Engineering Multifunctional Thylakoid as an Oxygen Self-Supplying Photosensitizer for Esophageal Squamous Cell Carcinoma-Targeted Photodynamic Therapy

作     者：Yingqiu Qi Hui Wang Anni Du Chen Liu Xiaofan Sun Xiaocao Meng Jinxiu Shen Sai-Yang Zhang Li-Rong Zhang Bing Jiang Guangjun Nie Huan Min 

作者机构：Department of PharmacologySchool of Basic Medical SciencesState Key Laboratory of Esophageal Cancer Prevention and TreatmentNanozyme Medical CenterZhengzhou UniversityZhengzhou 450001 Henan Institute of Advanced TechnologyZhengzhou UniversityZhengzhou 450001 CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety&CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology of ChinaZhongguancunBeijing 100190 

出 版 物：《CCS Chemistry》 (中国化学会会刊（英文）)

年 卷 期：2023年第5卷第11期

页      面：2519-2533页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by grants from the National Basic Research Plan of China(grant no.2018YFA0208900) the National Natural Science Foundation of China(grant nos.32000998,32000996,,U2004123) The Young Elite Scientists Sponsorship Program by Henan Association for Science and Technology(grant no.2022HYTP046) the China Postdoctoral Science Foundation(grant nos.2019TQ0285,2019M662513,2020M682358,2020TQ0280,2021TQ0298) 

主　　题：esophageal squamous cell carcinoma thylakoid tumor targeting photodynamic therapy 

摘      要：Photodynamic therapy(PDT)has emerged as an alternative treatment strategy for esophageal squamous cell carcinoma(ESCC).However,the clinical therapeutic efficiency of PDT is severely limited by poorly targeted photosensitizer delivery,insufficient oxygen supply,and neutralization by excessive glutathione(GSH)in tumor ***,an engineered multifunctional thylakoid nanostructure,TMEM@PLGA@GA(abbreviated as TEPG),composed of a thylakoid membrane(TM)and ESCC cell membrane(EM)-fused biomembrane(TM-EM)shell and gambogic acid(GA)-loaded poly(lactic-co-glycolic acid)nanocore,was designed for enhanced PDT for *** fused with EM,TM-EM exhibits a tumor targeting advantage due to the homologous affinity of tumor membrane *** catalase present on TM-EM catalytically decomposes endogenous hydrogen peroxide into oxygen to alleviate hypoxia in the tumor ***,when TEPG was selectively internalized by ESCC cells,GA was released to consume the excessive intracellular *** infrared irradiation,the PDT effects were enhanced by the self-oxygen supply and GSH scavenging ability provided by *** in vivo study showed that TEPG effectively induced ESCC tumor cell apoptosis and greatly inhibited the growth of ESCC tumors under infrared *** study constructed an engineered multifunctional thylakoid-based nanomedicine as an integrated solution to enhance PDT for ESCC.