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Inhibition of hepatitis B virus DNA replicative intermediate forms by recombinant interferon-γ

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World Journal of Gastroenterology 2006年第19期12卷 3006-3014页

作者： Mohammad khalid Parvez Deepak Sehgal Shiv Kumar Sarin Seemi Farhat Basir Shahid jameel Department of Biosciences Jamia Millia Islamia New DelhiVirology GroupInternational Centre for Genetic Engineering and BiotechnologyNew DelhiDepartment of GastroenterologyG.B.Pant HospitalNew DelhiIndia Virology Group International Centre for Genetic Engineering and Biotechnology New DelhiIndia Department of Gastroenterology G.B.Pant Hospital New DelhiIndia Department of Biosciences Jamia Millia Islamia New DelhiIndia

AIM: To evaluate the in vitro anti-HBV activity of recombinant human IFN-γ, alone and in combination with lamivudine. METHODS: A recombinant baculovirus-HBV/HepG2 culture system was developed which could support productive HBV infection in vitro. Expression of HBsAg and HBeAg in infected HepG2 culture medium was detected by commercial enzyme immunoassays. HBV DNA replication intermediates were detected in infected cells by Southern hybridization and viral DNA load was determined by dot hybridization. RESULTS: IFN-γat 0.1 to 5μg/L efficiently down regulated HBsAg expression in transduced HepG2 cells. At 5μg/L, IFN-γalso suppressed HBV DNA replication in these cells. While treatment with a combination of lamivudine and IFN-γshowed no additive effect, sequential treatment first with lamivudine and then IFN-γwas found to be promising. In this culture system the best HBV suppression was observed with a pulse of 2μmol/L lamivudine for two days, followed by 1μg/L IFN-γfor another four days. Compared to treatment with lamivudine alone, the sequential use of 0.2μmol/L lamivudine for two days, followed by 5μg/L IFN-γfor six days showed a 72% reduction in HBV cccDNA pool. CONCLUSION: This in vitro study warrants further evaluation of a combination of IFN-γand lamivudine, especially in IFN-αnon-responder chronic hepatitis B patients. A reduced duration of lamivudine treatment would also restrict the emergence of drug-resistant HBV mutants.

关键词： Hepatitis B virus (HBV) Lamivudine Interferon-γ Replicative intermediates cccDNA

Spatial and Temporal Assessment of Drought in the Northern Prone of Iraq Using Standardized Precipitation Index

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Engineering（科研） 2023年第10期15卷 691-708页

作者： Mazin jameel Saif Hameed khalid Shemal Nadhir Al-Ansari Salwan Ali Abed Dams Department Center of Studies and Engineering Design Ministry of Water Resources Baghdad Iraq Design Department Center of Studies and Engineering Design Ministry of Water Resources Baghdad Iraq State Commission for Irrigation Projects and Reclamation Ministry of Water Resources Baghdad Iraq Department of Civil Environmental and Natural Resources Engineering Lulea University of Technology Lulea Sweden College of Science University of Al-Qadisiyah Diwaniyah Iraq

Drought becomes a serious issue in Iraq as upstream countries water policies and climate change consequences. It has negative impacts on different sectors, the environment, biodiversity, economy, and water resources. Long periods of severe drought and no rainfall winter are continuing during the last decades and the trend lines of the drought index gravitate toward unrecorded levels. This research studied the drought by using the standardized precipitation index “SPI” by analyzing the rainfall record since 1980 for the northern prone of Iraq which includes Kurdistan Region Governorates “KRG” (Sulaymaniya, Erbil, and Dohuk), Mosul, and Kirkuk to find out the drought pattern, magnitude, and duration, and mapping the results. This index is a very powerful index that is used worldwide when only rainfall data are available. SPI generator is used for more accuracy and confidence. The results show that all governorate has a vital issue and has a drought magnitude passed the thresholds of M = -1.0, -1.5, -2.0, -2.5, -3.0, and -4.0 which means a deficit in the soil moisture content, surface water, and groundwater. In Sulaymaniyah, the record for SPI3, SPI6, and SPI48 respectively is about -3.4, -3.54, and -2.63;in Erbil -2.73, -4.67, and -2.72;in Dohuk -4.22, -4.34, and -2.25;in Mosul -2.57, -2.16: in Kirkuk -3.39, -3.04, and -3.41. It is clear that all governorates have depletion in groundwater except Mosul which has contentious recharge, and in Erbil, both soil moisture and surface water has no huge deficit due to high rainfall and snowpack in the region. The results concluded that the whole region is subject to drought and under threat of water resources depletion;it needs urgent long-term plans in a sustainable manner to manage and conserve those sources and mitigate the climate change consequences.

关键词： SPI Drought Climate Change

Improving Quantitative and Qualitative Characteristics of Wheat (Triticum aestivum L.) through Nitrogen Application under Semiarid Conditions

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Phyton-International Journal of Experimental Botany 2023年第4期92卷 1001-1017页

作者： Muhammad Rafiq Muhammad Saqib Husnain Jawad Talha Javed Sadam Hussain Muhammad Arif Baber Ali Muhammad Sultan Ali Bazmi Ghulam Abbas Marjan Aziz Mohammad khalid Al-Sadoon Aneela Gulnaz Sobhi F.Lamlom Muhammad Azeem Sabir jameel Akhtar Agronomic Research Institute Ayub Agricultural Research InstituteFaisalabad38850Pakistan Depertment of Agronomy University of AgricultureFaisalabad38040Pakistan Department of Agronomy Northwest A&F UniversityYangling712100China Department of Plant Sciences Quaid-i-Azam UniversityIslamabad45320Pakistan Fodder Research Institute Sargodha Sargodha40100Pakistan Department of Agricultural Engineering Barani Agricultural Research InstituteChakwal48800Pakistan Department of Zoology College of ScienceKing Saud UniversityRiyadh11451Saudi Arabia Department of Biotechnology Yeungnam UniversityGyeongbuk38641Korea Plant Production Department Faculty of Agriculture Saba BashaAlexandria UniversityAlexandria21531Egypt Department of Forestry Range and Wildlife ManagementThe Islamia University of BahawalpurBahawalpur63100Pakistan

Nitrogen(N),the building block of plant proteins and enzymes,is an essential macronutrient for plant functions.A field experiment was conducted to investigate the impact of different N application rates(28,57,85,114,142,171,and 200 kg ha^(−1))on the performance of spring wheat(***-2016)during the 2017–2018 and 2018–2019 growing seasons.A control without N application was kept for *** years mean data showed optimum seed yield(5,461.3 kg ha^(−1))for N-application at 142 kg ha^(−1) whereas application of lower and higher rates of N did not result in significant and economically higher seed yield.A higher seed yield was obtained in the 2017–2018(5,595 kg ha^(−1))than in the 2018–2019(5,328 kg ha^(−1))growing seasons under an N application of 142 kg ha^(−1).It was attributed to the greater number of growing degree days in the first(1,942.35°C days)than in the second year(1,813.75°C).Higher rates of N(171 and 200 kg ha^(−1))than 142 kg ha^(−1) produced more number of tillers(i.e.,948,300 and 666,650 ha^(−1),respectively).However,this increase did not contribute in achieving higher *** of 142,171,and 200 kg ha^(−1) resulted in 14.15%,15.0%and 15.35%grain protein concentrations in comparison to 13.15%with the application of 114 kg ha^(−1).It is concluded that the application of N at 142 kg ha^(−1) could be beneficial for attaining higher grain yields and protein concentrations of wheat cultivar Ujala-2016.

关键词： Economical yield growing degree days nitrogen Ujala-2016 wheat

Optimal Resource Allocation Method for Device-to-Device Communication in 5G Networks

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Computers, Materials & Continua 2022年第4期71卷 1-15页

作者： Fahd N.Al-Wesabi Imran Khan Saleem Latteef Mohammed Huda Farooq jameel Mohammad Alamgeer Ali M.Al-Sharafi Byung Seo Kim Department of Computer Science King Khalid UniversityMuhayel AseerKSA Faculty of Computer and IT Sana’a UniversityYemen Department of Electrical Engineering University of Engineering and TechnologyPeshawarPakistan Department of Medical Instrumentation Techniques Engineering Electrical Engineering Technical CollegeMiddle Technical UniversityBaghdad10013Iraq Department of Information Systems King Khalid UniversityMayahel AseerKSA Department of Computer Science College of Computers and Information TechnologyUniversity of BishaKSA Department of Software and Communications Engineering Hongik UniversityKorea

With the rapid development of the next-generation mobile network,the number of terminal devices and applications is growing ***,how to obtain a higher data rate,wider network coverage and higher resource utilization in the limited spectrum resources has become the common research goal of ***-to-Device(D2D)communication technology and other frontier communication technologies have ***-to-Device communication technology is the technology that devices in proximity can communicate directly in cellular *** has become one of the key technologies of the fifth-generation mobile communications system(5G).D2D communication technology which is introduced into cellular networks can effectively improve spectrum utilization,enhance network coverage,reduce transmission delay and improve system throughput,but it would also bring complicated and various interferences due to reusing cellular resources at the same *** resource management is one of the most challenging and importing issues to give full play to the advantages of D2D *** resource allocation is an important factor that needs to be addressed in D2D ***,this paper proposes an optimization method based on the game-matching *** main idea is to model the optimization problem of the quality-of-experience based on user fairness and solve it through game-matching *** results show that the proposed algorithm effectively improved the resource allocation and utilization as compared with existing algorithms.

关键词： D2D communication resource allocation optimization networks

Pomegranate peel extract lessens histopathologic changes and restores antioxidant homeostasis in the hippocampus of rats with aluminium chloride-induced Alzheimer’s disease

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Asian Pacific Journal of Tropical Medicine 2020年第10期13卷 456-463页

作者： Steve Harakeh Wafaa S.Ramadan Mohammed S.Al Muhayawi Soad Al Jaouni Shaker Mousa khalid Rehman Hakeem Special Infectious Agent Unit King Fahd Medical Research CenterKing Abdulaziz UniversityKingdom of Saudi Arabia Department of Anatomy Faculty of MedicineKing Abdulaziz UniversityKingdom of Saudi Arabia Department of Anatomy Faculty of MedicineAin Shams UniversityCairoEgypt Department of Medical Microbiology/Parasitology and Molecular Microbiology Laboratory KAUHKing Abdulaziz UniversityKingdom of Saudi Arabia Department of Hematology/Pediatric Oncology King Abdulaziz University Hospital(KAUH)Faculty of MedicineKing Abdulaziz UniversityKingdom of Saudi Arabia Yousef Abdul Latif jameel Scientific Chair of Prophetic Medicine Application Faculty of MedicineKing Abdulaziz UniversityKingdom of Saudi Arabia Pharmaceutical Research Institute Albany College of Pharmacy and Health SciencesRensselaerNYUSA Department of Biological Sciences Faculty of SciencesKing Abdulaziz UniversityJeddahSaudi Arabia

Objective:To investigate the neuroprotective efficacy of pomegranate and ellagic acid on the histopathological changes in the hippocampus of an aluminium chloride(AlCl3)induced rat model of Alzheimer’s ***:Sprague Dawley rats were divided into 4 groups(n=10each):GroupⅠ:serving as negative control;GroupⅡ,Alzheimer model,induced by administration of 17 mg/kg bw AlCl3;GroupⅢ,administered the same dose of AlCl3 with 50 mg/kg of pomegranate peel extract and GroupⅣ:administered ellagic acid(50 mg/kg)in addition to the same dose of *** medication given to all groups continued for 28 *** were given the compounds by gastric *** arm maze test,hippocampus antioxidant markers,histopathology of the dentate gyrus,and CA3 of the hippocampus were ***:Rats treated with pomegranate peel extract exposed to radial arm maze test showed less number of errors and reduced time needed to reach the *** was an increase in the levels of glutathione,catalase,and total antioxidant capacity and decreased lipid peroxidation *** features in dentate gyrus and CA3 as apoptosis and chromatolysis of pyramidal cells and granular layer,respectively,were *** characteristic neurofibrillary tangles and senile plaques were *** with ellagic acid ameliorated the pathological results but to a statistically lower ***:Pomegranate peel extract alleviates memory deficit and restores antioxidant homeostasis following degenerative changes in the hippocampus induced by aluminium chloride in rats.

关键词： Pomegranate Peel extract Ellagic acid Antioxidants Hippocampus Behavioural test

A Study on Factors Influencing Cost Overrun in High-rise Building Construction across India

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Journal of Smart Buildings and Construction Technology 2023年第1期5卷 52-83页

作者： Mohammed Tayyab Mohammed Furkhan Mohammed Rizwan M.jameel, Aaron Chadee Lords Institute of Engineering and Technology Osmania UniversityHyderabad500007India Department of Civil Engineering King Khalid University62529Kingdom of Saudi Arabia Department of Civil and Environmental Engineering University of the West IndiesBB11000Trinidad and Tobago

Cost overrun is a common problem in construction projects *** Indian construction projects,particularly those involving high-rise buildings,have had severe cost *** managers,architects,engineers,and contractors,completing building projects within the specified cost budget has become the most important and hard *** it is common for high-rise building projects to go over budget,the aim of this study is to find out the causes of cost overruns and provide effective *** study found 70 cost overrun factors based on a comprehensive literature review and expert opinions.A Google form questionnaire was distributed to 150 construction professionals across *** following up,101 of the 150 responses were received.A five-point Likert scale was used and the acquired data was analyzed and ranked using the Relative Importance Index(RII)*** to the findings of RII,the top ten critical factors influencing cost overruns were frequent change orders during construction by the owner,delay in construction,escalation of material prices,market inflation or deflation,rework,frequent changes in design,inaccurate evaluation of the project timeline,unforeseen ground condition,inaccurate quantity take-off,and delay in progressive payment by the ***’s rank correlation test revealed that there is a very significant relationship between the rankings of factors provided by the owner,the consultant,and the *** addition,a factor analysis tool in the SPSS software was also used to categorize the seventy factors into sixteen core *** top ten critical factors were presented to subject matter experts,and their suggestions were being *** results are expected to help construction professionals minimize cost overruns,improve cost control measures,and initiate future research.

关键词： Cost overrun High-rise buildings RII Factor analysis Subject matter expert(SME) India

Review of bonding behavior, mechanisms, and characterization approach in bituminous materials under different conditions

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第6期 1291-1316页

作者： Hanizah Osman Muhamad Zulfatah Izham Muhamad Rodzey Mohd Rosli Mohd Hasan Tracy Leh Xin Wong Mohd Fahmi Haikal Mohd Ghazali Zulfirdaus Zakaria Mohammed jameel School of Civil Engineering Universiti Sains Malaysia Politeknik Sultan Abdul Halim Muadzam Shah Institute for Advanced Studies Universiti Malaya Department of Civil Engineering College of EngineeringKing Khalid University

Bituminous materials play a crucial role in the construction industry, serving as essential binders in asphalt mixtures. Understanding their bonding behavior, mechanism, and characterization is imperative for enhancing pavement performance, durability, and sustainability. Despite the widespread use of bituminous materials, challenges persist in optimizing their physical, rheological, and mechanical properties, addressing aging effects,and developing eco-friendly alternatives. The modification can be made by incorporating modifiers or additives, such as anti-stripping agents, surfactants, and bonding promoters,at their optimal dosages. Technically, the cohesion and adhesion bonds could be reinforced by adding a designated percentage of additives to the asphalt binder and within the asphalt-aggregate interfaces in asphalt mixtures. Prior to improving the pavement materials for road construction, adhesion and wetting properties also need to be given crucial attention. The inter-surface characteristics and their morphological behavior significantly influence the adhesion and cohesion bonding within binder-aggregate matrices, as indicated by the good correlations in both dry and wet conditions between failure pattern and bond strength. This review highlights recent breakthroughs in bituminous material research, emphasizing innovative approaches to enhance performance, durability, and environmental compatibility, providing insights for future advancements in asphalt pavement engineering. To advance the development of robust, environmentally sensitive asphalt pavements and guarantee a sustainable and effective transportation infrastructure for years to come, cooperation between researchers, engineers, and industry stakeholders is important.

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