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Effect of naringenin in Qianggu capsule on population pharmacokinetics in Chinese women with primary osteoporosis

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Journal of Traditional Chinese Medicine 2015年第2期35卷 141-153页

作者： wang jiannong Jiang Junjie Xie Yanming Wei Xu Li Jianpeng Duan Jingli Xiong Xin Institute of Basic Medical Sciences Xi Yuan HospitalChina Academy of Chinese Medical Sciences Chinese Clinical Basic Institute China Academy of Chinese Medical Sciences Department of Pharmaceutics Third Hospital Affiliated Peking University

OBJECTIVE:To characterize naringenin(NAR) population pharmacokinetics(PPK) in Chinese women with primary ***:Ninety-eight female patients with primary osteoporosis from the Jingshan,Beixinqiao,Jiaodaokou,Chaoyangmen,and Donghuamen communities in Beijing,China,aged 40 to 80 years,received oral Qianggu capsules(250 mg).Blood samples were collected before and at 0.5,1,2,3,4,6,8,10,12,and 24 h after *** concentration of NAR in the blood samples was measured using high performance liquid chromatography-tandem mass *** analyses were performed with nonlinear mixed-effect modeling software(version 7.1.2,PsN3.2.12).The clearance(C1),central distribution volume(V),absorption rate constant(Ka1),peripheral distribution volume(VII),and inter-compartmental clearance(CLII) were set as parameters and estimated by the base model,covariate model,and final ***-Yang deficiency[Shenyangxu(SYAX)]and liver-kidney-Yin deficiency(Ganshenyinxu) are patterns of symptoms in Traditional Chinese Medicine that were set as covariates,along with age,height,blood urea nitrogen,serum creatinine,alanine transaminase,aspartate transaminase,and *** stepwise forward and backward procedures were accomplished to build *** final model was evaluated by internal and external validation,visual predictive check,bootstrap,and leverage ***:A one compartment open model with first order degradation was the best fitted to the concentration-time profiles following oral administration of *** mean of population parameters of the final model,C1,SYAX on C1,V,Ka1,CLII,and VII,were measured to be 37.6 L/h,0.427 L,123 L/h,0.12/h,0.3056,and 1.446,***-individual variability was estimated and SYAX was identified as a significant ***:The population pharmacokinetic model described in this study could effectively characterize the pharmacokinetic profile of NAR following administration of a single dose of o

关键词： Naringenin Pharmacokinetics Medicine Chinese traditional Qianggu capsule Total flavonoids of Drynaria fortunei

Metabonomics analysis of the urine of rats with Qi deficiency and blood stasis syndrome based on NMR techniques

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Chinese Science Bulletin 2007年第22期52卷 3068-3073页

作者： LI Lin wang jiannong REN JianXun XIANG JunFeng TANG YaLin LIU JianXun HANDing State Key Laboratory for Structural Chemistry of Unstable and Stable Species Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China Xi Yuan Hospital China Academy of Chinese Medical Sciences Beijing 100091 China

Metabonomics analysis of the urine of rats with Qi deficiency and blood stasis syndrome has been performed by comparison with those of normal rats based on NMR techniques. The relative contents of formate,creatinine,2-oxoglutarate(2-OG) ,citrate,taurine,trimethylamine-N-oxide(TMAO) ,succinate and hippurate in the urine of the rats with Qi deficiency and blood stasis syndrome have been changed. These results have provided evidence for understanding the mechanism and the therapy of Qi defi-ciency and blood stasis syndrome.

关键词：代谢组学尿大鼠血液核磁共振技术

Low-efficiency-droop InGaN quantum dot light-emitting diodes operating in the “green gap”

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Photonics Research 2020年第5期8卷 750-754页

作者： CHUNYU ZHAO CHAK WAH TANG BILLY LAI GUANGHUI CHENG jiannong wang KEI MAY LAU Department of Electronic and Computer Engineering Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Department of Physics Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina

Gallium nitride(Ga N)-based light-emitting diodes(LEDs)are important for lighting and display *** this paper,we demonstrate green-emission(512 nm)In Ga N quantum dot(QD)LEDs grown on a c-plane sapphire substrate by metal-organic chemical vapor deposition.A radiative lifetime of 707 ps for the uniform In Ga N self-assembled QDs is obtained by time-resolved photoluminescence measurement at 18 *** screening of the built-in fields in the QDs effectively improves the performance of QD *** high quantum efficiency and high temperature stability green QD LEDs are able to operate with negligible efficiency droop and with current density up to 106 A∕cm^*** results show that In Ga N QDs may be a viable option as the active medium for stable LEDs.

关键词： diodes sapphire quantum

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连铸初始凝固行为的热模拟研究

钢铁 1998年第9期33卷 18-20,13页

作者：汪建农马金昌陈刚上海大学

在归纳分析前人工作的基础上，通过热模拟试验和对振痕形貌、凝固组织的观测，研究了振痕凝固组织和初始凝固机理以及影响它们的重要工艺因素。

关键词：热模拟凝固连铸结晶器

Fabrication and Characteristics of a Si-Based Single Electron Transistor

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Journal of Semiconductors 2002年第3期23卷 246-250页

作者：卢刚陈治明王建农葛惟昆西安理工大学电子工程系西安710048 香港科技大学物理系

Si based single electron transistor (SET) is fabricated successfully on p type SIMOX substrate,based on electron beam (EB) lithography,reactive ion etching (RIE) and thermal *** particular,using thermal oxidation and etching off the oxide layer,a one dimensional Si quantum wire can be converted into several quantum dots inside quantum wire in connection with the source and drain *** differential conductance (d I ds /d V ds ) oscillations and the Coulomb staircases in the source drain current ( I ds ) are shown clearly dependent on the source drain voltage at 5 *** I ds V gs (gate voltage) oscillations are observed from the I ds V gs characteristics as a function of V gs at different temperatures and various values of V ds .For a SET whose total capacitance is about 9 16aF,the I ds V gs oscillations can be observed at 77K.

关键词： single electron transistor Coulomb blockade single electron tunneling quantum dot electron beam lithography

用于质子交换膜燃料电池的高活性、高稳定性PtIrFe/C三元合金催化剂

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材料导报 2016年第20期30卷 1-6,11页

作者：杜鑫鑫王晓霞贺阳王健农华东理工大学机械与动力工程学院碳纳米材料研究中心上海200237

采用催化裂解法制备了多孔碳,将其作为催化剂载体,利用液相还原和真空热处理工艺制备出PtIrFe/C三元合金催化剂。采用X射线衍射、透射电子显微镜等手段对样品的结构形貌进行表征。使用电化学测试手段研究了不同热处理温度对其催化性能... 详细信息

采用催化裂解法制备了多孔碳,将其作为催化剂载体,利用液相还原和真空热处理工艺制备出PtIrFe/C三元合金催化剂。采用X射线衍射、透射电子显微镜等手段对样品的结构形貌进行表征。使用电化学测试手段研究了不同热处理温度对其催化性能的影响。实验结果表明,热处理带来的合金化作用使催化剂的催化活性和耐久性得到了极大的提高。经过700℃热处理的样品,其面积比活性和质量比活性分别是传统商业Pt/C催化剂的3～4倍。

关键词：质子交换膜燃料电池催化剂电化学催化氧还原反应合金

Three previously undescribed steroidal glycoalkaloids from Solanum lyratum and their anti-tumor activities

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Journal of Chinese Pharmaceutical Sciences 2022年第3期31卷 192-201页

作者： Liangyu Liu Yuke Yang Xiao Du Tong Wu jiannong wang Key Laboratory of Chinese Medicine Pharmacology Institute of Basic Medical Sciences of Xiyuan HospitalChina Academy of Chinese Medical Sciences100091 BeijingChina China Resources Sanjiu Medical&Pharmaceutical Co.Ltd. Shenzhen 518110China Postdoctoral Mobile Research Station of China Academy of Chinese Medical Sciences Beijing 100700China

In the present study,three previously undescribed steroidal glycoalkaloids(compounds 1–3)were isolated from Solanum *** structures were elucidated based on comprehensive spectroscopic *** anti-angiogenesis and anti-metastatic activities were evaluated by MTT and wound-healing assays,***-derived vascular endothelial cells(TdECs),obtained by co-culture of A549 and human umbilical vein endothelial cells(HUVECs),were treated with compounds 1–*** showed that compounds 1–3 significantly inhibited the migration of TdECs at 25μM despite the weak cytotoxic activities,which indicated that the compounds exerted anti-tumor activities by inhibiting metastasis,rather than directly inhibiting the proliferation of TdECs.

关键词： Solanum lyratum Steroidal glycoalkaloids Anti-tumor Metastasis Angiogenesis

AT89C2051单片机与MT8880接口设计

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微计算机信息 2005年第1Z期21卷 86-87页

作者：王建农常州工学院计算机信息工程学院副教授213002

本文介绍了AT89C2051单片机与MT8880接口的设计,说明了MT8880芯片时钟信号的产生方法,给出了用C51编制的DTMF发送和接收程序。

关键词： 2051 单片机 MT8880 接口

Two new glycoalkaloids from Solanum lyratum Thunb.

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Journal of Chinese Pharmaceutical Sciences 2021年第6期30卷 518-523页

作者： Tong Wu Xiao Du jiannong wang Liangyu Liu Yuke Yang Institute of Basic Medical Sciences ofXiyuan Hospital China Academy of Chinese Medical SciencesBeijing100091China

To study the alkaloids of Solanum lyratum *** and silica gel column chromatography combined with HPLC were used to separate and purify the *** alkaloids were identified via UHPLC-ESI-Q-TOF-MS,1 D and 2 D NMR,respectively 15β-ethoxy-(3β,5α,25 R)-16,23-epoxy-23,24-imino-cholestan-16,20,23(N)-triene-3β-ol-3-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl-(1→4)-β-D-galactopyran-oside(1),15β-hydroxyl-(3β,25 R)-16,23-epoxy-23,24-imino-cholestan-5,16,20,23(N)-tetraene-3β-ol-3-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl-(1→4)-β-D-galactop-yranoside(2),Solalyraine A(3),Solalyraine B(4),16,23-epoxy-22,26-imino-cholest-22(N),23,25(26)-trien-3β-ol-3-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside(5),N-(4-amino-butyl)-3-(3-hydroxy-4-methoxy-phenyl)-E-acrylamide(6)and magnoflorine(7).Among them,compounds 1 and 2 were two new steroidal glycoalkaloids that has not been reported in the literature,and compound 7 was isolated from *** for the first time.

关键词： Solanum lyratum Thunb. Steroidal glycoalkaloids Chemical constituents Structure identification