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Prediction model establishment and validation for enteral nutrition aspiration during hospitalization in patients with acute pancreatitis

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2583-2591页

作者： Ping Hou Hao-Jun Wu Tang Li jia-Bin Liu Quan-qing Zhao Hong-jiang Zhao Zi-Ming Liu Division II of General Surgery West China Hospital-Chengdu Shangjin NanfuWest China HospitalSichuan UniversityChengdu 611730Sichuan ProvinceChina Division of Biliary Tract Surgery West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Hepatobiliary and Pancreatic Surgery West China Hospital-Chengdu Shangjin NanfuWest China HospitalSichuan UniversityChengdu 611730Sichuan ProvinceChina Department of Thyroid Surgery West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Oncology West China Hospital-Chengdu Shangjin NanfuWest China HospitalSichuan UniversityChengdu 611730Sichuan ProvinceChina Division of Biliary Tract Surgery Department of General SurgeryWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Acute pancreatitis(AP)is a disease caused by abnormal activation of pancreatic enzymes and can lead to self-digestion of pancreatic tissues and dysfunction of other *** nutrition plays a vital role in the treatment of AP because it can meet the nutritional needs of patients,promote the recovery of intestinal function,and maintain the barrier and immune functions of the ***,the risk of aspiration during enteral nutrition is high;once aspiration occurs,it may cause serious complications,such as aspiration pneumonia,and suffocation,posing a threat to the patient’s *** study aims to establish and validate a prediction model for enteral nutrition aspiration during hospitalization in patients with *** To establish and validate a predictive model for enteral nutrition aspiration during hospitalization in patients with *** A retrospective review was conducted on 200 patients with AP admitted to Chengdu Shangjin Nanfu Hospital,West China Hospital of Sichuan University from January 2020 to February *** data were collected from the electronic medical record *** were randomly divided into a validation group(n=40)and a modeling group(n=160)in a 1:4 ratio,matched with 200 patients from the same time *** modeling group was further categorized into an aspiration group(n=25)and a non-aspiration group(n=175)based on the occurrence of enteral nutrition aspiration during *** and multivariate logistic regression analyses were performed to identify factors influencing enteral nutrition aspiration in patients with AP during hospitalization.A prediction model for enteral nutrition aspiration during hospitalization was constructed,and calibration curves were used for *** operating characteristic curve analysis was conducted to evaluate the predictive value of the *** There was no statistically significant difference in general data between the validation and mode

关键词： Acute pancreatitis Hospitalization Enteral nutrition Predictive model Aspiration

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新型氨基酸-钨砷多金属氧酸盐K_6[Cu(Ala)_2·(H_2O)_2]_2[Cu_4(H_2O)_2(AsW_9O_(34))_2]·16H_2O的合成与晶体结构

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高等学校化学学报 2001年第3期22卷 362-364页

作者：王永慧胡长文王恩波胡宁海贾恒庆邢彦东北师范大学化学学院多酸化学研究所长春130024 中国科学院长春应用化学研究所长春130022

The novel amino acid containing polyoxometalate K 6[Cu(Ala) 2(H 2O) 2] 2[Cu 4(H 2O) 2\5(AsW 9O 34 ) 2]·16H 2O was synthesized from the reaction of K 10 [Cu 4(H 2O) 2(AsW 9O 34 ) 2]·20H 2O with β alanine. Its structure has been determined by single crystal X ray diffraction. It crystallizes in the triclinic space group P1 , with a =1.196 3(2) nm, b =1.536 5(3) nm, c =1.591 4(3) nm, α=93.97(3)°, β=110.88(3)°, γ=101.07(3)°, V =2.651 8(9) nm 3 and Z =1. Least squares refinement of the structure leads to R and R w factors of 0.067 3 and 0.162 8, respectively. An unusual structural feature of the compound is that the polyanion [Cu 4(H 2O) 2(AsW 9O 34 ) 2] 10- is linked with the amino acid complex of Cu 2+ by a μ oxygen atom.

关键词：氨基酸钨砷多金属氧酸盐合成晶体结构

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完成类连续行动的逻辑刻画

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世界哲学 2024年第5期 154-159,F0003页

作者：贾青中国社会科学院大学哲学院中国社会科学院哲学研究所

作为一种特殊类型的连续行动,完成类连续行动最大的特点就是行动结果是否实现并不能完全决定其真值。例如语句“丽丽修理手机”中,丽丽的行动结果或者说目标是将她的手机修理好,但是即使这个目标不能被实现,这个语句也会为真,只要丽丽... 详细信息

作为一种特殊类型的连续行动,完成类连续行动最大的特点就是行动结果是否实现并不能完全决定其真值。例如语句“丽丽修理手机”中,丽丽的行动结果或者说目标是将她的手机修理好,但是即使这个目标不能被实现,这个语句也会为真,只要丽丽确实执行了行动“修理手机”。因此,为了刻画完成类连续行动的这一特点,我们需要将时间段因素引入到STIT逻辑的语义中来并将完成类连续行动的语义解释进行修改以容纳结果不为真这种情况。本文在简单介绍完成类连续行动和STIT逻辑的基础上,将给出一个刻画完成类连续行动的STIT逻辑系统CAac。

关键词：连续行动完成类连续行动 STIT逻辑主事性

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An ultrafast rechargeable hybrid potassium dual-ion capacitor based on carbon quantum dot@ultrathin carbon film cathode

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Rare Metals 2024年第10期43卷 5070-5081页

作者： Zhao-Meng Liu Da Wang Shang-Zhuo Li qing-Song Lai Dong-Run Yang Lu-Kang Zhao jian-jia Mu Xuan-Chen Wang Xuan-Wen Gao Wen-Bin Luo Institute for Energy Electrochemistry and Urban Mines Metallurgy School of MetallurgyNortheastern University Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai University

Ultrafast rechargeable hybrid potassium dualion capacitors （HPDICs） were designed by employing carbon quantum dot@ultrathin carbon film （CQD@CF） as the cathode *** designed CQD@CF is selfassembled by a simple catalytic graphitization route followed by an acid leaching *** special composite features a large adsorption interface,a remarkable anion hybrid storage capability and outstanding structure *** electrochemical performance of CQD@CF composite is fully tapped in a half-cell system at the operating voltage between 1.4 and 4.5 V,achieving an admirable specific discharge capacity of 128.5 mAh·g-1a 50 mA·g-1,an ultra-high capacity retention ratio of 97.97% after cycling 5000 times at 1000 mA·g-1and a 96.10%high capacity retention ratio after cycling 40,000 times at 5000 mA·g-1,***,with the support of ex situ TEM and XPS,the structural stability principle and anionic hybrid storage mechanism of CQD@CF electrode are investigated *** the full-cell system,HPDICs with the CQD@CF as cathode and nanographite powder as anode also present a 141.5 Wh·kg-1high energy density,a 5850 W·kg-1power density and a super-long cycle stability (90.2% capacity retention ratio after cycling 30,000 times at 5000 mA·g-1).

关键词： Anion hybrid storage mechanism Carbon quantum dots Potassium dual ion capacitor Ultrafast rechargeable Ultrathin carbon film

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VX-509 attenuates the stemness characteristics of colorectal cancer stem-like cells by regulating the epithelial-mesenchymal transition through Nodal/Smad2/3 signaling

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World Journal of Stem Cells 2024年第2期16卷 207-227页

作者： Yun Yuan Xu-Fan Zhang Yu-Chen Li Hong-qing Chen Tian Wen jia-Lian Zheng Zi-Yi Zhao Qiong-Ying Hu Department of Laboratory Medicine Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina Department of Nuclear Medicine Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina College of Medical Technology Chengdu University of Traditional Chinese MedicineChengdu 611137Sichuan ProvinceChina Department of Hepatology Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110032Liaoning ProvinceChina Hospital of Chengdu University of Traditional Chinese Medicine Chengdu 610072Sichuan ProvinceChina Traditional Chinese Medicine Regulating Metabolic Diseases Key Laboratory of Sichuan Province Chengdu 610072Sichuan ProvinceChina

BACKGROUND Colorectal cancer stem cells(CCSCs)are heterogeneous cells that can self-renew and undergo multidirectional differentiation in colorectal cancer(CRC)*** are generally accepted to be important sources of CRC and are responsible for the progression,metastasis,and therapeutic resistance of ***,targeting this specific subpopulation has been recognized as a promising strategy for overcoming *** To investigate the effect of VX-509 on CCSCs and elucidate the underlying *** CCSCs were enriched from CRC cell lines by in conditioned serum-free *** blot,Aldefluor,transwell and tumorigenesis assays were performed to verify the phenotypic characteristics of the *** anticancer efficacy of VX-509 was assessed in HCT116 CCSCs and HT29 CCSCs by performing cell viability analysis,colony formation,sphere formation,flow cytometry,and western blotting assessments in vitro and tumor growth,immunohistochemistry and immunofluorescence assessments in *** Compared with parental cells,sphere cells derived from HCT116 and HT29 cells presented increased expression of stem cell transcription factors and stem cell markers and were more potent at promoting migration and tumori-genesis,demonstrating that the CRC sphere cells displayed CSC ***-509 inhibited the tumor malignant biological behavior of CRC-stem-like cells,as indicated by their proliferation,migration and clonality in vitro,and suppressed the tumor of CCSC-derived xenograft tumors in ***,VX-509 suppressed the CSC character-istics of CRC-stem-like cells and inhibited the progression of epithelial-mesenchymal transition(EMT)signaling in *** was identified as the regulatory factor of VX-509 on CRC stem-like cells through analyses of differen-tially expressed genes and CSC-related database ***-509 markedly downregulated the expression of Nodal and its downstream phosphorylated Smad2/3 to inhibit EMT ***,VX-509 rev

关键词： Colorectal cancer stem cells Stemness VX-509 Epithelial-mesenchymal transition Nodal

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Ferroelastic domain engineering in layered-perovskite Bi_(2)WO_(6)thin films by post-annealing

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Journal of Advanced Dielectrics 2024年第2期14卷 71-76页

作者： jia Yang Minchuan Liang Huayu Yang Hui Ai Tong Zhang qing Han Ji Ma Houbing Huang Jing Wang Advanced Research Institute of Multidisciplinary Science and School of Materials Science and Engineering Beijing Institute of Technology Beijing 100081P.R.China Analysis&Testing Center Beijing Institute of Technology Beijing 100081P.R.China School of Material Science and Engineering Kunming University of Science and Technology Kunming Yunnan 650093P.R.China

Due to the strong magneto-elastic coupling in ferromagnetic/ferroelectric heterostructures and the potential applications in lowpower magnetoelectric nanodevices,ferroelastic domains and the corresponding dynamic evolution under external stimuli have attracted intense research *** pulsed laser deposition method,we have successfully grown layered-perovskite Bi_(2)WO_(6)thin films on SrTiO_(3)(001)***,for the as-grown thin films with step-flow morphology,the relationship between ferroelastic domain number and size shows a normal distribution,which is similar to the Boltzman distribution for confined gas molecules at *** addition,with post-annealing,the thin films with as-grown island-like morphology can be optimized for layered morphology,and the initial small ferroelastic domains can grow into large *** study provides an effective strategy for ferroelastic domain engineering,which can be applied for the design of multiferroic heterostructures and low-power nanodevices.

关键词： Aurivillius oxides Bi_(2)WO_(6)thin films domain structure Boltzman distribution post-annealing

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A biobank of patient derived glioma organoids

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Science China Life Sciences 2024年

作者： Yulin Wen Hongmin Bai qing Li Sainan Huang Xiaokun jia Guangjin Pan Hongjie Yao State Key Laboratory of Respiratory Disease Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences Guangzhou Medical University University of Chinese Academy of Sciences Department of Neurosurgery General Hospital of Southern Theatre Command Department of Basic Research Guangzhou National Laboratory

Dear Editor,Gliomas are the most prevalent malignant tumors affecting the central nervous system (CNS), categorized into low-grade gliomas (LGG) comprising CNS WHO grades 2–3, and high-grade gliomas(HGG) encompassing CNS WHO grade 4(Aldape et al., 2015). The current standard therapeutic approach involves maximal safe margin excision followed by radiotherapy and temozolomide (TMZ)treatment (Armstrong et al., 2020).However, due to the unique site and microenvironment of gliomas, patients experience limited benefits from emerging revolutionary therapies such as targeted therapy and immunotherapy (Sampson et al., 2020; Yang et al., 2022).

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Chemical Constituents and Pharmacological Properties of Frankincense:Implications for Anticancer Therapy

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Chinese Journal of Integrative Medicine 2024年第8期30卷 759-767页

作者： WU Yong-rong XIONG Wei DONG Ying-jing CHEN Xin ZHONG Yuan-yuan HE Xin-ling WANG Yu-jia LIN Qun-fang TIAN Xue-fei ZHOU qing College of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha410208China Department of Andrology the First Hospital of Hunan University of Chinese MedicineChangsha41007China College of Medicine Hunan University of Chinese MedicineChangsha410208China College of Traditional Chinese and Western Medicine Hunan University of Chinese MedicineChangsha410208China Hunan Provincial Key Laboratory of Traditional Chinese Medicine Prescription and Transformation Changsha410208China Hunan Sexual and Reproductive Health Clinical Medical Research Center of Traditional Chinese Medicine Changsha410021China

The discovery of novel antitumor agents derived from natural plants is a principal objective of anticancer drug ***,a widely recognized natural antitumor medicine,has undergone a systematic review encompassing its species,chemical constituents,and diverse pharmacological activities and *** different species of frankincense include Boswellia serrata,Somali frankincense,Boswellia frereana,and Boswellia *** frankincense extracts and compounds exhibit antitumor,anti-inflammatory,and hepatoprotective properties and antioxidation,memory enhancement,and immunological regulation *** also have comprehensive effects on regulating *** and its principal chemical constituents have demonstrated promising chemoprophylactic and therapeutic abilities against *** review provides a systematic summary of the mechanism of action underlying the antitumor effects of frankincense and its major constituents,thus laying the foundations for developing effective tumor-combating targets.

关键词： frankincense species chemical constituents anticancer therapy Chinesemedicine

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Security of quantum key distribution with virtual mutually unbiased bases

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 13-21页

作者： Hong-Wei Li Chen-Peng Hao Zhi-jiang Chen Li Gong Yi-Fei Lu Yang Wang jia-Ji Li Chun-Mei Zhang Rong Wang Zhen-Qiang Yin qing-Yu Cai Henan Key Laboratory of Quantum Information and Cryptography SSF IEUZhengzhou 450000China Institute of Quantum Information and Technology Nanjing University of Posts and TelecommunicationsNanjing 210003China Department of Physics University of Hong KongHong Kong 999077China Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China School of Information and Communication Engineering Hainan UniversityHaikou 570228China

In a perfect quantum key distribution(QKD)protocol,quantum states should be prepared and measured with mutually unbiased bases(MUBs).However,in a practical QKD system,quantum states are generally prepared and measured with imperfect MUBs using imperfect devices,possibly reducing the secret key rate and transmission *** analyze the security of a QKD system with imperfect MUBs,we propose virtual MUBs to characterize the quantum channel against collective attack,and analyze the corresponding secret key rate under imperfect state preparation and measurement *** generally,we apply the advantage distillation method for analyzing the security of QKD with imperfect MUBs,where the error tolerance and transmission distance can be sharply *** analysis method can be applied to benchmark and standardize a practical QKD system,elucidating the security analysis of different QKD protocols with imperfect devices.

关键词： quantum key distribution mutually unbiased bases advantage distillation

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Effects of triaxial deformation on the fission barrier in the Z=118−120 nuclei

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Communications in Theoretical Physics 2024年第6期76卷 92-101页

作者：柴清祯王佳利刘星汉 Institute of Theoretical Physics School of SciencesHenan University of TechnologyZhengzhou 450001China

By using potential energy surface(PES)calculations in the three-dimensional space(β_(2),γ,β_(4))within the framework of the macroscopic-microscopic model,the fission trajectory and fission barrier for Z=118(Og),119,120 nuclei has been systematically *** calculated PES includes macroscopic liquid-drop energy,microscopic shell correction and pairing *** the ^(294)Og176 nucleus as an example,we discuss the next closed shell after Z=82 and N=126 with the calculated Woods-Saxon single-particle ***,the results of PES in ^(294)Og is illustrated from the(X,Y)scale to the(β_(2),γ)***γdegree of freedom reveals the shape evolution clearly during the fission *** structure near the minimum and saddle point of the PES in the Z=118,119,120 nuclei is demonstrated *** on the potential energy curves,general trends of the evolution of the fission barrier heights and widths are also *** triaxial deformation in these superheavy mass regions plays a vital role in the first fission barrier,showing a significant reduction in both triaxial *** addition,the model-dependent fission barriers of proton-rich nuclei ^(295)Og,296119,and 297120 are analyzed *** studies could be valuable for synthesizing the superheavy new elements in the forthcoming HIAF and other facilities.

关键词： fission barrier potential energy surface calculation triaxiality Woods-Saxon potential superheavy new elements

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