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Regulation of c-SMAC formation and AKT-mTOR signaling by the TSG101-IFT20 axis in CD4^(+)T cells

Cellular & Molecular Immunology 2023年第5期20卷 525-539页

作者： Jiung jeong In Kang Yumin Kim Keun Bon Ku Jang Hyun Park Hyun-Jin Kim Chae Won Kim jeongwoo La Hi Eun Jung Hyeon Cheol Kim Young Joon Choi jaeho Kim Joon Kim Heung Kyu Lee Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea Department of Internal Medicine Seoul National University HospitalSeoul 03080Republic of Korea Department of Biological Sciences KAISTDaejeon 34141Republic of Korea Department of Convergent Research of Emerging Virus Infection Korea Research Institute of Chemical TechnologyDaejeon 34114Republic of Korea.

CD4^(+)T cells play major roles in the adaptive immune system,which requires antigen recognition,costimulation,and cytokines for its elaborate *** studies have provided new insight into the importance of the supramolecular activation cluster(SMAC),which comprises concentric circles and is involved in the amplification of CD4^(+)T cell ***,the underlying mechanism of SMAC formation remains poorly ***,we performed single-cell RNA sequencing of CD4^(+)T cells left unstimulated and stimulated with anti-CD3 and anti-CD28 antibodies to identify novel proteins involved in their *** found that intraflagellar transport 20(IFT20),previously known as cilia-forming protein,was upregulated in antibody-stimulated CD4^(+)T cells compared to unstimulated CD4^(+)T *** also found that IFT20 interacted with tumor susceptibility gene 101(TSG101),a protein that endocytoses ubiquitinated T-cell *** interaction between IFT20 and TSG101 promoted SMAC formation,which led to amplification of AKT-mTOR ***,IFT20-deficient CD4^(+)T cells showed SMAC malformation,resulting in reduced CD4^(+)T cell proliferation,aerobic glycolysis,and cellular ***,mice with T-cell-specific IFT20 deficiency exhibited reduced allergen-induced airway ***,our data suggest that the IFT20-TSG101 axis regulates AKT-mTOR signaling via SMAC formation.

关键词： CD4^(+)T cell Intraflagellar transport 20 Tumor susceptibility gene 101 AKT-mTOR signaling Asthma Supramolecular activation cluster

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A new approach for the discrimination of the adulterated vegetable oils

A new approach for the discrimination of the adulterated veg...

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第六届上海国际分析化学研讨会

作者： jaeho Ha Dongwon Seo Homoon Seog Miyoung Yoo Food Analysis Center Korea Food Research InstituiteBundangBaekhyonSeongnamGyeonggiKorea

＜正＞Oils and fats constitute one of the three major classes of food products. On the basis of the expanding market for vegetable oils,their authenticity has become an important subject from both a commercial and a health perspective. The differential between the price of original oils （olive oil and sesame oil）

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Wireless,multimodal sensors for continuous measurement of pressure,temperature,and hydration of patients in wheelchair

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npj Flexible Electronics 2023年第1期7卷 479-493页

作者： Seokjoo Cho Hyeonseok Han Hyunwoo Park Sung-Uk Lee Jae-Hwan Kim Sung Woo jeon Mengqiu Wang Raudel Avila Zhaoqian Xi Kabseok Ko Minsu Park Jungyup Lee Myungwoo Choi Je-Sang Lee Weon Gi Min Byeong-Ju Lee Soyeong Lee Jungrak Choi Jimin Gu jaeho Park Min Seong Kim Junseong Ahn Osman Gul Chankyu Han Gihun Lee Seunghwan Kim Kyuyoung Kim jeonghyun Kim Chang-Mo Kang Jahyun Koo Sung Soo Kwak Sungbong Kim Dong Yun Choi Seokwoo jeon Hyung Jin Sung Yong Bae Park Minkyu Je Young Tae Cho Yong Suk Oh Inkyu Park Department of Mechanical Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea School of Electrical Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea Advanced 3D Printing Technology Development Division Korea Atomic Energy Research InstituteDaejeon 34057Republic of Korea Department of Electrical and Computer Engineering University of Illinois at Urbana-ChampaignUrbanaIL 61801USA State Key Laboratory of Structural Analysis for Industrial Equipment Department of Engineering MechanicsDalian University of TechnologyDalian 116023P.R.China Department of Mechanical Engineering Northwestern UniversityEvanstonIL 60208USA DUT-BSU Joint Institute Dalian University of TechnologyDalian 116023China Ningbo Institute of Dalian University of Technology Ningbo 315016China Department of Electronics Engineering Kangwon National UniversityChuncheon 24341Republic of Korea Querrey-Simpson Institute for Bioelectronics Northwestern UniversityEvanstonIL 60208USA Sibel Health Inc NilesIL 60714USA Department of Materials Science and Engineering KAIST Institute for The Nanocentury(KINC)Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea Department of Rehabilitation Medicine Gimhae Hansol Rehabilitation&Convalescent HospitalGimhae 50924Republic of Korea Department of planning and development Gimhae Hansol Rehabilitation&Convalescent HospitalGimhae 50924Republic of Korea Department of rehabilitation medicine Pusan national university hospitalBusan 49241Republic of Korea Department of AI Convergence Network Ajou UniversitySuwon 16499Republic of Korea Department of Electronic Convergence Engineering Kwangwoon UniversitySeoul 01897Republic of Korea Korea Photonics Technology Institute Gwangju 61007Republic of Korea School of Biomedical Engineering Korea UniversitySeoul 02841Republic of Korea Interdisciplinary Program in Precision Public Health Korea UniversitySeoul 02841Republic of Korea Center

Individuals who are unable to walk independently spend most of the day in a *** population is at high risk for developing pressure injuries caused by ***,early diagnosis and prevention of these injuries still remain ***,we introduce battery-free,wireless,multimodal sensors and a movable system for continuous measurement of pressure,temperature,and hydration at skin *** device design includes a crack-activated pressure sensor with nanoscale encapsulations for enhanced sensitivity,a temperature sensor for measuring skin temperature,and a galvanic skin response sensor for measuring skin hydration *** movable system enables power harvesting,and data communication to multiple wireless devices mounted at skin-cushion interfaces of wheelchair users over full body *** evaluations and numerical simulations of the devices,together with clinical trials for wheelchair patients,demonstrate the feasibility and stability of the sensor system for preventing pressure injuries caused by sitting.

关键词： injuries modal mounted

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战略合作伙伴关系下的中韩军事关系

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现代国际关系 2009年第7期 57-60页

作者：黄载皓[韩] 韩国国防研究院安保战略研究中心

中韩两国领导人宣布两国建立战略合作伙伴关系,使两国再次关注最薄弱的军事领域合作。根据合作的深度,军事关系一般可分为军事交流、军事合作、军事同盟三个层次,目前中韩军事关系十分接近第一层次。由于韩美同盟、中朝关系以及中韩军... 详细信息

中韩两国领导人宣布两国建立战略合作伙伴关系,使两国再次关注最薄弱的军事领域合作。根据合作的深度,军事关系一般可分为军事交流、军事合作、军事同盟三个层次,目前中韩军事关系十分接近第一层次。由于韩美同盟、中朝关系以及中韩军队自身特点等原因,中韩军事关系不可能达到第三层次,但有可能达到第二层次。若双方都有将两国军事关系在目前基础上再向前发展一步的想法,那么两国应该从现在起就积极努力,因为这是建立相互信任的捷径。通过两国军队自身努力和相关国家的理解,中韩军事关系这种水平的发展还是可以实现的,而且两国军事关系的深化也将有助于东北亚地区的和平稳定。

关键词：战略合作伙伴关系中韩军事关系军事交流军事合作

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Zinc–Bromine Rechargeable Batteries:From Device Configuration,Electrochemistry,Material to Performance Evaluation

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纳微快报:英文版 2023年第11期15卷 349-384页

作者： Norah S.Alghamdi Masud Rana Xiyue Peng Yongxin Huang jaeho Lee Jingwei Hou Ian R.Gentle Lianzhou Wang Bin Luo Australian Institute for Bioengineering and Nanotechnology(AIBN) The University of QueenslandBrisbaneQLD 4072Australia School of Chemistry and Molecular Biosciences Faculty of ScienceThe University of QueenslandBrisbaneQLD 4072Australia School of Chemical Engineering The University of QueenslandBrisbaneQLD 4072Australia Department of Chemistry Faculty of ScienceImam Mohammad Ibn Saud Islamic University(IMSIU)11564 RiyadhSaudi Arabia

Zinc–bromine rechargeable batteries(ZBRBs)are one of the most powerful candidates for next-generation energy storage due to their potentially lower material cost,deep discharge capability,non-flammable electrolytes,relatively long lifetime and good ***,many opportunities remain to improve the efficiency and stability of these batteries for long-life ***,we discuss the device configurations,working mechanisms and performance evaluation of *** non-flow(static)and flow-type cells are highlighted in detail in this *** fundamental electrochemical aspects,including the key challenges and promising solutions,are discussed,with particular attention paid to zinc and bromine half-cells,as their performance plays a critical role in determining the electrochemical performance of the battery *** following sections examine the key performance metrics of ZBRBs and assessment methods using various ex situ and in situ/operando *** review concludes with insights into future developments and prospects for high-performance ZBRBs.

关键词： Zinc–bromine rechargeable batteries Cell configurations Electrochemical property Performance metrics Assessment methods

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韩国的新型政府治理和市民社会:稳固民主基础上的市民组织政治化(英文)

韩国的新型政府治理和市民社会:稳固民主基础上的市民组织政治化(...

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北京论坛（2004）文明的和谐与共同繁荣

作者： jaeho Yeom Korea University

Introduction New governance in civil society became a catchword in the analysis of politics at the advent of 21st century. With the prevailing ideas of neo-liberalism, the role of state has

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Evaluation of anti-aging activities of various ginsenosides by typeⅠprocollagen synthesis and expression of MMP-1

Evaluation of anti-aging activities of various ginsenosides ...

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第八届中国化妆品学术研讨会

作者： Ho Sik Rho Myung Hun Yeom Duck Hee Kim Han Gon Kim jaeho Yeon Amore-Pacific R&D Center Korea Amore-Pacific Shanghai R&D Center China

Anti-aging activities of various ginsenosides were evaluated by typeⅠprocollagen synthesis and the expression of *** typeⅠprocollagen synthesis,Rb1,Rh2 and compound K were *** them, compound K was the most active *** typeⅠprocollagen,which was treated with compound K, was found to be 114.8%.In inhibition of MMP-1,Rb1,Rc,Rd and compound K were *** case of MMP-1 inhibition,compound K was also most active *** these results,we suggest that compound K may be used as a good candidate for the treatment of skin aging.

关键词： Anti-aging activity Ginsenosides TypeⅠprocollagen MMP-1

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The Effects of Regional Climate and Aging on Seasonal Variations in Chinese Women’s Skin Characteristics

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Journal of Cosmetics, Dermatological Sciences and Applications 2017年第2期7卷 164-172页

作者： Eunjoo Kim Jiyeon Han Hyeokgon Park Minah Kim Beomjoon Kim jaeho Yeon Liu Wei Lai Wei Haekwang Lee Skin Care Research Institute Amorepacific R&D Center Yongin Korea Department of Dermatology Chung-Ang University College of Medicine Seoul Korea Amore Pacific Shanghai R&I Center Shanghai China Department of Dermatology the General Hospital of Air Force Beijing China Department of Dermatology the Third Affiliated Hospital of Sun Yat-Sen University Guangzhou China

OBJECTIVES: Skin characteristics change depending on the external environment such as UV, temperature and humidity. But the research how to affect the regional climate, age and seasonal variation on the skin conditions was not well studied. Therefore, we investigated the seasonal variation in the skin by comparing Beijing women and Guangzhou women by age groups. METHODS: 440 healthy Chinese women participated in this study. The skin hydration, sebum secretion, TEWL and skin pH were measured on the cheek front. All the parameters were analyzed in terms of the age, season and region. RESULTS: The skin hydration in Beijing was lower than that in Guangzhou and significantly decreased during winter than summer. The sebum secretion in their 20s and 30s was significantly high in summer in both regions, and this phenomenon was more remarkable in Guangzhou (p CONCLUSIONS: Skin hydration and barrier function decreased more during a cold, dry winter than summer. The barrier dysfunctions such as an increase in TEWL and pH occurred more commonly in old age groups. The greater the differences between summer and winter climates, the greater damage to skin barrier and skin hydration. The sebum secretion was more affected by hot, humid summers. Further, the aged skin was influenced by seasonal variation except for sebum secretion.

关键词： Seasonal Variation Regional Climate Age Chinese Skin Skin Barrier

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反式脂肪酸检测方法研究与应用

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中国油料作物学报 2009年第3期31卷 374-379,385页

作者：李培武谢立华魏丽芳 jaeho HA 丁小霞张文姜俊唐晓倩中国农业科学院油料作物研究所湖北武汉430062 西南大学生物科技学院重庆北碚400716 韩国食品研究院食品安全研究室京机道城南463746

研究了甲醇钠-甲醇、氢氧化钾-甲醇、浓硫酸-甲醇和三氟化硼-甲醇4种甲酯化试剂的浓度、用量及甲酯化时间和温度对反式脂肪酸检测的影响，优化了色谱条件，建立了以三氟化硼-甲醇法甲酯化，RT-2560（100m×0．25mm×0．2μm）毛细管柱... 详细信息

研究了甲醇钠-甲醇、氢氧化钾-甲醇、浓硫酸-甲醇和三氟化硼-甲醇4种甲酯化试剂的浓度、用量及甲酯化时间和温度对反式脂肪酸检测的影响，优化了色谱条件，建立了以三氟化硼-甲醇法甲酯化，RT-2560（100m×0．25mm×0．2μm）毛细管柱为基础的反式脂肪酸气相色谱检测方法，C18：1—9t，C18：1—11t，C18：2—9t，12t和C22：1—13t 4种反式脂肪酸的最小检出浓度在0．77—4．08mg／kg之间。4种反式脂肪酸不同添标浓度回收率为98．44％-101．23％，重复测定的相对标准差在0．22％-1．31％之间，有较好的准确度和重现性。应用该方法检测了武汉部分小型市场散装食用植物油和-些餐馆的废弃油脂，以所含脂肪为基准，其反式脂肪酸含量分别为：0．12％-0．25％、3．63％-6．58％。表明天然食用植物油中反式脂肪酸含量较低，但油脂在高温加工过程中会产生反式脂肪酸。

关键词：食品反式脂肪酸检测方法

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Fermented Lysate of Lactiplantibacillus Isolated From Green Tea Leaves Protects Keratinocytes Against Stress Hormone and Staphylococcus Aureus

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China Detergent & Cosmetics 2021年第3期6卷 54-60页

作者： Kilsun Myoung Eun-jeong Choi Hanbyul Kim Hung Su Baek Hyoung-June Kim Won-Seok Park Hyunhee Kim jaeho Yeon Research and Development Center AmorepacificKorea Amorepacific(Shanghai)R&I Center Co. Ltd.ChinaKilsun

Psychological stress can impair epidermal barrier function by inhibiting the proliferation and differentiation of *** this study,the effect of stress hormone on skin microorganisms was confirmed through an in vitro ***,a typical stress hormone,inhibited the growth of skin microbes,especially Staphylococcus epidermidis,which is a commensal skin *** cortisol enhanced the adhesion of the pathogenic bacterium Staphylococcus aureus to *** fermented lysate of Lactiplantibacillus isolated from green tea leaves(LFL)affected the growth of skin microbes in the opposite manner to cortisol,and increased the expression of a keratinocyte differentiation marker that was suppressed by cortisol and ***,LFL inhibited the adhesion of *** to *** modulating effect of LFL on the growth and adhesion of skin microbes was unaffected by the presence of *** also alleviated cell damage in reconstructed human epidermis caused by *** results suggest that LFL may be useful as a cosmetic ingredient capable of controlling skin microbiome balance and protecting skin health against psychological stress.

关键词： stress hormone skin microbiome lactobacillus ferment lysate

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