Bioinformatics Analysis of the Relationship between Lifestyle and Prostate Cancer

作     者：XIONG Youming YIN Qian YUAN Wen WANG Meng XIE Tian SUN Jiaxinq JAMAL Muhammad SONG Tianbao CHEN Bei HONG Zixi QIN Caiqin XIONG Youming;YIN Qian;YUAN Wen;WANG Meng;XIE Tian;SUN Jiaxing;JAMAL Muhammad;SONG Tianbao;CHEN Bei;HONG Zixi;QIN Caiqin

作者机构：Hubei Collaborative Innovation Center for Biomass Conversion and UtilizationHubei Engineering UniversityXiaogan 432000HubeiChina School of Basic Medical SciencesWuhan UniversityWuhan 430071HubeiChina Hubei Key Laboratory of Biomass-Resource Chemistry and Environmental BiotechnologyHubei Engineering UniversityXiaogan 432000HubeiChina 

出 版 物：《Wuhan University Journal of Natural Sciences》 (武汉大学学报（自然科学英文版）)

年 卷 期：2020年第25卷第3期

页      面：217-228页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by the Natural Science Foundation of Hubei Province(2012FFC010) the National Natural Science Foundation of China(31371750) 

主　　题：prostate cancer comprehensive lifestyle changes gene expression survival analysis immune infiltration miRNAs 

摘      要：In this study,we assessed the relationship between lifestyle and prostate *** selected the Gene Expression Omnibus(GEO)dataset GSE10306 to analyze the expression levels of ataxin10(ATXN10),interferon related developmental regulator 1(IFRD1),formin-binding protein 1 like(FNBP1 L)and THO complex 2(THOC2)in prostate biopsies pre and post intensive nutrition and lifestyle *** a three-month intervention of nutrition and lifestyle,these genes showed a significant *** database analysis showed that the four genes exhibited high expression in prostate cancer tissues compared with normal prostate tissues,which indicated that comprehensive lifestyle changes may modify the progression of prostate cancer mediated by altering the expression of ATXN10,FNBP1 L,THOC2 and *** the four genes,the high expression of IFRD1 was found to indicate a worse overall survival(OS)and disease-free survival(DFS).FNBP1 L and THOC2 were associated with CD8+T cell infiltration of prostate *** also speculated a possible regulatory network for lifestyle to influence miRNA,subsequently influencing the expression of relevant *** findings suggested that these genes may be used as potential target sites for the treatment of prostate cancer.