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Exploring multi-level risk factors and post-war burdens of trachomatous trichiasis among displaced population in Raya Kobo districts, implication for urgent action

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International Journal of Ophthalmology(English edition) 2023年第8期16卷 1299-1308页

作者： muhammad jamal Fassikaw Kebede Mersa Health Center Habru Woreda North WolloWoldiaAmhara 400Ethiopia School of Public Health College of Health ScienceWoldia UniversityWoldiaAmhara 400Ethiopia

AIM:To estimate post-war burdens of trachomatous trichiasis(TT)and multi-level risk factors among displaced population in Raya Kobo districts,implication for urgent ***:A community-based cross-sectional study was conducted among 603 participants from randomly selected 14 displaced slums in the Raya Kobo *** data was collected from February 16th to March 30th,*** participants were selected using the multistage sampling technique.A structured questionnaire and ophthalmic loupe with×2.5 magnificence were used to collect from ***-level binary logistic regression was used to determine associated factors with TT *** odds ratio(AOR)with 95%confidence interval(CI)were claimed for the strength of association at P<***:We recruited 602(99.9%)participants for the final *** the total,126(20.9%)and 98(16.3%,95%CI:13.5%-19.4%)participants were diagnosed with active trachoma&TT infection,*** age≥45y(AOR=7.9,95%CI:2.4-25.3),having multiple eye infections(AOR=2.73,95%CI:1.47-5.29),poor wealth index(AOR=9.2;95%CI:2.7-23.7)and twice face washing per day(AOR=0.082,95%CI:0.03-0.21)has identified as individual as factors for TT ***,distance between clean water source≥10 km(AOR=6.5,95%CI:3.9-31.3),and latrine availability(AOR=0.35,95%CI:0.21-0.58)were the two community-level factors associated with TT ***:The high prevalence of TT infection post-war throughout the study districts indicates a need for urgent clinical intervention in addition to rapid scaling up surgery,antibiotics,facial cleanliness,and environmental improvement(SAFE)strategies,strategy for high-risk ***≥45y,distance from the clean water source,poor wealth indexes,and eye infection are identified to be risk factors for TT ***,community-level preventative factors for TT infection are found as latrine availability and face washing practice.

关键词： trachoma risk factor displaced population

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Quality and Crop Yield Potential of Moderately Degraded Alfisols Under Different Nutrient Inputs and Cropping Patterns

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Pedosphere 2019年第2期29卷 235-247页

作者： Wiqar AHMAD Farmanullah KHAN Zahir SHAH muhammad jamal KHAN Department of Soil and Environmental Sciences The University of Agriculture PeshawarAMK Campus Department of Soil and Environmental Sciences The University of AgriculturePeshawar

Crop performance on degraded soil needs special management practices to overcome soil quality limitations. In a 2-year(from summer 2006 to winter 2007–2008) field trial on a moderately degraded Alfisol in Swabi District(34°7′12′′N, 72°28′20′′E), Pakistan,the effects of three cropping patterns, cereal-cereal(CC), cereal-legume(CL), and cereal-cereal and legume intercrop(CLI), were tested in main plots under four fertilization treatments in sub-plots, including no fertilization(control), farmers' practice(FP, 60:45 kg ha^(-1) N:P_2O_5), recommended dose(RD, 120:90:60 kg ha^(-1) N:P_2O_5:K_2O), and integrated nutrient management(INM, 20 t ha^(-1) farmyard manure integrated with 50% N, 100% P, and K of recommended dose), using a split-plot randomized complete block design. The performance of CL was superior than CC in plant height, leaf area index(LAI), cob length, grain yield, biological yield, and grain protein(8%, 26%, 8%, 5%, 10%, and 8% increases, respectively), while CLI confirmed significant improvement only in LAI(25%) over CC. Response to nutrient inputs from all sources was in the order of INM > RD > FP > control, and the maximum net economic return by INM(23% and 2.5 times higher than RD and FP, respectively) indicated severe deficiency of both macro-and micro-nutrients in the soil as well as degraded physical properties. Increases in soil organic matter, total N, total mineral N, available P and K, total porosity, and available water-holding capacity by 6%, 34%, 24%, 50%, 13%, 5%, and 7%, respectively, and decrease in soil bulk density by 4% after four crop seasons indicated optimistic changes in soil quality as a result of the combined effects of fertilization from organic and inorganic sources and legumes within crop rotation. This study suggests that keeping the soil covered under cereal-legume rotation crops all year round and treatment with INM(50% N from organic source and 50% from inorganic source) are the best management practice for sustained produc

关键词： crop rotation crop performance degraded soil farmyard manure integrated nutrient management legume intercrop sustained production

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Reprogramming the Endogeneous Type Ⅲ-A Crispr-Cas System for Genome Engineering in Mycobacterium Tuberculosis

Reprogramming the Endogeneous Type Ⅲ-A Crispr-Cas System fo...

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作者： muhammad jamal 华中农业大学

学位级别：硕士

结核(TB)是21世纪的一种严重的疾病,每年造成170余万人死亡。肺结核由革兰氏阳性的棒状杆菌——结核分枝杆菌造成。世界范围内大约三分之一的人口被潜伏性感染,疾病的再次爆发与传染现象十分严峻。对于抗结核药物的抗生素耐药性在全球... 详细信息

结核(TB)是21世纪的一种严重的疾病,每年造成170余万人死亡。肺结核由革兰氏阳性的棒状杆菌——结核分枝杆菌造成。世界范围内大约三分之一的人口被潜伏性感染,疾病的再次爆发与传染现象十分严峻。对于抗结核药物的抗生素耐药性在全球范围内对于结核的防控造成了巨大的阻碍。耐药性(多耐药,广泛耐药,全耐药)造成了结核在人与动物间广泛传播。抗生素的滥用是严重的耐药性产生的原因。分枝杆菌的耐药性对于研发合适的化学疗法戒指是一个很大的限制。对TB中全部耐药性的探究可通过阻止耐药性菌株的传播来大大减少防控TB的负担。目前仅有的TB疫苗是开发于上世纪初的BCG。这种疫苗主要的缺陷是不能保护成年人免受TB的感染。更有免疫缺陷的儿童在接种该种疫苗后出现感染的实例。一些疫苗对于通过体液免疫去除的病原十分有效,然而人体对于TB的免疫是通过细胞免疫的途径,因此能帮助启动细胞免疫的疫苗会有较好的效果。疫苗的开发通过敲除一些决定致病性的基因完成,目前,结核分枝杆菌中有目标的基因调控主要通过基于充足的方法完成。然而,该种方法因为对于时间的资金的巨大消耗以及较低的效率以及特异性而未被广泛采用。基于成簇的规律间隔短回文重复序列(CRISPR)以及CRISPR协同作用蛋白(CRISPR-Cas9)的基因标记技术在几种生物中的发现给针对几种病原开发有效的疫苗带来了可能。CRISPR可分为几大类,以及各自的小类。结核分枝杆菌中CRISPR-Cas Ⅲ-A系统的存在使我们可以探究其基因编辑的系统。本研究中我们重新编排了内源性的CRISPR-Cas Ⅲ-A系统,使得我们可以仅通过转入一个表达小CRISPR序列以及一个带有EGFP的供体DNA模板就就可以进行高效率的基因敲入。我们同样将该方法应用于基因敲除,高效率的敲除了总计10个与自噬相关的基因,并通过深度测序验证了五脱靶现象的发生。然后我们研究了该方法介导下的基因沉默,我们选择了一段与基因编码区五核苷酸模体5‘-GAAAC-3‘互补的40bp的DNA序列,该种方法只会调控转录,对于基因组序列没有影响。结果显示,5个基因均出现了较大程度的下调表达(60%-90%)。最终,我们研究了作用于lpqE,KatG,InhA三个基因mRNA的间隔序列,导致了其60%-70%的减少。我们的工作研究出了一种十分具有潜力的可以高效率,高特异性编辑任何位点,以及沉默某些基因例如对结核生长十分重要的基因的工具。对于结核生长十分重要的基因的敲除以及表型研究显示了这种方法对于进一步深度研究基因功能的重要性。同时新型的基因沉默技术可能会克服传统基因沉默中由于引入了标记抗生素抗药性标记基因出现的交叉抗性问题。因此,CRISPR-Cas Ⅲ-A系统提供了一种有效的方法来编辑基因,用于开发预防性疫苗。一个重要的研究领域将是深入了解目标识别的分子机制及将其破坏。

关键词：结核结核分枝杆菌 CRISPR-Cas Ⅲ-A型系统基因组编辑基因沉默

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Mining Software Repository for Cleaning Bugs Using Data Mining Technique

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Computers, Materials & Continua 2021年第10期69卷 873-893页

作者： Nasir Mahmood Yaser Hafeez Khalid Iqbal Shariq Hussain muhammad Aqib muhammad jamal Oh-Young Song University Institute of Information Technology Pir Mehr Ali Shah Arid Agriculture UniversityRawalpindi46000Pakistan Department of Computer Science COMSATS University IslamabadAttock CampusAttock43600Pakistan Department of Software Engineering Foundation University IslamabadIslamabad44000Pakistan Department of Mathematics and Statistics Pir Mehr Ali Shah Arid Agriculture UniversityRawalpindi46000Pakistan Department of Software Sejong UniversitySeoul05006Korea

Despite advances in technological complexity and efforts,software repository maintenance requires reusing the data to reduce the effort and ***,increasing ambiguity,irrelevance,and bugs while extracting similar data during software development generate a large amount of data from those data that reside in ***,there is a need for a repository mining technique for relevant and bug-free data *** paper proposes a fault prediction approach using a data-mining technique to find good predictors for high-quality *** predict errors in mining data,the Apriori algorithm was used to discover association rules by fixing confidence at more than 40%and support at least 30%.The pruning strategy was adopted based on evaluation ***,the rules were extracted from three projects of different domains;the extracted rules were then combined to obtain the most popular rules based on the evaluation measure *** evaluate the proposed approach,we conducted an experimental study to compare the proposed rules with existing ones using four different industrial *** evaluation showed that the results of our proposal are *** and developers can utilize these rules for defect prediction during early software development.

关键词： Fault prediction association rule data mining frequent pattern mining

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Enhancing Secure Development in Globally Distributed Software Product Lines: A Machine Learning-Powered Framework for Cyber-Resilient Ecosystems

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Computers, Materials & Continua 2024年第6期79卷 5031-5049页

作者： Marya Iqbal Yaser Hafeez Nabil Almashfi Amjad Alsirhani Faeiz Alserhani Sadia Ali Mamoona Humayun muhammad jamal University Institute of Information Technology PMAS-Arid Agriculture UniversityRawalpindiPakistan Department of Software Engineering College of Computer and Information SciencesJouf UniversityAl Jouf72388Saudi Arabia Department of Computer Science College of Computer and Information SciencesJouf UniversityAl Jouf72388Saudi Arabia Department of Computer Engineering&Networks College of Computer and Information SciencesJouf UniversityAl Jouf72388Saudi Arabia Department of Information Systems College of Computer and Information SciencesJouf UniversitySakakaAl Jouf72388Saudi Arabia Department of Mathematics Pir Mehr Ali Shah Arid Agriculture UniversityRawalpindiPakistan

Embracing software product lines(SPLs)is pivotal in the dynamic landscape of contemporary software ***,the flexibility and global distribution inherent in modern systems pose significant challenges to managing SPL variability,underscoring the critical importance of robust cybersecurity *** paper advocates for leveraging machine learning(ML)to address variability management issues and fortify the security of *** the context of the broader special issue theme on innovative cybersecurity approaches,our proposed ML-based framework offers an interdisciplinary perspective,blending insights from computing,social sciences,and ***,it employs ML for demand analysis,dynamic feature extraction,and enhanced feature selection in distributed settings,contributing to cyber-resilient *** experiments demonstrate the framework’s superiority,emphasizing its potential to boost productivity and security in *** digital threats evolve,this research catalyzes interdisciplinary collaborations,aligning with the special issue’s goal of breaking down academic barriers to strengthen digital ecosystems against sophisticated attacks while upholding ethics,privacy,and human values.

关键词： Machine Learning variability management cybersecurity digital ecosystems cyber-resilience

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Advancements of Nano-Hydroxyapatite in Sports Medicine from Bone Injury Perspectives

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Wuhan University Journal of Natural Sciences 2021年第3期26卷 269-277页

作者： XIONG Youming SONG Tianbao WEI Zimeng CHEN Bei HONG Zixi ZHANG Chengjie jamal muhammad ZHANG Qiuping QIN Caiqin School of Physical Education Hubei Engineering UniversityXiaogan 432000HubeiChina Hubei Collaborative Innovation Center for Biomass Conversion and Utilization Hubei Engineering UniversityXiaogan 432000HubeiChina School of Basic Medical Sciences Wuhan UniversityWuhan 430071HubeiChina

Nanotechnology has revolutionized the field of biology and medicine in the 21 st *** injury incidences during sports activities are common,and they are traditionally treated with allogeneic grafting,a common clinical practice but limited by the quality of the graft and some side ***-hydroxyapatite(nHA)is considered as an ideal bone graft material owing to its bone-like structure,excellent biological activity,bone conductivity,non-toxicity,and *** and its composite materials have been found suitable for the adhesion,proliferation,and differentiation of mesenchymal stem cells,which leads to their potential applications in treating the bone *** this review,we classified different applications of nHA to explore the role of these materials in bone repair and tendon healing,highlighting the superior characteristics of nanomaterials in the treatment of bone injury,hoping to provide ideas for nHA applied to clinical practices for the treatment of bone injury.

关键词： nano-hydroxyapatite bone injury treatment sports medicine

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Reprogramming Mycobacterium tuberculosis CRISPR System for Gene Editing and Genomewide RNA Interference Screening

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Genomics, Proteomics & Bioinformatics 2022年第6期20卷 1180-1196页

作者： Khaista Rahman muhammad jamal Xi Chen Wei Zhou Bin Yang Yanyan Zou Weize Xu Yingying Lei Chengchao Wu Xiaojian Cao Rohit Tyagi muhammad Ahsan Naeem Da Lin Zeshan Habib Nan Peng Zhen F.Fu Gang Cao State Key Laboratory of Agricultural Microbiology Huazhong Agricultural UniversityWuhan 430070China College of Veterinary Medicine Huazhong Agricultural UniversityWuhan 430070China Bio-Medical Center Huazhong Agricultural UniversityWuhan 430070China Key Laboratory of Preventive Veterinary Medicine in Hubei Province the Cooperative Innovation Center for Sustainable Pig ProductionWuhan 430070China

Mycobacterium tuberculosis is the causative agent of tuberculosis(TB), which is still the leading cause of mortality from a single infectious disease worldwide. The development of novel anti-TB drugs and vaccines is severely hampered by the complicated and time-consuming genetic manipulation techniques for M. tuberculosis. Here, we harnessed an endogenous type Ⅲ-A CRISPR/Cas10 system of M. tuberculosis for efficient gene editing and RNA interference(RNAi).This simple and easy method only needs to transform a single mini-CRISPR array plasmid, thus avoiding the introduction of exogenous protein and minimizing proteotoxicity. We demonstrated that M. tuberculosis genes can be efficiently and specifically knocked in/out by this system as confirmed by DNA high-throughput sequencing. This system was further applied to single-and multiple-gene RNAi. Moreover, we successfully performed genome-wide RNAi screening to identify M. tuberculosis genes regulating in vitro and intracellular growth. This system can be extensively used for exploring the functional genomics of M. tuberculosis and facilitate the development of novel anti-TB drugs and vaccines.

关键词： Mycobacterium tuberculosis Type III-A CRISPR system Gene editing Gene interference Genome-wide RNAi screening

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Bioinformatics Analysis of the Relationship between Lifestyle and Prostate Cancer

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Wuhan University Journal of Natural Sciences 2020年第3期25卷 217-228页

作者： XIONG Youming YIN Qian YUAN Wen WANG Meng XIE Tian SUN Jiaxinq jamal muhammad SONG Tianbao CHEN Bei HONG Zixi QIN Caiqin Hubei Collaborative Innovation Center for Biomass Conversion and Utilization Hubei Engineering UniversityXiaogan 432000HubeiChina School of Basic Medical Sciences Wuhan UniversityWuhan 430071HubeiChina Hubei Key Laboratory of Biomass-Resource Chemistry and Environmental Biotechnology Hubei Engineering UniversityXiaogan 432000HubeiChina

In this study,we assessed the relationship between lifestyle and prostate *** selected the Gene Expression Omnibus(GEO)dataset GSE10306 to analyze the expression levels of ataxin10(ATXN10),interferon related developmental regulator 1(IFRD1),formin-binding protein 1 like(FNBP1 L)and THO complex 2(THOC2)in prostate biopsies pre and post intensive nutrition and lifestyle *** a three-month intervention of nutrition and lifestyle,these genes showed a significant *** database analysis showed that the four genes exhibited high expression in prostate cancer tissues compared with normal prostate tissues,which indicated that comprehensive lifestyle changes may modify the progression of prostate cancer mediated by altering the expression of ATXN10,FNBP1 L,THOC2 and *** the four genes,the high expression of IFRD1 was found to indicate a worse overall survival(OS)and disease-free survival(DFS).FNBP1 L and THOC2 were associated with CD8+T cell infiltration of prostate *** also speculated a possible regulatory network for lifestyle to influence miRNA,subsequently influencing the expression of relevant *** findings suggested that these genes may be used as potential target sites for the treatment of prostate cancer.

关键词： prostate cancer comprehensive lifestyle changes gene expression survival analysis immune infiltration miRNAs

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Buffer Management and Auxiliary Routing in TODVRP

Buffer Management and Auxiliary Routing in TODVRP

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作者： Joulani Shadi muhammad jamal 中南大学

学位级别：硕士

Ad hoc网络是一个由具有无线通信功能的节点组成的多跳无线网络,由于其独有的自组织特性,使得Ad hoc网络适合需要临时架构网络的场所,在军事和民用等领域具有很大发展前景。移动自组网MANET中应用程序使用音频和视频流的有效运作需... 详细信息

Ad hoc网络是一个由具有无线通信功能的节点组成的多跳无线网络,由于其独有的自组织特性,使得Ad hoc网络适合需要临时架构网络的场所,在军事和民用等领域具有很大发展前景。移动自组网MANET中应用程序使用音频和视频流的有效运作需要大的带宽。这使本来就有限的网络资源更加难以满足需要。本论文提出了一种算法-飞越算法（ODWNR）,改善了的TODVRP的算法性能。选择TODVRP协议做改进协议是基于以下原因：·TODVRP（?）办议规定用于ODWNR与其他协议的执行情况比较至少修改,如DSR和TORA的讨论。·它需要一个相对较低的开销,并具有良好的带宽和节约能源。·它是一个常用的协议。该算法在TODVRP协议基本上做了的改善,防止缓冲区的数据包被丢弃,修改缓冲区溢出运行方式。该算法通过路由监测系统,以纾缓挤塞备份各自的节点和在节点重新路由交通缓冲水平。拥塞是假设在缓冲区接近一个阈值,随后找出替代路线路由。该修改后的协议在NS2仿真平台上使用各种场景环境下进行评估,如不同层次的流动性,高,低流量的模拟。仿真结果包括一个单一的目标对应几个来源的制约因素,以进一步验证了飞越算法（ODWNR）全而有效性。实验结果表明,在TODVRP的性能大幅改善。具有良好的分组投递率和终端到终端的延迟。

关键词：移动自组网 TODVRP协议性能分析路由协议缓冲区管理

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Synthetic data as an investigative tool in hypertension and renal diseases research

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World Journal of Methodology 2025年第1期15卷 9-13页

作者： Aleena jamal Som Singh Fawad Qureshi Sidney Kimmel Medical College Thomas Jefferson UniversityPhiladelphiaPA 19107United States School of Medicine University of Missouri Kansas CityKansasMO 64106United States Division of Nephrology and Hypertension Mayo ClinicRochesterMN 55905United States

There is a growing body of clinical research on the utility of synthetic data derivatives,an emerging research tool in *** nephrology,clinicians can use machine learning and artificial intelligence as powerful aids in their clinical decision-making while also preserving patient *** is especially important given the epidemiology of chronic kidney disease,renal oncology,and hypertension ***,there remains a need to create a framework for guidance regarding how to better utilize synthetic data as a practical application in this research.

关键词： Synthetic data Artificial intelligence Nephrology Blood pressure Research Editorial

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