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Pharmacokinetic comparison with different assays for simultaneous determination of cis-,trans-cefprozil diastereomers in human plasma

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Journal of Pharmaceutical Analysis 2021年第3期11卷 351-363页

作者： Seung-hyun Jeong Ji-Hun jang Hea-Young Cho Yong-Bok Lee College of Pharmacy Chonnam National University77 Yongbong-roBuk-guGwangju61186Republic of Korea College of Pharmacy CHA University335 Pangyo-roBundang-guSeongnam-siGyeonggi-Do13488Republic of Korea

The purpose of this study was to compare pharmacokinetic(PK)parameters obtained using two newly developed assays,HPLC-UV and UPLC-ESI-MS/*** of assay and results obtained therefrom are very important in PK studies and can have a major impact on the PK-based clinical dose and usage *** this study,we developed two new methods that are most commonly used in biosample analysis and focused on PK parameters obtained from *** HPLC-UV equipped with a Luna-C8 column using UV detector,cefprozil diastereomers were separated using water containing 2%(V/V)acetic acid and acetonitrile as a mobile *** UPLC-ESI-MS/MS equipped with a HALO-C18 column,cefprozil diastereomers were separated using 0.5%(V/V)aqueous formic acid containing 5 mM ammoniumformate buffer and methanol as a mobile *** showed high resolution,sensitivity,and selectivity without interference by plasma *** intra-and inter-day precisions(CV,%)were within 8.88%for HPLC-UV and UPLC-ESI-MS/*** of both methods was 95.67%-107.50%.These two analytical methods satisfied the criteria of international guidance and could be successfully applied to PK *** of PK parameters between two assays confirmed that there is a difference in the predicted minimum plasma concentrations at steady state,which may affect clinical dose and usage ***,we confirmed possible correlation between PK parameters and various biochemical parameters after oral administration of 1000 mg cefprozil to humans.

关键词： Cefprozil diastereomers Comparison HPLC-UV UPLC-ESI-MS/MS Pharmacokinetic parameter Biochemical parameters

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The cortical activation pattern during bilateral arm raising movements

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Neural Regeneration Research 2017年第2期12卷 317-320页

作者： Sung Ho jang Jung Pyo Seo Seung-hyun Lee Sang-hyun Jin Sang Seok Yeo Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University Daegu Republic of Korea Robot System Research Division Daegu Gyeongbuk Institute of Science & Technology Daegu Republic of Korea Department of Physical Therapy College of Health Sciences Dankook University Cheonan-si Chungnam Republic of Korea

Bilateral arm raising movements have been used in brain rehabilitation for a long time. However, no study has been reported on the effect of these movements on the cerebral cortex. In this study, using functional near infrared spectroscopy（f NIRS）, we attempted to investigate cortical activation generated during bilateral arm raising movements. Ten normal subjects were recruited for this study. f NIRS was performed using an f NIRS system with 49 channels. Bilateral arm raising movements were performed in sitting position at the rate of 0.5 Hz. We measured values of oxyhemoglobin and total hemoglobin in five regions of interest： the primary sensorimotor cortex, premotor cortex, supplementary motor area, prefrontal cortex, and posterior parietal cortex. During performance of bilateral arm raising movements, oxyhemoglobin and total hemoglobin values in the primary sensorimotor cortex, premotor cortex, supplementary motor area, and prefrontal cortex were similar, but higher in these regions than those in the prefrontal cortex. We observed activation of the arm somatotopic areas of the primary sensorimotor cortex and premotor cortex in both hemispheres during bilateral arm raising movements. According to this result, bilateral arm raising movements appeared to induce large-scale neuronal activation and therefore arm raising movements would be good exercise for recovery of brain functions.

关键词： nerve regeneration neuronal activation bilateral arm raising functional NIRS motor control corticospinal tract corticoreticulospinal tract neural regeneration

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Changes in endoscopic patterns before and during COVID-19 outbreak:Experience at a single tertiary center in Korean

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World Journal of Clinical Cases 2021年第15期9卷 3576-3585页

作者： Kook hyun Kim Sung Bum Kim tae Nyeun Kim Division of Gastroenterology and Hepatology Department of Internal MedicineYeungnam University College of MedicineDaegu 42415South Korea

BACKGROUND The surge of coronavirus disease 2019(COVID-19)patients has markedly influenced the treatment policies of tertiary hospitals because of the need to protect medical staff and contain viral transmission,but the impact COVID-19 had on emergency gastrointestinal endoscopies has not been *** To compare endoscopic activities and analyze the clinical outcomes of emergency endoscopies performed before and during the COVID-19 outbreak in Daegu,the worst-hit region in South *** This retrospective cohort study was conducted on patients aged≥18 years that underwent endoscopy from February 18 to March 28,2020,at a tertiary hospital in ***,laboratory findings,types and causes of emergency endoscopies,and endoscopic reports were reviewed and compared with those obtained for the same period in 2018 and *** From February 18 to March 28,a total of 366 emergent endoscopic procedures were performed:Upper endoscopy(170,50.6%),endoscopic retrograde cholangiopancreatography(113,33.6%),and colonoscopy with sigmoidoscopy(53,15.8%).The numbers of procedures performed in 2018 and 2019 dropped by 48.8%and 54.8%,respectively,compared with those in *** the COVID-19 outbreak,the main indications for endoscopy were melena(36.7%),hematemesis(30.6%),and hematochezia(10.2%).Of the endoscopic abnormalities detected,gastrointestinal bleeding was the most common:39 cases in 2018,51 in 2019,and 35 in *** The impact of COVID-19 is substantial and caused dramatic reductions in endoscopic procedures and changes in patient ***-term follow-up studies are required to determine the effects of COVID-19 induced changes in the endoscopy field.

关键词： COVID-19 Coronavirus Endoscopy Emergency endoscopy

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Neural Regeneration Research 2011年第4期6卷 283-287页

作者： Sung Ho jang Sang-hyun Cho Mi Young Lee Yong hyun Kwon Min Cheul Chang Department of Physical Medicine and Rehabilitation College of MedicineYeungnam UniversityDaegu 705-717Republic of Korea Department of Physical Therapy Institute of Health ScienceYonsei University College of Health ScienceWounju-siGangwon-do 220-710Republic of Korea Department of Physical Therapy College of Health and TherapyDaegu Haany UniversitySuseongkuDaegu 706-060Republic of Korea Department of Physical Therapy Yeungnam College of Science and TechnologyNamkuDaegu 705-703Republic of Korea

The corticospinal tract （CST） is one of the most important neural tracts for motor function in the human brain. Little is known about age-related changes of the CST. tn this study, we tried to evaluate age-related changes of the CST using diffusion tensor imaging in 60 healthy subjects. The diffusion tensor imaging result revealed that the tract number and fractional anisotropy value were decreased, and the apparent diffusion coefficient （ADC） value was increased with aging. The distribution showed a semilog pattern for tract number, fractional anisotropy and ADC of the CST, and the pattern of each graph was near-linear. When compared with the diffusion tensor imaging parameters of subjects in the 20 s age group, tract number and fractional anisotropy values were significantly decreased in the 50 s-70 s age groups. Likewise, the ADC value was significantly higher in the 50 s-70 s age groups. The CST in the brain of normal subjects degenerated continuously from the 20 s to the 70 s, with a near-linear pattern, and degeneration of the CST began to manifest significantly in the subjects in their 50 s, compared with the subjects in their 20 s.

关键词： corticospinal tract motor function aging diffusion tensor imaging

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Synthesis of Co/SiO2 hybrid nanocatalyst via twisted Co3Si2O5（OH）4 nanosheets for high-temperature Fischer- Tropsch reaction

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Nano Research 2017年第3期10卷 1044-1055页

作者： Ji Chan Park Shin Wook Kang Jeong-Chul Kim Jae In Kwon Sanha jang Geun Bae Rhim Mijong Kim Dong hyun Chun Ho-tae Lee Heon Jung hyunjoon Song Jung-li Yang Clean Fuel Laboratory Korea Institute of Energy Research Daejeon 34129 Republic of Korea Advanced Energy Technology University of Science and Technology Daejeon 34713 Republic of Korea Center for Nanomaterials & Chemical Reactions Institute for Basic Science Daejeon 34141 Republic of Korea Department of Chemistry Korea Advanced Institute of Science and Technology Daejeon 34141 Republic of Korea

A cobalt-silica hybrid nanocatalyst bearing small cobalt particles of diameter -5 nm was prepared through a hydrothermal reaction and hydrogen reduction. The resulting material showed very high CO conversion （〉82%） and high hydrocarbon productivity （-1.0gHC·gcat^-1·h^-1 ） with high activity （-8.5 × 10^-5 ***^-1.s-1） in the Fischer-Tropsch synthesis reaction.

关键词： hybrid nanostructure Fischer-Tropsch synthesis thermal stability metal silicate hydroxide cobalt catalyst

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Self-motivated,thermally oxidized hematite nanoflake photoanodes:Effects of pre-polishing and ZrO_(2) passivation layer

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Journal of Energy Chemistry 2022年第2期31卷 415-423页

作者： Love Kumar Dhandole hyun Hwi Lee Weon-Sik Chae Jum Suk jang Jae Sung Lee Department of Energy Engineering School of Energy and Chemical EngineeringUlsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea Division of Biotechnology College of Environmental and Bioresource SciencesChonbuk National UniversityIksan 54596Republic of Korea Pohang Accelerator Laboratory Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea Daegu Center Korea Basic Science InstituteDaegu 41566Republic of Korea

High-temperature thermal oxidation of an Fe foil produces a high-quality,crystalline hematite nanoflake suitable as a photoanode for the photoelectrochemical(PEC)water *** pre-polishing of the foil surface has a profound effect in the formation of a vertically-aligned nanoflakes of hematite phase with extended(110)planes by removing the loosely-bonded oxide *** the surface of the photoanode is modified with a ZrO_(2) passivation layer and a cobalt phosphate co-catalyst,the charge recombination at the photoanode-electrolyte interface is greatly suppressed to improve its overall PEC *** a result,the photocurrent density at 1.10 VRHE under 1 sun condition is enhanced from 0.22 mA cm^(-2) for an unmodified photoanode to 0.59 mA cm^(-2) for the fully modified photoanode,and the photocurrent onset potential is shifted cathodically by 400 ***,the photoanode demonstrates outstanding stability by showing steady production of H_(2) and O_(2) gases in the stoichiometric ratio of 2:1 in a continuous PEC operation for 10 h.

关键词： Fe foil Thermal oxidation Nanoflakes Photoelectrochemical water splitting Surface modifications

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An Enhanced Jacobi Precoder for Downlink Massive MIMO Systems

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Computers, Materials & Continua 2021年第7期68卷 137-148页

作者： Park Chan-Yeob hyun-Ro Jae Jun-Yong jang Song Hyoung-Kyu Department of Information and Communication Engineering and Convergence Engineering for Intelligent DroneSejong UniversitySeoul05006Korea

Linear precoding methods such as zero-forcing(ZF)are near optimal for downlink massive multi-user multiple input multiple output(MIMO)systems due to their asymptotic channel ***,as the number of users increases,the computational complexity of obtaining the inverse matrix of the gram matrix *** the computational complexity problem,this paper proposes an improved Jacobi(JC)-based precoder to improve error performance of the conventional JC in the downlink massive MIMO *** conventional JC was studied for solving the high computational complexity of the ZF algorithm and was able to achieve parallel ***,the conventional JC has poor error performance when the number of users increases,which means that the diagonal dominance component of the gram matrix is *** this paper,the preconditioning method is proposed to improve the error *** executing the JC,the condition number of the linear equation and spectrum radius of the iteration matrix are reduced by multiplying the preconditioning matrix of the linear *** further reduce the condition number of the linear equation,this paper proposes a polynomial expansion precondition matrix that supplements diagonal *** results show that the proposed method provides better performance than other iterative methods and has similar performance to the ZF.

关键词： Jacobi(JC) massive MIMO precondition polynomial expansion linear precoding

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Chemical modification of ordered/disordered carbon nanostructures for metal hosts and electrocatalysts of lithium-air batteries

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InfoMat 2022年第1期4卷 105-129页

作者： Jeongyeon Lee tae hyung Lee Ho Won jang Ho Seok Park School of Chemical Engineering Convergence Research Center for Energy and Environmental SciencesDepartment of Health Sciences and TechnologySamsung Advanced Institute for Health Sciences and Technology(SAIHST)Sungkyunkwan University(SKKU)SuwonRepublic of Korea Institute of Textiles Clothing The Hong Kong Polytechnic UniversityHung HomHong Kong SARChina Department of Materials Science and Engineering Research Institute of Advanced MaterialsSeoul National UniversitySeoulRepublic of Korea

Although lithium-air batteries(LABs)are considered the promising alternative of existing lithium–ion batteries owing to their high energy density of 11680 W h kg^(-1),their practical applications are limited by the technical issues,such as unstable solid electrolyte interface and dendrite formation from metal anode and insufficient bifunctional activities and durability from cathode *** order to resolve these bottlenecks,carbon nanostructures have been investigated owing to their high surface area,excellent electrical conductivity,electrochemical stability,and various modification ***,we comprehensively review a recent progress on the design of carbon nanostructures for their applications into metal hosts,protection layers,and bifunctional electrocatalysts of *** correlation between the crystalline,electronic,porous,and chemical structures and the electrochemical properties of carbon nanomaterials are discussed depending on their classification and *** chemical modifications,such as morphological control,hierarchical architecturing,heteroatom incorporation,and the formation of composites,for the improved electrochemical performances of anode and cathode will be also ***,we deal with the perspectives for the ongoing obstruction and future guidance.

关键词： bifunctional catalysts carbon nanostructures lithium-air batteries metal anodes surface modification

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Neural Regeneration Research 2014年第9期9卷 986-989页

作者： Yong hyun Kwon Sung Ho jang Sang Seok Yeo Department of Physical Therapy Yeungnam University College Department of Physical Medicine and Rehabilitation College of Medi-cine Yeungnam University Department of Physical Therapy College of Health Sciences Dankook University

Introduction Aging is the accumulation of multidimensional deterioration of process- ing of biological, psychological, and social changes with expansion over time （Bowen and Atwood, 2004; Grady, 2012）. Aging-related changes are typically accompanied by decline in cognitive function, urinary control, sensory-motor function, and gait ability （Bradley et al., 1991; Bowen and Atwood, 2004; Hedden and Gabrieli, 2004; Grady, 2012; Moran et al., 2012）. In addition, a number of studies have suggested changes in brain structure with normal aging, such as decrease in cortical thickness or increase in ventricular width （Blatter et al., 1995; Tang et al., 1997; Uylings and de Brabander, 2002; Preul et al., 2006; Apostolova et al., 2012）. In particular, ventricular enlargement has been suggested as a structural biomarker for normal aging and progression of some illnesses, such as Alzheimer＇s disease （Blatter et al., 1995; Tang et al.,

关键词： Age-related changes of lateral ventricular width and periventricular white matter in the human brain a diffusion tensor imaging study

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Detection of damage locations and damage steps in pile foundations using acoustic emissions with deep learning technology

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Frontiers of Structural and Civil Engineering 2021年第2期15卷 318-332页

作者： Alipujiang JIERULA tae-Min OH Shuhong WANG Joon-hyun LEE hyunwoo KIM Jong-Won LEE School of Resource&Civil Engineering Northeastern UniversityShenyang110819China School of Mechanical Engineering Pusan National UniversityBusan46241Korea Department of Civil and Environmental Engineering Pusan National UniversityBusan46241Korea Korea Institute of Geoscience and Mineral Resource(KIGAM) Daejeon34132Korea

The aim of this study is to propose a new detection method for determining the damage locations in pile foundations based on deep learning using acoustic emission ***,the damage location is simulated using a back propagation neural network deep learning model with an acoustic emission data set acquired from pile hit *** particular,the damage location is identified using two parameters:the pile location(PL)and the distance from the pile cap(DS).This study investigates the influences of various acoustic emission parameters,numbers of sensors,sensor installation locations,and the time difference on the prediction accuracy of PL and *** addition,correlations between the damage location and acoustic emission parameters are ***,the damage step condition is determined using a classification model with an acoustic emission data set acquired from uniaxial compressive strength ***,a new damage detection and evaluation method for pile foundations is *** new method is capable of continuously detecting and evaluating the damage of pile foundations in service.

关键词： pile foundations damage location acoustic emission deep learning damage step

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