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10B-doped MCP detector developed for neutron resonance imaging at Back-n white neutron source

Nuclear Science and Techniques 2024年第8期35卷 58-68页

作者： Qiang Li Li‑jiao Wang jing‑Yu Tang Xiang‑Biao Qiu Zhen Chen Mao‑Yuan Zhao Chang‑Jun Ning Kai Pan Wei Xu Tao Li Su‑Peng Lu Han Yi Rui‑Rui Fan Chang‑qing Feng Rong zhang Xiao‑Yang Sun Qi An Hao‑Fan Bai jiang‑Bo Bai jie Bao ping Cao Qi‑ping Chen yong‑Hao Chen Zeng‑Qi Cui An‑Chuan Fan Fan‑Zhen Feng Min‑Hao Gu Chang‑cai Han Zi‑jie Han Guo‑zhu He yong‑Cheng He Yang Hong Yi‑Wei Hu Han‑Xiong huang Wei jiang Zhi‑jie jiang Zheng‑Yao jin ling Kang Bo Li Gong Li Xiao Li Yang Li jie Liu Rong Liu Shu‑Bin Liu Yi‑Na Liu Guang‑Yuan Luan jie Ren Zhi‑Zhou Ren Xi‑Chao Ruan Zhao‑Hui Song Kang Sun Zhi‑Xin Tan Sheng‑Da Tang jin‑Cheng Wang Peng‑Cheng Wang Zhao‑Hui Wang Zhong‑Wei Wen Xiao‑Guang Wu Xuan Wu Cong Xia yong‑ji Yu Guo‑Hui zhang Hang‑Chang zhang Lin‑Hao zhang Qi‑Wei zhang Xian‑Peng zhang Yu‑Liang zhang Yue zhang Zhi‑yong zhang Zhi‑Hao Zhou Ke‑Jun zhu Chong Zou Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China North Night Vision Science and Technology(Nanjing)Research Institute Co.Ltd Nanjing 211106China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Modern Physics Fudan UniversityShanghai 200433China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China China Academy of Engineering Physics Institute of Nuclear Physics and ChemistryMianyang 621900China USTC archaeometry lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China China Shipbuilding Trading Co. LtdBeijing 100044China

Neutron resonance imaging(NRI)has recently emerged as an appealing technique for neutron *** complexity surpasses that of conventional transmission imaging,as it requires a high demand for both a neutron source and ***,the progression of NRI technology has been sluggish since its inception in the 1980s,particularly considering the limited studies analyzing the neutron energy range above *** white neutron source(Back-n)at the China Spallation Neutron Source(CSNS)provides favorable beam conditions for the development of the NRI technique over a wide neutron energy range from eV to ***-sensitive microchannel plates(MCP)have emerged as a cutting-edge tool in the field of neutron detection owing to their high temporal and spatial resolutions,high detection efficiency,and low *** this study,we report the development of a 10B-doped MCP detector,along with its associated electronics,data processing system,and NRI experiments at the *** heavy elements such as gold,silver,tungsten,and indium can be easily identified in the transmission images by their characteristic resonance peaks in the 1–100 eV energy range;the more difficult medium-weight elements such as iron,copper,and aluminum with resonance peaks in the 1–100 keV energy range can also be *** particular,results in the neutron energy range of dozens of keV(Aluminum)are reported here for the first time.

关键词： Neutron resonance imaging 10B doped MCP detector White neutron source Sample nuclide identification

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In-beam gamma rays of CSNS Back-n characterized by black resonance filter

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Nuclear Science and Techniques 2024年第10期35卷 149-160页

作者： jin-Cheng Wang jie Ren Wei jiang Xi-Chao Ruan Ying-Yi Liu Hao-Lan Yang Kuo-Zhi Xu Xin-Yi Pan Qi Sun jie Bao Han-Xiong huang Hao-Fan Bai jiang-Bo Bai ping Cao Qi-ping Chen yong-Hao Chen Wen-Hao Duan An-Chuan Fan Rui-Rui Fan Chang-qing Feng Min-Hao Gu Chang-cai Han Zi-jie Han Guo-zhu He yong-Cheng He Yang Hong Yi-Wei Hu Zhi-jie jiang ling Kang Chang-Lin Lan Bo Li Feng Li Qiang Li Xiao Li Yang Li jie Liu Rong Liu Shu-Bin Liu Yi-Na Liu Guang-Yuan Luan Chang-Jun Ning Yi-jia Qiu Wen-Kai Ren Zhi-Zhou Ren Zhao-Hui Song Kang Sun Zhi-Xin Tan jing-Yu Tang Sheng-Da Tang Li-jiao Wang Peng-Cheng Wang Zhao-Hui Wang Zhong-Wei Wen Xiao-Guang Wu Xuan Wu Ze-Peng Wu Cong Xia Li-Kun Xie Han Yi Tao Yu yong-ji Yu Guo-Hui zhang Hang-Chang zhang Qi-Wei zhang Xian-Peng zhang Yu-Liang zhang Zhi-yong zhang Mao-Yuan Zhao Zhi-Hao Zhou Ke-Jun zhu Chong Zou Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Modern Physics Fudan UniversityShanghai 200433China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China USTC Archaeometry Lab University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China Institute of Advanced Technology University of Science and Technology of ChinaHefei 230027China

The back-streaming white-neutron beamline(Back-n)of the China Spallation Neutron Source is an essential neutronresearch platform built for the study of nuclear data,neutron physics,and neutron *** types of cross-sectional neutron-reaction measurements have been performed at Back-n since early *** measurements have shown that a significant number of gamma rays can be transmitted to the experimental stations of Back-n along with the neutron *** gamma rays,commonly referred to as in-beam gamma rays,can induce a non-negligible experimental background in neutron-reaction *** the characteristics of in-beam gamma rays is important for understanding the experimental ***,measuring in-beam gamma rays is challenging because most gamma-ray detectors are sensitive to neutrons;thus,discriminating between neutron-induced signals and those from in-beam gamma rays is *** this study,we propose the use of the black resonance filter method and a CeBr_(3) scintillation detector to measure the characteristics of the in-beam gamma rays of *** types of black resonance filters,^(181)Ta,^(59)Co,^(nat)Ag,and^(nat)Cd,were used in this *** time-of-flight(TOF)technique was used to select the detector signals remaining in the absorption region of the TOF spectra,which were mainly induced by in-beam gamma *** energy distribution and flux of the in-beam gamma rays of Back-n were determined by analyzing the deposited energy spectra of the CeBr_(3) scintillation detector and using Monte Carlo *** on the results of this study,the background contributions from in-beam gamma rays in neutron-reaction measurements at Back-n can be reasonably evaluated,which is beneficial for enhancing both the experimental methodology and data analysis.

关键词： In-beam gamma rays Back-n CeBr_(3)scintillator Black filter resonance technique

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The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-Li Luo yong-Heng Zhao Gang Zhao Li-cai Deng Xiao-Wei Liu Yi-Peng jing Gang Wang Hao-Tong zhang jian-Rong Shi Xiang-Qun Cui Yao-Quan Chu Guo-ping Li Zhong-Rui Bai Yue Wu Yan cai Shu-Yun Cao Zi-huang Cao Jeffrey L.Carlin hai-Yuan Chen jian-Jun Chen Kun-Xin Chen Li Chen xue-Lei Chen Xiao-Yan Chen Ying Chen Norbert Christlieb jia-Ru Chu Chen-Zhou Cui Yi-Qiao Dong Bing Du Dong-Wei Fan Lei Feng jian-Ning Fu Peng Gao xue-Fei Gong Bo-Zhong Gu Yan-Xin Guo Zhan-Wen Han Bo-Liang He jin-Liang Hou yong-Hui Hou Wen Hou Hong-zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Zhi-Ying Huo Lei jia Fang-Hua jiang Xiang jiang Zhi-Bo jiang Ge jin Xiao Kong Xu Kong Ya-Juan Lei Ai-Hua Li Chang-Hua Li Guang-Wei Li hai-Ning Li jian Li Qi Li Shuang Li Sha-Sha Li Xin-Nan Li Yan Li Yin-Bi Li Ye-ping Li Yuan Liang Chien-Cheng Lin Chao Liu Gen-Rong Liu Guan-Qun Liu Zhi-Gang Liu Wen-Zhi Lu Yu Luo Yin-Dun Mao Heidi Newberg ji-Jun Ni Zhao-Xiang Qi yong-Jun Qi Shi-Yin Shen Huo-Ming Shi jing Song Yi-Han Song Ding-Qiang Su Hong-Jun Su Zheng-Hong Tang qing-Sheng Tao Yuan Tian Dan Wang Da-Qi Wang Feng-Fei Wang Guo-Min Wang hai Wang Hong-Chi Wang jian Wang jia-Ning Wang jian-ling Wang jian-ping Wang Jun-Xian Wang Lei Wang Meng-Xin Wang Shou-Guan Wang Shu-qing Wang Xia Wang Ya-Nan Wang You Wang Yue-Fei Wang You-Fen Wang Peng Wei Ming-Zhi Wei Hong Wu Ke-Fei Wu xue-Bing Wu Yu-Zhong Wu Xiao-Zheng Xing ling-Zhe Xu Xin-Qi Xu Yan Xu Tai-Sheng Yan De-Hua Yang hai-Feng Yang Hui-Qin Yang Ming Yang Zheng-Qiu Yao yong Yu Hui Yuan hai-Bo Yuan hai-Long Yuan Wei-Min Yuan Chao Zhai En-Peng zhang Hua-Wei zhang jian-Nan zhang Li-Pin zhang Wei zhang yong zhang Yan-Xia zhang Zheng-Chao zhang Ming Zhao Fang Zhou Xu Zhou jie zhu yong-Tian zhu Si-Cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University Yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

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Increased circulating level of interleukin-6 and CD8+T cell exhaustion are associated with progression of COVID-19

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Infectious Diseases of Poverty 2020年第6期9卷 42-50页

作者： Peng-Hui Yang Yi-Bo Ding Zhe Xu Rui Pu ping U jin Yan ji-Luo Liu Fan-ping Meng Lei huang Lei Shi Tian-Jun jiang En-Qiang Qin Min Zhao Da-Wei zhang Peng Zhao ling-Xiang Yu Zhao-hai Wang Zhi-Xian Hong Zhao-Hui Xiao qing Xi De-Xi Zhao Peng Yu cai-Zhong zhu zhu Chen Shao-Geng zhang Jun-Sheng ji Fu-Sheng Wang Guang-Wen Cao Department of Hepatobiliary The Fifth Medical Center of PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijing100039China Treatment and Research Center for Infectious Diseases The Fifth Medical Center of PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijing100039China Department of Epidemiology Second Military Medical UniversityShanghai200433China

Background: Coronavirus disease 2019(COVID-19)is *** is critical to identify COVID-19 patients who are most likely to develop a severe *** study was designed to determine the clinical and epidemiological features of COVID-19 patients associated with the development of pneumonia and factors associated with disease ***:: Seventy consecutive patients with etiologically confirmed COVID-19 admitted to PLA General Hospital in Beijing,China from December 27,2019 to March 12,2020 were enrolled in this study and followed-up to March 16,*** in clinical and laboratory findings between COVID-19 patients with pneumonia and those without were determined by theχ2 test or the Fisher exact test(categorical variables)and independent group t test or Mann–Whitney U test(continuous variables).The Cox proportional hazard model and Generalized Estimating Equations were applied to evaluate factors that predicted the progression of ***: The mean incubation was 8.67(95%confidence interval,6.78–10.56)*** duration from the first test severe acute respiratory syndrome coronavirus 2-positive to conversion was 11.38(9.86–12.90)*** to pneumonia-free patients,pneumonia patients were 16.5 years older and had higher frequencies of having hypertension,fever,and cough and higher circulating levels of neutrophil proportion,interleukin-6,low count(<190/µl)of CD8+T cells,and neutrophil/lymphocyte *** patients deteriorated during *** regression analysis indicated that older age and higher serum levels of interleukin-6,C-reactive protein,procalcitonin,and lactate at admission significantly predicted the progression of *** hospitalization,circulating counts of T lymphocytes,CD4+T cells,and CD8+T cells were lower,whereas neutrophil proportion,neutrophil/lymphocyte ratio,and the circulating levels of interleukin-6,C-reactive protein,and procalcitonin were higher,in pneumonia patients than in pneumo

关键词： COVID-19 Progression Interleukin-6 CD8+T cell exhaustion Prospective case series

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The Lyman-alpha Solar Telescope(LST) for the ASO-S mission——Ⅱ. design of LST

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Research in Astronomy and Astrophysics 2019年第11期19卷 33-48页

作者： Bo Chen Hui Li Ke-Fei Song Quan-Feng Guo Pei-jie zhang ling-ping He Shuang Dai Xiao-Dong Wang hai-Feng Wang Chun-Long Liu Hong-ji zhang Guang zhang Yunqi Wang Shi-jie Liu Hong-Xin zhang Lei Liu Shi-Lei Mao Yang Liu jia-Hao Peng Peng Wang Liang Sun Yang Liu Zhen-Wei Han Yan-Long Wang Kun Wu Guang-Xing Ding Peng Zhou Xin Zheng Ming-Yi Xia qing-Wen Wu jin-jiang Xie Ya Chen Shu-Mei Song Hong Wang Bo zhu Chang-Bo Chu Wen-Gang Yang Li Feng Yu huang Wei-Qun Gan Ying Li jing-Wei Li Lei Lu jian-Chao xue Bei-Li Ying Ming-Zhe Sun Cheng zhu Wei-Min Bao Lei Deng Zeng-Shan Yin Changchun Institute of Optics FineMechanics and PhysicsChinese Academy of SciencesChangchun 130033China State Key Laboratory of Applied Optics Changchun 130033China Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210034China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China Xi’an Institute of Optics and Precision Mechanics Chinese Academy of SciencesXi’an 710119China Shandong University Weihai 264209China Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 201210China

As one of the three payloads for the Advanced Space-based Solar Observatory(ASO-S)mission,the Lyman-alpha(Lyα)Solar Telescope(LST)is composed of three instruments:a Solar Corona Imager(SCI),a LyαSolar Disk Imager(SDI)and a full-disk White-light Solar Telescope(WST).When working in-orbit,LST will simultaneously perform high-resolution imaging observations of all regions from the solar disk to the inner corona up to 2.5 R⊙(R⊙stands for the mean solar radius)with a spatial resolution of 4.8′′and 1.2′′for coronal and disk observations,respectively,and a temporal resolution of 30–120 s and 1–120 s for coronal and disk observations,*** maximum exposure time can be up to20 s due to precise pointing and image stabilization *** the three telescopes of LST,SCI is a dual-waveband coronagraph simultaneously and independently observing the inner corona in the HI Lyα(121.6±10 nm)line and white light(WL)(700±40 nm)wavebands by using a narrowband Lyαbeam splitter and has a field of view(FOV)from 1.1 to 2.5 R⊙.The stray-light suppression level can attain<10^-6 B⊙(B⊙is the mean brightness of the solar disk)at 1.1 R⊙and≤5×10^-8 B⊙at 2.5 R⊙.SDI and WST are solar disk imagers working in the Lyαline and 360.0 nm wavebands,respectively,which adopt an off-axis two-mirror reflective structure with an FOV up to 1.2 R⊙,covering the inner coronal edge area and relating to coronal *** present the up-to-date design for the LST payload.

关键词： telescopes—instrumentation high angular resolution—Sun flares—Sun coronal mass ejections(CMEs)—Sun UV radiation

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Timing analysis of the black hole candidate EXO 1846–031 with Insight-HXMT monitoring

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Research in Astronomy and Astrophysics 2021年第3期21卷 193-204页

作者： He-Xin Liu Yue huang Guang-Cheng Xiao qing-Cui Bu jin-Lu Qu Shu zhang Shuang-Nan zhang Shu-Mei jia Fang-Jun Lu Xiang Ma Lian Tao Wei zhang Li Chen Li-Ming Song Ti-Pei Li Yu-Peng Xu xue-Lei Cao yong Chen Cong-Zhan Liu Ce cai Zhi Chang Gang Chen Tian-Xiang Chen Yi-Bao Chen Yu-Peng Chen Wei Cui Wei-Wei Cui jing-Kang Deng yong-Wei Dong Yuan-Yuan Du Min-xue Fu Guan-Hua Gao He Gao Min Gao Ming-Yu Ge Yu-Dong Gu Ju Guan Cheng-Cheng Guo Da-Wei Han jia Huo Lu-Hua jiang Wei-Chun jiang jing jin yong-jie jin ling-Da Kong Bing Li Cheng-Kui Li Gang Li Mao-Shun Li Wei Li Xian Li Xiao-Bo Li Xu-Fang Li Yang-Guo Li Zheng-Wei Li Xiao-Hua Liang jing-Yuan Liao Bai-Sheng Liu Guo-qing Liu Hong-Wei Liu Xiao-jing Liu Yi-Nong Liu Bo Lu xue-Feng Lu Qi Luo Tao Luo Bin Meng Yi Nang jian-Yin Nie Ge Ou Na Sai Ren-Cheng Shang Xin-Ying Song Liang Sun Ying Tan You-Li Tuo Chen Wang Guo-Feng Wang Juan Wang ling-Jun Wang Weng-Shuai Wang Yu-Sa Wang Xiang-Yang Wen Bai-Yang Wu Bo-Bing Wu Mei Wu Shuo Xiao Shao-Lin Xiong He Xu jia-Wei Yang Sheng Yang Yan-ji Yang Yi-Jung Yang Qi-Bin Yi Qian-qing Yin Yuan You Ai-Mei zhang Cheng-Mo zhang Fan zhang Hong-Mei zhang Juan zhang Tong zhang Wan-Chang zhang Wen-Zhao zhang Yi zhang Yi-Fei zhang yong-jie zhang Yuan-Hang zhang Yue zhang Zhao zhang Zhi zhang Zi-Liang zhang hai-Sheng Zhao Xiao-Fan Zhao Shi-jie Zheng Yao-Guang Zheng Deng-Ke Zhou jian-Feng Zhou Yu-Xuan zhu Ren-Lin Zhuang Yue zhu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Institut fur Astronomie und Astrophysik Kepler Center for Astro and Particle PhysicsEberhard Karls Universität72076 TubingenGermany Department of Astronomy Beijing Normal UniversityBeijing 100088China Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China College of Physics Sciences&Technology Hebei UniversityBaoding 071002Hebei ProvinceChina

We present the observational results from a detailed timing analysis of the black hole candidate EXO 1846-031 during its outburst in 2019 with the observations of Insight-HXMT,NICER and *** outburst can be classified roughly into four different ***-C quasi-periodic oscillations(QPOs)observed by NICER(about 0.1-6 Hz)and Insight-HXMT(about 0.7-8 Hz)are also reported in this ***,we study various physical quantities related to QPO *** QPO rms-frequency relationship in the energy band 1-10 keV indicates that there is a turning pointing in frequency around2 Hz,which is similar to that of GRS 1915+105.A possible hypothesis for the relationship above may be related to the inclination of the source,which may require a high inclination to explain *** relationships between QPO frequency and QPO rms,hardness,total fractional rms and count rate have also been found in other transient sources,which can indicate that the origin of type-C QPOs is non-thermal.

关键词： X-ray binaries black hole candidate QPO EXO 1846–031

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甲状腺乳头状癌首次手术治疗不当的第二次处理

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中国癌症杂志 2007年第8期17卷 644-646页

作者：朱永学陈小平王玉龙张凌黄彩平嵇庆海复旦大学附属肿瘤医院头颈外科复旦大学上海医学院肿瘤学系上海200032

背景与目的:甲状腺乳头状癌首次外科治疗常有不当,需要再次手术。我们探讨这类患者的处理原则和手术方式。方法:回顾性分析本院收治的外院已手术治疗的甲状腺乳头状癌患者132例(为了排除肿瘤局部复发因素,本组不包括在外院手术已经超过... 详细信息

背景与目的:甲状腺乳头状癌首次外科治疗常有不当,需要再次手术。我们探讨这类患者的处理原则和手术方式。方法:回顾性分析本院收治的外院已手术治疗的甲状腺乳头状癌患者132例(为了排除肿瘤局部复发因素,本组不包括在外院手术已经超过6个月以上的患者),比较手术并发症,分析原发灶局部癌肿残留及Ⅵ区淋巴结转移的临床资料。结果:原发灶局部有癌肿残留占66.7%(88/132),同时Ⅵ区淋巴结有转移的65例,Ⅵ区淋巴结转移率73.9%(65/88)。在44例原发灶未有癌残留中,Ⅵ区淋巴结转移的有34例,Ⅵ区淋巴结转移率77.3%(34/44)。原发灶局部癌肿残留+Ⅵ区淋巴结转移共有122例,占92.4%(122/132)。初次手术的并发症:声音嘶哑占3.79%(5/132)。再次手术并发症:发生声音嘶哑占1.57%(2/127)。结论:我们推荐以下处理原则:①对于甲状腺肿块术中冰冻病理诊断为恶性的,应行一侧腺叶加峡部切除。同期行Ⅵ区淋巴结清扫。②术中冰冻病理良恶性不能鉴别的情况下,应当推行腺叶切除加峡部切除;怀疑是恶性的,同期行Ⅵ区淋巴结清扫。③在行Ⅵ区淋巴结清扫中,喉返神经应常规暴露,保证Ⅵ区淋巴结的清扫彻底性。

关键词：甲状腺乳头状癌冰冻病理 Ⅵ区淋巴结

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趋化因子受体CXCR4在下咽鳞癌组织中的表达及其意义

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中国癌症杂志 2008年第6期18卷 420-423页

作者：孙国华朱永学黄彩平王宇张凌王学辰嵇庆海复旦大学附属肿瘤医院头颈外科复旦大学上海医学院肿瘤学系上海200032

背景与目的:有研究表明,趋化因子受体CXCR4及其配体SDF-1(stromal cell-derived factor 1)与肿瘤的增殖、分化和转移等恶性表现密切相关。本研究探讨趋化因子受体CXCR4在下咽鳞状细胞癌(下咽鳞癌)组织中的表达情况及其与下咽鳞癌各临床... 详细信息

背景与目的:有研究表明,趋化因子受体CXCR4及其配体SDF-1(stromal cell-derived factor 1)与肿瘤的增殖、分化和转移等恶性表现密切相关。本研究探讨趋化因子受体CXCR4在下咽鳞状细胞癌(下咽鳞癌)组织中的表达情况及其与下咽鳞癌各临床病理资料的关系,为临床治疗提供理论基础。方法:下咽鳞癌原发灶组织标本43例,其中淋巴结阳性34例,淋巴结阴性9例,通过免疫组化技术检测CXCR4表达,并取相应27例正常癌旁下咽部组织与原发灶作为对照,探讨其与下咽鳞癌的关系。结果:下咽鳞癌原发灶及正常下咽部对照组织CXCR4阳性表达率分别为95.3%和22.2%(P<0.01)。淋巴结阳性转移灶CXCR4表达率(82.4%)显著高于阴性淋巴结(22.2%)(P<0.01)。随着病理分化程度的降低,CXCR4阳性表达率增加(P<0.05)。结论:CXCR4在下咽鳞癌组织呈高表达,其表达水平与肿瘤T分期、有无淋巴结转移、病理分级有关,对评估下咽癌的生物学行为有意义。

关键词：下咽肿瘤鳞状细胞癌 CXC类趋化因子受体4 免疫组织化学

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Fascin和Ki67在口腔鳞癌中的表达及其临床意义

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中国癌症杂志 2009年第4期19卷 257-261页

作者：王宇嵇庆海陆洪芬吴毅黄彩平朱永学张凌孙国华复旦大学附属肿瘤医院头颈外科复旦大学上海医学院肿瘤学系上海200032 复旦大学附属肿瘤医院病理科复旦大学上海医学院肿瘤学系上海200032

背景与目的:Fascin蛋白是一种结构独特的细胞骨架蛋白,能促使活性细胞胞膜突起并增加细胞运动性。目前已经观察到Fascin在人类食管、胆管、乳腺、结肠、卵巢、胰腺和胃等上皮组织起源的肿瘤中有表达,其表达水平和部分肿瘤的预后有关。但... 详细信息

背景与目的:Fascin蛋白是一种结构独特的细胞骨架蛋白,能促使活性细胞胞膜突起并增加细胞运动性。目前已经观察到Fascin在人类食管、胆管、乳腺、结肠、卵巢、胰腺和胃等上皮组织起源的肿瘤中有表达,其表达水平和部分肿瘤的预后有关。但Fascin与口腔鳞癌的研究较少。本研究应用组织芯片技术研究Fascin和Ki67在口腔鳞癌中的表达情况及其临床意义。方法:回顾性分析1991-2005年在我科诊治的84例口腔鳞癌患者,并将患者手术标本的病理蜡块制作组织芯片。应用免疫组化法检测Fascin和Ki67在口腔鳞癌组织中的表达情况。收集相关临床病理资料进行统计分析。研究淋巴结转移、T分期(T1与T2～4)、肿瘤分期(Ⅰ/Ⅱ期与Ⅲ/Ⅳ)、分化、肌肉侵犯(54例舌鳞癌)与Fascin的相关性。结果:Fascin高表达与淋巴结转移、较高T分期、较高肿瘤分期、较差分化相关;在54例舌鳞癌中与肌肉侵犯相关(P=0.002)。Fascin和Ki67表达呈正相关,两个指标中高表达与低表达患者的生存率间差异有显著性(P=0.034)。结论:Fascin在口腔鳞癌的进展中可能起有重要作用,可作为口腔鳞癌的肿瘤标志物,并与患者预后有关。

关键词： Fascin Ki67 免疫组化口腔鳞癌预后

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Efficacy and safety of the long-acting fusion inhibitor albuvirtide in antiretroviral-experienced adults with human immunodeficiency virus-1:interim analysis of the randomized,controlled,phase 3,non-inferiority TALENT study

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Chinese Medical Journal 2020年第24期133卷 2919-2927页

作者： Bin Su Cheng Yao qing-Xia Zhao Wei-ping cai Min Wang Hong-Zhou Lu Yuan-Yuan Chen Li Liu Hui Wang Yun He Yu-huang Zheng ling-Hua Li jin-Feng Chen jian-Hua Yu Biao zhu Min Zhao yong-Tao Sun Wen-Hui Lun Wei Xia Li-Jun Sun Li-Li Dai Tai-Yi jiang Mei-Xia Wang qing-Shan Zheng hai-Yan Peng Yao Wang Rong-jian Lu jian-Hua Hu Hui Xing Yi-Ming Shao Dong Xie Tong zhang Fu-jie zhang Hao Wu TALENT Study Team Center for Infectious Diseases Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Frontier Biotechnologies Inc. NanjingJiangsu 211122China Department of Infectious Diseases Infectious Disease Hospital of Henan ProvinceZhengzhouHenan 450061China Infectious Disease Center Guangzhou Eighth People’s HospitalGuangzhou Medical UniversityGuangzhouGuangdong 510060China Institute of HIV/AIDS The First Hospital of ChangshaChangshaHunan 410005China Department of Infectious Diseases Shanghai Public Health Clinical CenterFudan UniversityShanghai 201508China Department of Infectious Diseases National Clinical Center for Infectious DiseasesShenzhen Third People’s HospitalShenzhenGuangdong 518112China Department of Infectious Diseases The Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China Department of Infectious Diseases Xixi Hospital of HangzhouHangzhouZhejiang 310023China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesThe First Affiliated HospitalZhejiang UniversityHangzhouZhejiang 310003China National Clinical Research Center for Infectious Diseases the Fifth Medical Center of PLA General HospitalBeijing 100039China Department of Infectious Diseases Tangdu HospitalThe Fourth Military Medical UniversityXi’anShaanxi 710038China Clinical and Research Center of Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Center for Drug Clinical Research Shanghai University of Traditional Chinese MedicineShanghai 201203China Beijing Co-CRO Medical Development Co. Ltd.Beijing 100711China State Key Laboratory for Infectious Disease Prevention and Control National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China 不详

Background:Albuvirtide is a once-weekly injectable human immunodeficiency virus(HIV)-1 fusion *** present interim data for a phase 3 trial assessing the safety and efficacy of albuvirtide plus lopinavir-ritonavir in HIV-1-infected adults already treated with antiretroviral ***:We carried out a 48-week,randomized,controlled,open-label non-inferiority trial at 12 sites in *** on the World Health Organization(WHO)-recommended first-line treatment for>6 months with a plasma viral load>1000 copies/mL were enrolled and randomly assigned(1:1)to receive albuvirtide(once weekly)plus ritonavir-boosted lopinavir(ABT group)or the WHO-recommended second-line treatment(NRTI group).The primary endpoint was the proportion of patients with a plasma viral load below 50 copies/mL at 48 ***-inferiority was prespecified with a margin of 12%.Results:At the time of analysis,week 24 data were available for 83 and 92 patients,and week 48 data were available for 46 and 50 patients in the albuvirtide and NRTI groups,*** 48 weeks,80.4%of patients in the ABT group and 66.0%of those in the NRTI group had HIV-1 RNA levels below 50 copies/mL,meeting the criteria for *** the per-protocol population,the superiority of albuvirtide over NRTI was *** frequency of grade 3 to 4 adverse events was similar in the two groups;the most common adverse events were diarrhea,upper respiratory tract infections,and grade 3 to 4 increases in triglyceride *** function was significantly more impaired at 12 weeks in the patients of the NRTI group who received tenofovir disoproxil fumarate than in those of the ABT ***:The TALENT study is the first phase 3 trial of an injectable long-acting HIV *** interim analysis indicates that once-weekly albuvirtide in combination with ritonavir-boosted lopinavir is well tolerated and non-inferior to the WHO-recommended second-line regimen in patients with first-line treatme

关键词： HIV Fusion inhibitor Albuvirtide LPV/r Phase 3 clinical trial

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