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A PARTIALLY-AVERAGED NAVIER-STOKES MODEL FOR HILL AND CURVED DUCT FLOW

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Journal of Hydrodynamics 2011年第4期23卷 466-475页

作者： MA jia-mei WANG Fu-jun YU Xin LIU Zhu-qing College of Water Conservancy and Civil Engineering China Agricultural University Beijing 100083 China

Turbulent flows past hill and curved ducts exist in many engineering applications. Simulations of the turbulent flow arc carried out based on a newly developed technique, the Partially-Averaged Navier-Stokes （PANS） model, including separation, recirculation, reattachment, turbulent vortex mechanism. The focus is on how to accurately predict typical separating, reattaching and secondary motion at a reasonable computational expense. The effect of the parameter, the unresolved-to-total ratio of kinetic energy （ fk ）, is examined with a given unresolved-to-total ratio of dissipation （ fE ） for the hill flow with a much coarser grid system than required by the LES. An optimal value of fk can be obtained to predict the separation and reattachment locations and for more accurate simulation of the resolved turbulence. In addition, the turbulent secondary motions are captured by a smaller fi as compared with the RANS method with the same grid.

关键词： Partially-Averaged Navier-Stokes (PANS) flow separation recirculation reattachment resolved turbulence

Effects of four regulating-intestine prescriptions on pathology and ultrastructure of colon tissue in rats with ulcerative colitis

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World Journal of Gastroenterology 2005年第31期11卷 4800-4806页

作者： Heng Fan Ming-Yi Qiu jia-jun mei Guan-Xin Shen Song-Lin Liu Rui Chen Department of Integrated Traditional Chinese and Western Medicine Union Hospital Tongji Medical CollegeHuazhong University of Science and Technology Wuhan 430022Hubei Province China Hubei College of Traditional Chinese Medicine Wuhan 430061 Hubei ProvinceChina Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 Hubei Province China

AIM: To observe different histomorphologic changes of ulcerative colitis (UC) rats that were treated with four regulating-intestine prescriptions (FRIP), to investigate the curative effects of FRIP and to analyze their treatment ***: The UC rat model was made by the method of 2,4-dinitro chloro benzene (DNCB) immunity and acetic acid local enema. Ninety-eight SD rats were randomly divided into seven groups, namely, the normal control group, model group, salicylazosulfapyridine (SASP) group,Wumeiwan (WMW) group, Baitouwengtang (BTWT) group,Senglingbaishusan (SLBSS) group, and Tongxieyaofang (TXYF) group. Each group had 14 rats (with equal ratio of male and female). The six animal model groups of UC-SASP, TXYF, WMW, BTWT, SLBSS, TXYF-were treated by distilled water except the normal control group. Changes of the rat's general conditions after treatment were respectively observed, the colon tissue damage scores were given out, the pathology of colonic mucosa and changes of ultrastructure were ***: Different pathological changes on histology were shown after treatment by FRIP. The colon tissue damage score in model group was higher than that of FRIP groups and SASP group (q = 4.59, 4.77, P＜0.05 or q = 5.48,6.25, 5.97, P＜0.01). The scores of WMW group, BTWT group and SLBSS group were lower than that of SASP (q = 4.13, P＜0.05 or q = 5.31, 5.12, P＜0.01). There was no remarkable difference between the damage score of TXYF group and SASP group (q = 3.75, P＞0.05). In addition, some apoptosis cells were found in the pathologic control ***: The model made with DNCB and acetic acid was successful, and FRIP had better curative effect and WMW was the best curative effect, BTW, SLBSS and TXYF were similar to SASP, and we discovered that apoptosis was possibly related to UC.

关键词： Ulcerative colitis TCM therapy Experimentalresearch Pathology Ultrastructure Apoptosis

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间变性多发性骨髓瘤3例临床病理学分析

诊断病理学杂志 2024年第3期31卷 226-230页

作者：曾麟舒赵媛张之钰贾俊梅陈红首都医科大学附属北京朝阳医院石景山院区病理科北京100043 首都医科大学附属北京朝阳医院石景山院区检验科北京100043

目的探讨间变性多发性骨髓瘤(AMM)的临床病理学特征。方法收集首都医科大学附属北京朝阳医院石景山院区2017—2022年诊断的3例AMM,对其病理学形态、免疫表型及分子病理特征进行回顾性分析。结果男性2例、女性1例,其中2例表现为多发性骨... 详细信息

目的探讨间变性多发性骨髓瘤(AMM)的临床病理学特征。方法收集首都医科大学附属北京朝阳医院石景山院区2017—2022年诊断的3例AMM,对其病理学形态、免疫表型及分子病理特征进行回顾性分析。结果男性2例、女性1例,其中2例表现为多发性骨质破坏;1例以髓外病变引发的压迫症状就诊。镜下:由异型性明显的幼稚浆细胞构成,可见多形性核、奇异形核和多核细胞。免疫组化显示肿瘤细胞CD38、CD138和MUM1均弥漫阳性,CD20、CD79α均阴性。免疫球蛋白均为Lambda链限制性表达。分子检测均为高危细胞遗传学异常,主要出现1q21基因扩增。结论AMM较为罕见,组织学形态多形性明显,需与多种肿瘤进行鉴别,具有高危细胞遗传学异常和侵袭性病程,需要引起临床和病理医师的高度重视。

关键词：多发性骨髓瘤间变性临床病理特征免疫组化鉴别诊断

高能量代谢肺癌患者临床特征分析及其预测模型建立

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解放军医学杂志 2024年第9期49卷 1004-1010页

作者：任江珊贾军梅孙萍平梅张琼琼刘燕燕赵和平陈妍戎冬文王康仇海乐刘宸安樊羽羽于德刚山西医科大学第一临床医学院山西太原030001 山西医科大学第一医院肿瘤科山西太原030001 山西医科大学第一医院营养科山西太原030001 首都医科大学附属北京世纪坛医院胃肠外科与临床营养科北京100038

目的分析肺癌患者高能量代谢的临床特征及其与人体成分、营养状况、生活质量的相关性,并建立高能量代谢风险预测模型。方法回顾性选取2022年1月-2023年5月山西医科大学第一医院收治的132例原发性肺癌患者,根据是否出现高能量代谢分为高... 详细信息

目的分析肺癌患者高能量代谢的临床特征及其与人体成分、营养状况、生活质量的相关性,并建立高能量代谢风险预测模型。方法回顾性选取2022年1月-2023年5月山西医科大学第一医院收治的132例原发性肺癌患者,根据是否出现高能量代谢分为高能量代谢组(n=94)和非高能量代谢组(n=38)。比较两组临床资料、人体成分、患者主观整体营养状况评估量表(PG-SGA)评分、EORTC生命质量测定量表(QLQ-C30)评分的差异。采用logistic回归分析肺癌患者高能量代谢的危险因素,并据此建立风险预测模型;采用Hosmer-Lemeshow检验评估模型拟合度,采用受试者工作特征(ROC)曲线下面积(AUC)检测其预测效能。结果132例原发性肺癌中,94例(71.2%)出现高能量代谢。与低能量代谢组比较,高能量代谢组患者吸烟指数≥400、疾病分期为Ⅲ或Ⅳ期、IL-6水平、低脂肪指数、低骨骼肌指数、营养不良风险均增高(P0.05)。Logistic回归分析结果显示,吸烟指数≥400、疾病分期为晚期、IL-6≥3.775 ng/L、PNI<46.43为肺癌患者高能量代谢的独立危险因素;据此建立的预测模型预测肺癌患者高能量代谢风险ROC曲线的AUC为0.834(95%CI 0.763~0.904)。结论本研究建立的肺癌患者高能量代谢风险预测模型具有较好的拟合度和预测效能。

关键词：肺癌高能量代谢预测模型人体成分生活质量

Bayesian inference of neutron-skin thickness and neutron-star observables based on effective nuclear interactions

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 97-105页

作者： jia Zhou jun Xu Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China School of Physics Science and Engineering Tongji UniversityShanghai 200092China

We have obtained the constraints on the density dependence of the symmetry energy from neutron-skin thickness data by parityviolating electron scatterings and neutron-star observables using a Bayesian approach,based on the standard Skyrme-HartreeFock(SHF)model and its extension as well as the relativistic mean-field(RMF)*** the neutron-skin thickness data(neutron-star observables)mostly constrain the symmetry energy at subsaturation(suprasaturation)densities,they may more or less constrain the behavior of the symmetry energy at suprasaturation(subsaturation)densities,depending on the energy-density functional *** showing the final posterior density dependence of the symmetry energy,we also compare the slope parameters of the symmetry energy at 0.10 fm-3as well as the values of the symmetry energy at twice saturation density from three effective nuclear *** present work serves as a comparison study based on relativistic and non-relativistic energy-density functionals,for constraining the nuclear symmetry energy from low to high densities using a Bayesian approach.

关键词： symmetry energy neutron skin neutron star

Homochirality in Ferroelectrochemistry

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Chinese Journal of Chemistry 2024年第10期42卷 1133-1144页

作者： Hang Peng jun-Chao Qi Yu-Si Liu jia-mei Zhang Wei-Qiang Liao Ren-Gen Xiong Ordered Matter Science Research Center Nanchang UniversityNanchangJiangxi 330031China

What is the most favorite and original chemistry developed in your research group?We originally proposed the design principle for molecular ferroelectrics:ferroelectrochemistry,including quasi-spherical theory,the introduction of homochirality,and H/F *** changed the blind search for molecular ferroelectrics into targeted chemical design,which will develop into a new discipline.

关键词： Molecular ferroelectrics Homochirality Ferroelectricity Chemical design Point groups

New method for multibody dynamics based on unknown constraint force

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Science China(Technological Sciences) 2024年第3期67卷 791-808页

作者： TIAN Ying jia YingHong ZHANG jun School of Astronautics Beihang UniversityBeijing 100191China Beijing Institute of Control Engineering Beijing 100190China National Laboratory of Space Intelligent Control Beijing 100190China

This paper presents a new method for the dynamics of multibody systems based on unknown constraint force. The method can uniformly solve multibody systems with typical configurations, including the system with rigid-flexible coupling, the system in tree topology, and the system with loop constraints. Unlike common methods, the proposed method can model the loop system without “cutting off” loop constraints, leading to the exact same modelling process as the tree-like system performs. Based on graph theory, a topological record matrix M_(rec) is proposed to capture the arbitrary system configuration. Moreover, constraint forces are selected as the key variables in semi-recursive framework. With the recursive kinematics relationship between adjacent bodies, the constraint force equation is further assembled to achieve the full-state system solution. The numerical simulations demonstrate the accuracy of the proposed method.

关键词： multibody system dynamic modelling rigid-flexible coupling unknown constraint force graph theory semi-recursive algorithm

Diagnosis and treatment of biliary mucinous cystic neoplasms: A single-center experience

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 495-501页

作者： jun-jun jia Ya-Fen Cheng mei-Bao Feng Li Liu Ming-Qi Shuai Xiao-Dong Shen Xiao-Feng Tang Shu-Sen Zheng Division of Hepatobiliary and Pancreatic Surgery Department of Surgerythe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of International Healthcare Center the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Pathology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Library the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Background: Biliary mucinous cystic neoplasms(BMCNs) are rare hepatobiliary cystic tumors, which can be divided into noninvasive and invasive types. This study aimed to investigate the diagnosis, treatment, and prognosis of BMCNs in a large single center. Methods: We analyzed 49 patients with BMCNs confirmed by postoperative pathology at the First Afflliated Hospital, Zhejiang University School of Medicine between January 2007 and December 2021. Results: Among the 49 patients, 37 were female(75.5%), and the average age was 57.04 years. Common symptoms included abdominal discomfort, jaundice and fever, while 22 patients(44.9%) had no symptoms. Serum carbohydrate antigen(CA) 19-9 and CA125 concentrations were elevated in 34.8% and 19.6% of patients, respectively. Forty-eight patients had tumors in the intrahepatic bile ducts and only one had a tumor in the extrahepatic bile duct. Forty-eight patients with noninvasive intrahepatic BMCNs were further analyzed in terms of pathological features: 34(70.8%) had low-grade intraepithelial neoplasms(LGINs), and 14(29.2%) had high-grade intraepithelial neoplasms(HGINs). The potential immunohistochemical markers of BMCNs were cytokeratin(CK) 19, CK7, estrogen receptor and progesterone receptor. Follow-up data for 37 patients with intrahepatic BMCNs were obtained. The median overall survival(OS) of BMCNs was not reached. The longest survival time was 137 *** 5-and 10-year OS rates were 100% and 85.4%, respectively. The 5-and 10-year recurrence-free survival(RFS) rates were 93.9% and 80.2%, respectively. Conclusions: BMCNs are rare cystic neoplasms that commonly occur in middle-aged females. BMCNs can only be diagnosed and classified by postoperative pathology, as there are no specific clinical presentations, serological indicators or imaging modalities for preoperative diagnosis. Complete surgical resection is necessary for BMCNs, and the postoperative prognosis is favorable.

关键词： Biliary mucinous cystic neoplasms Low-grade intraepithelial neoplasms High-grade intraepithelial neoplasms Overall survival Recurrence-free survival

Chimeric Monkey Born Alive with a High Contribution of Donor Cells

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Neuroscience Bulletin 2024年第6期40卷 849-851页

作者： jia Huang jun Wu Department of Molecular Biology University of Texas Southwestern Medical CenterDallasTX75390USA Hamon Center for Regenerative Science and Medicine University of Texas Southwestern Medical CenterDallasTX75390USA Cecil H.and Ida Green Center for Reproductive Biology Sciences University of Texas Southwestern Medical CenterDallasTX75390USA

Chimeras,which consist of cells from different individuals or different species,represent an important tool in biological *** in the early twentieth century,studies on chimeras have been focusing on understanding fundamental genetic and cellular developmental *** the advances in genetic engineering and embryonic stem cell(ESC)technology,chimeras have become an important tool for the generation of transgenic animals.

关键词： mechanisms advances developmental