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Bioactive Materials 2023年第3期21卷 358-380页

作者： Nem Singh Jungryun kim jaewon kim Kyungwoo Lee Zehra Zunbul Injun Lee Eunji kim Sung-Gil Chi Jong Seung kim Department of Chemistry Korea UniversitySeoul02841South Korea Department of Life Science Korea UniversitySeoul02841South Korea

Nanomedicines for drug delivery and imaging-guided cancer therapy is a rapidly growing research *** unique properties of nanomedicines have a massive potential in solving longstanding challenges of existing cancer drugs,such as poor localization at the tumor site,high drug doses and toxicity,recurrence,and poor immune ***,inadequate biocompatibility restricts their potential in clinical ***,advanced nanomaterials with high biocompat-ibility and enhanced therapeutic efficiency are highly desired to fast-track the clinical translation of *** properties of nanoscale covalent organic frameworks(nCOFs),such as suitable size,modular pore geometry and porosity,and straightforward post-synthetic modification via simple organic transformations,make them incredibly attractive for future *** ability of COFs to disintegrate in a slightly acidic tumor microenvironment also gives them a competitive advantage in targeted *** review summarizes recently published applications of COFs in drug delivery,photo-immuno therapy,sonodynamic therapy,photothermal therapy,chemotherapy,pyroptosis,and combination *** we mainly focused on modifications of COFs to enhance their biocompatibility,efficacy and potential clinical *** review will provide the fundamental knowledge in designing biocompatible nCOFs-based nano-medicines and will help in the rapid development of cancer drug carriers and theranostics.

关键词： doses medicines compatibility

Regulating the microenvironment with nanomaterials:Potential strategies to ameliorate COVID-19

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药学学报:英文版 2023年第9期13卷 3638-3658页

作者： Zhicheng Liu Zhuolei Han Xin Jin Jusung An jaewon kim Wenting Chen Jong Seung kim Ji Zheng Jun Deng Department of Urology Xinqiao HospitalThird Military Medical University(Army Medical University)Chongqing 400037China Department of Urology Urological Surgery Research InstituteSouthwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Institute of Burn Research Southwest HospitalState Key Lab of TraumaBurn and Combined InjuryChongqing Key Laboratory for Disease ProteomicsThird Military Medical University(Army Medical University)Chongqing 400038China Tianjin Key Laboratory of Composite and Functional Materials School of Materials Science and EngineeringTianjin UniversityTianjin 300350China Department of Chemistry Korea UniversitySeoul 02841South Korea Department of Rheumatology and Clinical Immunology Army Medical CenterThird Military Medical University(Army Medical University)Chongqing 400042China

COVID-19,caused by SARS-CoV-2,has resulted in serious economic and health *** treatments remain inadequate to extinguish the epidemic,and efficient therapeutic approaches for COVID-19 are urgently being ***,accumulating evidence suggests that microenvironmental disorder plays an important role in the progression of COVID-19 in *** addition,recent advances in nanomaterial technologies provide promising opportunities for alleviating the altered homeostasis induced by a viral infection,providing new insight into COVID-19 *** literature reviews focus only on certain aspects of microenvironment alterations and fail to provide a comprehensive overview of the changes in homeostasis in COVID-19 *** fill this gap,this review systematically discusses alterations of homeostasis in COVID-19 patients and potential ***,advances in nanotechnology-based strategies for promoting homeostasis restoration are ***,we discuss the challenges and prospects of using nanomaterials for COVID-19 *** review provides a new strategy and insights into treating COVID-19 and other diseases associated with microenvironment disorders.

关键词： Coronavirus disease 19 Severe acute respiratory syndrome coronavirus 2 Therapeutic approaches Nanotechnology Nanomaterial technologies Microenvironment Microenvironmental disorder Altered homeostasis

Postmortem ^(7)Li NMR analysis for assessing the reversibility of lithium metal electrodes in lithium metal batteries

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Journal of Energy Chemistry 2024年第7期94卷 430-440页

作者： jaewon Baek Sunha kim Hee-Tak kim Oc Hee Han Department of Chemical&Biomolecular Engineering KAISTDaejeon 34141Republic of Korea Metropolitan Seoul Center Korea Basic Science InstituteSeoul 03759Republic of Korea Graduate School of Analytical Science&Technology Chungnam National UniversityDaejeon 34134Republic of Korea

Despite the proficiency of lithium(Li)-7 NMR spectroscopy in delineating the physical and chemical states of Li metal electrodes,challenges in specimen preparation and interpretation impede its *** this study,we conducted a comprehensive postmortem analysis utilizing ^(7)Li NMR,employing a stan-dard magic angle spinning probe to examine protective-layer coated Li metal electrodes and LiAg alloy electrodes against bare Li metal electrodes within Li metal batteries(LMBs).Our investigation explores the effects of sample burrs,alignment with the magnetic field,the existence of liquid electrolytes,and precycling on the ^(7)Li NMR *** contrasting NMR spectra before and after cycling,we identi-fied alterations in Li^(0) and Li^(+) signals attributable to the degradation of the Li metal *** NMR analyses decisively demonstrate the efficacy of the protective layer in mitigating dendrite and solid elec-trolyte interphase ***,we noted that Li*ions near the Li metal surface exhibit magnetic susceptibility anisotropy,revealing a novel approach to studying diamagnetic species on Li metal elec-trodes in *** study provides valuable insights and practical guidelines for characterizing distinct lithium states within LMBs.

关键词： NMR spectroscopy Lithium-7 Lithium metal battery Electrolyte Electrode-protective layer Solid electrolyte interface Magnetic susceptibility anisotropy Lithium-metal NMR signal Diamagnetic^(7)Li NMR signal

Nanowire-assisted freestanding liquid metal thin-film patterns for highly stretchable electrodes on 3D surfaces

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npj Flexible Electronics 2022年第1期6卷 956-963页

作者： Minwoo kim Chulmin Cho Wooseop Shin Jung Jae Park jaewon kim Phillip Won Carmel Majidi Seung Hwan Ko Applied Nano and Thermal Science Lab Department of Mechanical EngineeringSeoul National UniversitySeoulGwanak-guKorea Mechatronics Research Samsung ElectronicsHwaseong-siGyeonggi-doKorea Soft Machines Lab Department of Mechanical EngineeringCarnegie Mellon UniversityPittsburghPAUSA Institute of Advanced Machines and Design/Institute of Engineering Research Seoul National UniversitySeoulKorea

Stretchable electronics is playing an integral role in fields such as wearable electronics and soft *** soft conductive materials,liquid metal is drawing intense attention as an electrode material due to its liquid nature at room ***,the merits of liquid metal conductor are limited by the presence of substrates or enclosed microchannels from physical disturbances by the underlying substrate when applying it to 3D surface and modifying complex *** overcome this limitation,we develop freestanding patterned liquid metal thin-film conductor(FS-GaIn).FS-GaIn was achieved by introducing metal nanowires to liquid metal and subsequent sequential selective laser processing and etching of directly patterned *** can be applied directly to nonflat surface without *** incorporated into electrical circuits,FS-GaIn shows high electrical conductivity,stretchability,and *** concept of freestanding liquid metal can open a functionality to the conventional liquid metal electronics.

关键词： liquid film free

Hybridization of different types of exceptional points

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Photonics Research 2019年第12期7卷 1473-1478页

作者： JINHYEOK RYU SUNJAE GWAK jaewon kim HYEON-HYE YU JI-HWAN kim JI-WON LEE CHANG-HWAN YI CHIL-MIN kim Department of Emerging Materials Science DGISTDaegu 42988South Korea Institut fur Physik Technische Universitat IlmenauD-98693 IlmenauGermany Samsung Electro-Mechanics Suwon 16674South Korea

A large number of different types of second-order non-Hermitian degeneracies called exceptional points(EPs)were found in various physical systems depending on the mechanism of coupling between *** show that these EPs can be hybridized to form higher-order EPs,which preserve the original properties of the initial EPs before *** a demonstration,we hybridize chiral and supermode second-order EPs,where the former and the latter are the results of intra-disk and inter-disk mode coupling in an optical system comprised of two Mie-scale microdisks and one Rayleigh-scale *** high sensitivity of the resulting third-order EP against external perturbations in our feasible system is emphasized.

关键词： exceptional coupling system

Azimuthal rotation-controlled nanoinscribing for continuous patterning of period-and shapetunable asymmetric nanogratings

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Microsystems & Nanoengineering 2024年第3期10卷 207-218页

作者： Useung Lee Hyein kim Dong Kyo Oh Nayeong Lee Jonggab Park jaewon Park Hyunji Son Hyunchan Noh Junsuk Rho Jong G.Ok Department of Mechanical and Automotive Engineering Seoul National University of Science and TechnologySeoul 01811Republic of Korea Department of Mechanical Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea Department of Chemical Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea POSCO-POSTECH-RIST Convergence Research Center for Flat Optics and Metaphotonics Pohang 37673Republic of Korea National Institute of Nanomaterials Technology(NINT) Pohang 37673Republic of Korea Present address:Department of Mechanical Engineering Korea University145 Anam-roSeongbuk-guSeoul 02841Republic of Korea Research Team Hyundai Motor Group150 Hyundaiyeonguso-roHwaseong-siGyeonggi 18280Republic of Korea

We present an azimuthal-rotation-controlled dynamic nanoinscribing(ARC-DNI)process for continuous and scalable fabrication of asymmetric nanograting structures with tunable periods and shape profiles.A sliced edge of a nanograting mold,which typically has a rectangular grating profile,slides over a polymeric substrate to induce its burrfree plastic deformation into a linear *** this continuous nanoinscribing process,the“azimuthal angle,”that is,the angle between the moving direction of the polymeric substrate and the mold’s grating line orientation,can be controlled to tailor the period,geometrical shape,and profile of the inscribed *** modulating the azimuthal angle,along with other important ARC-DNI parameters such as temperature,force,and inscribing speed,we demonstrate that the mold-opening profile and temperature-and time-dependent viscoelastic polymer reflow can be controlled to fabricate asymmetric,blazed,and slanted nanogratings that have diverse geometrical profiles such as trapezoidal,triangular,and ***,period-and profile-tunable ARC-DNI can be utilized for the practical fabrication of diverse optical devices,as is exemplified by asymmetric diffractive optical elements in this study.

关键词： tunable asymmetric rotation

Multifocal skull-compensated transcranial focused ultrasound system for neuromodulation applications based on acoustic holography

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Microsystems & Nanoengineering 2023年第2期9卷 367-379页

作者： Geon Kook Yehhyun Jo Chaerin Oh Xiaojia Liang jaewon kim Sang-Mok Lee Subeen kim Jung-Woo Choi Hyunjoo Jenny Lee School of Electrical Engineering Korea Advanced Institute of Science and Technology291 Daehak-roYuseong-guDaejeon 34141South Korea KAIST Institute for NanoCentury(KINC) 291 Daehak-roYuseong-guDaejeon 34141Republic of Korea

Transcranial focused ultrasound stimulation is a promising therapeutic modality for human brain disorders because of its noninvasiveness,long penetration depth,and versatile spatial control capability through beamforming and beam ***,the skull presents a major hurdle for successful applications of ultrasound ***,skull-induced focal aberration limits the capability for accurate and versatile targeting of brain *** addition,there lacks a fully functional preclinical neuromodulation system suitable to conduct behavioral ***,we report a miniature ultrasound system for neuromodulation applications that is capable of highly accurate multiregion targeting based on acoustic *** work includes the design and implementation of an acoustic lens for targeting brain regions with compensation for skull aberration through time-reversal recording and a phase conjugation ***,we utilize MEMS and 3D-printing technology to implement a 0.75-g lightweight neuromodulation system and present in vivo characterization of the packaged system in freely moving *** preclinical system is capable of accurately targeting the desired individual or multitude of brain regions,which will enable versatile and explorative behavior studies using ultrasound neuromodulation to facilitate widespread clinical adoption.

关键词： versatile utilize recording

Microfluidic systems for axonal growth and regeneration research

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Neural Regeneration Research 2014年第19期9卷 1703-1705页

作者： Sunja kim jaewon Park Arum Han Jianrong Li Department of Veterinary Integrative Biosciences Texas A&M UniversityCollege Station Institution for Neuroscience Texas A&M UniversityCollege Station Department of Electrical and Computer Engineering Texas A&M UniversityCollege Station

Damage to the adult mammalian central nervous system （CNS） often results in persistent neurological deficits with limited recovery of functions. The past decade has seen in- creasing research efforts in neural regeneration research with the ultimate goal of achieving functional recovery. Many studies have focused on prevention of further neural damage and restoration of functional connections that are com- promised after iniurY or pathological damage.

关键词： Microfluidic systems for axonal growth and regeneration research CNS Figure

Comparison of numerical codes for coupled thermo-hydro-mechanical simulations of fractured media

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Journal of Rock Mechanics and Geotechnical Engineering 2020年第4期12卷 850-865页

作者： Ahmad Zareidarmiyan Hossein Salarirad Victor Vilarrasa Kwang-Il kim jaewon Lee Ki-Bok Min Department of Mining Engineering Amirkabir University of Technology-Tehran Polytechnic(AUT)TehranIran Institute of Environmental Assessment and Water Research(IDAEA) Spanish National Research Council(CSIC)BarcelonaSpain Associated Unit:Hydrogeology Group UPC-CSIC BarcelonaSpain Department of Energy Resources Engineering Seoul National UniversitySeoulRepublic of Korea Radioactive Waste Disposal Research Division Korea Atomic Energy Research Institute(KAERI)DaejeonRepublic of Korea

Geo-energy and geo-engineering applications,such as improved oil recovery(IOR),geologic carbon storage,and enhanced geothermal systems(EGSs),involve coupled thermo-hydro-mechanical(THM)processes that result from fluid injection and *** some cases,reservoirs are highly fractured and the geomechanical response is controlled by ***,fractures should explicitly be included into numerical models to realistically simulate the THM responses of the *** this study,we perform coupled THM numerical simulations of water injection into naturally fractured reservoirs(NFRs)using CODE_BRIGHT and TOUGH-UDEC ***_BRIGHT is a finite element method(FEM)code that performs fully coupled THM analysis in geological media and TOUGH-UDEC sequentially solves coupled THM processes by combining a finite volume method(FVM)code that solves nonisothermal multiphase flow(TOUGH2)with a distinct element method(DEM)code that solves the mechanical problem(UDEC).First,we validate the two codes against a semi-analytical solution for water injection into a single deformable fracture considering variable permeability based on the cubic ***,we compare simulation results of the two codes in an idealized conceptual model that includes one horizontal fracture and in a more realistic model with multiple *** code models fractures *** calculates fracture deformation from the fracture normal and shear stiffnesses,while CODE_BRIGHT treats fractures as equivalent porous media and uses the equivalent Young’s modulus and Poisson’s ratio of the ***,we obtain comparable results of pressure,temperature,stress and displacement distributions and evolutions for the single horizontal fracture *** some similarities,the two codes provide increasingly different results as model complexity *** differences highlight the challenging task of accurately modeling coupled THM processes in fractured media given their high nonlineari

关键词： Coupled thermo-hydro-mechanical(THM) analysis Improved oil recovery(IOR) Naturally fractured reservoir(NFR) CODE_BRIGHT TOUGH-UDEC

Fluoropolymer-based organic memristor with multifunctionality for flexible neural network system

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npj Flexible Electronics 2021年第1期5卷 296-303页

作者： Min-Hwi kim Hea-Lim Park Min-Hoi kim jaewon Jang Jin-Hyuk Bae In Man Kang Sin-Hyung Lee School of Electrical and Computer Engineering Seoul National University1 Gwanak-roGwanak-guSeoul 08826Republic of Korea Department of Materials Science and Engineering Seoul National University of Science and TechnologySeoul 01811Republic of Korea Department of Creative Convergence Engineering Hanbat National UniversityYuseong-guDaejeon 305-719Republic of Korea School of Electronics Engineering and School of Electronic and Electrical EngineeringKyungpook National University80 Daehak-roBuk-guDaegu 702-701Republic of Korea

In this study,we propose an effective strategy for achieving the flexible one organic transistor–one organic memristor(1T–1R)synapse using the multifunctional organic *** dynamics of the conductive nanofilament(CF)in a hydrophobic fluoropolymer medium is explored and a hydrophobic fluoropolymer-based organic memristor is *** flexible 1T–1R synapse can be fabricated using the solution process because the hydrophobic fluorinated polymer layer is produced on the organic transistor without degradation of the underlying *** developed flexible synapse exhibits multilevel conductance with high reliability and stability because of the fluoropolymer film,which acts as a medium for CF growth and an encapsulating layer for the organic ***,the synapse cell shows potential for high-density memory systems and practical neural *** effective concept for developing practical flexible neural networks would be a basic platform to realize the smart wearable electronics.

关键词： transistor network neural