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Collagen-binding basic fibroblast growth factor improves functional remodeling of scarred endometrium in uterine infertile women: a pilot study

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Science china(Life Sciences) 2019年第12期62卷 1617-1629页

作者： Peipei jiang Xiaoqiu Tang Huiyan Wang chenyan Dai Jing Su Hui Zhu Minmin Song Jingyu Liu Ziqing Nan Tong Ru Yaling Li Jingmei Wang Jun yang bing chen Jianwu Dai Yali Hu department of Obstetrics and Gynecology The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Center for Reproductive Medicine Department of Obstetrics and GynecologyThe Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China nanjing Drum Tower Hospital Chinese Academy of Medical Science&Peking Union Medical CollageNanjing 210008China department of Pathology The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Institute of Genetics and Developmental Biology Chinese Academy of SciencesBeijing 100190China

Intrauterine adhesion(IUA) is a common cause of uterine infertility and one of the most severe clinical features is endometrial fibrosis namely endometrial scarring for which there are few cures currently. Blocked angiogenesis is the main pathological change in the scarred endometrium. The fibroblast growth factor 2(b FGF), a member of FGF family, is usually applied to promote healing of refractory ulcer and contributes to angiogenesis of tissues. In this study, the sustained-release system of b FGF100 μg was administrated around scarred endometrium guiding by ultrasound every 4 weeks in 18 patients(2–4 times). Results showed that after treatment, the menstrual blood volume, endometrial thickness and the scarred endometrial area were *** study showed blood vessel density increased obviously. Three patients(3/18) achieved pregnancy over 20 gestational weeks. Therefore, administrating the b FGF surrounding scarred endometrium may provide a new therapeutic approach for the patients with endometrial fibrosis.

关键词： intrauterine adhesion CBD-bFGF endometrial scarring uterine infertility thin endometrium endometrial reconstruction

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Myocardial injury resulting from radiofrequency catheter ablation： comparison of circumferential pulmonary vein isolation and complex fractionated atrial electrograms ablation

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Chinese Medical Journal 2011年第17期124卷 2674-2677页

作者： ZHANG Feng-xiang yang bing chen Hong-wu JU Wei-zhu CAO Ke-jiang chen Ming-long department of Cardiology First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu 210029 China

Background Radiofrequency catheter ablation （RFCA） necessarily produces an area of myocardial necrosis. However, the difference of the extent of myocardial injury between circumferential pulmonary vein isolation （CPVI） and complex fractionated atrial electrograms （CFAE） ablation in patients with atrial fibrillation （AF） has not been investigated before. Methods Twenty-nine consecutive male patients （n=29） with either paroxysmal or persistent AF were selected for CPVI or CFAE ablation. The CPVI or CFAE ablation was performed with a three-dimensional electroanatomical mapping system （CARTO）. Serum cardiac biomarkers, for example, cardiac troponin T （cTnT）, aspartate transaminase （AST）, lactate dehydrogenase （LDH）, creatine kinase （CK）, and creatine kinase myocardial bound （CKMB） were determined by the Elecsys STATE immunoassay. Cardiac structure and function were measured with echocardiography. Results Echocardiography showed that there was no significant difference of atrioventricular structure or function parameters between the CPVI group and the CFAE ablation group. Serum cTnT showed a significant increase in the CFAE ablation group over the CPVI group at 12 and 24 hours after the procedure （P〈0.05, respectively）, and then it was reduced to a normal level after 48 hours. Serum AST showed a significant increase in the CFAE ablation group over the CPVI group at post-procedure, 4 and 12 hours after the procedure （P 〈0.05, respectively）, and then it reached to a normal level after 24 hours. There was no significant difference in LDH, CK, or CKMB levels between the CFAE ablation group and the CPVI group at any time point （P〉0.05）. Conclusions cTnT and AST other than LDH, total CK or CKMB activity significantly increased more in the CFAE ablation group than the CPVI group. However, the difference of the serum levels of cTnT, AST between two groups was temporary.

关键词： atrial fibrillation catheter ablation myocardial injury

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Engineering Multifunctional Thylakoid as an Oxygen Self-Supplying Photosensitizer for Esophageal Squamous Cell Carcinoma-Targeted Photodynamic Therapy

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CCS Chemistry 2023年第11期5卷 2519-2533页

作者： Yingqiu Qi Hui Wang Anni Du chen Liu Xiaofan Sun Xiaocao Meng Jinxiu Shen Sai-yang Zhang Li-Rong Zhang bing jiang Guangjun Nie Huan Min department of Pharmacology School of Basic Medical SciencesState Key Laboratory of Esophageal Cancer Prevention and TreatmentNanozyme Medical CenterZhengzhou UniversityZhengzhou 450001 Henan Institute of Advanced Technology Zhengzhou UniversityZhengzhou 450001 CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety&CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of ChinaZhongguancunBeijing 100190

Photodynamic therapy(PDT)has emerged as an alternative treatment strategy for esophageal squamous cell carcinoma(ESCC).However,the clinical therapeutic efficiency of PDT is severely limited by poorly targeted photosensitizer delivery,insufficient oxygen supply,and neutralization by excessive glutathione(GSH)in tumor ***,an engineered multifunctional thylakoid nanostructure,TMEM@PLGA@GA(abbreviated as TEPG),composed of a thylakoid membrane(TM)and ESCC cell membrane(EM)-fused biomembrane(TM-EM)shell and gambogic acid(GA)-loaded poly(lactic-co-glycolic acid)nanocore,was designed for enhanced PDT for *** fused with EM,TM-EM exhibits a tumor targeting advantage due to the homologous affinity of tumor membrane *** catalase present on TM-EM catalytically decomposes endogenous hydrogen peroxide into oxygen to alleviate hypoxia in the tumor ***,when TEPG was selectively internalized by ESCC cells,GA was released to consume the excessive intracellular *** infrared irradiation,the PDT effects were enhanced by the self-oxygen supply and GSH scavenging ability provided by *** in vivo study showed that TEPG effectively induced ESCC tumor cell apoptosis and greatly inhibited the growth of ESCC tumors under infrared *** study constructed an engineered multifunctional thylakoid-based nanomedicine as an integrated solution to enhance PDT for ESCC.

关键词： esophageal squamous cell carcinoma thylakoid tumor targeting photodynamic therapy

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Sudden cardiovascular collapse caused by carbon dioxide embolism during endoscopic saphenectomy for coronary artery bypass grafting

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Chinese Medical Journal 2006年第4期119卷 345-348页

作者： chen Xin-chun TANG Xiao-yang jiang Yi-fan PAN Yan-bing FU cheng-zhang department of Anesthesia First Affiliated Hospital of Nanjing Medical University Nanjing 210029 China

Endoscopic vein harvesting （EVH） for coronary artery bypass grafting （CABG） has gained increasing acceptance as a less invasive alternative to conventional open vein harvesting. With this procedure, carbon dioxide （CO2） is insufflated to create a subcutaneous tunnel to facilitate the harvest of the great saphenous vein. The technique seems to be safe because there are no adverse hemodynamic consequences or systemic CO2 absorption during EVH. We report a case of massive right heart gas embolism which occurred during a routine EVH performance of the saphenous vein. Techniques for early diagnosis of this rare but life-threatening complications, transesophageal echocardiography （TEE） is a sensitive tool in detecting CO2 embolism [except end-tided CO2 （ETCO2）] and pulmonary arterial pressure （PAP） monitoring. The rapid recovery of CO2 embolism in the patient who underwent EVH with CO2 insufflation and CABG surgery was due to immediate and accurate diagnosis and prompt treatment.

关键词： anesthesia coronary artery bypass grafting carbon dioxide

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Long-term clinical observation of patients with acute and chronic complete spinal cord injury after transplantation of Neuro Regen scaffold

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Science china(Life Sciences) 2022年第5期65卷 909-926页

作者： Fengwu Tang Jiaguang Tang Yannan Zhao Jiaojiao Zhang Zhifeng Xiao bing chen Guang Han Na Yin Xianfeng jiang Changyu Zhao Shixiang cheng Ziqiang Wang Yumei chen Qiaoling chen Keran Song Zhiwei Zhang Junjie Niu Lingjun Wang Qin Shi Liang chen Huilin yang Shuxun Hou Sai Zhang Jianwu Dai Characteristics Medical Center of the Chinese People’s Armed Police Forces(CAPF) Tianjin 300162China Fourth Medical Center of People’s Liberation Army(PLA)General Hospital Beijing 100048China department of Orthopaedics Beijing Tongren HospitalBeijing 100730China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100190China Beijing ZhongKeZaiKang Biotechnology Co. LtdBeijing 101407China department of Rehabilitation the 983rd Hospital of the Joint Logistics Support Force of the Chinese People′s Liberation ArmyTianjin 300141China department of Orthopaedics the First Affiliated Hospital of Soochow UniversitySuzhou 215006China

Spinal cord injury(SCI)often results in an inhibitory environment at the injury *** our previous studies,transplantation of a scaffold combined with stem cells was proven to induce neural regeneration in animal models of complete *** on these preclinical studies,collagen scaffolds loaded with the patients’own bone marrow mononuclear cells or human umbilical cord mesenchymal stem cells were transplanted into SCI *** patients with acute complete SCI and 51 patients with chronic complete SCI were enrolled and followed up for 2 to 5 *** serious adverse events related to functional scaffold transplantation were *** the patients with acute SCI,five patients achieved expansion of their sensory positions and six patients recovered sensation in the bowel or ***,four patients regained voluntary walking ability accompanied by reconnection of neural signal *** patients with chronic SCI,16 patients achieved expansion of their sensation level and 30 patients experienced enhanced reflexive defecation sensation or increased skin sweating below the injury *** half of the patients with chronic cervical SCI developed enhanced finger *** long-term follow-up results suggest that functional scaffold transplantation may represent a feasible treatment for patients with complete SCI.

关键词： complete spinal cord injury collagen scaffold function recovery clinical study

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国产图迈机器人在腹腔镜根治性前列腺切除术的应用研究

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中华男科学杂志 2024年第8期30卷 696-700页

作者：位志峰陈宇豪朱泽鹏蒋齐熊宇陆烽烽宋震乾江斌朱晓峰冯天昊徐晓峰杨刚魏武姚爱兵葛京平南京医科大学第四附属医院泌尿外科江苏南京210000 东部战区总医院泌尿外科江苏南京210002 南京中医药大学附属南京市中医院泌尿外科江苏南京210000

目的:使用国产图迈机器人行腹腔镜根治性前列腺切除手术,观察其安全性及使用效果。方法:收集2023年1月至2023年5月前列腺癌患者40例,患者均行机器人辅助腹腔镜根治性前列腺切除术,采取保留膀胱颈和最大长度功能性尿道的手术方法。按使... 详细信息

目的:使用国产图迈机器人行腹腔镜根治性前列腺切除手术,观察其安全性及使用效果。方法:收集2023年1月至2023年5月前列腺癌患者40例,患者均行机器人辅助腹腔镜根治性前列腺切除术,采取保留膀胱颈和最大长度功能性尿道的手术方法。按使用机器人系统不同,分为观察组(图迈机器人组)和对照组(达芬奇机器人组),观察机械臂安装时间、腔内手术时间、尿道吻合时间、术中出血量、术后尿控等指标。结果:所有患者均顺利完成手术,观察组和对照组机械臂中位安装时间分别为6 min vs 5 min(P>0.05),腔内手术中位时间分别为146 min vs 130 min(P0.05)。术后即刻、1个月、3个月、6个月尿控恢复率分别为9/15(60.0%)vs 16/25(64.0%)、12/15(80.0%)vs 19/25(76.0%)、14/15(93.3%)vs 23/25(92.0%),15/15(100%)vs 24/25(96%),两组比较无显著差异(P>0.05)。结论:国产图迈机器人系统行腹腔镜根治性前列腺切除手术安全可靠,术后尿控效果满意。

关键词：机器人手术前列腺癌根治性前列腺切除术尿控

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Searching for^(76)Ge neutrinoless double beta decay with the CDEX-1B experiment

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Chinese Physics C 2024年第10期48卷 11-22页

作者： bing-Tao Zhang Jun-Zheng Wang Li-Tao yang Qian Yue Ke-Jun Kang Yuan-Jing Li Hai-Peng An C.Greeshma Jian-Ping Chang Yun-Huan chen Jian-Ping cheng Wen-Han Dai Zhi Deng Chang-Hao Fang Xin-Ping Geng Hui Gong Qiu-Ju Guo Xu-Yuan Guo Li He Sheng-Ming He Jin-Wei Hu Han-Xiong Huang Tu-chen Huang Hai-Tao Jia Xi jiang S.Karmakar Hao-Bin Li Jian-Min Li Jin Li Qian-Yun Li Ren-Ming-Jie Li Xue-Qian Li Yu-Lan Li Yi-Fan Liang Bin Liao Fong-Kay Lin Shin-Ted Lin Jia-Xuan Liu Shu-Kui Liu Yan-Dong Liu Yu Liu Yuan-Yuan Liu Zhong-Zhi Liu Hao Ma Yu-Cai Mao Qi-Yuan Nie Jin-Hua Ning Hui Pan Ning-Chun Qi Jie Ren Xi-Chao Ruan Ze She Manoj Kumar Singh Tian-Xi Sun Chang-Jian Tang Wei-You Tang yang Tian Guang-Fu Wang Li Wang Qing Wang Yu-Feng Wang Yun-Xiang Wang Henry-Tsz-King Wong Shi-Yong Wu Yu-cheng Wu Hao-yang Xing Rui Xu Yin Xu Tao Xue Yu-Lu Yan Nan Yi Chun-Xu Yu Hai-Jun Yu Jian-Feng Yue Ming Zeng Zhi Zeng Feng-Shou Zhang Lei Zhang Zhen-Hua Zhang Zhen-Yu Zhang Kang-Kang Zhao Ming-Gang Zhao Ji-Fang Zhou Zu-Ying Zhou Jing-Jun Zhou Key Laboratory of Particle and Radiation Imaging(Ministry of Education)and department of Engineering Physics Tsinghua UniversityBeijing 100084 department of Physics Tsinghua UniversityBeijing 100084 Institute of Physics Academia SinicaTaipei 11529 NUCTECH Company Beijing 100084 YaLong River Hydropower Development Company Chengdu 610051 College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875 College of Physics Sichuan UniversityChengdu 610065 School of Physics Peking UniversityBeijing 100871 department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413 Sino-French Institute of Nuclear and Technology Sun Yat-sen UniversityZhuhai 519082 School of Physics Nankai UniversityTianjin 300071 department of Physics Banaras Hindu UniversityVaranasi 221005 department of Physics Beijing Normal UniversityBeijing 100875

We operated a p-type point contact high purity germanium(PPCGe)detector(CDEX-1B,1.008 kg)in the china Jinping Underground Laboratory(CJPL)for 500.3 days to search for neutrinoless double beta(0νββ)decay of^(76)Ge.A total of 504.3 kg⋅day effective exposure data was *** anti-coincidence and the multi/single-site event(MSE/SSE)discrimination methods were used to suppress the background in the energy region of interest(ROI,1989–2089 keV for this work)with a factor of 23.A background level of 0.33 counts/(keV⋅kg⋅yr)was *** lower limit on the half life of^(76)Ge 0νββdecay was constrained as T_(1/2)^(0ν)>1.0×10^(23)yr(90%C.L.),corresponding to the upper limits on the effective Majorana neutrino mass:<3.2–7.5 eV.

关键词： neutrinoless double beta decay CDEX point-contact germanium detector ^(76)Ge

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磁有序CoH_(2)SeO_(4)薄片中的室温铁电性

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Science china Materials 2024年第5期67卷 1654-1660页

作者：陈璐秋余冰沈阳刘逸飞王号南冯光迪朱秋香罗卫东刘俊明万建国赵庆彪田博博褚君浩段纯刚 Key Laboratory of Polar Materials and Devices(MOE) Shanghai Center of Brain-inspired Intelligent Materials and Devicesand Department of ElectronicsEast China Normal UniversityShanghai200241China Zhejiang Lab Hangzhou310000China Laboratory of Solid State Microstructures and Innovation Center of Advanced Microstructures Nanjing UniversityNanjing210093China Key Laboratory of Artificial Structures and Quantum Control School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai200240China School of Chemistry and Environmental Engineering Wuhan Institute of TechnologyWuhan430205China State Key Laboratory of Infrared Physics Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai200083China Institute of Optoelectronics Fudan UniversityShanghai200433China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan030006China

本文通过第一性原理计算和实验表征证明了二维CoH_(2)SeO_(4)薄膜的磁有序和滑移铁电性.首先,实验结果证实了粉末CoH_(2)SeO_(4)样品的反铁磁序.同时,第一性原理计算表明单层CoH_(2)SeO_(4)具有反铁磁(AFM-I)基态(TN≈75 K),且预测了二... 详细信息

本文通过第一性原理计算和实验表征证明了二维CoH_(2)SeO_(4)薄膜的磁有序和滑移铁电性.首先,实验结果证实了粉末CoH_(2)SeO_(4)样品的反铁磁序.同时,第一性原理计算表明单层CoH_(2)SeO_(4)具有反铁磁(AFM-I)基态(TN≈75 K),且预测了二维CoH_(2)SeO_(4)薄膜具有以不对称的三重势阱态为特征的滑移铁电性,并在实验中测得了180°压电滞回线、可反转铁电畴和二次谐波信号.此外,在基于二维CoH_(2)SeO_(4)薄膜的电容器中获得铁电材料所特有的电滞回线和蝴蝶状的电容曲线.介电温谱测试表明二维CoH_(2)SeO_(4)薄膜的铁电转变温度约为370 ***_(2)SeO_(4)中滑移铁电性和反铁磁性的出现为获得低维多铁材料指出了一条新的途径.

关键词： two-dimensional materials sliding ferroelectricity multiferroic materials

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Probing dark matter particles from evaporating primordial black holes via electron scattering in the CDEX-10 experiment

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Science china(Physics,Mechanics & astronomy) 2024年第10期67卷 83-91页

作者： Zhenhua Zhang Litao yang Qian Yue Kejun Kang Yuanjing Li Haipeng An Greeshma C. Jianping Chang Yunhua chen Jianping cheng Wenhan Dai Zhi Deng Changhao Fang Xinping Geng Hui Gong Qiuju Guo Tao Guo Xuyuan Guo Li He Shengming He Jinwei Hu Hanxiong Huang Tuchen Huang Lin jiang S.Karmakar Haubin Li Hanyu Li Jianmin Li Jin Li Qianyun Li Renmingjie Li Xueqian Li Yulan Li Yifan Liang Bin Liao FongKay Lin ShinTed Lin Jiaxuan Liu Shukui Liu Yandong Liu Yu Liu Yuanyuan Liu Hao Ma Yucai Mao Qiyuan Nie Jinhua Ning Hui Pan Ningchun Qi Jie Ren Xichao Ruan Monoj Kumar Singh Tianxi Sun Changjian Tang yang Tian Guangfu Wang Junzheng Wang Li Wang Qing Wang Yufeng Wang Yunxiang Wang Henry Tsz-King Wong Shiyong Wu Yucheng Wu Haoyang Xing Rui Xu Yin Xu Tao Xue Yulu Yan Nan Yi Chunxu Yu Haijun Yu Jianfeng Yue Ming Zeng Zhi Zeng bingtao Zhang Fengshou Zhang Lei Zhang Zhenyu Zhang Jizhong Zhao Kangkang Zhao Minggang Zhao Jifang Zhou Zuying Zhou Jingjun Zhu CDEX Collaboration Key Laboratory of Particle and Radiation Imaging(Ministry of Education)and department of Engineering Physics Tsinghua UniversityBeijing 100084China department of Physics Tsinghua UniversityBeijing 100084China Institute of Physics Academia SinicaTaipei 11529China NUCTECH Company Beijing 100084China YaLong River Hydropower Development Company Chengdu 610051China College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875China College of Physics Sichuan UniversityChengdu 610065China School of Physics Peking UniversityBeijing 100871China department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413China Sino-French Institute of Nuclear and Technology Sun Yet-sen UniversityZhuhai 519082China School of Physics Nankai UniversityTianjin 300071China department of Physics Banaras Hindu UniversityVaranasi 221005India department of Physics Beijing Normal UniversityBeijing 100875China 不详

Dark matter(DM)is a major constituent of the ***,no definite evidence of DM particles(denoted as“χ”)has been found in DM direct detection(DD)experiments to *** is a novel concept of detectingχfrom evaporating primordial black holes(PBHs).We search forχemitted from PBHs by investigating their interaction with target *** examined PBH masses range from 1×10^(15)to 7×10^(16)g under the current limits of PBH abundance *** 205.4 kg·day data obtained from the CDEX-10 experiment conducted in the china Jinping Underground Laboratory,we exclude theχ-electron(χ-e)elastic-scattering cross sectionσ_(χe)~5×10^(-29)cm^(2)forχwith a mass■keV from our *** the higher radiation background but lower energy threshold(160 eV),CDEX-10 fills a part of the gap in the previous ***(m_(χ),σ_(χe))can be determined in the future,DD experiments are expected to impose strong constraints on fPBHfor large MPBHs.

关键词： CDEX primordial black hole light dark matter particle dark matter-electron scattering high purity germanium detector

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Remote ischemic perconditioning prevents liver transplantation-induced ischemia/reperfusion injury in rats: Role of ROS/RNS and e NOS

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World Journal of Gastroenterology 2017年第5期23卷 830-841页

作者： Ning He Jun-Jun Jia Jian-Hui Li Yan-Fei Zhou bing-Yi Lin Yi-Fan Peng Jun-Jie chen Tian-Chi chen Rong-Liang Tong Li jiang Hai-yang Xie Lin Zhou Shu-Sen Zheng Key Lab of Combined Multi-Organ Transplantation Ministry of Public Health Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryFirst Affiliated HospitalZhejiang University School of Medicine

AIM To investigate the underlying mechanisms of the protective role of remote ischemic perconditioning (RIPerC) in rat liver transplantation. METHODS Sprague-Dawley rats were subjected to sham, orthotopic liver transplantation (OLT), ischemic postconditioning (IPostC) or RIPerC. After 3 h reperfusion, blood samples were taken for measurement of alanine aminotransferase, aspartate aminotransferase, creatinine (Cr) and creatinine kinase-myocardial band (CK-MB). The liver lobes were harvested for the following measurements: reactive oxygen species (ROS), H2O2, mitochondrial membrane potential (Delta psi m) and total nitric oxide (NO). These measurements were determined using an ROS/H2O2, JC1 and Total NOx Assay Kit, respectively. Endothelial NO synthase (eNOS) was analyzed by reverse transcription-polymerase chain reaction (RTPCR) and western blotting, and peroxynitrite was semiquantified by western blotting of 3-nitrotyrosine. RESULTS Compared with the OLT group, the grafts subjected to RIPerC showed significantly improved liver and remote organ functions (P < 0.05). ROS (P < 0.001) including H2O2 (P < 0.05) were largely elevated in the OLT group as compared with the sham group, and RIPerC (P < 0.05) reversed this trend. The collapse of Delta psi m induced by OLT ischemia/reperfusion (I/R) injury was significantly attenuated in the RIPerC group (P < 0.001). A marked increase of NO content and phosphoserine eNOS, both in protein and mRNA levels, was observed in liver graft of the RIPerC group as compared with the OLT group (P < 0.05). I/R-induced 3-nitrotyrosine content was significantly reduced in the RIPerC group as compared with the OLT group (P < 0.05). There were no significant differences between the RIPerC and IPostC groups for all the results except Cr. The Cr level was lower in the RIPerC group than in the IPostC group (P < 0.01). CONCLUSION Liver graft protection by RIPerC is similar to or better than that of IPostC, and involves inhibition of oxidative stres

关键词： Liver transplantation Ischemia/reperfusion injury Remote ischemic perconditioning Endothelial nitric oxide synthase Reactive oxygen species

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