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3D Printing of Tough Hydrogel Scaffolds with Functional Surface Structures for Tissue Regeneration

Nano-Micro Letters 2025年第2期17卷 18-45页

作者： Ke Yao Gaoying Hong Ximin Yuan Weicheng Kong Pengcheng Xia Yuanrong Li Yuewei Chen Nian Liu jing he Jue Shi Zihe Hu Yanyan Zhou Zhijian Xie Yong he State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Liangzhu Laboratory Zhejiang UniversityHangzhou 310027People’s Republic of China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Stomatology Hospital School of StomatologyZhejiang University School of MedicineHangzhou 310027People’s Republic of China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001People’s Republic of China Institute of Digital Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006People’s Republic of China

Hydrogel scaffolds have numerous potential applications in the tissue engineering ***,tough hydrogel scaffolds implanted in vivo are seldom reported because it is difficult to balance biocompatibility and high mechanical *** by Chinese ramen,we propose a universal fabricating method(printing-P,training-T,cross-linking-C,PTC&PCT)for tough hydrogel scaffolds to fill this ***,3D printing fabricates a hydrogel scaffold with desired structures(P).Then,the scaffold could have extraordinarily high mechanical properties and functional surface structure by cycle mechanical training with salting-out assistance(T).Finally,the training results are fixed by photo-cross-linking processing(C).The tough gelatin hydrogel scaffolds exhibit excellent tensile strength of 6.66 MPa(622-fold untreated)and have excellent ***,this scaffold possesses functional surface structures from nanometer to micron to millimeter,which can efficiently induce directional cell ***,this strategy can produce bionic human tissue with mechanical properties of 10 kPa-10 MPa by changing the type of salt,and many hydrogels,such as gelatin and silk,could be improved with PTC or PCT *** experiments show that this scaffold can effectively promote the new generation of muscle fibers,blood vessels,and nerves within 4 weeks,prompting the rapid regeneration of large-volume muscle loss injuries.

关键词： 3D printing Tough hydrogel scaffold Functional surface structure Tissue regeneration Biomaterials

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Mantle transition zone structure beneath the Central Asian Orogenic Belt

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Science China Earth Sciences 2020年第4期63卷 548-560页

作者： jing he Qingju WU Key Laboratory of Crustal Dynamics Institute of Crustal DynamicsChina Earthquake AdministrationBeijing 100085China Key Laboratory of Seismic Observation and Geophysical Imaging Institute of GeophysicsChina Earthquake AdministrationBeijing 100081China

Over the past decades, there have been hot debates in the geodynamic community regarding to the deep evolution mechanisms of Cenozoic volcanism in the Central Asian Orogenic Belt(CAOB). Of all the constraints available, high resolution structure of upper mantle discontinuities, especially the discontinuities at depths of 410 km(D410) and 660 km(D660), is of the most important, which may provide reliable clues on the magma channel as well as its evolution. In this work, we adopt the common conversion point stacking technique with teleseismic radial P-wave receiver functions to examine the D410 and D660 discontinuities. The primary results exhibit that the major characteristics of the mantle transition zone(MTZ) obtained by different velocity models are largely consistent. Obviously elevated D410 and slightly depressed D660 are observed beneath the Hannuoba Volcano, suggesting possible delamination of the local lithosphere deposited at the D410. This process may induce upwelling of the asthenospheric materials filling the space left by the delaminated lithosphere, and subsequently trigger volcanic eruptions. Strong depressions are observed at both D410 and D660 depths beneath west of the Dariganga Volcano, and the depression of D660 is more pronounced. It leads to the apparently thickened MTZ, indicating the presence of cold material at the D660. This cold material is speculated as a stagnant slab from the subducted Pacific Plate or the remains of a detached island arc system from the collision and formation of the CAOB. Slightly thinner MTZ is found beneath the hentey Mountains and the Middle Gobi Volcano. Apparently, this thinner MTZ is not significant enough to support the existence of high thermal anomalies,which may rule out the possibility of large-scale hot material upwelling from either the local MTZ or even the lower mantle.

关键词： Central Asian Orogenic Belt Cenozoic Volcano Mantle transition zone Receiver function

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Semi-supervised community detection on attributed networks using non-negative matrix tri-factorization with node popularity

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Frontiers of Computer Science 2021年第4期15卷 61-71页

作者： Di JIN jing he Bianfang CHAI Dongxiao he College of Intelligence and Computing Tianjin UniversityTianjin 300350China Department of Information Engineering Hebei GEO UniversityShijiazhuang 050031China

The World Wide Web generates more and more data with links and node contents,which are always modeled as attributed *** identification of network communities plays an important role for people to understand and utilize the semantic functions of the data.A few methods based on non-negative matrix factorization(NMF)have been proposed to detect community structure with semantic information in attributed ***,previous methods have not modeled some key factors(which affect the link generating process together),including prior information,the heterogeneity of node degree,as well as the interactions among *** three factors have been demonstrated to primarily affect the *** this paper,we propose a semi-supervised community detection method on attributed networks by simultaneously considering these three ***,a semi-supervised non-negative matrix tri-factorization model with node popularity(i.e.,PSSNMTF)is designed to detect communities on the topology of the *** then node contents are integrated into the PSSNMTF model to find the semantic communities more accurately,namely *** of the PSSNMTFC model is estimated by using the gradient descent *** on some real and artificial networks illustrate that our new method is superior over some related stateof-the-art methods in terms of accuracy.

关键词： community detection non-negative matrix trifactorization node popularity attributed networks

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Regulation of insect behavior by non-coding RNAs

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Science China(Life Sciences) 2024年第6期67卷 1106-1118页

作者： jing he Le Kang State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101China Beijing Institutes of Life Sciences Chinese Academy of SciencesBeijing 100101China College of Life Science Hebei UniversityBaoding 071002China

The adaptation of insects to environments relies on a sophisticated set of behaviors controlled by molecular and physiological *** the past several decades,accumulating studies have unveiled the roles of non-coding RNAs(nc RNAs)in regulating insect *** RNAs assume particularly pivotal roles in the behavioral plasticity of insects by rapidly responding to environmental *** RNAs also contribute to the maintenance of homeostasis of insects by fine-tuning the expression of target ***,a comprehensive review of nc RNAs'roles in regulating insect behaviors has yet to be ***,we present the recent progress in our understanding of how nc RNAs regulate various insect behaviors,including flight and movement,social behavior,reproduction,learning and memory,and *** refine the intricate mechanisms by which nc RNAs modulate the function of neural,motor,reproductive,and other physiological systems,as well as gene expression in insects like fruit flies,social insects,locusts,and ***,we discuss potential avenues for future studies in nc RNA-mediated insect behaviors.

关键词： ncRNAs insect behavior plasticity fine-tuning environmental adaptation

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Binary Nonlinearization of the Nonlinear Schr?dinger Equation Under an Implicit Symmetry Constraint

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Acta Mathematicae Applicatae Sinica 2014年第2期30卷 379-388页

作者： jing YU jing-song he Yi CheNG School of Science Hangzhou Dianzi University Department of Mathematics University of Science and Technology of China School of Science Ningbo University

By modifying the procedure of binary nonlinearization for the AKNS spectral problem and its adjoint spectral problem under an implicit symmetry constraint, we obtain a finite dimensional system from the Lax pair of th... 详细信息

关键词： an implicit symmetry constraint binary nonlinearization AKNS system completely integrable Hamiltonian system

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Design of a memory polynomial predistorter for wideband envelope tracking amplifiers

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Journal of Systems Engineering and Electronics 2011年第2期22卷 193-199页

作者： jing Zhang Songbai he Lu Gan School of Electronic Engineering University of Electronic Science and Technology of China Chengdu 610054 P. R. China

Efficiency and linearity of the microwave power amplifier are critical elements for mobile communication systems. A memory polynomial baseband predistorter based on an indirect learning architecture is presented for improving the linearity of an envelope tracing （ET） amplifier with application to a wireless transmitter. To deal with large peak-to-average ratio （PAR） problem, a clipping procedure for the input signal is employed. Then the system performance is verified by simulation results. For a single carrier wideband code division multiple access （WCDMA） signal of 16-quadrature amplitude modulation （16-QAM）, about 2% improvement of the error vector magnitude （EVM） is achieved at an average output power of 45.5 dBm and gain of 10.6 dB, with adjacent channel leakage ratio （ACLR） of -64.55 dBc at offset frequency of 5 MHz. Moreover, a three-carrier WCDMA signal and a third-generation （3G） long term evolution （LTE） signal are used as test signals to demonstrate the performance of the proposed linearization scheme under different bandwidth signals.

关键词： envelope tracking memory polynomial predistorter,indirect learning architecture power amplifier memory effects.

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Emergency material scheduling optimization model and algorithms:A review

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Journal of Traffic and Transportation Engineering(English Edition) 2019年第5期6卷 441-454页

作者： Hui Hu jing he Xiongfei he Wanli Yang jing Nie Bin Ran School of Automobile Chang'an University Xi'an 710064 China School of Civil and Environmental Engineering University of Wisconsin at Madison Madison WI 53706 USA

In the emergency management of disruptions,efficient emergency material scheduling(EMS) is a key factor to save people’s lives and reduce *** on the literature of EMS and related areas in recent years,the research was summarized from two aspects of EMS optimization model and *** is concluded that the EMS optimization models mainly aim at the shortest time,shortest distance,minimum cost,maximum satisfaction and fairness,*** constraints usually include the quantity of supply depots,relief supply and vehicles,the types of commodities,the road network conditions,the budgets and the demand forecast of emergency ***-objective model is more complex and it usually considers more than one *** find the optimized solution,the multiobjective model with complex constraints needs more efficient *** existing algorithms,including mathematic algorithm and heuristic algorithm,have been *** NP-hard(non-deterministic polynomial hard) problems,heuristic algorithms should be designed,which mainly include genetic algorithm(GA),ant colony optimization(ACO),particle swarm optimization(PSO),*** on the characteristics of the optimization model and various algorithms,appropriate algorithm or tools should be chosen and designed to obtain the optimized solution of EMS ***,the development trends of EMS optimization model and algorithm in the future are proposed.

关键词： Emergency material scheduling (EMS) Optimization model heuristic algorithm Disruption

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On the Gerber-Shiu Discounted Penalty Function for a Surplus Process Described by PDMPs

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Acta Mathematica Sinica,English Series 2010年第5期26卷 951-962页

作者： jing Min he Rong WU College of Science Tianjin University of Technology Tianjin 300384 P. R. China School of Mathematical Sciences Nankai University Tianjin 300071 P. R. China

In this paper, we investigate the Gerber-Shiu discounted penalty function for the surplus process described by a piecewise deterministic Markov process （PDMP）. We derive an integral equation for the Gerber-Shiu discounted penalty function, and obtain the exact solution when the initial surplus is zero. Dickson formulae are also generalized to the present surplus process.

关键词： Gerber-Shiu discounted penalty function piecewise deterministic Markov process ulti- mate ruin probability Volterra integral equation

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Total Duration of Negative Surplus for a Brownian Motion Risk Model with Interest

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Acta Mathematica Sinica,English Series 2014年第1期30卷 163-168页

作者： Wei WANG jing Min he College of Mathematical Science Tianjin Normal University College of Science Tianjin University of Technology

In this paper,we consider the Brownian motion risk model with *** Laplace transform of the first exit time from the upper barrier before hitting the lower barrier is *** the obtained result and exploiting the limitati... 详细信息

关键词： First exit time confluent hypergeometric function negative surplus ruin probability

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Control of MSC Differentiation by Tuning the Alkyl Chain Length of Phe- nylboroinc Acid Based Low-molecular-weight Gelators

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Journal of Bionic Engineering 2018年第4期15卷 682-692页

作者： jing he Yalong Hu Fang Wu Bin he Wenxia Gao National Engineering Research Centre for Biomaterials Sichuan University Chengdu 610064 China College of Chemistry and Materials Engineering Wenzhou University Wenzhou 325027 China

The physical environment plays a critical role in modulating stem cell differentiation into specific lineages. In this study, we designed and synthesized a series of low-molecular-weight gels （LMWGs） with different moduli based on phenylboronic acid derivatives. The moduli of the LMWGs were readily tuned by varying the alkyl chain without any chemical crosslinker. The cell responses to the gels were evaluated with mesenchymal stem cell （MSCs）, in respect of cell morphology, proliferation and differentiation. The prepared gels were non-toxic to MSCs, suggesting good biocompatibility. The hydrogel stiffness exerted a striking modulation effect on MSC fate decisions, where MSCs were inclined to differentiate into osteoblasts in stiff LMWGs and into chondrocytes in soft LMWGs. The pivotal elastic modulus of the LMWGs to drive MSC differentiation into osteoblastic lineage and chondrocytic lineage were approximately 20 kPa - 40 kPa and 1 kPa - 10 kPa, respectively. Overall, our results demonstrated that the modification ofhydrogel stiffness via tuning the alkyl chain was a simple but effective approach to regulate MSC differentiation into specific lineage, which might have important implications in the design of LMWGs for tissue engineering applications.

关键词： low-molecular-weight gels phenylboronic acid alkyl chain mesenchymal stem cell osteoblast differentiation chondrocytic differentiation

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