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Registration of intervention trials of Traditional Chinese Medicine for four neurological diseases on Chinese Clinical Trial Registry and Clinical Trials.gov:a narrative review

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Journal of Traditional Chinese Medicine 2022年第1期42卷 148-153页

作者： WEI Jingjing GUO Rongjuan FU Guojing LIANG Xiao XU Zhenmin JIA Min ZENG Zixiu DU Wanqing jiao weiwei SUN Linjuan LIU Hongmei GUO Chunli TONG Chenguang ZHANG Yunling LIAO Xing Graduate school Beijing University of Chinese MedicineBeijing 10029China Center for Evidence Based Chinese Medicine Institute of Basic Research in Clinical MedicineChina Academy of Chinese Medical SciencesBeijing 100700China Department of Neurology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China Department of Neurology Dongfang HospitalBeijing University of Chinese MedicineBeijing 100078China

OBJECTIVE:To analyze the current status of clinical trial registration of Traditional Chinese Medicine(TCM)for the treatment of neurological diseases.METHODS:Interventional clinical trials of TCM treatment for ischemic stroke,hemorrhagic stroke,vascular cognitive impairment,tension-type headache before September 22,2020 on the platform of Chinese Clinical Trial Registry(Chi CTR),and Clinical Trials.gov were searched.Two researchers independently selected the literature and extracted data.RESULTS:A total of 180 interventional clinical trials were included for analysis.Out of 180 trials,127 were from Chi CTR and 53 from Clinical Trials.gov.The countries primary sponsoring the included trials were China(176,97.8%),and the common categories of primary sponsors were hospital(131,72.8%).Among the study design,the largest proportion of allocation was randomized(172,95.6%),interventional model assignment was parallel(163,90.6%),masking was double blind 49(27.2%),and the sample size was≤400(144,80.0%).The trials were most carried out at a single center(102,56.7%).Among the included studies,112(62.2%)registered on Chi CTR attached the ethical approval documents.In terms of trial stages,50(27.7%)studies were in phaseⅣ.The mostly used intervention was Chinese herbal medicines(99,55%),acupuncture(68,37.8%)was the second.By searching the registration number on China National Knowledge Infrastructure Database and Pub Med,38(21.1%)registered trials were published,including 25 protocol studies and 14 research results with one(NCT02275949)published both the protocol and the results.CONCLUSIONS:Irregular and inadequate reporting,untimely update and publication,insufficient information on traditional medicine unique characteristics,and lack of international collaborations are the problems existing in the interventional clinical registration trials of traditional medicine treatment on neurological diseases.More efforts need to be made from the above aspects to standardize and improve the registration of traditional medicine trials.

关键词： medicine Chinese traditional ischemic stroke cognitive dysfunction tension-type headache hemorrhagic stroke Chinese Clinical Trial Registry Clinical Trials.gov critical appraisal

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基于非靶向脂质组学分析脂蛋白Rv1411c对结核分枝杆菌脂质代谢的影响

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中国防痨杂志 2024年第5期46卷 538-548页

作者：孙玉亭全舒婷孙柏旭田雪綦辉焦伟伟申阿东孙琳国家儿童医学中心/首都医科大学附属北京儿童医院/北京市儿科研究所/儿科学国家重点学科/儿科重大疾病研究教育部重点实验室/国家呼吸系统疾病临床医学研究中心/儿童呼吸道感染性疾病研究北京市重点实验室北京100045

目的:基于非靶向脂质组学探索结核分枝杆菌(Mycobacterium tuberculosis,MTB)脂蛋白Rv1411c在该菌脂质代谢中的作用。方法:构建敲除编码脂蛋白Rv1411c基因的MTB(ΔRv1411c)菌株,测定ΔRv1411c与MTB标准株H37Rv的吸光度值(A 600值)并绘... 详细信息

目的:基于非靶向脂质组学探索结核分枝杆菌(Mycobacterium tuberculosis,MTB)脂蛋白Rv1411c在该菌脂质代谢中的作用。方法:构建敲除编码脂蛋白Rv1411c基因的MTB(ΔRv1411c)菌株,测定ΔRv1411c与MTB标准株H37Rv的吸光度值(A 600值)并绘制两者生长曲线。提取ΔRv1411c与H37Rv菌液上清脂质成分,使用液相色谱-质谱(LC-MS)联用技术及非靶向脂质组学分析平台对菌株的差异脂质进行分析。采用偏最小二乘法判别分析(PLS-DA)、京都基因和基因组百科全书(KEGG)富集分析等方法分析两者的差异脂质代谢产物及差异脂质分子的富集通路。结果:通过色谱分离及质谱分析,从ΔRv1411c与H37Rv菌株中成功鉴定出归属于28种脂质亚类的460个不同的脂质分子,再通过PLS-DA模型分析获得其中归属于17种脂质亚类的158个差异脂质分子[变量权重值(VIP)>1]。以变异倍数(FC)>1.5或<0.67且P<0.05为筛选标准,共筛选出36个具有显著差异的脂质分子,其中有12个脂质分子上调,24个脂质分子下调。经KEGG通路富集分析,差异脂质代谢产物主要富集于以下8种通路,即:甘油磷脂代谢、亚麻酸代谢、α-亚麻酸代谢、糖基磷脂酰肌醇(GPI)-锚的生物合成、甘油脂代谢、鞘脂代谢、花生四烯酸代谢及不饱和脂肪酸的生物合成通路;其中又以甘油磷脂的代谢通路最为重要,其次为甘油脂代谢及糖基磷脂酰肌醇(GPI)-锚的生物合成通路。结论:脂蛋白Rv1411c可显著影响MTB的脂质代谢,可能参与MTB脂质代谢的调控。

关键词：分枝杆菌,结核脂蛋白类脂类代谢脂质组

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Deep structure of the Southeast Asian curved subduction system and its dynamic process

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Journal of Oceanology and Limnology 2024年第3期42卷 701-704页

作者： weiwei DING Key Laboratory of Submarine Geoscience&Second Institute of Oceanography Ministry of Natural ResourcesHangzhou 310012China School of Oceanography Shanghai Jiao Tong UniversityShanghai 200030China

The deep structure,material circulation,and dynamic processes in the Southeast Asia have long been an elusive scientific puzzle due to the lack of systematic scientific observations and recognized theoretical models.Based on the deep seismic tomography using long-period natural earthquake data,in this study,the deep structure and material circulation of the curved subduction system in Southeast Asia was studied,and the dynamic processes since 100 million years ago was reconstructed.It is pointed out that challenges still exist in the precise reconstruction of deep mantle structures of the study area,the influence of multi-stage subduction on deep material exchange and shallow magma activity,as well as the spatiotemporal evolution and coupling mechanism of multi-plate convergence.Future work should focus on high-resolution land-sea joint 3-D seismic tomography imaging of the curved subduction system in the Southeast Asia,combined with geochemical analysis and geodynamic modelling works.

关键词： curved subduction system deep structure material recycling dynamic process Southeast Asia

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Severe cases of BCGosis-susceptible primary immunodeficiency diseases identified by next-generation sequencing:Implications for adjustment of BCG vaccination timing in China

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Journal of Genetics and Genomics 2020年第4期47卷 229-232页

作者： Gang Liu Haijuan Xiao Linlin Liu Lingyun Guo Ruolan Guo Xuyun Hu Chanjuan Hao Jingang Gui weiwei jiao Fang Xu Adong Shen Wei Li Department of Infectious Disease Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China Beijing Pediatric Research Institute Genetics and Birth Defects Control CenterBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China

The World Health Organization(WHO)recommends neonatal Bacillus Calmette-Guerin(BCG)vaccination in countries with a high prevalence of tuberculosis(TB),which has been practiced in more than 150 countries(WHO,2004).The prevalence of TB is a serious condition in China,ranking as the second in the high epidemic countries globally(WHO,2018).China initiated a neonatal BCG vaccination program in 1986 and reached an average vaccination rate of 99%in 2016 with a great success in preventing the incidence of TB(WHO,2018).

关键词： vaccination neonatal diseases

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儿童结核病诊断与治疗面临的问题与思考

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中华实用儿科临床杂志 2022年第7期37卷 486-489页

作者：刘芳焦伟伟申阿东国家儿童医学中心国家呼吸系统疾病临床医学研究中心教育部儿科重大疾病研究重点实验室首都医科大学附属北京儿童医院儿童呼吸道感染性疾病研究北京市重点实验室北京100045

结核病(TB)是严重危害儿童健康的重要疾病,由于儿童TB的特殊性,其在诊断和治疗方面存在诸多问题:儿童TB临床表现和症状缺乏特异性、临床医师对疾病的重视程度不够、病原学检测标本难以获取、现有诊断方法的敏感性不足、缺乏儿童友好型... 详细信息

结核病(TB)是严重危害儿童健康的重要疾病,由于儿童TB的特殊性,其在诊断和治疗方面存在诸多问题:儿童TB临床表现和症状缺乏特异性、临床医师对疾病的重视程度不够、病原学检测标本难以获取、现有诊断方法的敏感性不足、缺乏儿童友好型抗结核药物、缺乏儿童抗结核药物药代动力学/药效学研究数据和基于儿童数据的抗结核治疗方案等。现就上述问题及其应对策略和展望进行总结。

关键词：结核病儿童诊断治疗进展

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基于遗传算法优化小波网络的柔性喷管力矩特性辨识方法

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航空动力学报 2022年第9期37卷 1936-1945页

作者：杨弘枨刘山靳广在焦玮玮姜玉峰北京精密机电控制设备研究所航天伺服驱动与传动技术实验室北京100076

为准确辨识负载力矩并提高主动加载负载模拟的真实度,使用了一种基于遗传算法优化的神经网络辨识方法。使用小波分析方法对测试信号进行预处理,将消噪与分解后得到的信息作为神经网络训练的扩充样本,提高了辨识精度。使用遗传算法选择... 详细信息

为准确辨识负载力矩并提高主动加载负载模拟的真实度,使用了一种基于遗传算法优化的神经网络辨识方法。使用小波分析方法对测试信号进行预处理,将消噪与分解后得到的信息作为神经网络训练的扩充样本,提高了辨识精度。使用遗传算法选择最优输入信息、网络结构和隐含层规模,加快网络收敛速度并简化计算过程,实现对柔性喷管力矩的快速准确辨识。仿真结果表明该辨识方法可以准确地描述柔性喷管在典型测试信号激励下的力矩特性,平均辨识误差为2%,对于实现精确主动加载控制和验证伺服控制性能具有重要意义。

关键词：伺服系统柔性喷管系统辨识小波网络小波分析遗传算法

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鸟苷酸结合蛋白家族在感染性疾病中调控炎症小体活化的研究进展

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遗传 2023年第11期45卷 1007-1017页

作者：全舒婷焦伟伟徐放孙琳綦辉申阿东国家儿童医学中心首都医科大学附属北京儿童医院北京市儿科研究所国家呼吸系统疾病临床医学研究中心儿科学国家重点学科儿科重大疾病研究教育部重点实验室儿童呼吸道感染性疾病研究北京市重点实验室北京100045 首都医科大学附属北京儿童医院保定医院保定市儿童感染性疾病精准诊治重点实验室保定071000 国家儿童医学中心首都医科大学附属北京儿童医院北京市儿科研究所儿科学国家重点学科儿科重大疾病研究教育部重点实验室出生缺陷遗传学研究北京市重点实验室遗传与出生缺陷防治中心北京100045

鸟苷酸结合蛋白(guanylate-binding proteins,GBP)是一类干扰素诱导蛋白,在应对细菌、病毒、衣原体以及寄生虫等病原体感染时,其发挥的作用存在差异,并且影响感染性疾病的发展和结局。目前,研究者发现在细菌等病原体感染引发的细胞自主... 详细信息

鸟苷酸结合蛋白(guanylate-binding proteins,GBP)是一类干扰素诱导蛋白,在应对细菌、病毒、衣原体以及寄生虫等病原体感染时,其发挥的作用存在差异,并且影响感染性疾病的发展和结局。目前,研究者发现在细菌等病原体感染引发的细胞自主免疫中,GBP蛋白通过影响炎症小体的经典和非经典活化途径调控细胞焦亡。本文对GBP家族成员结构、进化特征以及炎症小体的经典和非经典活化途径进行了介绍,综述了GBP蛋白调控炎症小体活化的相关研究进展,归纳总结了GBP蛋白影响不同病原体感染的作用机制,以期为感染性疾病的发病机制和诊疗提供新的基础研究线索。

关键词：鸟苷酸结合蛋白感染性疾病炎症小体炎症小体经典活化途径炎症小体非经典活化途径

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Self-derivation and reconstruction of silver nanoparticle reinforced cobalt-nickel bimetallic hydroxides through interface engineering for overall water splitting

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Journal of Energy Chemistry 2024年第3期90卷 590-599,I0013页

作者： Yan Li Jie Han weiwei Bao Junjun Zhang Taotao Ai Mameng Yang Chunming Yang Pengfei Zhang National and Local Joint Engineering Laboratory for Slag Comprehensive Utilization and Environmental Technology School of Materials Science and EngineeringShaanxi University of TechnologyHanzhong 723000ShaanxiChina State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering College of Chemistry&Chemical EngineeringNingxia UniversityYinchuan 750021NingxiaChina College of Chemistry&Chemical Engineering Yan’an UniversityYan’an 716000ShaanxiChina School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Designing efficient and long-lasting non-metal electrocatalysts is an urgent task for addressing the issue of kinetic hysteresis in electrochemical oxidation reactions.The bimetallic hydroxides,catalyzing the oxygen evolution reaction(OER),have significant research potential because hydroxide reconstruction to generate an active phase is a remarkable advantage.Herein,the complete reconstruction of ultrathin CoNi(OH)_(2) nanosheets was achieved by embedding Ag nanoparticles into the hydroxide to induce a spontaneous redox reaction(SRR),forming heterojunction Ag@CoNi(OH)_(2) for bifunctional hydrolysis.Theoretical calculations and in situ Raman and ex situ characterizations revealed that the inductive effect of the Ag cation redistributed the charge to promote phase transformation to highly activate Ag-modified hydroxides.The Co-Ni dual sites in Co/NiOOH serve as novel active sites for optimizing the intermediates,thereby weakening the barrier formed by OOH^*.Ag@CoNi(OH)_(2) required a potential of 1.55 V to drive water splitting at a current density of 10 mA cm^(-2),with nearly 98.6% Faraday efficiency.Through ion induction and triggering of electron regulation in the OER via the synergistic action of the heterogeneous interface and surface reconstruction,this strategic design can overcome the limited capacity of bimetallic hydroxides and bridge the gap between the basic theory and industrialization of water decomposition.

关键词： Surface reconstruction Bimetallic hydroxides Ag nanoparticle Operando Raman Overall water splitting

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风机叶片的覆冰机理与模拟分析

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电子技术（上海） 2023年第3期52卷 236-237页

作者：焦伟卫大唐三门峡发电有限责任公司石牛岭风电场河南472000

阐述主成分分析法对风机叶片覆冰机制的分析,模拟分析环境因素对风机叶片覆冰的影响、叶片几何参数的影响,探讨风速、温度与叶片的角度都是影响风机叶片覆冰的因素。

关键词：模拟分析环境因素几何参数叶片覆冰

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Oncogenic β-catenin-driven liver cancer is susceptible to methotrexate-mediated disruption of nucleotide synthesis

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Chinese Medical Journal 2024年第2期137卷 181-189页

作者： Fangming Liu Yuting Wu Baohui Zhang Shuhui Yang Kezhuo Shang Jie Li Pengju Zhang weiwei Deng Linlin Chen Liang Zheng Xiaochen Gai Hongbing Zhang Department of Physiology State Key Laboratory of Common Mechanism Research for Major DiseasesHaihe Laboratory of Cell EcosystemInstitute of Basic Medical Sciences and School of Basic MedicineChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Department of Physiology Institute of Basic Medical Sciences and School of Basic MedicineGraduate School of Peking Union Medical CollegeChinese Academy of Medical SciencesBeijing100005China Department of Physiology School of Life ScienceChina Medical UniversityShenyangLiaoning 110122China School of Life Sciences Westlake UniversityHangzhouZhejiang 310024China Key Laboratory of Pediatric Hematology and Oncology Ministry of HealthInstitute of Pediatric Translational MedicineShanghai Children’s Medical CenterShanghai Jiao Tong School of MedicineShanghai 200127China

Background:Liver cancer is largely resistant to chemotherapy.This study aimed to identify the effective chemotherapeutics forβ-catenin-activated liver cancer which is caused by gain-of-function mutation of catenin beta 1(CTNNB1),the most frequently altered proto-oncogene in hepatic neoplasms.Methods:Constitutiveβ-catenin-activated mouse embryonic fibroblasts(MEFs)were established by deleting exon 3(β-catenin^(Δ(ex3)/+)),the most common mutation site in CTNNB1 gene.A screening of 12 widely used chemotherapy drugs was conducted for the ones that selectively inhibitedβ-catenin^(Δ(ex3)/+)but not for wild-type MEFs.Untargeted metabolomics was carried out to examine the alterations of metabolites in nucleotide synthesis.The efficacy and selectivity of methotrexate(MTX)onβ-catenin-activated human liver cancer cells were determined in vitro.Immuno-deficient nude mice subcutaneously inoculated withβ-catenin wild-type or mutant liver cancer cells and hepatitis B virus(HBV);β-catenin^(lox(ex3)/+)mice were used,respectively,to evaluate the efficacy of MTX in the treatment ofβ-catenin mutant liver cancer.Results:MTX was identified and validated as a preferential agent against the proliferation and tumor formation ofβ-catenin-activated cells.Boosted nucleotide synthesis was the major metabolic aberration inβ-catenin-active cells,and this alteration was also the target of MTX.Moreover,MTX abrogated hepatocarcinogenesis of HBV;β-catenin^(lox(ex3)/+)mice,which stimulated concurrent Ctnnb1-activated mutation and HBV infection in liver cancer.Conclusion:MTX is a promising chemotherapeutic agent forβ-catenin hyperactive liver cancer.Since repurposing MTX has the advantages of lower risk,shorter timelines,and less investment in drug discovery and development,a clinical trial is warranted to test its efficacy in the treatment ofβ-catenin mutant liver cancer.

关键词： Liver cancer β-catenin Methotrexate Nucleotide synthesis Chemotherapy

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