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Quantitative Analysis of the Effectiveness of Antigen-and Polymerase Chain Reaction-Based Combination Strategies for Containing COVID-19 Transmission in a Simulated Community

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Engineering 2023年第9期28卷 234-242页

作者： Qiangru Huang Yanxia Sun mengmeng jia Ting Zhang Fangyuan Chen Mingyue jiang Qing Wang Luzhao Feng Weizhong Yang School of Population Medicine and Public Health Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China School of Arts and Sciences Beijing Institute of Fashion TechnologyBeijing 100105China

The number of coronavirus disease 2019(COVID-19)cases continues to surge,overwhelming healthcare systems and causing excess mortality in many *** of infectious populations remains a key strategy to contain the COVID-19 outbreak,delay the exponential spread of the disease,and flatten the epidemic *** the Omicron variant outbreak as a background,this study aimed to evaluate the effectiveness of testing strategies with different test combinations and frequencies,analyze the factors associated with testing effectiveness,and optimize testing strategies based on these influencing *** developed a stochastic,agent-based,discrete-time susceptible–latent–infectious–recovered model simulating a community to estimate the association between three levels of testing strategies and COVID-19 *** testing and its combination strategies were more efficient than polymerase chain reaction(PCR)-related *** testing also showed better performance in reducing the demand for hospital beds and intensive care unit *** delay in the turnaround time of test results had a more significant impact on the efficiency of the testing strategy compared to the detection limit of viral load and detection-related *** main advantage of antigen testing strategies is the short turnaround time,which is also a critical factor to be optimized to improve PCR *** modifying the turnaround time,the strategies with less frequent testing were comparable to daily *** choice of testing strategy requires consideration of containment goals,test efficacy,community prevalence,and economic *** study provides evidence for the selection and optimization of testing strategies in the post-pandemic era and provides guidance for optimizing healthcare resources.

关键词： COVID-19 Antigen testing PCR testing Testing strategies

Nonlinear relationship between enteric-coated mycophenolate sodium dose and mycophenolic acid exposure in Han kidney transplantation recipients

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Acta Pharmaceutica Sinica B 2017年第3期7卷 347-352页

作者： Jun Zhang mengmeng jia Lihua Zuo Na Li Yonggang Luo Zhi Sun Xiaojian Zhang Zhenfeng Zhu Department of Pharmacy The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Integrated Intensive Care Unit The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

The aim of the research was to investigate the pharmacokinetics(PK) of enteric-coated mycophenolate sodium(EC-MPS) by quantification of the active metabolite of mycophenolic acid(MPA)after multiple escalating oral doses in Han kidney transplant recipients. A total of 28 Han postoperative kidney transplant recipients were given a multiple-dose of 540, 720 or 900 mg of EC-MPS two times a day in combination with tacrolimus for 6 days. Blood specimens were collected at each time point from0 to 12 h after EC-MPS administration. MPA plasma concentrations were measured by UPLC–UV. The relationship between the EC-MPS dose and its PK parameters was assessed. In the range from 540 to900 mg, C_(max) and AUC_(0–12h) did not increase with dose escalation. The AUC_(0–12h), C_(max), C_0 and T_(max) for the 540 720 and 900 mg doses were not significantly different, respectively(P 40.05). AUC_0–12 h and C_(max) were increased less than proportionally with increasing EC-MPS dose levels. Inter-individual variability in AUC_(0–12h), C_(max) and C_0 were considerable. Nonlinear PK relationships were found from the doses of 540–900 mg of EC-MPS.

关键词： Enteric-coated Mycophenolate sodium Mycophenolic acid Nonlinear dynamics Kidney transplantation Pharmacokinetics UPLC-UV Human plasma

An effectiveness study of vaccination and quarantine combination strategies for containing mpox transmission on simulated college campuses

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Infectious Disease Modelling 2024年第3期9卷 805-815页

作者： Qiangru Huang Yanxia Sun mengmeng jia Mingyue jiang Yunshao Xu Luzhao Feng Weizhong Yang School of Population Medicine and Public Health Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100730China National Institute of Pathogen Biology Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100730China

The ongoing transmission of mpox in specific countries and regions necessitates urgent *** is essential to implement targeted containment strategies that concentrate on high-risk populations and critical locations,such as college campuses,to effectively curb the spread of *** study is dedicated to evaluating the performance of various vaccination and quarantine strategies in curbing the spread of mpox and estimating the outbreak *** accomplish this,we constructed a stochastic,agent-based,discrete-time susceptible-latent-infectious-recovered(SLIR)model,to examine mpox transmission on a simulated college *** findings reveal that relying solely on PEP is insufficient in containing mpox *** bolster the population immunity and protect the vulnerable,pre-exposure vaccination among high-risk populations prior to an outbreak is *** study demonstrates that a pre-exposure vaccination rate of 50%in high-risk populations can led to a remarkable 74.2%reduction of *** translated to a mere 1.0%cumulative infection incidence in the overall *** cases where the desired vaccination coverage is not attainable,enhancing case detection and isolation measures can serve as an effective emergency response to contain mpox *** pre-exposure vaccination coverage of 20%or lower,a 40%isolation ratio is necessary to keep the cumulative number of infections in ***,when the coverage exceeds 30%,a reduced isolation ratio of 20%becomes sufficient to manage the outbreak *** insights underscore the importance of strategic pre-exposure vaccination in conjunction with robust surveillance and isolation protocols to safeguard public health and prevent the escalation of mpox outbreaks.

关键词： Infectious diseases Mpox Vaccination Quarantine

Long-term outcomes in COVID-19 patients who recovered from the first wave of the pandemic

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National Science Review 2022年第11期9卷 87-96页

作者： Dan Cui Simiao Chen Luzhao Feng mengmeng jia Yeming Wang Weijun Xiao Yanxia Sun Qiangru Huang Libing Ma Zhiwei Leng Hao Wang Bin Cao Weizhong Yang Juntao Yang Chen Wang Department of Pulmonary and Critical Care Medicine The Second Affiliated Hospital of Harbin Medical UniversityHarbin Medical University Department of Pulmonary and Critical Care Medicine National Center for Respiratory Medicine Center of Respiratory MedicineNational Clinical Research Center for Respiratory Diseases China-Japan Friendship Hospital Heidelberg Institute of Global Health Faculty of Medicine and University Hospital Heidelberg University School of Population Medicine and Public Health Chinese Academy of Medical Sciences &Peking Union Medical College Department of Respiratory and Critical Care Medicine the Affiliated Hospital of Guilin Medical University Institute of Respiratory Medicine Chinese Academy of Medical Science State Key Laboratory of Medical Molecular Biology Department of Biochemistry and Molecular BiologyInstitute of Basic Medical Sciences Chinese Academy of Medical Sciences & Peking Union Medical College

This cross-sectional study evaluated the long-term health effects of coronavirus disease 2019(COVID-19)in jianghan District(Wuhan, China). The results showed that 61.4% of COVID-19 patients reported at least one symptom and 8.8% had depressive symptoms at the 17-month follow-up. The proportion of patients with chest radiographic abnormalities in Fangcang shelter hospitals and designated COVID-19hospitals was 31.6% and 41.1%, respectively, and the proportion of patients with impaired pulmonary diffusion capacity in these hospitals was 52.8% and 60.9%, respectively. Female sex(odds ratio[OR] = 1.48, 95% confidence interval [CI]: 1.16–1.88), severe disease(OR = 1.46, 95% CI: 1.01–2.10)and a higher number of initial symptoms(OR = 1.31, 95% CI: 1.23–1.40) were associated with the development of sequelae symptoms at 17 months. This study involving community-dwelling COVID-19adults may help determine the long-term effects of COVID-19 during the first pandemic ***, larger follow-up studies are needed to characterize the post-COVID-19 condition.

关键词： SARS-CoV-2 post-COVID-19 syndrome follow-up studies

A Scenario-Based Evaluation of COVID-19-Related Essential Clinical Resource Demands in China

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Engineering 2021年第7期7卷 948-957页

作者： Ting Zhang Qing Wang Zhiwei Leng Yuan Yang Jin Yang Fangyuan Chen mengmeng jia Xingxing Zhang Weiran Qi Yunshao Xu Siya Chen Peixi Dai Libing Ma Luzhao Feng Weizhong Yang School of Population Medicine and Public Health Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Division of Infectious Diseases Chinese Center for Disease Control and PreventionBeijing 102206China Department of Respiratory and Critical Care Medicine The Affiliated Hospital of Guilin Medical UniversityGuilin 541001China

The coronavirus disease 2019(COVID-19)pandemic is a global crisis,and medical systems in many countries are overwhelmed with supply shortages and increasing demands to treat patients due to the surge in cases and severe *** study aimed to assess COVID-19-related essential clinical resource demands in China,based on different scenarios involving COVID-19 spreads and *** used a susceptible–exposed–infectious–hospitalized/isolated–removed(SEIHR)transmission dynamics model to estimate the number of COVID-19 infections and hospitalizations with corresponding essential healthcare resources *** found that,under strict non-pharmaceutical interventions(NPIs)or mass vaccination of the population,China would be able to contain community transmission and local outbreaks ***,under scenarios involving a low intensity of implemented NPIs and a small proportion of the population vaccinated,the use of a peacetime–wartime transition model would be needed for medical source stockpiles and preparations to ensure a normal functioning healthcare *** implementation of COVID-19 vaccines and NPIs in different periods can influence the transmission of COVID-19 and subsequently affect the demand for clinical diagnosis and *** increased proportion of asymptomatic infections in simulations will not reduce the demand for medical resources;however,attention must be paid to the increasing difficulty in containing COVID-19 transmission due to asymptomatic *** study provides evidence for emergency preparations and the adjustment of prevention and control strategies during the COVID-19 *** also provides guidance for essential healthcare investment and resource allocation.

关键词： COVID-19 Transmission dynamics model Clinical resource demands Vaccination

Analysis of Food Consumption and Its Characteristics in Uzbekistan based on the Emergy Method

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Journal of Resources and Ecology 2022年第5期13卷 842-850页

作者： jia mengmeng ZHEN Lin ZHANG Changshun Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101China School of Resource and Environment University of Chinese Academy of SciencesBeijing 100049China

Food resources play a great role in human livelihood,so it is meaningful to investigate their utilization and structural evolution,especially in developing *** study takes data from FAOSTAT and the World Bank,and applies the emergy method to analyze Uzbek food consumption changes and characteristics from 1992 to *** main results were obtained:(1)National food consumption showed a persistent increase and had a remarkable change in stages,with the first stage of low-level repetition,the second stage of speeding up and the third stage of high *** increase of animal-based food consumption was more notable than that of plant-based food consumption.(2)Per capita annual food consumption had a tendency of change that was similar to that of national food *** proportion of animal-based food in the total per capita annual food consumption usually remained about 2-fold higher than that of plant-based food *** main food consumption pattern was the combination of crops such as wheat and rice with meat such as *** fruit and vegetable consumption also *** the growing population,various changes in food demand will inevitably happen,so it is necessary to take sustainable measures in time to satisfy the new demand and to protect resources and the environment.

关键词： food consumption emergy method Uzbekistan

Association between influenza vaccination and SARS-CoV-2 infection and its outcomes: systematic review and meta-analysis

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Chinese Medical Journal 2022年第19期135卷 2282-2293页

作者： Binshan jiang Qiangru Huang mengmeng jia Xinai Xue Qing Wang Weizhong Yang Luzhao Feng School of Population Medicine and Public Health Chinese Academy of Medical Sciences&Peking Union Medical CollegeBejing 100730China Department of Medical Records Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China.

Background:World Health Organization recommends that influenza vaccines should benefit as much of the population as possible,especially where resources are *** virus disease 2019(COVID-19)has become one of the greatest threats to health systems *** present study aimed to extend the evidence of the association between influenza vaccination and COVID-19 to promote the ***:In this systematic review,four electronic databases,including the Cochrane Library,PubMed,Embase,and Web of Science,were searched for related studies published up to May *** odds ratios(ORs)with 95%confidence intervals(CIs)were pooled by ***:A total of 36 studies,encompassing 55,996,841 subjects,were included in this *** meta-analysis for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection provided an OR of 0.80(95%CI:0.73–0.87).The statistically significant estimates for clinical outcomes were 0.83(95%CI:0.72–0.96)for intensive care unit admission,0.69(95%CI:0.57–0.84)for ventilator support,and 0.69(95%CI:0.52–0.93)for fatal infection,while no effect seen in hospitalization with an OR of 0.87(95%CI:0.68–1.10).Conclusion:Influenza vaccination helps limit SARS-CoV-2 infection and severe outcomes,but further studies are ***:PROSPERO,CRD42022333747.

关键词： Influenza vaccine COVID-19 Infection Outcomes Prevention

Tactile tribotronic reconfigurable p-n junctions for artificial synapses

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Science Bulletin 2022年第8期67卷 803-812,M0003页

作者： mengmeng jia Pengwen Guo Wei Wang Aifang Yu Yufei Zhang Zhong Lin Wang Junyi Zhai CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 100083China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049China Center on Nanoenergy Research School of Physical Science and TechnologyGuangxi UniversityNanning 530004China School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

The emulation of biological synapses with learning and memory functions and versatile plasticity is significantly promising for neuromorphic computing ***,a robust and continuously adjustable mechanoplastic semifloating-gate transistor is demonstrated based on an integrated graphene/hexagonal boron nitride/tungsten diselenide van der Waals heterostructure and a triboelectric nanogenerator(TENG).The working states(p-n junction or n;-n junction)can be manipulated and switched under the sophisticated modulation of triboelectric potential derived from mechanical actions,which is attributed to carriers trapping and detrapping in the graphene ***,a reconfigurable artificial synapse is constructed based on such mechanoplastic transistor that can simulate typical synaptic plasticity and implement dynamic control correlations in each response mode by further designing the amplitude and *** artificial synapse can work with ultra-low energy consumption at 74.2 f J per synaptic event and the extended synaptic *** the synergetic effect of the semifloating gate,the synaptic device can enable successive mechanical facilitation/depression,short-/long-term plasticity and learning-experience behavior,exhibiting the mechanical behavior derived synaptic *** reconfigurable and mechanoplastic features provide an insight into the applications of energyefficient and real-time interactive neuromodulation in the future artificial intelligent system beyond von Neumann architecture.

关键词： Reconfigurable p-n junction Semifloating-gate transistor Triboelectric potential Artificial synapses Synaptic plasticity

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中国消除传染病的历史进程与展望

中华流行病学杂志 2021年第11期42卷 1907-1911页

作者：杨维中贾萌萌中国医学科学院北京协和医学院群医学及公共卫生学院北京100730

在漫长的历史长河中,传染病不仅对公众健康造成了巨大的影响,甚至威胁到国家安全和社会经济的发展。新中国成立以来,我国高度重视传染病防治工作,取得了举世瞩目的成就。本文主要回顾了我国消灭天花,消除脊髓灰质炎、麻风病、丝虫病、... 详细信息

在漫长的历史长河中,传染病不仅对公众健康造成了巨大的影响,甚至威胁到国家安全和社会经济的发展。新中国成立以来,我国高度重视传染病防治工作,取得了举世瞩目的成就。本文主要回顾了我国消灭天花,消除脊髓灰质炎、麻风病、丝虫病、新生儿破伤风、致盲性沙眼和疟疾的历史进程,并对未来有望被消除的传染病进行了展望。

关键词：中国传染病消灭消除