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6-Thioguanine incorporates into RNA and induces adenosine-to-inosine editing in acute lymphoblastic leukemia cells

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Chinese Chemical Letters 2023年第1期34卷 539-543页

作者： Xue-jiao You Lin Li Tong-Tong Ji Neng-Bin Xie Bi-feng yuan yu-Qi feng Department of Chemistry Sauvage Center for Molecular SciencesWuhan UniversityWuhan 430072China School of Public Health Wuhan UniversityWuhan 430071China School of Pharmacy Shanghai Jiao Tong UniversityShanghai 200240China

6-Thioguanine(6TG)is a widely used chemotherapeutic agent for the treatment of a variety of human diseases including acute lymphoblastic *** entry into cells,6TG is metabolically converted into 6-thioguanosine(^(S)G)nucleotide that can be incorporated into the genome during DNA replication.^(S)G in genomic DNA could induce cell death by triggering the post-replicative mismatch repair(MMR)***,incorporation of 6TG into the Cp G sites could perturb the global DNA methylation and gene ***,the effect of 6TG on RNA modifications is still ***-toinosine(A-to-I)editing in RNA is one of the most common post-transcriptional modifications in mammals and there is growing evidence showing the significant alteration of A-to-I RNA editing in tumor tissues compared to normal *** the current study,we examined the incorporation of 6TG into RNA and investigated its effect on A-to-I editing of bladder cancer-associated protein(BLCAP)transcript in acute lymphoblastic leukemia *** results demonstrated that ^(S)G could be incorporated into various RNA species,with m RNA having the most abundant ^(S)*** addition,the results showed 6TG treatment elevated A-to-I editing in BLCAP transcript through upregulating adenosine deaminase 2 acting on RNA(ADAR2),which eventually contributes to the decreased cell *** study highlights a new mechanism of the cytotoxicity of 6TG in inducing cell death.

关键词： 6-Thioguanine RNA modification Inosine Leukemia Mass spectrometry

Process mineralogy of Dalucao rare earth ore and design of beneficiation process based on AMICS

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Rare Metals 2020年第8期39卷 959-966页

作者： yu jiao Ke-Hui Qiu Pei-Cong Zhang Jun-feng Li Wen-Tao Zhang Xian-Fei Chen School of Materials and Chemistry and Chemical Engineering Chengdu University of TechnologyChengdu 610059China School of Science Xichang UniversityXichang 615000China Institute of Materials Science and Technology Chengdu University of TechnologyChengdu 610059China

The test results of the automated mineral identification and characterization system(AMICS),including the mineral composition,particle size distribution,dissemination state and degree of liberation of the target minerals,could be used to improve the beneficiation *** the Dalucao rare earth ore located in Dechang,Sichuan Province,China(with an average content of 2.40 wt%)as the research object in this paper,the chemical composition,phase composition and dissemination state of the minerals were tested by AMICS,and the minerals of different fineness were *** concentrate yield,grade and recovery rate of the minerals of different fineness were compared through flotation *** the grinding lasted for 5 min and 82.60%of mineral grains passed through the-74-μm sieve,the yield,grade and recovery rate could reach 20.19%,8.75%and 73.64%,respectively(as the best grinding fineness),under the same flotation conditions.

关键词： Automated mineral identification and characterization system(AMICS) Bastnasite Dalucao Flotation

Phosphorus-doped NiS_(2)electrocatalyst with a hybrid structure for hydrogen evolution

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Science China(Technological Sciences) 2022年第7期65卷 1506-1512页

作者： ZHOU Qi LIU HaoRui jiao SunZhi feng ChenChen State Key Laboratory of Advanced Processing and Recycling of Non-ferrous Metals Lanzhou University of TechnologyLanzhou 730050China School of Materials Science and Engineering Lanzhou University of TechnologyLanzhou 730050China College of Mechanical Engineering Longdong UniversityQingyang 745000China

In this article,P-NiS_(2)/Ni_(x)P electrocatalysts were synthesized by dealloying the Ni-Al precursor followed by phosphosulfide *** found that the hybrid structure of P-NiS_(2)/Ni_(x)P provides rich active sites for the surface hydrogen evolution reaction (HER),and the doping of P enhances the electronic conductivity of *** particular,the obtained electrode shows a low overpotential of 196 mV at 10 mA cm^(-2)and a small Tafel slope of only 110 mV dec^(-1)in the ***,longterm constant current electrolysis test experiments indicate that P-NiS_(2)/Ni_(x)P has good service *** research will help to open a new window on the design and fabrication of HER electrocatalysts.

关键词： nickle phosphosulfides hybrid structure hydrogen evolution reaction dealloying

How to apply polar codes in high throughput space communications

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Science China(Technological Sciences) 2020年第8期63卷 1371-1382页

作者： feng BoWen jiao Jian WU ShaoHua ZHANG Qinyu Communication Engineering Research Center Harbin Institute of Technology(Shenzhen)Shenzhen 518055China

This paper describes how to apply polar codes in high-throughput space *** high throughput space communications can enable terabit data rate capacity wideband wireless transmissions,and offer service availability of anywhere and *** paper investigates the channel characteristics in space *** channels are lossy,time-varying,intermittent,long-latency,and with imperfect channel state information(CSI).In order to make the polar codes suitable for the space channel,some improvements and designs on the polar codes are provided in this *** encoding and decoding methods of polar codes are discussed,which are the key to determine the *** describe some rateless polar coding schemes that can guide the construction of suitable codes for time-varying channels with no-CSI in long-haul ***,a high-rate parallel concatenation scheme of polar codes is introduced,which can improve the anti-interrupt ability of polar ***,in order to support the massive connectivity requirements of future space communication networks,polar-coded sparse-code-multiple-access(SCMA)schemes are investigated.

关键词： space communications polar code concatenated coding high throughput

工程认证背景下的毕业生跟踪反馈及社会评价机制研究与实践

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铸造设备与工艺 2023年第3期 49-52页

作者：贾克明荣守范李俊刚朱永长焦玉凤佳木斯大学材料科学与工程学院黑龙江佳木斯154007

毕业生跟踪反馈及社会评价机制是修订培养目标的制度保障,也是开展工程教育认证工作的外部评价依据。佳木斯大学材料成型及控制工程专业基于工程认证理念和要求,构建了毕业生跟踪反馈评价机制和社会评价机制,通过对反馈评价结果的分析,... 详细信息

毕业生跟踪反馈及社会评价机制是修订培养目标的制度保障,也是开展工程教育认证工作的外部评价依据。佳木斯大学材料成型及控制工程专业基于工程认证理念和要求,构建了毕业生跟踪反馈评价机制和社会评价机制,通过对反馈评价结果的分析,对专业培养目标、毕业要求、课程体系和教学质量进行持续改进,形成了有效的外部评价体系。使得毕业生能够顺利到达职业发展的预期目标,提高了人才培养质量。

关键词：工程认证跟踪反馈机制社会评价机制

适变与应变:“十五五”时期人口发展规划的新格局、新挑战及其实践路径

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河北学刊 2025年第1期45卷 130-139页

作者：陆杰华冯雨欣北京大学中国社会与发展研究中心北京大学社会学系

“十五五”时期是中国基本实现社会主义现代化承上启下的关键时期,同时也是人口发展深度转型的重要节点。“十五五”人口发展规划的制定必须准确识别人口规模、结构、素质、分布等要素呈现的趋势性变化,及时把握当前人口发展的潜在机遇... 详细信息

“十五五”时期是中国基本实现社会主义现代化承上启下的关键时期,同时也是人口发展深度转型的重要节点。“十五五”人口发展规划的制定必须准确识别人口规模、结构、素质、分布等要素呈现的趋势性变化,及时把握当前人口发展的潜在机遇和堵点难点,根据人口发展新格局适时调整应变思路,不断推进人口自身均衡发展,以及人口与经济社会、资源环境的协调发展。从长远来看,人口发展规划的制定还需要纵向锚定人口高质量发展的战略目标,形成应对未来人口发展新变化的超前预案。

关键词： “十五五” 人口发展规划人口高质量发展适变与应变

基于工程教育认证的材料成型及控制工程专业毕业要求达成度评价体系研究

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铸造设备与工艺 2022年第6期 50-53页

作者：贾克明荣守范李俊刚焦玉凤朱永长佳木斯大学材料科学与工程学院黑龙江佳木斯1504007

毕业要求达成度评价是工程教育认证持续改进的主线工作,是支撑人才培养目标的主要环节,是搭建课程体系平台的重要依据,更是检测学生学习效果的有力手段。佳木斯大学材料成型及控制工程专业基于工程教育认证理念和要求,构建了一套较为完... 详细信息

毕业要求达成度评价是工程教育认证持续改进的主线工作,是支撑人才培养目标的主要环节,是搭建课程体系平台的重要依据,更是检测学生学习效果的有力手段。佳木斯大学材料成型及控制工程专业基于工程教育认证理念和要求,构建了一套较为完善的毕业要求达成度评价体系,建立了毕业要求达成度评价机制,采用“多维”的毕业要求达成度评价方法,形成“评价—反馈—改进—评价”的闭环评价模式,并将评价结果用于持续改进,使毕业要求对专业培养目标形成强有力的支撑,提高人才培养质量。

关键词：工程认证毕业要求评价机制评价方法

Modulated hydrocarbon distribution of gasoline deriving from butene conversion in the presence of syngas

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Journal of Energy Chemistry 2022年第10期31卷 416-421,I0010页

作者： Yi Ding feng jiao Xiulian Pan Xinhe Bao Department of Chemical Physics University of Science and Technology of ChinaHefei 230026AnhuiChina State Key Laboratory of Catalysis Dalian National Laboratory for Clean Energy2011-Collaborative Innovation Center of Chemistry for Energy MaterialsDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina University of Chinese Academy of Sciences Beijing 100049China

With the expansion of butene production capacity,clean and efficient conversion of mixed butene attracts increasing *** we report direct co-conversion of butene and syngas to highquality gasoline enabled by a bifunctional OXZEO catalyst comprising ZnCrO_(x) oxide and ZSM-5 zeolite.A gasoline selectivity of 71.6% at 98.1% butene conversion and 26.2% CO conversion have been obtained under the reaction conditions of 360℃,3 MPa and 3000 mL g^(-1) h^(-1).The space time yield of gasoline of0.25 g·g^(-1) h^(-1) is ***,the presence of syngas can effectively facilitate iso-paraffin production while hindering the formation of *** is attributed to the prohibited hydrogen transfer aromatization process of butene on ZSM-5 in the presence of *** rthermore,the formation of isomers of gasoline range hydrocarbons is favored because the active intermediates generated from CO/H_(2) activation over ZnCrO_(x) oxide could react with butene over ZSM-5 ***,the product distribution among gasoline range hydrocarbons is modulated with reduced heavy aromatics and improved iso-paraffins,which is desirable for application as *** provides an alternative environmentally friendly technology to utilize still increasing mixed butene.

关键词： Butene utilization Bifunctional catalysts OXZEO Syngas conversion Gasoline

A NEW CASCADING FAILURE MODEL WITH DELAY TIME IN CONGESTED COMPLEX NETWORKS

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Journal of Systems Science and Systems Engineering 2009年第3期18卷 369-381页

作者： Jian WANG Yanheng LIU yu jiao College of Computer Science and Technology Jilin University Changchun 130012 China Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin University Changchun 130012 China

Cascading failures often occur in congested complex networks. Cascading failures can be expressed as a three-phase process： generation, diffusion, and dissipation of congestion. Different from the betweenness centrality, a congestion function is proposed to represent the extent of congestion on a given node. Inspired by the restart process of a node, we introduce the concept of ＂delay time,＂ during which the overloaded node Cannot receive or forward any traffic, so an intergradation between permanent removal and nonremoval is built and the flexibility of the presented model is demonstrated. Considering the connectivity of a network before and after cascading failures is not cracked because the overloaded node are not removed from network permanently in our model, a new evaluation function of network efficiency is also proposed to measure the damage caused by cascading failures. Finally, we investigate the effects of network structure and size, delay time, processing ability, and traffic generation speed on congestion propagation. Cascading processes composed of three phases and some factors affecting cascade propagation are uncovered as well.

关键词： Complex networks cascading failures congestion effects propagation model