Severe cases of BCGosis-susceptible primary immunodeficiency diseases identified by next-generation sequencing:Implications for adjustment of BCG vaccination timing in China

作     者：Gang Liu Haijuan Xiao Linlin Liu Lingyun Guo Ruolan Guo Xuyun Hu Chanjuan Hao Jingang Gui Weiwei Jiao Fang Xu Adong Shen Wei Li Gang Liu;Haijuan Xiao;Linlin Liu;Lingyun Guo;Ruolan Guo;Xuyun Hu;Chanjuan Hao;Jingang Gui;Weiwei Jiao;Fang Xu;Adong Shen;Wei Li

作者机构：Department of Infectious DiseaseBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China Beijing Pediatric Research InstituteGenetics and Birth Defects Control CenterBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China 

出 版 物：《Journal of Genetics and Genomics》 (遗传学报（英文版）)

年 卷 期：2020年第47卷第4期

页      面：229-232页

核心收录：

学科分类：0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：partially supported by grants from The Ministry of Science and Technology of the People’s Republic of China(2016YFC1000306) The Special Fund of the Pediatric Medical Coordinated Development Center of Beijing Hospitals Authority(XTZD201805) 

主　　题：vaccination neonatal diseases 

摘      要：The World Health Organization(WHO)recommends neonatal Bacillus Calmette-Guerin(BCG)vaccination in countries with a high prevalence of tuberculosis(TB),which has been practiced in more than 150 countries(WHO,2004).The prevalence of TB is a serious condition in China,ranking as the second in the high epidemic countries globally(WHO,2018).China initiated a neonatal BCG vaccination program in 1986 and reached an average vaccination rate of 99%in 2016 with a great success in preventing the incidence of TB(WHO,2018).