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Curcuma wenyujin Y. H. Chen et C. Ling n-Butyl Alcohol Extract Inhibits AGS Cell Helicobacter pyloriCagA+VacA+ Promoted Invasiveness by Down-Regulating Caudal Type Homeobox Transcription Factor and Claudin-2 Expression

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Chinese Journal of Integrative Medicine 2020年第2期26卷 122-129页

作者： jin hai-feng DAI jin-feng MENG Li-na LU Bin Department of Gastrointerology the First Affiliated Hospital of Zhejiang Chinese Medical University

Objective:To investigate the effects and possible mechanisms of action of Curcuma wenyujin *** et *** n-Butyl alcohol extract(CWNAE)on repression of human gastric cancer(GC)AGS cell invasion induced by co-culturing with Helicobacter pylori(HP).Methods:AGS cells were cultured with HP of positive or negative cytotoxin-associated gene A(Cag A)and vacuolating cytotoxin gene A(Vac A)expression(Cag A+/-or Vac A+/-)and divided into 5 *** A was cultured without HP as a control,Group B with HPCagA+VacA+,Group C with HPCagA-VacA-,Group D with HPCagA+VacA+and CWNAE,and Group E with HPCag A-Vac Aand ***-tetrazolium bromide(MTT)and tumor invasion assays,examinations of morphology and ultramicroscopic structures,quantitative real-time polymerase chain reaction and Western blots were performed to measure the effects and uncover the mechanisms behind these effects of HPCagA+VacA+and CWNAE on the epithelial-mesenchymal transition(EMT)of AGS ***:The 10%inhibitory concentration of CWNAE against AGS cells after a 48 h incubation was 19.73±1.30μg/m *** AGS cells were elongated after co-culturing with HPCagA+VacA+than after culturing with HPCagA-VacA-.In tumor invasion assays,HPCagA+VacA+significantly enhanced the invasiveness of AGS cells compared to the other experimental groups(all P value<0.05),and this effect was inhibited by *** with CWNAE normalized tight junctions and reduced the number of pseudopodia of AGS cells co-cultured with HPCagA+VacA+.HPCagA+VacA+up-regulated zincfinger ebox binding homeobox 1(ZEB1)in AGS cells after co-culturing for 24 *** of caudal type homeobox transcription factor(CDX-2)and claudin-2 was significantly increased by HPCagA+VacA+(P<0.05),but not by HPCagA-VacA-.Conclusions:HPCagA+VacA+promoted the invasiveness of AGS cells through up-regulation of ZEB1 transcription and claudin-2 and CDX-2 *** inhibited these effects of HPCagA+VacA+on AGS cells by down-regulating ZE

关键词： Helicobacter pylori gastric cancer AGS zinefinger ebox binding homeobox 1 caudal type homeobox transcription factor claudin・2 Chinese medicine

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甲醇制烯烃工业反应器产品选择性预测及操作条件优化研究

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现代化工 2024年第9期44卷 236-241页

作者：南海明邢爱华文尧顺孙保全林华东关丰忠金海峰神华工程技术有限公司北京设计中心北京100010 北京低碳清洁能源研究院北京102209 中国神华煤制油化工有限公司北京100010 国家能源集团化工部北京100010

基于甲醇制烯烃固定流化床反应器的反应结果,建立了产品气组成与醇剂比的关联函数,同时假定催化剂在工业反应器内的停留时间分布符合全混流模型且一定条件下产品选择性只与醇剂比有关,最终形成了适用于MTO工业反应器产品气选择性预测及... 详细信息

基于甲醇制烯烃固定流化床反应器的反应结果,建立了产品气组成与醇剂比的关联函数,同时假定催化剂在工业反应器内的停留时间分布符合全混流模型且一定条件下产品选择性只与醇剂比有关,最终形成了适用于MTO工业反应器产品气选择性预测及操作条件优化的计算模型。模型对于甲醇制烯烃工业装置正常运行期间主要产品选择性的预测比较准确,其中对于乙烯、丙烯、乙烯+丙烯选择性的预测误差分别为0.91%、0.80%和0.55%,对于C_4的预测误差为1.81%。该模型还可用于甲醇制烯烃工业装置操作参数的优化,以提升低碳烯烃的收率。

关键词：甲醇制烯烃预测模型产品气组成优化

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Inhibition of Metalloproteinase Activity by Chinese Formulations Used to Treat Inflammatory Diseases

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Chemical Research in Chinese Universities 2006年第2期22卷 245-247页

作者： jin feng-hai WANG Hui-ling ZHAO Shu-hua YANG jin-gang FANG Xue-xun Key Laboratory of Molecular Enzymology and Engineering the Ministry of Education Jilin University Changchun 130021 P. R. China School of Pharmacy Jilin University Changchun 130021 P. R. China College of Life Science Jilin University Changchun 130021 P. R. China The China-Japan Union Hospital Jilin University Changchun 130021 P. R. China

Matrix metalloproteinases （MMPs） are known to be involved in a number of pathological processes including cancer, atherosclerosis, arthritis and neurodegenerative disease among others. The drive to develop MMP inhibitors as therapeutics has been put forward for years by pharmaceutical companies as well as academicians. In an attempt to screen for MMP inhibitors from Traditional Chinese Medicines （TCMs） , a number of Chinese formulations used to treat inflammatory diseases such as nephritis and hepatitis have been studied. Strong inhibitory effects of three Chinese formulations toward the activity of MMP-16 have been discovered. These results suggest that these anti-inflammatory medicines contain some unknown MMP inhibitory compound（s） and provide reasonable molecular mechanisms for their theraoeutic effects.

关键词： Matrix metalloproteinase (MMP) Matrix metalloproteinase inhibitor ( MMPI ) Traditional Chinese Medicine(TCM) Herbal formulation

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Expression Optimization and Characterization of the Catalytic Domain of Human MT3-MMP

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Chemical Research in Chinese Universities 2006年第2期22卷 129-133页

作者： SHI Xiu-juan jin feng-hai WANG Hui-ling YANG jin-gang WANG Zhi-yong FANG Xue-xun Key Laboratory of Molecular Enzymology and Engineering the Ministry of Education School of Pharmacy College of Life Science Jilin University Changchun 130021 P. R. China

Matrix metalloproteinases（MMPs） are a family of proteases that are required for many biological processes and are also elevated in many pathological conditions. MMP inhibitors （MMPIs） may therefore be useful as therapeutic agents in treating a number of diseases including cancer, cardiovascular diseases and arthritis. Attempts have been made to develop MMPIs. Recombinant MMPs have been used to screening MMPs in vitro assays. In this work, we report the expression of MMP-16 in E. coli and the characterization of the recombinant MMP-16 with a commonly used MMP substrate DQ-gelatin.

关键词： Matrix metalloproteinase(MMP) Protein expression Catalytic domain MMP-16

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Inhibitory Effects of Polygoni Multiflori Caulis Extracts on Matrix Metalloproteinase Activities

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Chemical Research in Chinese Universities 2009年第2期25卷 211-215页

作者： LIU Jun-song YANG jin-gang HONG Yuan jin feng-hai WANG Ming-cui ZHAO Shu-hua FANG Xue-xun Key Laboratory of Molecular Enzymology and Enzyme Engineering of Ministry of Education Jilin University Changchun 130021 P. R. China College of Life Science Jilin University Changchun 130012 P. R. China College of Medicine Jilin University Changchun 130021 P. R. China Department of Traditional Chinese Medicine China-Japan Union Hospital Jilin University Changchun 130033 P. R. China State key Laboratory of Superhard Materials Jilin University Changchun 130012 P. R. China

Matrix metalloproteinases（MMPs） play an essential role in development and tissue remodeling of living organisms. However, the overexpression of MMPs has lead to a series of diseases, such as cancer, arthritis, and atherosclerosis; and inhibition of MMPs may have therapeutic benefits. The discovery of MMP inhibitors from herbal has become a prospective event. We showed that the extract of Polygoni multiflori caulis from ethyl acetate or water（ethyl acetate extract and water extract） can inhibit the activities of MMPs 9, 14, and 16 in a dose-dependent manner and n-butyl alcohol extract of it can also inhibit these MMPs. Furthermore, we found that n-butyl alcohol extract and water extract of it influence the cell viability. These discoveries may contribute to the development of MMP in- hibitors for the therapy of a variety of pathological conditions.

关键词： Matrix metalloproteinases(MMPs) Polygoni multi/lori caulis Water extract Cell viability assay

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Dependability Analysis for Fault-Tolerant Computer Systems Using Dynamic Fault Graphs

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China Communications 2014年第9期11卷 16-30页

作者： ZHAO feng jin hai ZOU Deqing QIN Pan Services Computing Technology and System Lab & Cluster and Grid Computing Lab School of Computer Scienceand Technology Huazhong University of Science and Technology Wuhan 430074 Hubei Province P. R. China

Dependability analysis is an important step in designing and analyzing safety computer systems and protection *** multi-processor and virtual machine increases the system faults' complexity,diversity and dynamic,in particular for software-induced failures,with an impact on the overall ***,it is very different for safety system to operate successfully at any active phase,since there is a huge difference in failure rate between hardware-induced and softwareinduced *** handle these difficulties and achieve accurate dependability evaluation,consistently reflecting the construct it measures,a new formalism derived from dynamic fault graphs(DFG) is developed in this *** exploits the concept of system event as fault state sequences to represent dynamic behaviors,which allows us to execute probabilistic measures at each timestamp when change *** approach automatically combines the reliability analysis with the system *** this paper,we describe how to use the proposed methodology drives to the overall system dependability analysis through the phases of modeling,structural discovery and probability analysis,which is also discussed using an example of a virtual computing system.

关键词： fault-tolerant system depend-ability analysis dynamic fault-graph structural link probability forecast

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Derivation of Expanded Isospectral-Nonisospectral Integrable Hierarchies via the Column-vector Loop Algebra

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 778-800页

作者： hai-feng WANG Yu-feng ZHANG School of Science Jimei UniversityXiamen 361021China School of Mathematics China University of Mining and TechnologyXuzhou 221116China

A scheme for generating nonisospectral integrable hierarchies is *** on the method,we deduce a nonisospectral hierarchy of soliton equations by considering a linear spectral *** follows that the corresponding expanded isospectral and nonisospectral integrable hierarchies are deduced based on a 6 dimensional complex linear space ■.By reducing these integrable hierarchies,we obtain the expanded isospectral and nonisospectral derivative nonlinear Schr?dinger *** using the trace identity,the biHamiltonian structure of these two hierarchies are also ***,some symmetries and conserved quantities of the resulting hierarchy are discussed.

关键词： expanded isospectral-nonisospectral integrable hierarchies column-vector loop algebra bi-Hamiltonian structure symmetry

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急诊无X线透视治疗急性化脓性胆管炎的临床价值

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临床消化病杂志 2024年第2期36卷 125-128页

作者：靳海峰刘贞冯子坛冯佳郭丽丽马春柳刘珊张欣悦刘文格胡阳中国人民解放军联勤保障部队第九八〇医院&白求恩国际和平医院消化内科河北石家庄050082

[目的]探讨无X线透视急诊内镜下胆道支架置入术治疗急性化脓性胆管炎的安全性及临床价值。[方法]回顾性分析307例急性胆管炎患者的临床资料。根据手术方式,分为不透视组86例、透视组221例。比较2组患者的临床资料、并发症发生率及手术... 详细信息

[目的]探讨无X线透视急诊内镜下胆道支架置入术治疗急性化脓性胆管炎的安全性及临床价值。[方法]回顾性分析307例急性胆管炎患者的临床资料。根据手术方式,分为不透视组86例、透视组221例。比较2组患者的临床资料、并发症发生率及手术成功率。[结果]不透视组高血压、冠心病、服用抗凝药比例明显高于透视组,2组比较差异有统计学意义。前者手术操作时间远低于后者(P=0.000)。2组均无穿孔及死亡患者,并发症及手术成功率比较均差异无统计学意义。[结论]无X线透视下行内镜下胆道支架置入术可有效解除急诊重症高危患者的胆道梗阻症状,手术成功率高,且不增加术后并发症发生率,在急诊患者中安全可靠。

关键词：急性胆管炎无X线透视胆道支架

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Effect of microalloying on wettability and interface characteristics of Zr-based bulk metallic glasses with W substrate

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China Foundry 2024年第4期21卷 352-359页

作者： Zhen Zhang Lin-na feng jin-he Wang Zheng-kun Li Hua-meng Fu Hong Li Zheng-wang Zhu hai-feng Zhang School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China School of Metallurgy Northeastern UniversityShenyang 110004China

The infiltration casting method is widely employed for the preparation of ex-situ composite ***,the production of composite materials using this method must necessitates a comprehensive understanding of the wettability and interface characteristics between the reinforcing phase and the bulk metallic glasses(BMGs).This work optimized the composition of Zr-based BMGs through microalloying methods,resulting in a new set of Zr-based BMGs with excellent glass-forming *** experiments between the Zr-based BMGs melts and W substrates were conducted using the traditional sessile drop method,and the interfaces were characterized utilizing a scanning electron microscope(SEM)equipped with energy dispersive X-ray spectroscopy(EDS).The work demonstrates that the microalloying method substantially enhances the wettability of the Zr-based BMGs ***,the incorporation of Nb element impedes the formation of W-Zr phases,but the introduction of Nb element does not alter the extent of interdiffusion between the constituent elements of the amorphous matrix and W element,indicating that the influence of Nb element on the diffusion of individual elements is minute.

关键词： Zr-based BMGs infiltration casting method wettability interface characteristics W-Zr phases

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Effect of heat treatment on corrosion behaviors of Mg-6Gd-3Y-0.5Zr alloy

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China Foundry 2024年第5期21卷 599-612页

作者： Fei Wang Bin-guo Fu Yu-feng Wang Tian-shun Dong Guo-lu Li jin-hai Liu Hebei Key Laboratory of New Functional Materials School of Materials Science and EngineeringHebei University of TechnologyTianjin 300401China Tianjin Institute of Aerospace Mechanical and Electrical Equipment Tianjin 300301China Tianjin Aerospace Long March Technology and Equipment Co. Ltd.Tianjin 300462China

The microstructures and corrosion behaviors of as-cast,T4-treated,and T6-treated Mg-6Gd-3Y-0.5Zr alloys were systematically investigated by SEM,TEM,immersion test,and electrochemical corrosion *** results show that the microstructure of the as-cast alloy is composed ofα-Mg and Mg_(24)(Gd,Y)_(5)eutectic phase,and in T4-treated alloy,Mg_(24)(Gd,Y)_(5)phase dissolves into theα-Mg matrix,leading to an increase in the(Y,Gd)H_(2)*** T6 treatment,nanoscale Mg_(24)(Gd,Y)_(5)phase dispersedly precipitates from theα-Mg matrix,and exhibits a specific orientation relationship with theα-Mg:(332)Mg_((24)(Gd,Y)_(5))//(1011)_(α-Mg),[136]Mg_((24)(Gd,Y)_(5))//[1210]_(α-Mg).The corrosion resistance of the Mg-6Gd-3Y-0.5Zr alloys can be ranked in the following order:T6-treated alloy exhibits the highest corrosion resistance,followed by the T4-treated alloy,and finally,the as-cast *** corrosion products of the alloys are all composed of MgO,Mg(OH)_(2),Gd_(2)O_(3),Y_(2)O_(3),and MgCl_(2).The corrosion behavior of Mg-6Gd-3Y-0.5Zr alloy is closely related to the precipitated *** establishing the relationship between corrosion rate,hydrogen evolution rate,and corrosion potential,it is further demonstrated that during the micro galvanic corrosion process,the coarse Mg_(24)(Gd,Y)_(5)phase in the as-cast alloy undergoes extensive dissolution,and(Y,Gd)H_(2)phase promotes the dissolution of theα-Mg matrix in the T4-treated alloy,intensifying the hydrogen evolution *** T6-treated alloy,with dispersive precipitation of nanoscale Mg_(24)(Gd,Y)_(5)phase,exhibits better corrosion resistance performance.

关键词： Mg-6Gd-3Y-0.5Zr alloy heat treatment microstructure precipitated phase corrosion resistance

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