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The 6-hour lactate clearance rate in predicting 30-day mortality in cardiogenic shock

Journal of Intensive Medicine 2024年第3期4卷 393-399页

作者： Junfeng Wang mingxia ji Department of Intensive Care Unit Yiwu Central HospitalYiwuZhejiangChina

Background Early evaluation of prognosis in cardiogenic shock(CS)is crucial for tailored treatment *** lactate clearance and lactate levels are considered useful prognostic biomarkers in patients with ***,there is yet no literature comparing the 6-hour lactate clearance rate(Δ6Lac)with lactate levels measured at admission(L1)and after 6 h(L2)to predict 30-day mortality in *** In this observational cohort study,95 patients with CS were treated at Department of Intensive Care Unit,Yiwu Central Hospital between January 2020 and December *** these,88 patients met the eligibility *** lactate levels were measured after admission(L1)as the baseline lactate value,and were measured after 6 h(L2)following *** primary endpoint of the study was survival rate at 30 days.A receiver operating characteristic curve was used for data *** and multivariate Cox regression analyses were performed based onΔ***–Meier(KM)survival curves were generated to compare the 30-day survival rates among L1,L2,andΔ*** TheΔ6Lac model showed the highest area under the curve value(0.839),followed by the L2(0.805)and L1(0.668)***Δ6Lac model showed a sensitivity of 84.2%and specificity of 75.4%.The L1 and L2 models had sensitivities of 57.9%each and specificities of 89.9%and 98.6%,*** cut-off values forΔ6Lac,L1,and L2 were 18.2%,6.7 mmol/L,and 6.1 mmol/L,*** Cox regression analysis revealed a significant association betweenΔ6Lac and 30-day *** adjusting for five models in multivariate Cox regression,Δ6Lac remained a significant risk factor for 30-day mortality in patients with *** our fifth multivariate Cox regression model,Δ6Lac remained a risk factor associated with 30-day mortality(hazard ratio[HR]=5.14,95%confidence interval[CI]:1.48 to 17.89,P=0.010)as well as L2(HR=8.42,95%CI:1.26 to 56.22,P=0.028).The KM survival curve analysis revealed that L1>6.7 mmol/L(HR=8.08,95%

关键词： Lactates The 6-h lactate clearance rate Cardiogenic shock Mortality Cox regression

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Dryland Expansion in Northern China from 1948 to 2008

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Advances in Atmospheric Sciences 2015年第6期32卷 870-876页

作者： LI Yue HUANG jianping ji mingxia RAN jinjiang Key Laboratory for Semi-Arid Climate Change of the Ministry of Education College of Atmospheric Sciences Lanzhou University

This study examines the expansion of drylands and regional climate change in northern China by analyzing the variations in aridity index （AI）, surface air temperature （SAT）, precipitation and potential evapotranspiration （PET） from 1948 to 2008. It is found that the drylands of northern China have expanded remarkably in the last 61 years. The area of drylands of the last 15 years （1994--2008） is 0.65 × 106 km2 （12%） larger than that in the period 1948-62. The boundary of drylands has extended eastward over Northeast China by about 2 °of longitude and by about 1° of latitude to the south along the middle- to-lower reaches of the Yellow River. A zonal band of expansion of semi-arid regions has occurred, stretching from western Heilongjiang Province to southern Gansu Province, while shifts to the east of semi-arid regions in dry subhumid regions have also occurred. Results show that the aridity trend of drylands in northern China is highly correlated with the long-term trend of precipitation and PET, and the expansion of semi-arid regions plays a dominant role in the areal extent of drylands, which is nearly 10 times larger than that in arid and subhumid regions.

关键词： aridity index dryland expansion climate variation northern China

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Impacts of meteorological parameters on the occurrence of air pollution episodes in the Sichuan basin

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Journal of Environmental Sciences 2022年第4期34卷 308-321页

作者： Qian Guo Dongyou Wu Chunxue Yu Tianshuang Wang mingxia ji Xin Wang Key Laboratory for Semi-Arid Climate Change of the Ministry of Education College of Atmospheric SciencesLanzhou UniversityLanzhou 730000China Research Center for Eco-environmental Engineering Dongguan University of TechnologyDongguan 523808China

Episodes of fine-particulate matter(PM_(2.5))pollution are a widespread and common occurrence in China,and have potentially serious implications for human *** conditions play an important role in air quality and influence the formation of regional air pollution *** study applied a new classification method and daily PM_(2.5)concentration data to(a)evaluate different levels of air pollution in the Sichuan-Chongqing region between 2015 and 2017,and(b)investigate their relationships with meteorological parameters including atmospheric boundary layer height,wind speed,temperature inversion,weather type,and atmospheric *** identified a total of 40 air pollution episodes,the most severe of which occurred in winter when the atmospheric layer height was *** heavy pollution events also coincided with low surface(10 m)wind speeds and temperature inversions,weather conditions that generally result from low pressure over the northwestern Sichuan Basin(90-102°E,28-36°N)and southerly atmospheric transport.

关键词： Air pollution Pollution episode PM_(2.5) Meteorological factors

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6小时血乳酸及乳酸清除率对心源性休克早期死亡的预测价值

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实用休克杂志（中英文） 2024年第2期8卷 98-103页

作者：王俊峰季明霞何建新义乌市中心医院重症医学科

目的探讨心源性休克患者入科后第6小时血乳酸及乳酸清除率对早期预后的影响。方法收集2020年1月至2022年12月义乌市中心医院收治的88例心源性休克患者临床资料,根据30d转归情况分为存活组(69例)和死亡组(19例),对入科第6小时乳酸(Lac_6h... 详细信息

目的探讨心源性休克患者入科后第6小时血乳酸及乳酸清除率对早期预后的影响。方法收集2020年1月至2022年12月义乌市中心医院收治的88例心源性休克患者临床资料,根据30d转归情况分为存活组(69例)和死亡组(19例),对入科第6小时乳酸(Lac_6h)、乳酸清除率(Δ6Lac)行受试者工作特征(ROC)曲线分析,根据截断值分3个亚组:group A:Lac_6h≤6.1mmol/L且Δ6Lac>18.2%;group B:Lac_6h≤6.1mmol/L且Δ6Lac≤18.2%;group C:Lac_6h>6.1mmol/L且Δ6Lac取任意值,对亚组绘制生存曲线并进行多因素COX分析。结果(1)死亡组入科第6小时乳酸7.9(1.7,11.0)mmol/L,高于存活组1.6(1.2,2.0)mmol/L,而6h乳酸清除率7.9%(30.6%,-17.2%),低于存活组37.5%(20.0%,53.9%),差异均有统计学意义(P0.05),多因素COX回归校正Lac_6h>6.1mmol/L是死亡的危险因素HR 24.22,95%CI:4.31-138.52。结论联合入科第6小时乳酸及6h乳酸清除率可作为心源性休克早期监测和评估预后重要指标,临床上可互为参考,入科后第6小时乳酸>6.1mmol/L是心源性休克患者30d死亡的重要危险因素。

关键词：心源性休克 6小时乳酸清除率入科第6小时乳酸 30天病死率

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Seasonal to sub-seasonal variations of the Asian Tropopause Aerosols Layer affected by the deep convection,surface pollutants and precipitation

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Journal of Environmental Sciences 2022年第4期34卷 53-65页

作者： Dongyou Wu Tenglong Shi Xiaoying Niu Ziqi Chen jiecan Cui Yang Chen Xueying Zhang Jun Liu mingxia ji Xin Wang Wei Pu College of Atmospheric Sciences Lanzhou UniversityLanzhou 730000China jilin Weather Modification Office Changchun 130000China School of Earth System Science Tianjin UniversityTianjin 300072China

The Asian Tropopause Aerosols Layer(ATAL)refers to an accumulation of aerosols in the upper troposphere and lower stratosphere during boreal summer over Asia,which has a fundamental impact on the monsoon system and climate *** this study,we primarily analyze the seasonal to sub-seasonal variations of the ATAL and the factors potentially influencing those variations based on MERRA2 *** ability of the reanalysis to reproduce the ATAL is well validated by CALIPSO observations from May to October *** results reveal that the ATAL has a synchronous spatiotemporal pattern with the development and movement of the Asian Summer *** enhancement of ATAL intensity is found during the prevailing monsoon period of July-August,with two maxima centered over South Asia and the Arabian *** to the fluctuations of deep convection,the ATAL shows an episodic variation on a timescale of 7-12 *** analysis indicates that deep convection dominates the variability of the ATAL with a contribution of 62.7%,followed by a contribution of 36.6%from surface *** impact of precipitation is *** ATAL further shows a clear diurnal variation:the peak of ATAL intensity occurs from 17:30 to 23:30 local time(LT),when the deep convection becomes strongest;the minimum ATAL intensity occurs around 8:30 LT owing to the weakened deep convection and photochemical reactions in *** aerosol components of the ATAL show different spatiotemporal patterns and imply that black carbon and organic carbon come mainly from India,whereas sulfate comes mainly from China during the prevailing monsoon period.

关键词： ATAL Seasonal to sub-seasonal variations Deep convection Asian Summer Monsoon

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香豆素通过调控组蛋白去甲基化酶3和骨髓分化蛋白2改善脓毒症相关AKI的机制研究

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浙江医学 2024年第7期46卷 682-687,695,I0003页

作者：金光军赵金凯徐步海张建成潘旭鸣季明霞浙江中医药大学附属第二医院医务部杭州310005 浙江中医药大学附属第二医院全科医学科杭州310005 浙江中医药大学附属第二医院急诊医学科杭州310005 浙江中医药大学第二临床医学院义乌市中心医院重症医学科

目的探讨香豆素(Sco)通过调控组蛋白去甲基化酶3(JMJD3)和骨髓分化蛋白2(MD-2)改善脓毒症相关急性肾损伤(AKI)的作用机制。方法24只C57BL6小鼠根据随机数字表法分为对照组、脂多糖(LPS)组、LPS+40 mg/kg Sco组和LPS+80 mg/kg Sco组。除... 详细信息

目的探讨香豆素(Sco)通过调控组蛋白去甲基化酶3(JMJD3)和骨髓分化蛋白2(MD-2)改善脓毒症相关急性肾损伤(AKI)的作用机制。方法24只C57BL6小鼠根据随机数字表法分为对照组、脂多糖(LPS)组、LPS+40 mg/kg Sco组和LPS+80 mg/kg Sco组。除对照组外,其余3组小鼠腹腔注射LPS 10 mg/kg建立脓毒症相关AKI模型,LPS+40 mg/kg Sco组和LPS+80 mg/kg Sco组小鼠在造模成功后分别腹腔注射Sco 40 mg/kg和80 mg/kg,对照组小鼠腹腔注射0.9%氯化钠溶液2 mL/kg。采用HE染色和原位末端转移酶标记法染色检测小鼠肾脏组织损伤程度和细胞凋亡程度,ELISA法检测小鼠血清血肌酐(Scr)、血尿素氮(BUN)水平,Western blot法检测小鼠肾脏组织中JMJD3和MD-2蛋白表达水平。使用LPS(1μg/mL)处理人肾小管上皮细胞系HK-224 h,建立脓毒症细胞模型,随机分为对照组、LPS组、LPS+30μmol/L Sco组、LPS+60μmol/L Sco组、LPS+60μmol/L Sco+过表达对照组和LPS+60μmol/L Sco+过表达JMJD3组。采用流式细胞术检测细胞凋亡情况,Western blot法检测细胞中JMJD3和MD-2蛋白表达水平。结果与对照组小鼠相比,LPS组小鼠肾组织出现明显病理变化,部分肾小管变形,肾小管上皮细胞水肿,肾间质周围炎症细胞浸润,凋亡信号(棕褐色)增强,JMJD3和MD-2蛋白表达水平升高,血清中Scr、BUN水平均升高。而与LPS组相比,LPS+40 mg/kg Sco组和LPS+80 mg/kg Sco组小鼠肾脏组织以上病理变化明显改善,JMJD3和MD-2蛋白表达水平均降低,血清中Scr、BUN水平也均降低,并且LPS+80 mg/kg Sco组变化更明显。与对照组细胞相比,LPS组细胞凋亡水平升高,JMJD3和MD-2蛋白表达水平升高。而相较于LPS组,使用Sco处理后以上变化趋势发生逆转,且Sco浓度越高,趋势变化越显著。此外,过表达JMJD3后细胞凋亡水平升高,JMJD3和MD-2蛋白表达水平均升高。结论Sco通过抑制肾小管上皮细胞JMJD3和MD-2表达,减少细胞凋亡,从而改善脓毒症相关AKI。

关键词：脓毒症急性肾损伤香豆素蛋白去甲基化酶3 骨髓分化蛋白2

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中央国术馆馆刊及其社会功能

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上海体育学院学报 2019年第2期43卷 115-121页

作者：吉灿忠纪铭霞郭强河南师范大学体育学院河南新乡453007

对中央国术馆馆刊及其社会功能进行分析。中央国术馆在武术意识转变、传承传播、训练教学、理论研究、思想延承等方面做出了积极探索,其创办的《中央国术馆汇刊》《中央国术旬刊》《国术周刊》3种刊物,为近代武术发展注入了新能量:强有... 详细信息

对中央国术馆馆刊及其社会功能进行分析。中央国术馆在武术意识转变、传承传播、训练教学、理论研究、思想延承等方面做出了积极探索,其创办的《中央国术馆汇刊》《中央国术旬刊》《国术周刊》3种刊物,为近代武术发展注入了新能量:强有力地推动了尚武思潮,为武术走上竞赛道路扫除主观障碍,促进武术技术的整合、传承和扩散,诱发尚武者从科学和人文社会学科学理的角度认识武术。

关键词：中央国术馆武术刊物中央国术馆汇刊中央国术旬刊国术周刊武术传播

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Integrated interconnected porous and lamellar structures realized fast ion/electron conductivity in high-performance lithium-sulfur batteries

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Chinese Chemical Letters 2024年第6期35卷 161-167页

作者： Ya Song mingxia Zhou Zhu Chen Huali Nie jiao-jing Shao Guangmin Zhou School of Materials and Metallurgy Guizhou UniversityGuiyang 550025China Medical College of Guizhou University Guiyang 550025China College of Biological Science and Medical Engineering Donghua UniversityShanghai 201620China Shenzhen Geim Graphene Center Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China

The practical application of high-energy-density lithium-sulfur(Li-S)batteries have been highly praised for energy storage devices,while are largely hindered by the“shuttling effect”.Herein,core-shell carbon spheres composed of interlinked porous core and lamellar shell were designed to restrain the polysulfide *** microporous structure with pore size of around 1 nm effectively trap lithium ***,the interconnected porous core shortens the ion transfer distance and the lamellar carbon shell endows the carbon spheres with fast electron conduction,finally facilitating polysulfide conversion ***,the Li-S batteries with the carbon spheres as the interlayer show high discharge specific capacity of 1002 m Ah/g at 2 C with 574 m Ah/g remaining after 600 cycles,and high areal capacity of 5.48 m Ah/cm^(2) with sulfur loading of 4.67 mg/cm^(2) at 0.1 *** corresponding pouch cells also exhibit stable cycling stability with an initial discharge specific capacity of 1082 m Ah/g at 0.1 C.

关键词： Interlayer Shuttle effect Strong adsorption Porous carbon spheres Lithium-sulfur batteries

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Plasmon Bi in-situ anchored on BiOCl nanosheets assembled microspheres towards optimized photothermal-photocatalytic performance

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Chinese Chemical Letters 2024年第2期35卷 469-476页

作者： Dongxue Song mingxia Li Fan Yang Menghan Yu Zhenzi Li jie Chen Xiaoshuang Zhang Wei Zhou School of Chemistry and Materials Science Key Laboratory of Functional Inorganic Material ChemistryMinistry of Education of the People's Republic of ChinaHeilongjiang UniversityHarbin 150080China Shandong Provincial Key Laboratory of Molecular Engineering School of Chemistry and Chemical EngineeringQilu University of Technology (Shandong Academy of Sciences)Ji'nan 250353China

Interface engineering is of great importance to improve the photocatalytic ***,in-situ formation plasmon Bi/BiOCl nanosheets assembled heterojunction microspheres are fabricated via facile reductive solvothermal *** aldehyde group in the DMF structure is used to exert the weak reducing property of the solvent and thus strip out the metal Bi in *** metal Bi is anchored on surface of BiOCl firmly due to in-situ formation engineered interface,which could realize efficient charge transfer *** resultant Bi/BiOCl heterojunctions assemblies with narrow bandgap of 3.05 eV and mesoporous structure extend the photoresponse to visible light region and could provide sufficient surface active *** visible-light-driven photocatalytic degradation of high-toxic norfloxacin for Bi/BiOCl heterojunctions is up to 95.5%within 20 min,representing several times that of pristine BiOCl nanosheets and the physical *** is attributed to the in-situ formation of Bi/BiOCl heterojunctions and surface plasmon resonance(SPR)effect of plasmon Bi promoting charge transfer,and the obvious photothermal effect promoting the photocatalytic reaction,which are verified by experimental and density functional theory(DFT)*** strategy provides ideal perspectives for fabricating metal/semiconductor heterojunctions photocatalysts with high-performance.

关键词： Photocatalysis BiOCl Heterojunction Plasmon Bi Mesoporous structure

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从百年前汀州土白看长汀客话的动态演变

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励耘语言学刊 2018年第2期 300-315页

作者：季明霞福建师范大学文学院

对1919年汀州话土白圣经《马太福音书》的声韵调系统进行研究,确定其所反映的音系性质;将汀州土白与今闽西客话进行音系比较,探索近一百年来长汀客话的动态演变规律。另外,此书所采用的罗马字注音系统在拼写方面有些地方比较混乱,对其... 详细信息

对1919年汀州话土白圣经《马太福音书》的声韵调系统进行研究,确定其所反映的音系性质;将汀州土白与今闽西客话进行音系比较,探索近一百年来长汀客话的动态演变规律。另外,此书所采用的罗马字注音系统在拼写方面有些地方比较混乱,对其不足之处进行修改。

关键词：汀州土白音系闽西客话动态演变

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