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Rational Daily Administration Times of Yinchenhao Decoctionin Rats with Jaundice Based on PD/PK

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Chinese Herbal Medicines 2012年第2期4卷 150-156页

作者： LV Jun-lan jin shi-ying YUAN Hai-long HAN jin FU Shan-shan jin shi-xiao GUO jing-jing XIAO Xiao-he China Military Institute of Chinese Materia Medica 302 Military HospitalBeijing 100039China School of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu 611731China

Objective To study the rational daily administration times of Yinchenhao Decoction(YCHD)when it was used to treat experimental jaundice in rats based on pharmacodynamics/pharmacokinetics *** Rats were modeled by 4%1-naphthylisothiocyanate(75 mg/kg)for 48 h,then YCHD was drenched with doses of 0.324 g/kg (extract,calculated with the clinical dosage)once,0.162 g/kg twice,and 0.108 g/kg thrice a day,*** total bile and the flow rate of bile were observed after the first administration;Blood samples collected from the orbital sinus at different intervals were used to investigate the levels of liver enzymes(ALT and AST)and bilirubins (TBIL and DBIL),and determine the concentration of 6,7-dimethoxycoumarin(DME)in the plasma using UPLC at the same time,then we obtained the time-effect and time-dose *** rational daily administration times of YCHD when treating experimental jaundice were determined based on the comprehensive analysis of time-effect and time-concentration *** Within 10 h the total bile of rats which were administered once daily(G1) was 1.65 and 1.33 times higher than that of twice and thrice(G2 and G3)a day,respectively,and the four biochemical indexes(TBIL,ALT,DBIL,and AST)of G1 decreased faster than those of G2 and G3(P<0.05).On the other hand, the blood drug level of DME when administrated once daily could maintain at a higher level for a longer time,and its Cmax and AUC0→t were higher than those of G2 and G3,which might be the main reason why its effect was the most *** It is more appropriate to administrate once daily when YCHD is used to treat jaundice.

关键词： bilirubins 6,7-dimethoxycoumarin jaundice pharmacodynamics/pharmacokinetics Yinchenhao Decoction

Small-cell carcinoma of the prostate with negative CD56,NSE,Syn,and CgA indicators:A case report

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World Journal of Clinical Cases 2022年第5期10卷 1630-1638页

作者： Hong-jin shi Zhi-Nan Fan jin-Song Zhang Bo-Bo Xiong Hai-Feng Wang Jian-Song Wang Department of Urology The Second Affiliated HospitalKunming Medical UniversityKunming 650000Yunnan ProvinceChina

BACKGROUND Small-cell carcinoma of the prostate(SCCP)is a clinically rare malignant tumor,accounting for<1%of all prostate ***,negativity for all SCCP neuroendocrine markers is ***,we report a case of SCCP with completely negative neuroendocrine markers and explore its clinicopathologic features,thus improving the understanding of its clinical diagnosis and *** SUMMARY We report the case of a 48-year-old patient with SCCP negative for common sensitive neuroendocrine-staining *** was the first symptom,and rectal examination revealed a hard prostate,palpable nodules,diffuse prostate enlargement,no pressure pain,no blood staining in the finger sleeve,1.33 ng/mL total prostate-specific antigen level,and a free-to-total prostate-specific antigen ratio of 0.21 ng/*** suggested a prostate size of 5.3 cm×5.8 cm×5.6 cm,and magnetic resonance imaging suggested prostate *** lower posterior bladder wall,rectal mesentery,and bilateral seminal vesicles were invaded,with multiple lymph node metastases in the pelvis.A whole-body bone scan suggested an abnormally active multiple bone metabolism and possible bone *** and lungs computed tomography revealed no significant nodal *** a pathological diagnosis of SCCP after a prostate puncture,with negative indicators of common sensitive neuroendocrine staining,chemotherapy was administered;the patient died 4-5 mo after SCCP *** SCCP is a rare disease characterized by atypical clinical symptoms,limited treatment options,a short survival period,and a poor prognosis.

关键词： Prostate cancer Small cell carcinoma Neuroendocrine tumor Therapeutics Diagnosis Case report

Accurate and broadband manipulations of harmonic amplitudes and phases to reach 256 QAM millimeter-wave wireless communications by time-domain digital coding metasurface

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National Science Review 2022年第1期9卷 36-46页

作者： Ming Zheng Chen Wankai Tang Jun Yan Dai Jun Chen Ke Lei Zhang Cheng Zhang jin Yang Lianlin Li Qiang Cheng shi jin Tie Jun Cui Institute of Electromagnetic Space Southeast University State Key Laboratory of Terahertz and Millimeter Waves City University of Hong Kong State Key Laboratory of Advanced Optical Communication Systems and Networks Department of Electronics Peking University National Mobile Communications Research Laboratory Southeast University State Key Laboratory of Millimeter Waves Southeast University Center of Intelligent Metamaterials Pazhou Laboratory

We propose a theoretical mechanism and new coding strategy to realize extremely accurate manipulations of nonlinear electromagnetic harmonics in ultrawide frequency band based on a time-domain digital coding metasurface(TDCM).Using the proposed mechanism and coding strategy,we design and fabricate a millimeter-wave(mmWave) TDCM,which is composed of reprogrammable meta-atoms embedded with positive-intrinsic-negative *** controlling the duty ratios and time delays of the digital coding sequences loaded on a TDCM,experimental results show that both amplitudes and phases of different harmonics can be engineered at will simultaneously and precisely in broad frequency band from 22 to33 GHz,even when the coding states are imperfect,which is in good agreement with theoretical *** on the fabricated high-performance TDCM,we further propose and experimentally realize a large-capacity mmWave wireless communication system,where 256 quadrature amplitude modulation,along with other schemes,is *** new wireless communication system has a much simpler architecture than the currently used mmWave wireless systems,and hence can significantly reduce the hardware *** believe that the proposed method and system architecture can find vast application in future mmWave and terahertz-wave wireless communication and radar systems.

关键词： metasurface time-domain digital coding accurate and broadband harmonic control 256 QAM millimeter-wave wireless communications

Preparation and properties of thermal insulation coatings with a sodium stearate-modified shell powder as a filler

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International Journal of Minerals,Metallurgy and Materials 2017年第10期24卷 1192-1199页

作者： Qiang Tang Ya-mei Zhang Pei-gen Zhang jin-jie shi Wu-bian Tian Zheng-ming Sun Jiangsu Key Laboratory of Construction Materials School of Materials Science and Engineering Southeast University Nanjing 211189 China Jiangsu Key Laboratory of Advanced Metallic Materials School of Materials Science and Engineering Southeast University Nanjing 211189 China

Waste shell stacking with odor and toxicity is a serious hazard to our living environment. To make effective use of the natural resources, the shell powder was applied as a filler of outdoor thermal insulation coatings. Sodium stearate(SS) was used to modify the properties of shell powder to reduce its agglomeration and to increase its compatibility with the emulsion. The oil absorption rate and the spectrum reflectance of the shell powder show that the optimized content of SS as a modifier is 1.5wt%. The total spectrum reflectance of the coating made with the shell powder that is modified at this optimum SS content is 9.33% higher than that without any modification. At the optimum SS content of 1.5wt%, the thermal insulation of the coatings is improved by 1.0℃ for the cement mortar board and 1.6℃ for the steel plate, respectively. The scouring resistance of the coating with the 1.5wt% SS-modified shell powder is three times that of the coating without modification.

关键词： heat insulation coatings shell powder sodium stearate scrub resistance

Behavior of Medium-frequency Core Loss in Fe-based Nanocrystalline Soft Magnetic Alloys

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Journal of Materials Science & Technology 2000年第3期16卷 332-336页

作者： Yanzhong ZHANG, Huijuan jin and Ying shi (Research Centre, Shanghai Iron and Steel Research Institute, Shanghai 200940, China) Research Centre Shanghai Iron and Steel Research Institute Shanghai 200940 China

The dependences of the power loss per cycle on frequency have been investigated in the ranges of 100 Hz<= f<=25000 Hz and 0.1 T< =Bm <=1.0 T for three main original magnetic states in five sorts of Fe-based nanocrystalline soft magnetic alloys. The measured and calculated results showed that the total power loss per cycle clearly exhibited a nonlinear behavior in the range below 3 kHz～5 kHz depending on both the magnetic state and the value of Dm, whereas it showed a quasi-linear behavior above this range. The total loss was decomposed into hysteresis loss, classical eddy current loss and excess loss, the obvious nonlinear behavior has been confirmed to be completely determined by the dependence of the excess loss on frequency. It has been indicated that the change rate of the excess loss per cycle with respect to frequency sharp decreases with increasing frequency in the range below about 3 kHz～5 kHz, wherease the rate of change slowly varies above this range, thus leading to the quasilinear behavior of the total loss per cycle. In this paper, some linear expressions of the total loss per cycle has been given in a wider medium-frequency segment, which can be used for roughly estimating the total loss.

关键词： Behavior of Medium-frequency Core Loss in Fe-based Nanocrystalline Soft Magnetic Alloys Core Fe high

Vulnerable Region-Aware Greybox Fuzzing

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Journal of Computer Science & Technology 2021年第5期36卷 1212-1228页

作者： Ling-Yun Situ Zhi-Qiang Zuo Le Guan Lin-Zhang Wang Xuan-Dong Li jin shi Peng Liu State Key Laboratory for Novel Software Technology Nanjing UniversityNanjing 210023China School of Information Management Nanjing UniversityNanjing 210023China Department of Computer Science University of GeorgiaAthensGA 30602U.S.A. College of Information Sciences and Technology Pennsylvania State UniversityState CollegePA 16802U.S.A

Fuzzing is known to be one of the most effective techniques to uncover security vulnerabilities of large-scale software *** fuzzing,it is crucial to distribute the fuzzing resource appropriately so as to achieve the best fuzzing performance under a limited *** distribution strategies of American Fuzzy Lop(AFL)based greybox fuzzing focus on increasing coverage blindly without considering the metrics of code regions,thus lacking the insight regarding which region is more likely to be vulnerable and deserves more fuzzing *** tackle the above drawback by proposing a vulnerable region-aware greybox fuzzing ***,we distribute more fuzzing resources towards regions that are more likely to be vulnerable based on four kinds of code *** implemented the approach as an extension to AFL named ***-scale experimental evaluations validate the effectiveness and efficiency of RegionFuzz-11 new bugs including three new CVEs are successfully uncovered by RegionFuzz.

关键词： vulnerability detection greybox fuzzing code metrics resource distribution

Nutrient maximums related to low oxygen concentrations in the southern Canada Basin

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Acta Oceanologica Sinica 2005年第6期24卷 88-96页

作者： jin Ming-ming shi Jiuxin LU Yong CHEN Jianfang GAO Guoping WU jingfeng ZHANG Haisheng Laboratory for Marine Biogeochemistry and Ecosystem State Oceanic Administration Hangzhou 310012 China Laboratory of Ocean Dynamic Processes and Satellite Oceanography State Oceanic Administration Hangzhou 310012 China Laboratory of Marine Science and Numerical Modeling State Oceanic Administration Qingdao 266061 China Laboratory for Marine Biogeochemistry and Ecosystem State Oceanic Administration Hangzhou 310012 China Laboratory of Ocean Dynamic Processes and Satellite Oceanography State Oceanic Administration Hangzhou 310012 China Laboratory for Marine Biogeochemistry and Ecosystem State Oceanic Administration Hangzhou 310012 China College of Physical and Environmental Oceanography Ocean University of China Qingdao 266003 China International Arctic Research Center University of Alaska Fairbanks Fairbanks USA Laboratory for Marine Biogeochemistry and Ecosystem State Oceanic Administration Hangzhou 310012 China

The phenomenon of nutrient maximums at 70～200 m occurred only in the regionof the Canada Basin among the world oceans. The prevailing hypothesis was that the direct injectionof the low-temperature high-nutrient brines from the Chukchi Sea shelf (jin et al. considered that the formation of nutrient maximums can be a process oflocally long-term regeneration. Here we propose a regeneration-mixture process. Data of temperature,salinity, oxygen and nutrients were collected at three stations in the southern Canada Basin duringthe summer 1999 cruise. We identified the cores of the surface, near-surface, potential temperaturemaximum waters and Arctic Bottom Water by the diagrams and vertical profiles of salinity, potentialtemperature, oxygen and nutrients. The historical ^(129)I data indicated that the surface andnear-surface waters were Pacific-origin, but the waters below the potential temperature maximum coredepth was Atlantic-origin. Along with the correlation of nutrient maximums and very low oxygencontents in the near-surface water, we hypothesize that, the putative organic matter was decomposedto inorganic nutrients; and the Pacific water was mixed with the Atlantic water in the transitionzone. The idea of the regeneration-mixture process agrees with the historical observations of noapparent seasonal changes, the smooth nutrient profiles, the lowest saturation of CaCO_3 above 400m, low rate of CFC-11 ventilation and ~3H-~3He ages of 8～18 a around the nutrient maximum depths.

关键词： nutrient maximum regeneration mixture water mass canada basin

Identification of reservoir types in deep carbonates based on mixedkernel machine learning using geophysical logging data

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Petroleum Science 2024年第3期21卷 1632-1648页

作者： jin-Xiong shi Xiang-Yuan Zhao Lian-Bo Zeng Yun-Zhao Zhang Zheng-Ping Zhu Shao-Qun Dong Key Laboratory of Exploration Technologies for Oil and Gas Resources of the Ministry of Education Yangtze UniversityWuhan4310HubeiChina School of Geosciences Yangtze UniversityWuhan430100HubeiChina College of Geosciences China University of Petroleum(Beijing)Beijing102249China Petroleum Exploration and Production Research Institute of SINOPEC Beijing100083China School of Earth Sciences and Engineering Xi'an Shiyou UniversityXi'an 710065ShaanxiChina

Identification of reservoir types in deep carbonates has always been a great challenge due to complex logging responses caused by the heterogeneous scale and distribution of storage *** cross-plot analysis and empirical formula methods for identifying reservoir types using geophysical logging data have high uncertainty and low efficiency,which cannot accurately reflect the nonlinear relationship between reservoir types and logging ***,the kernel Fisher discriminant analysis(KFD),a kernel-based machine learning technique,attracts attention in many fields because of its strong nonlinear processing ***,the overall performance of KFD model may be limited as a single kernel function cannot simultaneously extrapolate and interpolate well,especially for highly complex data *** address this issue,in this study,a mixed kernel Fisher discriminant analysis(MKFD)model was established and applied to identify reservoir types of the deep Sinian carbonates in central Sichuan Basin,*** MKFD model was trained and tested with 453 datasets from 7 coring wells,utilizing GR,CAL,DEN,AC,CNL and RT logs as input *** particle swarm optimization(PSO)was adopted for hyper-parameter optimization of MKFD *** evaluate the model performance,prediction results of MKFD were compared with those of basic-kernel based KFD,RF and SVM ***,the built MKFD model was applied in a blind well test,and a variable importance analysis was *** comparison and blind test results demonstrated that MKFD outperformed traditional KFD,RF and SVM in the identification of reservoir types,which provided higher accuracy and stronger *** MKFD can therefore be a reliable method for identifying reservoir types of deep carbonates.

关键词： Reservoir type identification Geophysical logging data Kernel Fisher discriminantanalysis Mixedkernel function Deep carbonates

五边形石墨烯双层电子性能及磁性调控的第一性原理研究

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原子与分子物理学报 2025年第5期42卷 67-71页

作者：吴旌贺丁雅妮郭梦雨陈卫光王美娟史金磊河南财政金融学院创新创业学院郑州450046 郑州师范学院物理与电子工程学院郑州市低维纳米材料重点实验室郑州450044

基于密度泛函理论的第一性原理计算方法,我们研究了五边形石墨烯双层结构表面氢氟化对其电子结构及磁性的调控.计算结果表明,氢氟化的五边形石墨烯双层可以在价带顶和导带底出现自旋极化态,从而诱导出磁性且有效降低带隙.基于这一特性,... 详细信息

基于密度泛函理论的第一性原理计算方法,我们研究了五边形石墨烯双层结构表面氢氟化对其电子结构及磁性的调控.计算结果表明,氢氟化的五边形石墨烯双层可以在价带顶和导带底出现自旋极化态,从而诱导出磁性且有效降低带隙.基于这一特性,我们进一步发现通过调控氢氟化覆盖度能够有效调节体系带隙及磁矩,并且随着覆盖度增加实现了五边形石墨烯双层从半导体-金属-半导体的转变.

关键词：五边形石墨烯双层电子结构和磁性调控第一性原理计算