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Chinese Chemical Letters 2006年第3期17卷 299-301页

作者： Yi hu Ping WEI hua ZHOU Ping Kai OUYANG Zhen Chu CHEN College of Life science and {1. Engineering Nanjing University of Technology Nanjing 210009 department of Chemistry Zhejiang University （Xi Xi Campus） Hangzhou 310028

An efficient and environmental benign method is reported for the condensation of 3-methyl-1.phenyl-5-pyrazolone with carbonyl compounds in ionic liquids [Bmim]BF4 and [Bmim]PF6 catalyzed by ethylenediammonium diacetate.

关键词： Ionic liquids condensation 3-methyl-1.phenyl-5-pyrazolone.

Controllable synthesis of novel nanoporous manganese oxide catalysts for the direct synthesis of imines from alcohols and amines

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Chinese Journal of Chemical Engineering 2019年第10期27卷 2438-2446页

作者： Fushan Chen Songlin Zhao Tao Yang Taotao jiang Jun Ni Houfeng Xiong Qunfeng Zhang Xiaonian Li Industrial Catalysis Institute of zhejiang university of technology Hangzhou 310014China jiangxi Province Engineering Research Center of Ecological Chemical Industry Jiujiang UniversityJiujiang 332005China School of pharmaceutical and Chemical Engineering Taizhou UniversityTaizhou 318000China

A novel template-free oxalate route was applied to synthesize different mesoporous manganese oxides(amorphous manganese oxide(AMO),Mn5 O8,Mn3 O4,Mn O2.in the narrow temperature range from 350°C to 400°C by controlling the calcination conditions,which were employed as the efficient catalysts for the oxidative coupling of alcohols with amines to *** chemical and structural properties of the manganese oxides were characterized by the methods of thermogravimetry analysis and heat flow(TG-DSC),X-ray diffraction(XRD),nitrogen sorption,scanning electron microscope(SEM),transmission electron microscopy(TEM),X-ray photoelectron spectroscopy(XPS),H2.temperature-programmed reduction(H2.TPR),and inductively coupled plasma optical emission spectrometry(ICP-OES)*** structures of different manganese oxides were confirmed by *** M-350(AMO)presented the maximum surface area,amorphous nature,the lowest reduction temperature,the higher(Mn3++Mn4+)/Mn2.ratio,and the higher adsorbed oxygen species compared to other *** the catalysts,M-350 showed the best catalytic performance using air as an oxidant,and the conversion of benzyl alcohol(BA)and the selectivity of N-benzylideneaniline(NBA)reached as high as 1.0%and 97.1.respectively at the lower reaction temperature(80°C)for 1.h.M-350 had also the highest TOF value(0.01.0 mmol·mg-1.h-1.compared to the other manganese oxide *** catalyst was reusable and gave 95.8%conversion after 5 reuse tests,the XRD pattern of the reactivated M-350 did not show any obvious *** oxygen mobility and(Mn3++Mn4+)/Mn2.ratio were found to play the important roles in the catalytic activity of aerobic reactions.

关键词： Oxalate route Controllable synthesis Manganese oxide Imine synthesis Heterogeneous catalysis Aerobic oxidation

Transmission of Carbapenem Resistance Between human and Animal NDM-Positive Escherichia coli Strains

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Engineering 2022年第8期8卷 24-33页

作者： Yingbo Shen Fupin hu Yongqiang Wang Dandan Yin Lu Yang Yiqiang Chen Chunyan Xu Jiyun Li Junyao {2. Xueyang Wang Yulin Fu Dongyan Shao Dejun Liu Tengfei Ma Chang Cai Zhangqi Shen Shaolin Wang Juan Li Rong Zhang Yuebin Ke Congming Wu Jianzhong Shen Timothy R.Walsh Yang Wang Beijing Key Laboratory of Detection technology for Animal-Derived Food Safety College of Veterinary MedicineChina Agricultural UniversityBeijing 100193China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Institute of Antibiotics&Key Laboratory of Clinical Pharmacology of Antibiotics(MoH) Huashan HospitalFudan UniversityShanghai 200040China department of Preventive Veterinary Medicine College of Veterinary MedicineChina Agricultural UniversityBeijing 100193China State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China College of Animal science and {1. College of Veterinary MedicineZhejiang A and F UniversityHangzhou 311300China State Key Laboratory for Infectious Disease Prevention and Control Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseaseNational Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and Prevention(CDC)Beijing 102206China The Second Affiliated Hospital of zhejiang {1. Zhejiang UniversityHangzhou 310009China Key Laboratory of Genetics&Molecular Medicine of Shenzhen Shenzhen Center for Disease Control and PreventionShenzhen 518055China department of Zoology University of OxfordOxford OX13SZUK

Although carbapenem use is prohibited in animals in China,carbapenem-resistant Escherichia coli(CREC),especially New Delhi metallo-β-lactamase(NDM)-producing strains,are widely prevalent in foodproducing *** present,the impact of livestock-associated CREC strains on human populations at the national level is ***,we conduct a retrospective cross-sectional study to investigate the prevalence of CREC from clinical settings across 2. Chinese provinces or municipalities and analyze anthropogenic factors associated with their *** also ascertain the blaNDMand blaKPCabundance among pig and chicken farms and present a detailed genomic framework for CREC of animal and human ***,63{2.2.799(2.{2.)clinical Escherichia coli(***)isolates were identified as *** analysis revealed that being male,an age below {2.an age between {2. and {2.,provinces with greater chicken production,and provinces with higher pig production were associated with higher odds of CREC *** general,73.8%(n=45/6{2.of pig farms and 62.2.(n=2./45)of chicken farms had a blaNDMabundance of {2.{2.^(-5)to {2.{2.^(-3)and {2.{2.^(-3)to {2.{2.^(-2.,*** all the Chinese NDM-positive ***(n=463)available at the National Center for Biotechnology Information(NCBI),the genomic analysis revealed that blaNDM-5and Inc X3 were the predominant carbapenemase gene-plasmid combination,while a highly homogeneous relationship between NDM-positive isolates from humans and animals was demonstrated at the plasmid and core genome *** the findings suggest frequent CREC transmission between humans and animals,indicating that further discussions on the use of antibiotics in animals and humans are needed,both in China and across the globe.

关键词： Carbapenem resistance Escherichia coli blaNDM-5 One Health Antimicrobial resistance transmission

基于人工智能的全自动化一站式CT血流储备分数在冠心病患者中的诊断与预后价值

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science Bulletin 2024年第10期69卷 1472-1485页

作者：郭邦俊姜孟春郭翔唐春香钟健陆梦洁刘春雨张晓蕾乔红艳周帆许棚棚薛艺郑敏文侯阳王怡宁张佳胤张波张代民徐磊胡秀华周长圣李建华杨志文毛新生卢光明张龙江 department of Radiology Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210002China department of Radiology Affiliated Hospital of Jining Medical UniversityJining 272007China department of Radiology Xijing HospitalFourth Military Medical UniversityXi’an 733399China department of Radiology Shengjing Hospital of China Medical UniversityShenyang 110022China department of Radiology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Institute of Diagnostic and Interventional Radiology and Department of CardiologyShanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200235China department of Radiology Jiangsu Taizhou People’s HospitalTaizhou 225399China department of Cardiology Nanjing First HospitalNanjing Medical UniversityNanjing 210012China department of Radiology Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China department of Radiology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310020China department of Cardiology Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210002China Shukun(Beijing)Network {1. Co. Ltd.Beijing 102200China

Currently,clinically available coronary CT angiography(CCTA)derived fractional flow reserve(CT-FFR)is time-consuming and *** propose a novel artificial intelligence-based fully-automated,on-site CT-FFR technology,which combines the automated coronary plaque segmentation and luminal extraction model with reduced order 3 dimentional(3D)computational fluid dynamics.A total of 463 consecutive patients with 600 vessels from the updated China CT-FFR study in Cohort 1.undergoing both CCTA and invasive fractional flow reserve(FFR)within 90 d were collected for diagnostic performance *** Cohort 2.a total of 901.chronic coronary syndromes patients with index CT-FFR and clinical outcomes at 3-year follow-up were retrospectively *** Cohort 3,the association between index CT-FFR from triple-rule-out CTA and major adverse cardiac events in patients with acute chest pain from the emergency {1. was further *** diagnostic accuracy of this CT-FFR in Cohort 1.was 0.82.with an area under the curve of 0.82.on a per-patient *** with the manually dependent CT-FFR techniques,the operation time of this technique was substantially shortened by 3 times and the number of clicks from about 60 to *** CT-FFR technique has a highly successful(>99%)calculation rate and also provides superior prediction value for major adverse cardiac events than CCTA alone both in patients with chronic coronary syndromes and acute chest ***,the novel artificial intelligencebased fully automated,on-site CT-FFR technique can function as an objective and convenient tool for coronary stenosis functional evaluation in the real-world clinical setting.

关键词： Artificial intelligence Coronary CTA CT-derived fractional flow reserve Fully-automated Outcomes

Biosynthesis of 4-hydroxyphenylpyruvic acid from L-tyrosine using recombinant Escherichia coli cells expressing membrane bound L-amino acid deaminase

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Chinese Journal of Chemical Engineering 2018年第2期26卷 380-385页

作者： huanru Ding Weirui Zhao Chang{1. Lu Jun huang Sheng hu Shanjing Yao Lehe Mei Jinbo Wang Jiaqi Mei School of Biotechnology and Chemical Engineering Ningbo Institute of TechnologyZhejiang UniversityNingbo 315100China department of Chemical and Biolagical Engineering Zhejiang UniversityHangzhou 310027China School of Biological and Chemical Engineering Zhejiang University of Science and TechnologyHarlgzhou 310023China department of Chemical Engineering The University of utahSalt Lake City 84102America

4-Hydroxyphenylpyruvic acid （4-HPPA）, a kind of α-keto acid, is an intermediate in the metabolism of tyrosine and has a wide range of application in food, pharmaceutical and chemical industry. Using amino acids as raw material to prod uce the corresponding α-keto acid is thought to be both economic and efficient. Among the enzymes that convert amino acid to α-keto acid, membrane bound L-amino acid deaminase （mL-AAD）, which is anchored to the outer side of the cytomembrane, becomes an ideal enzyme to prepare α-keto acid since there is no cofactors needed and H2.2.production during the reaction. In this study, the mL-AAD from Proteus vulgaris was used to prepare whole-cell catalysts to produce 4-HPPA from L-tyrosine. The secretory efficiency of mL-AAD conducted by its own twin-arginine signal peptide （twin-arginine translocation pathway, Tat） and integrated pelB （the general secretory pathway, Sec）-Tat signal peptide was determined and compared firstly, using two pET systems （pET2.a and pET2.b）. It was found that the Tat pathway （pET2.a-mlaad） resulted in higher cell-associated mL-AAD activity and cell biomass, and was more beneficial to prepare biocatalyst. In addition, expression hosts BI2.1}（DE3） and 0.05 mmol. L- 1.IPTG were found to be suitable for mL-AAD expression. The reaction conditions for mL-AAD were optimized and 72.72.mmol,L 1.4-HPPA was obtained from 1.0 mmol.L 1.tyrosine in 1. h under the optimized conditions. This bioprocess, which is more eco-friendly and economical than the traditional chemical synthesis ways, has great potential for industrial application.

关键词： 4-Hydroxyphenylpyruvic acidc-tyrosine Membrane-bound L-amino acid deaminases Biocatalysis Molecular biology Biological engineering

Janus γ-Fe2.3/SiO2.based nanotheranostics for dual-modal imaging and enhanced synergistic cancer starvation/chemodynamic therapy

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science Bulletin 2020年第7期65卷 564-572,M0004页

作者： Yifan Zhang Yilin Wan Yunyan Liao Yanjie hu Tao {1. Ting He Wei Bi Jing Lin Peng Gong Longhua Tang Peng huang Marshall Laboratory of Biomedical Engineering International Cancer CenterLaboratory of Evolutionary Theranostics(LET)School of Biomedical EngineeringShenzhen University Health Science CenterShenzhen 518060China State Key Laboratory of Modern Optical Instrumentation College of Optical Science and EngineeringZhejiang UniversityHangzhou 310027China Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China department of General Surgery Shenzhen University General HospitalShenzhen 518055China

Multimodal cancer synergistic therapy exhibited remarkable advantages over monotherapy in producing an improved therapeutic efficacy. In this work, Janus-type γ-Fe2.O3/SiO2.nanoparticles(JFSNs) are conjugated with glucose oxidase(GOx) for synergistic cancer starvation/chemodynamic therapy. The γ-Fe2.3 hemisphere of JFSNs can perform photoacoustic/T2.magnetic resonance dual-modal imaging of *** on the surface of JFSNs catalyzes the decomposition of glucose and produces H2.2.for cancer starvation therapy. Subsequently, the γ-Fe2.3 hemisphere catalyzes the disproportionation of H2.2.to generate highly reactive hydroxyl radicals in an acidic tumor microenvironment. The close distance between GOx and JFSNs ensures adequate contact between the γ-Fe2.3 hemisphere and its substrate H2.2. thus enhancing the catalytic efficiency. This synergy of glucose depletion, biotoxic H2.2.and hydroxyl radicals significantly suppresses 4 T1.mammary tumor growth with minimal adverse effects.

关键词： Synergistic therapy Janus nanoparticles Glucose oxidase Fenton-like reaction Theranostics

The transcription factors TLR1.and TLR2.negatively regulate trichome density and artemisinin levels in Artemisia annua

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Journal of Integrative Plant Biology 2022年第6期64卷 1212-1228页

作者： Zongyou Lv JinXing Li Shi Qiu Fei Qi Hang Su Qitao Bu Rui jiang Kexuan Tang Lei Zhang Wansheng Chen Research and Development Center of Chinese Medicine Resources and Biotechnology Shanghai University of Traditional Chinese MedicineShanghai 201203China department of Pharmacy Changzheng HospitalSecond Military Medical UniversityShanghai 200003China department of {1. Botany School of PharmacySecond Military Medical UniversityShanghai 200433China Joint International Research Laboratory of Metabolic&Developmental sciences Key Laboratory of Urban Agriculture(South)Ministry of AgriculturePlant Biotechnology Research CenterFudan‐SJTU‐Nottingham Plant Biotechnology R&D CenterShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Subtropical Silviculture Zhejiang A&F UniversityHangzhou 311300China

The important antimalarial drug artemisinin is biosynthesized and stored in Artemisia annua glandular trichomes and the artemisinin content correlates with trichome density;however,the factors affecting trichome development are largely ***,we demonstrate that the *** R2.3 MYB transcription factor TrichomeLess Regulator 1.TLR1.negatively regulates trichome *** ***,TLR1.overexpression lines had 44.7%–64.0%lower trichome density and 1..5%–49.4%lower artemisinin contents and TLR1.RNAi lines had 33%–93.3%higher trichome density and 32.2.–84.0%higher artemisinin contents compared with non-transgenic ***1.also negatively regulates the expression of anthocyanin biosynthetic pathway genes in *** heterologously expressed in Arabidopsis thaliana,TLR1.interacts with GLABROUS3a,positive regulator of trichome development,and represses trichome *** two-hybrid and pull-down assays indicated that TLR1.interacts with the WUSCHEL homeobox(WOX)protein AaWOX1.which interacts with the LEAFY-like transcription factor ***2.overexpression in Arabidopsis and *** showed that TLR2.reduces trichome development by reducing gibberellin ***,artemisinin contents were 1.%–43%lower in TLR2.overexpressing *** plants compared to *** data indicate that TLR1.and TLR2.negatively regulate trichome density by lowering gibberellin levels and may enable approaches to enhance artemisinin yields.

关键词： artemisinin Artemisia annua L. LFY MYB transcription factor trichome WOX

Ferrimagnetic m PEG-b-PHEP copolymer micelles loaded with iron oxide nanocubes and emodin for enhanced magnetic hyperthermia–chemotherapy

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National science Review 2020年第4期7卷 723-736页

作者： Yonghong Song Dongdong Li Yang Lu Kun jiang Yi Yang Yunjun Xu Liang Dong Xu Yan Dais{1.n Ling Xianz{1. Yang S{1.-Hong Yu Key Laboratory of Advanced Catalytic Materials and Reaction Engineering School of Chemistry and Chemical EngineeringKey Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes Hefei University of Technology Institutes for Life sciences School of Medicine South China University of Technology Division of Nanomaterials & Chemistry Hefei National Laboratory for Physical Sciences at the Microscale CAS Center for Excellence in Nanoscience Hefei Science Center of CASDepartment of Chemistry Institute of Biomimetic Materials & Chemistry University of Science and Technology of China zhejiang Province Key Laboratory of Anti-Cancer Drug Research College of Pharmaceutical Sciences Key Laboratory of Biomedical Engineering of the Ministry of Education Zhejiang University

As a non-invasive therapeutic method without penetration-depth limitation, magnetic hyperthermia therapy(MHT) under alternating magnetic field(AMF) is a clinically promising thermal ***, the poor heating conversion efficiency and lack of stimulus–response obstruct the clinical application of magnetofluid-mediated MHT. Here, we develop a ferrimagnetic polyethylene glycol-poly(2.hexoxy-2.oxo-1.3,2.dioxaphospholane)(m PEG-b-PHEP) copolymer micelle loaded with hydrophobic iron oxide nanocubes and emodin(denoted as EMM). Besides an enhanced magnetic resonance(MR) contrast ability(r2. 2.1.m M-1.-1. due to the high magnetization, the specific absorption rate(2.1. W/g at 35 k A/m) and intrinsic loss power(6.5 n Hm2.kg) of EMM are dozens of times higher than the clinically available iron oxide nanoagents(Feridex and Resovist), indicating the high heating conversion efficiency. Furthermore, this composite micelle with a flowable core exhibits a rapid response to magnetic hyperthermia, leading to an AMF-activated supersensitive drug release. With the high magnetic response, thermal sensitivity and magnetic targeting, this supersensitive ferrimagnetic nanocomposite realizes an above 70% tumor cell killing effect at an extremely low dosage(1. μg Fe/m L),and the tumors on mice are completely eliminated after the combined MHT–chemotherapy.

关键词： magnetic hyperthermia therapy sensitive thermal response chemotherapy magnetic targeting theranostics

CEPC Technical Design Report

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Radiation Detection technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen hua-Xing Chen huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH university of {1. and {2. Faculty of Physics and Applied Computer ScienceKrakow Anhui {1. HefeiAnhui Applied Physics department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu university Institute of ScienceVaranasi Bandirma Onyedi Eylul university Bandirma Beihang university Beijing Beijing Computational science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of technology Beijing Beijing Normal university Beijing Brown university ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad university Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo university Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal university WuhanHubei Central South university ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced science and {1. Beijing China Institute of Atomic Energy Beijing China Jiliang university HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China university of Geo{1.s Beijing China university of Geo{1.s WuhanHubei China university of Mining and {1. XuzhouJiangsu China West Normal university NanchongSichuan Chongqing university Department of PhysicsChongqing Chulalongkorn {1. Bangkok City university of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell university IthacaNY CPPM(AMU/IPhu&CNRS/INP) Marseille Dalian Minzu university DalianLiaoning Dalian university of {1. Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China university Of {1. And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1.GeV Damping Ring,a Booster capable of achieving energies up to 1.0 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 1.0 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×1.^(34)cm^(-2.s^(-1.per interaction point(IP),resulting in an integrated luminosity of 1. ab^(-1.for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2.1.)and the Conceptual Design Report(CDR,2.1.),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2.2.-2.2.,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2.30s.

关键词： initiated exceeding precise

Potential benefits of precise corticosteroids therapy for severe 2.1.-nCoV pneumonia

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2345-2347页

作者： Wei Zhou Yisi Liu Dongdong Tian Cheng Wang Sa Wang Jing Cheng Ming hu Minghao Fang Yue Gao department of {1. {2.s Beijing Institute of Radiation Medicine100850 BeijingP.R.China School of Nursing Capital Medical University100069 BeijingP.R.China department of Pharmacy Hebei General Hospital050000 ShijiazhuangP.R.China department of Orthopedics First Medical CenterGeneral Hospital of Chinese PLA100853 BeijingP.R.China Emergency department The Second Affiliated Hospital of Zhejiang University School of Medicine310009 HangzhouP.R.China Emergency Surgery department Tongji Hospital Affiliated to Tongji Medical CollegeHuazhong University of Science and Technology430030 WuhanP.R.China Intensive Care Unit Wuhan Pulmonary Hospital430030 WuhanP.R.China Emergency and Intensive Care Unit Tongji Hospital Affiliated to Tongji Medical CollegeHuazhong University of Science and Technology430030 WuhanP.R.China

Dear Editor,Since last December,the outbreak of 2.1.-nCoV in Wuhan has caused ever-increasing attention and public panic all over the *** to February 9,2.2.,40,1.1.patients had been diagnosed with 2.1.-nCoV infection,including 6484(1..1.%)severe cases and 908 deaths(2.2.%).Compared to SARS and MERS,2.1.-nCoV appears to be much more contagious but less lethal,as most patients have mild symptoms and good prognosis1.***,according to the Chinese government’s daily report,1..2.2.0}3%of patients with 2.1.-nCoV infection developed into severe or fatal illness(Fig.S1.),which is characterized by the rapid development to acute respiratory distress syndrome(ARDS)or septic *** with an increasing number of confirmed cases,the cumulative total of severe patients with 2.1.-nCoV is growing(Fig.S1.).Treatment of these critically ill patients is becoming one of the major challenges we are facing.

关键词： distress acute precise