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RF Optimizer Model for Predicting Compressive Strength of Recycled Concrete

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期 215-223页

作者：刘琳王柳燕 WANG Hui sun Huayue School of Civil Engineering and Architecture Shenyang University

Traditional machine learning （ML） encounters the challenge of parameter adjustment when predicting the compressive strength of reclaimed *** address this issue,we introduce two optimized hybrid models:the Bayesian optimization model （B-RF） and the optimal model （Stacking model）.These models are applied to a data set comprising 438 observations with five input variables,with the aim of predicting the compressive strength of reclaimed ***,we evaluate the performance of the optimized models in comparison to traditional machine learning models,such as support vector regression （SVR）,decision tree （DT）,and random forest （RF）.The results reveal that the Stacking model exhibits superior predictive performance,with evaluation indices including R2=0.825,MAE=2.818 and MSE=14.265,surpassing the traditional ***,we also performed a characteristic importance analysis on the input variables,and we concluded that cement had the greatest influence on the compressive strength of reclaimed concrete,followed by water. Therefore,the Stacking model can be recommended as a compressive strength prediction tool to partially replace laboratory compressive strength testing,resulting in time and cost savings.

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中国儿童道德情感发展的动态演变及生态系统模型建构——基于三轮大样本实证调查

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华东师范大学学报（教育科学版） 2025年第1期43卷 96-112页

作者：孙彩平葛丹丹南京师范大学道德教育研究所南京210024 南京工程学院学生工作处南京211167

道德情感是品德现实化的动力因素,是考察儿童知行统一性的关键点。基于2016、2019、2022年中国儿童道德发展的大样本整体动态数据(77953,77367,79914),采用回归分析、夏普里值分解发现中国儿童道德情感的发展:(1)类型不均衡,同情心表现... 详细信息

道德情感是品德现实化的动力因素,是考察儿童知行统一性的关键点。基于2016、2019、2022年中国儿童道德发展的大样本整体动态数据(77953,77367,79914),采用回归分析、夏普里值分解发现中国儿童道德情感的发展:(1)类型不均衡,同情心表现需要关注;(2)水平随年龄的增高呈现先增高后降低的发展趋势,10岁为儿童道德情感发展的关键点;(3)存在性别和城乡区域的结构差异;(4)按因素影响强度呈现独特的生态系统逻辑,从高到低排列为“个体-学校-社会支持-家庭”;生活满意度、了解儿童的人、学校和家庭心理环境是高影响因素;不同因素对不同性别和学段儿童的道德情感发展影响存在差异。由上发现提出,中国儿童道德情感培育要重视道德情感类型的发展失衡、群体发展的差异和关键影响因素,优化儿童道德情感发展的生态系统,抓住发展的关键期,进一步明确教育的侧重点,提升针对性和时效性。

关键词：中国儿童道德情感发展动态影响因素生态系统

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我国“双一流”建设高校高层次人才政策研究

高校教育管理 2025年第1期19卷 36-48页

作者：陈英杰孙东东南京中医药大学科学技术处南京中医药大学人力资源处江苏南京210023

本研究抽样选取我国4个地区17所“双一流”建设高校高层次人才政策文本,构建“政策工具政策内容要素”二维分析框架,探讨高层次人才政策工具和政策内容要素的组合方式与地区差异。研究发现,我国“双一流”建设高校高层次人才政策的环境... 详细信息

本研究抽样选取我国4个地区17所“双一流”建设高校高层次人才政策文本,构建“政策工具政策内容要素”二维分析框架,探讨高层次人才政策工具和政策内容要素的组合方式与地区差异。研究发现,我国“双一流”建设高校高层次人才政策的环境型政策工具使用不足,尤其是西部高校的环境型政策工具亟待加强;需求型政策工具中教师培育政策子工具使用不足;南部、西部和北部地区高校对人才培养政策的关注度不够。我国“双一流”建设高校在制定高层次人才政策时,应适度增强环境型政策工具的运用,进一步完善和充实教师培育相关政策;西部地区高校应改善办公实验条件,提高团队建设水平;南部、西部和北部高校应加快制定人才培养相关政策。

关键词： “双一流”建设高校高层次人才政策文本分析政策工具政策内容要素二维分析框架

Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing

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Science China Life Sciences 2025年第1期 116-129页

作者： Jiangpeng Wu Siyu Xia Wenting Ye Yan sun Jing Cai Fubing Yu Haiping Wen Xiuwei Yi Taikang Li Mingwei Chen Jiayun Chen Ge Song Chuanbin Yang Yali Song Jigang Wang Department of Reproductive Medicine Dongguan Maternal and Child Health Care Hospital Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalSouthern University of Science and Technology State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical Sciences Reproductive Medicine Center Foshan Women and Children Hospital State Key Laboratory of Antiviral Drugs School of PharmacyHenan University

Ovarian endometrioma（OE）, also known as “chocolate cysts,” is a cystic mass that develops in the ovaries due to endometriosis and is a common gynecological condition characterized by the growth of endometrial tissue outside the uterus, leading to symptoms such as dysmenorrhea, pelvic pain, and infertility. However, the precise molecular and cellular mechanisms driving this pathophysiology remain largely unknown, posing challenges for diagnosis and treatment. Here, we employed integrated single-cell transcriptomic profiling of over 52,000 individual cells from endometrial tissues of OE patients and healthy donors and identified twelve major cell populations. We identified notable alterations in cell type-specific proportions and molecular signatures associated with OE. Notably, the activation of IGFBP5+macrophages with pro-inflammatory properties, NK cell exhaustion, and aberrant proliferation of IQCG+and KLF2+epithelium are key features and may be the potential mechanisms underlying the pathogenesis of OE. Collectively, our data contribute to a better understanding of OE at the single cell level and may pave the way for the development of novel therapeutic strategies.

关键词： ovary high-throughput sequencing transcriptomics gene expression analysis ligand-receptor analysis

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建设电子商务产业学院的探索与研究——以依托“新商科智慧学习工场”建设为例

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办公自动化 2025年第1期30卷 25-27页

作者：孙亮甘肃财贸职业学院兰州730207

文章以甘肃财贸职业学院“新商科智慧学习工场”为例,探讨电子商务产业学院的建设模式和实施路径。通过对学习工场的实际运营情况、校企合作模式、学生实训效果等方面的分析,揭示电子商务产业学院在培养高技能人才、促进教育与产业对接... 详细信息

文章以甘肃财贸职业学院“新商科智慧学习工场”为例,探讨电子商务产业学院的建设模式和实施路径。通过对学习工场的实际运营情况、校企合作模式、学生实训效果等方面的分析,揭示电子商务产业学院在培养高技能人才、促进教育与产业对接方面的成效。同时,提出在建设和运行过程中面临的挑战和解决方案。

关键词：电子商务产业学院新商科智慧学习工场校企合作实训教育

Shift control method for the local time at descendi ngnode based on sun-synchronous orbit satellite

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Journal of Systems Engineering and Electronics 2009年第1期20卷 141-145页

作者： Yang Yong'an Feng Zuren sun Linyan Tan Wei Xi'an Jiaotong Univ. Xi'an 710049 P. R. China Xi'an Satellite Control Center Xi'an 710043 P. R. China

This article analyzes the shift factors of the descending node local time for sun-synchronous satellites and proposes a shift control method to keep the local time shift within an allowance range. It is found that the satellite orbit design and the orbit injection deviation are the causes for the initial shift velocity, whereas the atmospheric drag and the sun gravitational perturbation produce the shift acceleration. To deal with these shift factors, a shift control method is put forward, through such methods as orbit variation design, orbit altitude, and inclination keeping control. The simulation experiment and practical application have proved the effectiveness of this control method.

关键词： space engineering sun-synchronous orbit satellite local time of descending node drift control method.

内质网应激与常见退行性骨骼疾病的发生与发展

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中国组织工程研究 2025年第6期29卷 1285-1295页

作者：钱琨李子卿孙水山东第一医科大学附属省立医院骨关节科山东省济南市250021 医学科技创新中心骨科实验室山东第一医科大学(山东省医学科学院)山东省济南市250117

背景:常见的退行性骨骼疾病,如骨关节炎、骨质疏松症和椎间盘退变,其具体的发病分子机制目前尚未明确,可能涉及内质网应激。目前,关于内质网应激在这些常见骨骼疾病发病机制中的系统作用和相关治疗进展的研究较为有限。目的:综述内质网... 详细信息

背景:常见的退行性骨骼疾病,如骨关节炎、骨质疏松症和椎间盘退变,其具体的发病分子机制目前尚未明确,可能涉及内质网应激。目前,关于内质网应激在这些常见骨骼疾病发病机制中的系统作用和相关治疗进展的研究较为有限。目的:综述内质网应激在常见的退行性骨骼疾病中的作用,深入探讨这些疾病的分子机制并提供新的防治思路和视角。方法:检索2000-2024年相关文献,以“内质网应激,骨骼疾病,未折叠蛋白反应,骨关节炎,骨质疏松症,椎间盘退变,自噬,凋亡,铁死亡,焦亡”为中文检索词检索中国知网、万方、维普数据库;以“endoplasmic reticulum stress,bone disease,unfolded protein response,osteoarthritis,osteoporosis,intervertebral disc degeneration,autophagy,apoptosis,ferroptosis,pyroptosis”为英文检索词检索PubMed、Web of Science数据库。排除重复和较陈旧的文献,共115篇文献符合纳入标准。结果与结论:①内质网应激在细胞生理调节中具有双重效应。轻度的内质网应激有助于促进成骨分化和细胞外基质合成,然而持续过度的内质网应激则会导致细胞死亡。②内质网应激诱导的细胞自噬、凋亡等与骨关节炎、骨质疏松症、椎间盘退变密切相关。③衰老、药物不良反应、代谢紊乱、钙平衡失调、不良生活习惯等多种原因可导致内质网应激的长期激活,从而引起骨重塑紊乱、软骨损伤、髓核细胞死亡等病理表现,最终导致骨关节炎、骨质疏松和椎间盘退变的发生。④对引发内质网应激的相关机制进行干预,有望在预防和治疗骨关节炎、骨质疏松症和椎间盘退变等常见退行性骨病方面发挥作用。

关键词：内质网应激骨骼疾病未折叠蛋白反应骨关节炎骨质疏松症椎间盘退变

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老年人群中开展结核病主动发现的研究进展

中国防痨杂志 2025年第1期47卷 96-101页

作者：孙丹雨辰刘宇红首都医科大学附属北京胸科医院/中国疾病预防控制中心结核病防治临床中心北京101149

结核病仍然是危害全球公共健康的重大传染病,其中老年人群的结核病负担日益严峻。我国是结核病高负担国家之一,且近年来老龄化趋势严重,因此,老年人群的结核病防治对终结结核病的进程至关重要,特别是老年人群患者的发现工作。笔者查阅... 详细信息

结核病仍然是危害全球公共健康的重大传染病,其中老年人群的结核病负担日益严峻。我国是结核病高负担国家之一,且近年来老龄化趋势严重,因此,老年人群的结核病防治对终结结核病的进程至关重要,特别是老年人群患者的发现工作。笔者查阅并总结国内外针对老年人群主动筛查的研究文献,对老年人群结核病流行病学现状、主动筛查的开展方式、筛查效果的影响因素及存在的挑战进行综述,旨在阐述在老年人群中开展结核病主动发现策略的重要性和必要性。

关键词：结核老年人人群监测综述

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu Xiao-Li Li Xiao-Ting sun Li-Ting Wang Xia Wu Ling-Jie Zhu Xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors