Age-related changes of lateral ventricular width and periventricular white matter in the human brain: a diffusion tensor imaging study

作     者：Yong Hyun Kwon Sung Ho Jang Sang Seok Yeo 

作者机构：Department of Physical Therapy Yeungnam University College Department of Physical Medicine and Rehabilitation College of Medi-cine Yeungnam University Department of Physical Therapy College of Health Sciences Dankook University 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2014年第9卷第9期

页      面：986-989页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology, No. 2012R1A1B4003477 

主　　题：Age-related changes of lateral ventricular width and periventricular white matter in the human brain a diffusion tensor imaging study 

摘      要：Introduction Aging is the accumulation of multidimensional deterioration of process- ing of biological, psychological, and social changes with expansion over time （Bowen and Atwood, 2004; Grady, 2012）. Aging-related changes are typically accompanied by decline in cognitive function, urinary control, sensory-motor function, and gait ability （Bradley et al., 1991; Bowen and Atwood, 2004; Hedden and Gabrieli, 2004; Grady, 2012; Moran et al., 2012）. In addition, a number of studies have suggested changes in brain structure with normal aging, such as decrease in cortical thickness or increase in ventricular width （Blatter et al., 1995; Tang et al., 1997; Uylings and de Brabander, 2002; Preul et al., 2006; Apostolova et al., 2012）. In particular, ventricular enlargement has been suggested as a structural biomarker for normal aging and progression of some illnesses, such as Alzheimer＇s disease （Blatter et al., 1995; Tang et al.,