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Biomarkers of Metabolic(Dysfunction)-associated Fatty Liver Disease:An Update

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Journal of Clinical and Translational Hepatology 2022年第1期10卷 134-139页

作者： jawaher Alharthi Mohammed Eslam Storr Liver Centre Westmead Institute for Medical ResearchWestmead Hospital and University of SydneySydneyNSWAustralia Department of Biotechnology Faculty of ScienceTaif UniversityTaifSaudi Arabi

The prevalence of metabolic(dysfunction)-associated fatty liver disease(MAFLD)is rapidly increasing and affects up to two billion individuals globally,and this has also resulted in increased risks for cirrhosis,hepatocellular carcinoma,and liver *** addition,it has also been linked to extrahepatic consequences,such as cardiovascular disease,diabetes,and various types of ***,only a small proportion of patients with MAFLD develop these ***,the identification of high-risk patients is *** fibrosis is the major determinant in developing these ***,liver biopsy is still considered the gold standard for the assessment of patients with *** of its invasive nature,among many other limitations,the search for noninvasive biomarkers for MAFLD remains an area of intensive *** this review,we provide an update on the current and future biomarkers of MAFLD,including a discussion of the associated genetics,epigenetics,microbiota,and *** also touch on the next wave of multiomic-based biomarkers.

关键词： Biomarkers Metabolic(dysfunction)-associated fatty liver disease Scores

Metabolic associated fatty liver disease(MAFLD):a milestone in the history of fatty liver disease

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Hepatobiliary Surgery and Nutrition 2021年第5期10卷 696-698页

作者： jawaher Alharthi Mohammed Eslam Storr Liver Centre Westmead Institute for Medical ResearchWestmead Hospital and University of SydneySydneyAustralia

With the widespread increase in energy intake and physical inactivity,the prevalence of metabolic health is ***,metabolic associated fatty liver disease(MAFLD)[formerly known as non-alcoholic fatty liver disease(NAFLD)]has risen in prevalence and present a significant challenge to global health causing considerable morbidity and mortality,particularly when fibrosis is present(1).

关键词： liver NAFLD MAF

Macrophages in metabolic associated fatty liver disease

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World Journal of Gastroenterology 2020年第16期26卷 1861-1878页

作者： jawaher Alharthi Olivier Latchoumanin Jacob George Mohammed Eslam Storr Liver Centre Westmead Institute for Medical ResearchWestmead Hospital and University of SydneySydney 2145NSWAustralia

Metabolic associated fatty liver disease(MAFLD),formerly named non-alcoholic fatty liver disease is the most common liver disorder in many *** inflammatory subtype termed steatohepatitis is a driver of disease progression to cirrhosis,hepatocellular carcinoma,liver transplantation,and death,but also to extrahepatic complications including cardiovascular disease,diabetes and chronic kidney *** plasticity of macrophages in response to various environmental cues and the fact that they can orchestrate cross talk between different cellular players during disease development and progression render them an ideal target for drug *** report reviews recent advances in our understanding of macrophage biology during the entire spectrum of MAFLD including steatosis,inflammation,fibrosis,and hepatocellular carcinoma,as well as for the extra-hepatic manifestations of *** discuss the underlying molecular mechanisms of macrophage activation and polarization as well as cross talk with other cell types such as hepatocytes,hepatic stellate cells,and adipose *** conclude with a discussion on the potential translational implications and challenges for macrophage based therapeutics for MAFLD.

关键词： Metabolic associated fatty liver disease Macrophages Inflammation Fibrosis Hepatic stellate cells

Leaf morpho-physiology and phytochemistry of olive trees as affected by cultivar type and increasing aridity

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Journal of Arid Land 2022年第10期14卷 1159-1179页

作者： Said TOUATI jawaher AYADI Abdelhakim BOUAJILA Smail ACILA Rami RAHMANI Jalloul BOUAJILA Mohamed DEBOUBA Laboratory of''Biodiversity Molecule and ApplicationsLR22ES02''Higher Institute of Applied Biology of MedenineUniversity of GabesZrig 6029Tunisia Laboratory of Geosystems Georessources and GeoenvironmentsFaculty of Science of GabesDepartment of Earth SciencesUniversity of GabesZrig 6029Tunisia Laboratory of Biology Environment and HealthDepartment of BiologyFaculty of Nature and Life SciencesUniversity of Echahid Hamma Lakhdar El-OuedChott 39000Algeria Laboratoire de Génie Chimique Universitéde Paul SabatierCNRSINPTUPSToulouseFrance

The olive species(Olea europaea L.)is an ancient traditional crop grown under rainfed conditions in the Mediterranean *** response to the growing national and international demand for olive oil,the olive cultivars are introduced into highly arid new bioclimatic ***,the morpho-physiology and phytochemistry of olive trees are potentially changing among cultivar types and geographical *** the present work,we have undertaken an assessment on the impacts of geographical location and cultivar types on the leaf morpho-physiology and phytochemistry of olive ***,leaves of the two most cultivated olive tree varieties,Chemlal and Sigoise,were collected from three geographical regions(Setif,Batna,and Eloued)with increasing aridity in *** samples from the geographical regions were analyzed using the standard physiological experiment,colorimetric method,and a chromatography *** of both cultivars exhibited a significant variance in terms of the leaf shape index but not for the leaf tissue density,specific leaf weight,and specific leaf *** pigment contents were affected by both cultivar type and geographical location,with the lowest pigment content recorded in the Sigoise cultivar from the Setif *** with the Setif and Batna regions,dried leaves of both cultivars from the Eloued region showed the higher levels of the total polyphenol,total flavonoid,and total tannin,as well as a better antioxidant *** chromatography-mass spectrometry analysis of all leaf extracts identified the following phenolic acids as major compounds:oleuropein,naringin,apigenin-7-O-glucoside,kaempferol,quercetin,quercitrin,luteolin-7-O-naringenin,and quinic *** contents were found for p-Coumaric acid,trans-Ferulic acid,hyperoside,rutin,apigenin,caffeic acid,protocatechuic acid,o-Coumaric acid,and gallic ***,epicatechin and catechin+were not found in the leaf extracts of the Sigoise *** leaf organ

关键词： Olea europaea L. aridity leaf morpho-physiology bioactivity olive cultivar geographical location Algeria

Bile acid indices as biomarkers for liver diseases Ⅱ: The bile acid score survival prognostic model

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World Journal of Hepatology 2021年第5期13卷 543-556页

作者： jawaher Abdullah Alamoudi Wenkuan Li Nagsen Gautam Marco Olivera Jane Meza Sandeep Mukherjee Yazen Alnouti Department of Pharmaceutical Sciences University of Nebraska Medical CenterOmahaNE 68198-6025United States Department of Pharmaceutical Sciences Princess Nourah Bint Abdulrahman UniversityRiyadh 11564Saudi Arabia Department of Internal Medicine University of Nebraska Medical CenterOmahaNE 68105United States Department of Biostatistics University of Nebraska Medical CenterOmahaNE 68198-4375United States Department of Internal Medicine Creighton University Medical CenterOmahaNE 68124United States

BACKGROUND Cholestatic liver diseases are characterized by an accumulation of toxic bile acids(BA)in the liver,blood and other tissues which lead to progressive liver injury and poor prognosis in *** To discover and validate prognostic biomarkers of cholestatic liver diseases based on the urinary BA *** We analyzed urine samples by liquid chromatography-tandem mass spectrometry and investigated the use of the urinary BA profile to develop survival models that can predict the prognosis of hepatobiliary *** urinary BA profile,a set of non-BA parameters,and the adverse events of liver transplant and/or death were monitored in 257 patients with cholestatic liver diseases for up to 7 *** BA profile was characterized by calculating BA indices,which quantify the composition,metabolism,hydrophilicity,formation of secondary BA,and toxicity of the BA *** have developed and validated the bile-acid score(BAS)model(a survival model based on BA indices)to predict the prognosis of cholestatic liver *** We have developed and validated a survival model based on BA(the BAS model)indices to predict the prognosis of cholestatic liver *** results demonstrate that the BAS model is more accurate and results in higher truepositive and true-negative prediction of death compared to both non-BAS and model for end-stage liver disease(MELD)*** 5-and 3-year survival probabilities markedly decreased as a function of ***,patients with high BAS had a 4-fold higher rate of death and lived for an average of 11 mo shorter than subjects with low *** increased risk of death with high vs low BAS was also 2-4-fold higher and the shortening of lifespan was 6-7-mo lower compared to MELD or ***,we have shown the use of BAS to predict the survival of patients with and without liver transplant(LT).Therefore,BAS could be used to define the most seriously ill patients,who need earlier intervention such as ***

关键词： Hepatobiliary diseases Bile acid indices Death Liver transplant Survival model Prognosis

Pattern of Thyroid Cancer at King Abdulaziz University Hospital, Jeddah: A 10-Year Retrospective Study

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Open Journal of Endocrine and Metabolic Diseases 2016年第3期6卷 121-125页

作者： Amani Alhozali Aisha Al-Ghamdi jawaher Alahmadi Department of Medicine King Abdulaziz University Hospital Jeddah Saudi Arabia

Background and objective: Thyroid cancer is the most common endocrine malignancy. This report aims to describe the pattern of thyroid cancer presentations at King Abdulaziz University Hospital, Jeddah. Methods: This was a retrospect chart review of all thyroid cancer cases diagnosed between 2001 and 2010 at King Abdulaziz University Hospital, Jeddah. We documented patients’ demographic and clinical data, including age at diagnosis, tumor type and size, extrathyroidal extension, and metastasis. Results: A total of 114 thyroid cancer cases were diagnosed from 2001 through 2010. Females comprise the majority of cases (female to male ratio of 4:1). The mean ages of patients diagnosed with different thyroid cancers were: papillary thyroid cancer, 39.6 years;follicular thyroid cancer, 43.2 years;medullary thyroid cancer, 55.8 years;and anaplastic thyroid cancer, 46.0 years. Papillary thyroid cancer was diagnosed in 88 cases (77%), follicular thyroid cancer in 19 cases (17%), medullary thyroid cancer in 5 cases (4%), and anaplastic thyroid cancer in 2 cases (2%). Conclusion: Thyroid cancers are more common among females. The disease is diagnosed at a relatively young age among our patients (40 years). Papillary thyroid cancer is the most common type of thyroid cancer.

关键词： Anaplastic Thyroid Cancer Follicular Thyroid Cancer Medullary Thyroid Cancer Papillary Thyroid Cancer Endocrine Malignancy

Bile acid indices as biomarkers for liver diseases I:Diagnostic markers

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World Journal of Hepatology 2021年第4期13卷 433-455页

作者： jawaher Abdullah Alamoudi Wenkuan Li Nagsen Gautam Marco Olivera Jane Meza Sandeep Mukherjee Yazen Alnouti Department of Pharmaceutical Sciences College of PharmacyUniversity of Nebraska Medical CenterOmahaNE 68198United States Department of Pharmaceutical Sciences College of PharmacyPrincess Nourah Bint Abdulrahman UniversityRiyadh 11564Saudi Arabia Department of Internal Medicine College of MedicineUniversity of Nebraska Medical CenterOmahaNE 68198United States Department of Biostatistics College of Public HealthUniversity of Nebraska Medical CenterOmahaNE 68198United States Department of Internal Medicine College of MedicineCreighton University Medical CenterOmahaNE 68124United States

BACKGROUND Hepatobiliary diseases result in the accumulation of toxic bile acids(BA)in the liver,blood,and other tissues which may contribute to an unfavorable *** To discover and validate diagnostic biomarkers of cholestatic liver diseases based on the urinary BA *** We analyzed urine samples by liquid chromatography-tandem mass spectrometry and compared the urinary BA profile between 300 patients with hepatobiliary diseases vs 103 healthy controls by statistical *** BA profile was characterized using BA indices,which quantifies the composition,metabolism,hydrophilicity,and toxicity of the BA *** indices have much lower interand intra-individual variability compared to absolute concentrations of *** addition,BA indices demonstrate high area under the receiver operating characteristic curves,and changes of BA indices are associated with the risk of having a liver disease,which demonstrates their use as diagnostic biomarkers for cholestatic liver *** Total and individual BA concentrations were higher in all *** percentage of secondary BA(lithocholic acid and deoxycholic acid)was significantly lower,while the percentage of primary BA(chenodeoxycholic acid,cholic acid,and hyocholic acid)was markedly higher in patients compared to *** addition,the percentage of taurine-amidation was higher in patients than *** increase in the non-12α-OH BA was more profound than 12α-OH BA(cholic acid and deoxycholic acid)causing a decrease in the 12α-OH/non-12α-OH ratio in *** trend was stronger in patients with more advanced liver diseases as reflected by the model for end-stage liver disease score and the presence of hepatic *** percentage of sulfation was also higher in patients with more severe forms of liver *** BA indices have much lower inter-and intra-individual variability compared to absolute BA concentrations and changes of BA indices are associated with the

关键词： Hepatobiliary diseases Bile acids Bile acid indices Diagnosis Biomarker Liver diseases

Extra-Oral Digital Panoramic Radiographic Interpretation and Clinical Findings of Stage IV Periodontitis among Some Samples Concerning Saudi/Non-Saudi Nationality

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Open Journal of Stomatology 2022年第2期12卷 42-61页

作者： Mohammed M. A. Abdulla Al-Abdaly Amer Hassan Alasmari Saeed J. Alqahtani Ahmed Abdulrahman Alzahrani jawaher Moshabab A. Al Ahmari Ghadeer Mohammed Mohammed Al-Abdaly Ibrahim Hassan Ibrahim Alqaysi Mohammed Dhafer Mohammed Al-Shamrani Periodontics and Community Dental Sciences Department College of Dentistry King Khalid University Abha Saudi Arabia College of Dentistry King Khalid University Abha Saudi Arabia Faculty of Dentistry Sana’a University Sana’a Republic of Yemen

Background: There are associations between the severity of periodontal diseases and some predisposing factors, such as age, race, and income rate. Therefore, the present study was designed to evaluate the extra-oral digital panoramic radiographic interpretation and clinical findings of stage IV periodontitis among some samples concerning Saudi/non-Saudi nationality. Material and Methods: The study comprised a random sample of 298 residents in Saudi Arabia referred to the internship program clinics at the College of Dentistry, King Khalid University. They were according to the age of participants as follows: youth (15 - 24 years), adults (25 - 64 years), and seniors (65 years and over) within two groups according to nationality (Saudi and non-Saudi). Clinical periodontal examination and radiographic extra oral digital panoramic radiographs were done, and then the periodontal parameters, the percentage of bone loss, and the pattern of bone loss were recorded. The data was collected, and the statistical analysis was performed with ANOVA test, Tukey’s test, Chi-square test, and T-test and considered a P-value at (p Results: The samples included 62 (20%) youth participants with mean of age (21.806 ± 3.390), 182 (57%) adults’ participants with mean age (42.802 ± 9.094), and 54 (23%) seniors participants with a mean age (69.074 ± 6.810). There were highly statistically significant differences in the comparison between the participants’ ages (P 0.05). Conclusion: At the end of this study, we concluded that there are alterations in clinical and radiographic and clinical findings of stage IV periodontitis with the alteration of participants’ ages and nationality.

关键词： Extra-Oral Digital Panoramic Radiographs Nationality Stage IV Periodontitis