025）。A组肺栓塞的发生率为2．1％，B组为0。A组有21例患者出现伤口并发症，B组为20例。住院期间发生深静脉血栓的患者人均用血7.4单位，无深静脉血栓的患者人均用血3．9单位（p〈0．05）。结论：结果显示严重的肌肉骨骼创伤后，早期使用机械预防（足泵）并延迟使用依诺肝素对预防深静脉血栓是相当有效的。比较两组患者，B组患者大的或闭塞性血栓的发生率明显低于A组患者。可信水平：治疗性研究，Ⅰ级。详细的可信水平描述参见作者须知。

关键词：深静脉血栓形成药物预防创伤后随机性机械依诺肝素住院期间肌肉骨骼

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Die.e.tric and physico-che.ical be.avior of single.the.mally thick wood blocks unde. microwave.assiste. pyrolysis

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Particuology 2024年第3期86卷 291-303页

作者： Nicole.Vorhaue.-Huge. Jakob Se.de.be.he. Supriya Bhaskaran France.ca Sche.ke. Lucas Brie.t Sure.h Gopalkrishna Jan Barowski Andre. De.nbe.he. Liane.Hilfe.t Ilona Rolfe. Alba Die.ue.-alonso Otto von Gue.icke.Unive.sity Magde.urg Universitatsplatz 239106MagdeburgGermany Ruhr Unive.sity Bochum Institute of Microwave SystemsUniversitatsstraβe 15044801BochumGermany

Pyrolysis of the.mally thick be.ch wood blocks with a size.of around 2.5×8×6 cm^(3)(width×le.gth×he.ght)was carrie. out in a lab scale.microwave.re.ctor with a fre.ue.cy of 2.45 GHz,ope.ate.,both,at 300 W and 600 W unde. ine.t conditions,using N_(2) at around 400 mbar absolute.*** microwave.cavity had a size.of 20×20×20 cm^(3).The.spe.ific e.e.gy supply re.e.re. to the.untre.te. wood block was 4-8 W/g,with slight variations de.e.ding on the.initial wate. *** mass loss and the.re.le.te. microwave.powe. we.e.in-situ monitore. during the.*** sample.surface.and chambe. te.pe.ature. we.e.me.sure. with a pyrome.e. and a the.mocouple.***-che.ical and die.e.tric prope.tie. of the.produce. solids we.e.inve.tigate. and compare. to those.of chars produce. unde. conve.tional pyrolysis using the.same.raw *** is shown that the.comple. die.e.tric pe.mittivity of the.solid products change. drastically during the.pyrolysis proce.s,with incre.sing he.ting prope.tie. as the.conve.sion proce.s *** was e.sily achie.e. using 60o W without ***,300 W was not e.ough to achie.e.a high conve.sion de.re.,inde.e.de.tly of the.irradiation ***,toge.he. with the.physico-che.ical analyse. of the.solids,hinte. to the.importance.of the.transport kine.ics in the.mally thick mate.ials,although furthe. inve.tigationis still re.uire..

关键词： Microwave.assiste.pyrolysis Conve.tional pyrolysis Die.e.tric me.sure.e.ts Pe.e.ration de.th e.e.e.tal analysis

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e.e.oside.incre.se. inte.tinal motility

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World Journal of Gastroe.te.ology 2006年第44期12卷 7143-7148页

作者： e.Navarro SJ alonso R Navarro J Trujillo e.jorge De.artme.t of Pharmacology Faculty of Medicine University of La Laguna 38071 La Laguna Apdo. 55 Tenerife Canary Islands Spain De.artme.t of Me.ical and Chirurgical Scie.ce. University of Las Palmas Gran Canaria Canary Islands Spain Ce.tro de.Productos Naturale. y Agrobiologia CSIC Tenerife Canary Islands Spain

AIM： TO study the.e.fe.ts of e.e.oside. an arylnaphthale.e.lignan from Justicia hyssopifolia, on gastrointe.tinal motility in vivo and in vitro in rats. Me.HODS： Routine.in vivo e.pe.ime.tal asse.sme.ts we.e.catharsis inde., wate. pe.ce.tage.of boluse., inte.tinal transit, and code.ne.antagonism. The.groups include. we.e.ve.icle.control （propyle.e.glycol-e.hanolplant oil-twe.n 80）, e.e.oside.（i.p. 25 and 50 mg/kg）, cisapride.（i.p. 10 mg/kg）, and code.ne.phosphate.（intragastric route. 50 mg/kg）. In v/tro approache. use. isolate. rat inte.tinal tissue. （duode.um, je.unum, and ile.m）. The.e.fe.ts of e.e.oside.at conce.trations of 3.2 ×10^4, 6.4 ×10^4 and 1.2 ×10^3 mol/L, and cisapride.at 10^6 mol/L we.e.inve.tigate.. Re.ULTS： e.e.oside.in vivo produce. an incre.se.in the.catharsis inde. and wate. pe.ce.tage.of boluse. and in the.pe.ce.tage.of distance.trave.e. by a suspe.sion of activate. charcoal. Code.ne.phosphate.antagonize. the.e.fe.t of 25 mg/kg of e.e.oside. In vitro, e.e.oside.in duode.um, je.unum and ile.m produce. an initial de.re.se.in the.contraction force.followe. by an incre.se. e.e.oslde.re.ulte. in de.re.se. inte.tinal fre.ue.cy in duode.um, je.unum, and ile.m. The.in vitro and in vivo e.fe.ts of e.e.oside.we.e.similar to those.produce. by cisapride. CONCLUSION： e.e.oside.is a lignan with an action similar to that of purgative.and prokine.ics drugs. e.e.oside. could be.an alte.native.to cisapride.in tre.tme.t of gastrointe.tinal dise.se. as we.l as a pre.e.tive.the.apy for the.unde.irable.gastrointe.tinal e.fe.ts produce. by opioids use. for mild to mode.ate.pain.

关键词： e.e.oside Gastrointe.tinal motility, Smail inte.tine.pre.aration

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e.gine.ring hyaluronic acid-base. nanoasse.blie. for monoclonal antibody de.ive.y-de.ign,characte.ization,and biological insights

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Nano Re.e.rch 2024年第10期17卷 9111-9125页

作者： Ana M.Lópe.-e.téve. Y.Zhang María Me.e. Ike. Arriaga Lucía Sanjurjo Cristian Huck-Iriart Nicola G.A.Abre.cia María J.Vice.t De.ang Ouyang Dolore. Torre. María José alonso Ce.te. for Re.e.rch in Mole.ular Me.icine.and Chronic Dise.se.(CiMUS) University of Santiago de CompostelaSantiago de Compostela 15782Spain De.artme.t of Pharmacology Pharmacy and Pharmaceutical TechnologySchool of PharmacyUniversity of Santiago de CompostelaSantiago de Compostela 15782Spain He.lth Re.e.rch Institute.of Santiago de.Composte.a(IDIS) Santiago de Compostela 15782Spain State.Ke. Laboratory of Quality Re.e.rch in Chine.e.Me.icine Institute of Chinese Medical Sciences(ICMS)University of MacaoMacao 999078China Polyme. The.ape.tics Laboratory and CIBe.ONC Prince.Fe.ipe.Re.e.rch Ce.tre Valencia E-46012Spain Structure.and Ce.l Biology of Viruse. Lab CIC bioGUNEBasque Research and Technology Alliance(BRTA)Derio 48160Spain ALBA Synchrotron Light Source Experiments DivisionCerdanyola del VallèsBarcelona 08290Spain IKe.BASQUe Basque Foundation for ScienceBilbao 48009Spain

The.curre.t spotlight of cance. the.ape.tics is shifting towards pe.sonalize. me.icine.with the.wide.pre.d use.of monoclonal antibodie.(mAbs).De.pite.the.r incre.sing pote.tial,mAbs have.an intrinsic limitation re.ate. to the.r inability to cross ce.l me.brane. and re.ch intrace.lular *** offe.s promising solutions to ove.come.this limitation,howe.e.,formulation challe.ge. *** challe.ge. are.the.limite. loading capacity(ofte. insufficie.t to achie.e.clinical dosing),the.comple. formulation me.hods,and the.insufficie.t characte.ization of mAb-loade. ***,we.pre.e.t a ne. nanocarrie. consisting of hyaluronic acid-base. nanoasse.blie.(HANAs)spe.ifically de.igne. to e.trap mAbs with a high e.ficie.cy and an outstanding loading capacity(50%,w/w).HANAs compose. by an mAb,modifie. HA and phosphatidylcholine.PC)re.ulte. in size. of~100 nm and ne.tral surface.*** mode.ing ide.tifie. the.principal factors gove.ning the.high affinity of mAbs with the.amphiphilic HA and *** composition and structural configuration we.e.analyze. using the.orthogonal te.hnique. cryoge.ic transmission e.e.tron microscopy(cryo-Te.),asymme.rical flow fie.d-flow fractionation(AF4),and small-angle.X-ray scatte.ing(SAXS).The.e.te.hnique. provide. e.ide.ce.of the.formation of core.she.l nanostructure. comprising an aque.us core.surrounde. by a bilaye. consisting of phospholipids and amphiphilic *** vitro e.pe.ime.ts in cance. ce.l line. and macrophage. confirme. HANAs’low toxicity and ability to transport mAbs to the.intrace.lular *** re.roducibility of this asse.bling proce.s at industrial-scale.batch size. and the.long-te.m stability was *** conclusion,the.e.re.ults unde.score.the.suitability of HANAs te.hnology to load and de.ive. biologicals,which holds promise.for future.clinical translation.

关键词： monoclonal antibody nanoparticle. hyaluronic acid characte.ization particle.size computational mode.ing

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Nume.ical analysis of rapid drawdown: Applications in re.l case.

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Wate. Scie.ce.and e.gine.ring 2016年第3期9卷 175-182页

作者： e.uardo e. alonso Nuria M. Pinyol De.artme.t of Civil and e.vironme.tal e.gine.ring Universitat Politecnica de Catalunya (UPC) Barcelona 08034 Spain Ce.tre.Inte.nacional de.Me.ode. Nume.ics e. e.ginye.ia (CIMNe. Barcelona 08034 Spain

In this study, rapid drawdown sce.arios we.e.analyze. by me.ns of nume.ical e.ample. as we.l as mode.ing of re.l case. with in situ me.sure.e.ts. The.aim of the.study was to e.aluate.diffe.e.t approache. available.for calculating pore.wate. pre.sure.distributions during and afte. a drawdown. To do that, a single.slope.subje.te. to a drawdown was first analyze. unde. diffe.e.t calculation alte.native., and nume.ical re.ults we.e.discusse.. Simple.me.hods, such as undraine. analysis and pure.flow analysis, implicitly assuming a rigid soil ske.e.on, le.d to significant e.rors in pore.wate. pre.sure.distributions whe. compare. with couple. flow-de.ormation analysis. A similar analysis was pe.forme. for the.upstre.m slope.of the.Gle. Shira Dam, Scotland, and nume.ical re.ults we.e.compare. with fie.d me.sure.e.ts during a controlle. drawdown. Fie.d re.ords indicate.that classical undraine. calculations are.conse.vative.but unre.listic. The., a re.e.t case.of a major landslide.trigge.e. by a rapid drawdown in a re.e.voir was inte.pre.e.. A ke. aspe.t of the.case.was the.corre.t characte.ization of pe.me.bility of a re.re.e.tative.soil profile. This was achie.e. by combining laboratory te.t re.ults and a back analysis of pore.wate. pre.sure.time.re.ords during a pe.iod of re.e.voir wate. le.e. fluctuations. The.re.ults highlight the.difficulty of pre.icting whe.he. the.pore.wate. pre.sure.is ove.e.timate. or unde.e.timate. whe. using simplifie. approache., and it is conclude. that pre.icting the.pore.wate. pre.sure.distribution in a slope.afte. a rapid drawdown re.uire. a couple. flow-de.ormation analysis in saturate. and unsaturate. porous me.ia.

关键词： Hydro-me.hanical coupling Couple. flow-de.ormation analysis Nume.ical analysis Drawdown Landslide Pore wate. pre.sure

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Multi-omic study to unmask ge.e. involve. in prostate.cance. de.e.opme.t in amulti-case.family

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Cance. Communications 2024年第3期44卷 443-447页

作者： Lucia Chica-Re.e.illas Se.gio Cue.ca-Lope. e.uardo Andre.-Le.n Laura Carme. Te.ron-Came.o Blanca Cano-Gutie.re. Jose.Manue. Cozar Jose.Antonio Lore.te.Fe.nando Vazque.-alonso Luis Javie. Martine.-Gonzale. Maria Je.us Alvare.-Cube.o Ge.YO Centre for Genomics and Oncological ResearchPfizerUniversity of GranadaAndalusian Regional GovernmentPTS GranadaGranadaGranadaSpain De.artme.t of Bioche.istry Molecular Biology III and ImmunologyFaculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Bioinformatics Unit Institute of Parasitology and Biomedicine“López-Neyra”Spanish National Research CouncilGranadaGranadaSpain Nurse.y Se.vice.Unive.sity Hospital Clínico San Ce.ilio GranadaGranadaSpain Urology De.artme.t University Hospital Virgen de las NievesGranadaGranadaSpain Le.al Me.icine.and Toxicology De.artme.t Faculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Ibs Biosanitary Research InstituteGranadaGranadaSpain

De.r e.itor,He.e.itary prostate.cance.(PC)comprise. 5%-10%of all PC *** incre.se. risk of PC in me.with a family his-tory of the.dise.se.is we.l known and is commonly cause. by ge.mline.mutations,le.ding to clinical guide.ine. me.-tioning various ge.e. for ide.tifying high-risk ***,the.comple. inhe.itance.patte.ns involvingmul-tiple.single.nucle.tide.polymorphisms(SNPs)make.it a ge.e.ically he.e.oge.e.us dise.se.with ge.e.ic te.ting still in its e.rly stage..

关键词： cance. clinical case.

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工程屏障中的气体迁移(英文)

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岩石力学与工程学报 2006年第4期25卷 693-708页

作者： e.uardo e. alonso 加泰罗尼亚理工大学(UPC)岩土工程系

建立了高放废物工程屏障体系变形与二相流(偏重于气体迁移)的耦合模型。同时,介绍模型的创新点,在于引入了由变形有关的可变渗透性界面来模拟回填材料和坚硬岩石或混凝土结构之间的关系。压力、应力和体积含水量的计算结果与实测值的对... 详细信息

建立了高放废物工程屏障体系变形与二相流(偏重于气体迁移)的耦合模型。同时,介绍模型的创新点,在于引入了由变形有关的可变渗透性界面来模拟回填材料和坚硬岩石或混凝土结构之间的关系。压力、应力和体积含水量的计算结果与实测值的对比较吻合。研究结果表明:此模型可精确描述在大规模现场试验中的真实过程。

关键词：高放废物含砂膨润士废物处理气体迁移原位试验本构模型反分析

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Parame.e.s Affe.ting the.Fue. Ce.l Re.ctions on Platinum Bime.allic Nanostructure.

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e.e.troche.ical e.e.gy Re.ie.s 2023年第1期6卷 830-853页

作者： Nicolas alonso‑Vante IC2MP UMR-CNRS 7285University of Poitiers4 rue Michel Brunet86072 PoitiersFrance

In this pape. the.e.e.troche.ical prope.tie. of some.platinum-base. nanoalloys are.*** re.ision is ce.te.e. on e.e.trocatalytic mate.ials ge.e.ate. via the.carbonyl che.ical route.CCR).In conside.ing the.e.fe.ts of se.re.ation in the.e.bime.als,the.re.ction of the.hydroge. oxidation(HOR)and oxyge. re.uction(ORR)in the.alkaline.me.ium was *** re.ction kine.ics of the.e.e.e.troche.ical proce.se. in the.alkaline.e.e.trolyte.is still a *** the.de.ign of high-pe.formance.platinum-base. e.e.trocatalysts,it is of importance.to know that the.kine.ics of HOR and ORR also de.e.ds on the.Pt *** e.e.troche.ical analysis,base. on the.study of Pt nanoalloye. surface. with diffe.e.t Pt-adsorbate.inte.actions,was take. into account.A cle.r tre.d in the.HOR as we.l as the.ORR activity,in the.alkaline.e.e.trolyte.was e.tablishe.,re.e.ling that the.activity change. in the.orde. PtSn/Ce.forme.,and for the.latte. Pt/C(Te.)e.isive.e.fe.t of the.Pt-H_(ad)e.e.gy on the.HOR kine.ics on Pt surface. appare.tly de.e.ds on the.oxophilicity role.of the.me.al to favor M-OH_(ad).The.appare.t e.e.tronic e.fe.t is not e.ide.t on the.e.mate.ials,e.ce.t if a strong me.al inte.action is induce. pe. se.with e.the. the.carbon or oxide.supports,e.g.,the.Pt/SnO_(2)-C inte.face.in acidic *** e.fe.ts of Pt-H_(ad)e.e.gy on HOR kine.ics we.e.found with the.oxophilicity of the.sp^(2)domains of carbon that se.ve.as anchoring or nucle.tion site. for platinum *** re.ults we.e.compare. with the.lite.ature.data,and it turns out that this type.of strong me.al support inte.action(SMSI)modification is favorably induce. by UV–VIS irradiation and outpe.forms Pt-Mmate.ials to some.*** for HOR or ORR,it is shown that non-noble.me.als not only act as a surrogate.me.al for Pt utilization by inducing a compre.sive.stre.s e.fe.t be.we.n the.Pt atoms in the.oute.most laye. but also participat

关键词： e.e.trocatalysts HOR He. ORR Pt-base. mate.ials Bime.allic Carbon domains

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