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Gut microbiome and serum metabolome analyses identify Bacteroides fragilis as regulators of serotonin content and PRL secretion in broody geese

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Journal of Integrative Agriculture 2024年第6期23卷 2033-2051页

作者： Yu Zhang Ning Zhou jia Wu Lina Song qiang Bao Kaiqi Weng Yang Zhang Wanwipa Vongsangnak Guohong Chen qi Xu College of Animal Science and Technology Yangzhou UniversityYangzhou 225009China Joint International Research Laboratory of Agriculture&Agri-Product Safety of Ministry of Education Yangzhou UniversityYangzhou 225009China Department of Zoology Faculty of ScienceKasetsart UniversityBangkok 10900Thailand

Broody behavior is regulated by hypothalamic prolactin secretion,which seriously affects egg production in poulty *** studies have provided evidence that animal behavior is governed by dynamic bidirectional communication between specific gut bacteria and their host via the brain-gut-microbiome ***,little research focused on how the gut microbiota influence broody behavior in *** this study,Zhedong white geese in laying and brooding phases were *** differentially abundant bacteria in cecum were detected between brooding and laying geese through metagenomic analyses and 16S rRNA sequencing(P<0.05),and Bacteroides fragilis was specifically identified as a key driver species in the brooding ***,the serum metabolites were quantified,and the 313 differentially abundant metabolites were found between the two groups of different physiological *** were primarily enriched in the tryptophan metabolism *** correlation analyses revealed there was a significant positive correlation between *** abundance and the context of 11 tryptophan metabolism-related metabolites(such as serotonin,etc.)in broody geese,which hinted that those tryptophan metabolites might be produced or driven by ***,the serum hormone levels were also *** found there was a positive correlation between *** abundance and content of ***,prolactin secreted by the pituitary gland was greater in brooding geese than that in laying geese,which was also highly correlated with *** *** result implied that *** could promote the secretion of prolactin by the pituitary ***,the current study findings provided the information on gut microbiota influencing broody behavior,*** produced or driven more serum serotonin,and stimulated the pituitary gland to secret more prolactin,which potentially offered a new enlightenment for the intervention of broody behavior in pou

关键词： geese broody behavior gut microbiota serotonin prolactin

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Extraction,chemical components,bioactive functions and adulteration identification of walnut oils:A review

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Grain & Oil Science and Technology 2024年第1期7卷 30-41页

作者： Yuan Gao jia Hu Xia Su qi Li Caihong Su Yongling Li Gaiqin Ma Siyu Zhang Xiuzhu Yu Engineering Research Center of Grain and Oil Functionalized Processing College of Food Science and EngineeringNorthwest A&F UniversityShaanxi 712100China Animal Products and Animal Medicine Feed Quality Inspection Center Hebei 050041China

Walnut oil is a functional wood oil known to researchers that may potentially be a large source of Chinese edible *** are various extraction methods for walnut oil,including traditional(pressing,solvent-and enzymeassisted extraction)and novel methods(microwave,ultrasound,supercritical CO_(2),subcritical and other extraction technologies).Walnut oil is rich in nutrients,including phytosterols,tocopherols,polyphenols,squalene and *** provides many health benefits,such as antioxidant,antitumor,anti-inflammatory,antidiabetic and lipid metabolism-related *** addition,the authentication of walnut oil has received much research *** present review provides detailed research on walnut oil extraction,composition,health benefits and adulteration identification *** path toward further walnut oil improvement in the context of the market value of walnut oil is also discussed.

关键词： Extraction technology Chemical composition Bioactive Authentication

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FDX1 as a novel biomarker and treatment target for stomach adenocarcinoma

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1803-1824页

作者： Xian-Ze Xie Lei Zuo Wei Huang qiao-Mei Fan Ya-Yun Weng Wen-Dong Yao jia-Li jiang jia-qi Jin Department of Pharmacy The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou 310018Zhejiang ProvinceChina Anhui Province Huainan City Shou County Agricultural Machinery Affairs Management Center Huainan 232200Anhui ProvinceChina

BACKGROUND Stomach adenocarcinoma(STAD)is one of the main reasons for cancer-related deaths *** investigation aimed to define the connection between STAD and Cuproptosis-related genes(CRGs).Cuproptosis is a newly identified form of mitochondrial cell death triggered by *** To explore the identification of potential biomarkers for STAD disease based on *** A predictive model using Gene Ontology(GO),Least Absolute Shrinkage and Selection Operator(LASSO),Kyoto Encyclopedia of Genes and Genomes(KEGG),Gene Set Variation Analysis(GSVA),and Gene Set Enrichment Analysis analyzed gene interconnections,focusing on 3 copper-related genes and their expression in The Cancer Genome *** for mRNA-miRNA and mRNA-transcription factor interactions were *** prognostic significance of CRG scores was evaluated using time-receiver operating characteristic,Kaplan-Meier curves,and COX regression *** was conducted with datasets GSE26942,GSE54129,and *** of copper-related differ-entially expressed genes was also analyzed in various human tissues and gastric cancer subpopulations using the human protein *** Three significant genes(FDX1,LIAS,MTF1)were identified and selected via LASSO analysis to predict and classify individuals with STAD into high and low CRG score *** genes were down-regulated in both risk *** and KEGG analyses highlighted their involvement mainly in the electron transport *** validating their differential expression,FDX1 emerged as the most accurate diagnostic marker for gastric ***,the RCircos package localized FDX1 on chromosome *** Our study revealed that FDX1 could be a potential biomarker and treatment target for gastric malignancy,providing new ideas for further scientific research.

关键词： Stomach adenocarcinoma disease Copper death FDX1 prognostic biomarkers Cuproptosis-related genes

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Enhanced cycling stability and rate performance of Co-doped and La_(2)O_(3)-coated LiNi_(0.9)Mn_(0.1)O_(2) toward power battery

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Rare Metals 2024年第2期43卷 658-670页

作者： jia-qi Peng Yuan-Yuan Wei Dong-Ming Liu Yun Li Bin Hu Bin Huang jian-Wen Yang Shun-Hua Xiao Ren-Heng Wang Guangxi Key Laboratory of Electrochemical and Magneto-Chemical Functional Materials College of Chemistry and BioengineeringGuilin University of TechnologyGuilin541004China Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen518060China

Ultra-high nickel layered oxide cathode material with high energy density is the most promising material to improve the electrochemical performance of lithium-ion batteries(LIBs).However,the poor structural stability and severe surface/interface side reactions of the material lead to poor rate performance and cyclic stability,which limits its application in *** this paper,the dual-modification strategy of Co doping and La_(2)O_(3) coating is used to meet the above *** doping can effectively widen layer spacing and reduce Li^(+)/Ni^(2+) mixing,and La_(2)O_(3) coating can effectively eliminate the residual alkali on the surface of active material,inhibit the thickening of cathode electrolyte interphase(CEI)film and reduce surface/interface side ***,the modified material(NM90-CL)with excellent electrochemical properties is achieved through the synergistic enhancement of Co doping and La_(2)O_(3) *** capacity retention rate can reach 77.9%after 200 cycles at 1.0℃ and 75.7%after 200 cycles at 5.0℃.Its reversible capacity can up to 153.5 mAh·g^(–1) at 10.0℃.This dual-modification strategy will provide theoretical guidance and technical support for the synthesis of other high-performance electrode materials.

关键词： High nickel cathode material Co doping La_(2)O_(3) coating Electrochemical performance Electrochemical mechanism

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Stem Cell-Based Hair Cell Regeneration and Therapy in the Inner Ear

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Neuroscience Bulletin 2024年第1期40卷 113-126页

作者： Jieyu qi Wenjuan Huang Yicheng Lu Xuehan Yang Yinyi Zhou Tian Chen Xiaohan Wang Yafeng Yu jia-qiang Sun Renjie Chai State Key Laboratory of Digital Medical Engineering Department of Otolaryngology Head and Neck SurgeryZhongda HospitalSchool of Life Sciences and TechnologyAdvanced Institute for Life and HealthJiangsu Province High-Tech Key Laboratory for Bio-Medical ResearchSoutheast UniversityNanjing 210096China Hospital of Southeast University Nanjing 210096China First Affiliated Hospital of Soochow University Suzhou 215006China Department of Otolaryngology-Head and Neck Surgery The First Affliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Otolaryngology Head and Neck Surgery Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Co-Innovation Center of Neuroregeneration Nantong UniversityNantong 226001China Institute for Stem Cell and Regeneration Chinese Academy of ScienceBeijing 100101China

Hearing loss has become increasingly prevalent and causes considerable disability,thus gravely burdening the global *** loss of hair cells is a main cause of sensorineural hearing loss,and currently,the only relatively effective clinical treatments are limited to digital hearing equipment like cochlear implants and hearing aids,but these are of limited benefit in *** is therefore urgent to understand the mechanisms of damage repair in order to develop new neuroprotective *** present,how to promote the regeneration of functional hair cells is a key scientific question in the field of hearing ***-ple signaling pathways and transcriptional factors trigger the activation of hair cell progenitors and ensure the maturation of newborn hair cells,and in this article,we first review the principal mechanisms underlying hair cell *** then further discuss therapeutic strategies involving the co-regulation of multiple signaling pathways in order to induce effective functional hair cell regeneration after degeneration,and we summarize current achievements in hair cell ***,we discuss potential future approaches,such as small molecule drugs and gene therapy,which might be applied for regenerating functional hair cells in the clinic.

关键词： Hearing loss Cochlea-Stem cell Hair cell regeneration

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Enhanced homing of mesenchymal stem cells for in situ niche remodeling and bone regeneration

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Nano Research 2024年第8期17卷 7449-7460页

作者： Yin Yuan Lijun Chen Jing Yang Sining Zhou Yangxin Fang qi Zhang Ning Zhang Yifei Li Li Yuan Fan jia Shuo Ni Charlie Xiang State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Biology The David H.Koch Institute for Integrative Cancer Research at MITMassachusetts Institute of TechnologyCambridgeMA 02139USA Research Units of Infectious disease and Microecology Chinese Academy of Medical SciencesHangzhou 310003China Innovative Precision Medicine(IPM)Group Hangzhou 311215China MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province Department of CardiologySir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Department of Cancer Immunology and Virology Dana-Farber Cancer InstituteBostonMA 02215USADepartment of ImmunologyHarvard Medical SchoolBoston MA 02115USA Department of Orthopedic Surgery and Shanghai Institute of Microsurgery on Extremities Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200233China

Mesenchymal stem cells(MSCs)transplantation is a promising strategy for osteoporosis ***,limited sources and poor tissue-homing efficiency limit their clinical *** this study,we isolated a kind of MSCs from women’s menstrual blood(MenSCs)noninvasively and established a novel MSCs bone marrow-targeted delivery system by utilizing waterin-oil-in-water droplet *** were encapsulated withinβ-cyclodextrin-functionalized alginate microcapsules loaded with zoledronates,which has a high affinity for *** this delivery system,MenSCs could be preferentially delivered to the bone marrow tissues via intravenous infusion,and restored bone mass by remodeling the bone marrow niche in situ in ovariectomized mouse ***,scRNA-seq analysis demonstrated that those MenSCs homed to the bone marrow recruited CD4^(+)FOXP3^(+)natural regulatory T(nT_(reg))cells by secreting *** recruited nTreg promoted CD8^(+)T cells to secret Wnt family member 10B(WNT10B),activating the Wnt signaling in osteoblasts and thus promoting bone formation in situ in the bone *** study reveals a promising application of MenSCs in postmenopausal osteoporosis treatment and highlights the clinical value of MenSCs by encouraging women to reserve autologous MenSCs before menopause to prevent and alleviate postmenopausal osteoporosis.

关键词： mesenchymal stem cells microfluidics bone marrow homing stem cell niche postmenopausal osteoporosis

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Surface engineering on MnO2 nanorods by La single atoms to accelerate oxygen reduction kinetics

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Rare Metals 2024年第9期43卷 4302-4311页

作者： Zhang-Long He Liu-qi Wang Min jiang jia-Nan Xie Shan Liu Jin-Can Ren Rui Sun Wen-Bin Lv Wei-Bin Guo Yu-Ling Liu Bing Li qi Liu Hao He School of Materials Science and Engineering Changsha University of Science and Technology School of Materials Science and Engineering NanjingUniversity of Science and Technology School of Materials Science and Engineering Shanghai JiaoTong University Department of Physics City University of Hong Kong

Surface engineering,which modulates the electronic structure and adsorption/desorption properties of electrocatalysts,is one of the key strategies for improving the catalytic ***,we demonstrate a facile solid-phase reaction for surface engineering of MnO2to boost the oxygen reduction *** reaction with surface hydroxy groups,La single atoms with loading amount up to 2.7 wt%are anchored onto *** surface engineering,the oxygen reduction reaction （ORR） kinetics is significantly improved with the half-wave potential from 0.70 to 0.84 V,the number of transferred electrons from 2.5 to 3.9 and the limiting current density from 4.8 to 6.0 mA·*** addition,the catalyst delivers superior discharge performance in both alkaline and neutral metal–air *** functional theory （DFT） calculations reveal that atomic La modulates the surface electronic configuration of MnO2,reduces its d-band center and thus lowers the OOH*and O*reaction energy *** work provides a new route for rational design of highly active electrocatalyst and holds great potential for application in various catalytic reactions.

关键词： Electron injection Metal–air batteries Oxygen reduction reaction Single atoms Surface engineering

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Indications of pro-inflammatory cytokines in laparoscopic and open liver resection for early-stage hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 257-264页

作者： Kevin Tak-Pan Ng Li Pang jia-qi Wang Wong Hoi She Simon Hing-Yin Tsang Chung Mau Lo Kwan Man Tan To Cheung Department of Surgery HKU-SZH&School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina

Background:Our clinical practice of laparoscopic liver resection(LLR)had achieved better short-term and long-term benefits for patients with hepatocellular carcinoma(HCC)over open liver resection(OLR),but the underlying mechanisms are not *** study was to find out whether systemic inflammation plays an important ***:A total of 103 patients with early-stage HCC under liver resection were enrolled(LLR group,n=53;OLR group,n=50).The expression of 9 inflammatory cytokines in patients at preoperation,postoperative day 1(POD1)and POD7 was quantified by Luminex Multiplex *** relationships of the cytokines and the postoperative outcomes were compared between LLR and ***:Seven of the circulating cytokines were found to be significantly upregulated on POD1 after LLR or OLR compared to their preoperative *** to OLR,the POD1 levels of granulocytemacrophage colony-stimulating factor(GM-CSF),interleukin-6(IL-6),IL-8,and monocyte chemoattractant protein-1(MCP-1)in the LLR group were significantly *** POD1 levels of these cytokines were significantly correlated with longer operative time and higher volume of blood loss during *** levels of these cytokines were positively associated with postoperative liver injury,and the length of hospital ***,a high level of IL-6 at POD1 was a risk factor for HCC recurrence and poor disease-free survival after liver ***:Significantly lower level of GM-CSF,IL-6,IL-8,and MCP-1 after liver resection represented a milder systemic inflammation which might be an important mechanism to offer better short-term and long-term outcomes in LLR over OLR.

关键词： Laparoscopic liver resection Open liver resection Hepatocellular carcinoma Postoperative cytokines Inflammatory responses

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Preparation and interface state of phosphate tailing-based geopolymers

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Journal of Central South University 2024年第6期31卷 1900-1914页

作者： ZHANG Shou-xun XIE Xian XIE Rui-qi TONG Xiong WU Yu-yao LI jia-wen LI Yue Faculty of Land Resource Engineering Kunming University of Science and TechnologyKunming 650093China National&Regional Engineering Research Center for Green Comprehensive Utilization of Gangue Resources from Metal Mine Kunming 650093China

The long-term storage of phosphate tailings will occupy a large amount of land,pollute soil and groundwater,thus,it is crucial to achieve the harmless disposal of phosphate *** this study,high-performance geopolymers with compressive strength of 38.8 MPa were prepared by using phosphate tailings as the main raw material,fly ash as the active silicon-aluminum material,and water glass as the alkaline *** solid content of phosphate tailings and fly ash was 60% and 40%,respectively,and the water-cement ratio was *** results of XRD,FTIR,SEM-EDS and XPS show that the reactivity of phosphate tailings with alkaline activator is weak,and the silicon-aluminum material can react with alkaline activator to form zeolite and gel,and encapsulate/cover the phosphate tailings to form a dense phosphate tailings-based *** the formation of geopolymers,part of the aluminum-oxygen tetrahedron replaced the silicon-oxygen tetrahedron,causing the polycondensation reaction between geopolymers and increasing the strength of *** leaching toxicity test results show that the geopolymer has a good solid sealing effect on heavy metal *** preparation of geopolymer from phosphate tailings is an important way to alleviate the storage pressure and realize the resource utilization of phosphate tailings.

关键词： phosphate tailing geopolymer interface state toxicity leaching

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Highly anti-corrosive NiFe LDHs–NiFe alloy hybrid enables long-term stable alkaline seawater electrolysis

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Rare Metals 2024年第9期43卷 4321-4332页

作者： jia-Hong Li Hao Chen Si-Hang You Gan-Xin Yang Peng Liu Meng-qi Gao Shu-Guang Chen Fei-Fei Zhang School of Materials Science and Engineering Changsha University of Science and Technology Department of Materials Science and Engineering Faculty of Engineering National University of Singapore School of Materials Science and Engineering Jilin University

Owing to the signi?cant potential of alkalin seawater electrolysis for converting surplus power into eco friendly hydrogen fuel,we developed bifunctional elec trodes that integrate low-crystalline NiFe LDHs and amorphous NiFe alloy on a Ni foam （NF） substrate to enhance this *** by the battery-like charac teristics of NiFe LDHs,an anti-corrosive and active oute layer of NiFevacOOH continuously forms over time in th hybrid on the anode for the oxygen evolution reaction（OER）,effectively mitigating powder shedding caused by corrosion induced by multiple anions in *** while,the strong bond between the hybrid and the NF substrate maintains intact hybrid coatings to ensure a rel atively high overall conductivity of the electrodes,signif icantly reducing the negative effects of structura degradation during the OER and hydrogen evolution reaction （HER）,as well as the accumulation of contami nants on the electrode *** long-term tests,thes bifunctionalhybridelectrodesmaintained stable performance,even at a high current density o500 mA·*** cell voltage increased by only 88 m V over 1000 h to 1.970 V during saline electrolysis and by103 mV over 500 h to 2.062 V during seawater electroly ***,this study provides valuable insights into ef?cient and stable seawater electrolysis using NiFe LDHs–NiFe alloy hybrids.

关键词： Bifunctional Corrosion NiFe LDHs Seawater electrolysis Stability

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