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SARS-CoV-2 RBD and Its Variants Can Induce Platelet Activation and Clearance:Implications for Antibody therapy and Vaccinations against COVID-19

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Research 2024年第3期2023卷 1-15页

作者： Xiaoying Ma jady Liang Guangheng Zhu Preeti Bhoria Aron A.Shoara Daniel t.MacKeigan Christopher j.Khoury Sladjana Slavkovicl Lisha Lin Danielle Karakas Ziyan Chen Viktor Prifti Zhenze Liu Chuanbin Shen Yuchong Li Cheng Zhang jiayu Dou Zack Rousseau jiamin Zhang tiffany Ni Xi Lei Pingguo Chen Xiaoyu Wu Hamed Shaykhalishahi Samira Mubareka Kim AConnelly Haibo Zhang Ori Rotstein Heyu Ni Department of Laboratory Medicine and Pathobiology University of TorontoTorontoONCanada Department of Laboratory Medicine Keenan Research Centre for Biomedical Science of St.Michael’s HospitalTorontoONCanada toronto Platelet Immunobiology Group TorontoONCanada Department of Physiology University of TorontoTorontoONCanada CCOA therapeutics Inc. TorontoONCanada Canadian Blood Services Centre for Innovation TorontoONCanada the State Key Laboratory of Respiratory Disease Guangzhou Institute of Respiratory DiseaseThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdongChina Department of Laboratory Medicine The Second Affliated Hospital of Guangzhou University of Chinese MedicineGuangzhouChina Advanced Pharmaceutics&Drug Delivery Laboratory Leslie Dan Faculty of PharmacyUniversity of TorontoTorontoONCanada Department of Medical Microbiology and Infectious Disease Sunnybrook Health Science CentreToronto ONCanada Department of Medicine University of TorontoTorontoONCanada Division of Cardiology.St.Michael's Hospital TorontoONCanada Department of Anesthesiology and Pain Medicine and Division of Critical Care Medicine University of TorontoTorontoONCanada interdepartmental Division of Critical Care Medicine University of TorontoTorontoONCanada Department of Surgery University of Toronto TorontoONCanada.

the COVID-19 pandemic caused by SARS-CoV-2 virus is an ongoing global health *** cases of COVID-19 and the rare cases of COVID-19 vaccine-induced-thrombotic-thrombocytopenia(VItt)are both associated with thrombosis and thrombocytopenia;however,the underlying mechanisms remain inadequately *** infection and vaccination utilize the spike protein receptor-binding domain(RBD)of *** found that intravenous injection of recombinant RBD caused significant platelet clearance in *** investigation revealed the RBD could bind platelets,cause platelet activation,and potentiate platelet aggregation,which was exacerbated in the Delta and Kappa *** RBD–platelet interaction was partially dependent on theβ3 integrin as binding was significantly reduced inβ3−/−***,RBD binding to human and mouse platelets was significantly reduced with relatedαIIbβ3 antagonists and mutation of the RGD(arginine-glycine-aspartate)integrin binding motif to RGE(arginine-glycine-glutamate).We developed anti-RBD polyclonal and several monoclonal antibodies(mAbs)and identified 4F2 and 4H12 for their potent dual inhibition of RBD-induced platelet activation,aggregation,and clearance in vivo,and SARS-CoV-2 infection and replication in Vero E6 *** data show that the RBD can bind platelets partially thoughαIIbβ3 and induce platelet activation and clearance,which may contribute to thrombosis and thrombocytopenia observed in COVID-19 and *** newly developed mAbs 4F2 and 4H12 have potential not only for diagnosis of SARS-CoV-2 virus antigen but also importantly for therapy against COVID-19.

关键词： Antibody diagnosis vaccine

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祁连山北坡沙尘天气气溶胶特征的飞机观测

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应用气象学报 2024年第3期35卷 311-322页

作者：奚立宗把黎庞朝云李宝梓黄山甘肃省人工影响天气办公室兰州730020

了解沙尘天气下气溶胶的垂直分布特征对于进一步认识气溶胶-云相互作用及其天气、气候效应至关重要。基于2023年9月6日沙尘天气下的飞机观测数据,分析祁连山北坡沙尘气溶胶的垂直分布特征。结果表明:此次沙尘天气是在高空锋区及地面冷... 详细信息

了解沙尘天气下气溶胶的垂直分布特征对于进一步认识气溶胶-云相互作用及其天气、气候效应至关重要。基于2023年9月6日沙尘天气下的飞机观测数据,分析祁连山北坡沙尘气溶胶的垂直分布特征。结果表明:此次沙尘天气是在高空锋区及地面冷高压的共同作用下形成。受沙尘天气影响,气溶胶粒径谱宽增宽;气溶胶数浓度较背景可上升约2~3倍,且气溶胶数浓度大值区呈悬垂状态分布,粒子数浓度大值层位于4000~4500 m和3000~4000 m高度;对沙尘气溶胶数浓度贡献最大的细粒子和粗粒子粒径分别为1.2~1.8μm和6.5~16.6μm,且气溶胶数浓度的增大在粗粒子段更为明显。气溶胶来源及输送层、以及气象要素垂直分布演变在气溶胶垂直分布及谱分布中发挥了重要作用。

关键词：沙尘气溶胶飞机观测祁连山北坡垂直分布

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Contribution of High Sensible C-Reactive Protein (hsCRP) in the Assessment of the Risk of Onset of type 2 Diabetes and Its Cardiovascular Complications

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journal of Diabetes Mellitus 2024年第2期14卷 95-107页

作者： Maïmouna touré Léopold Ngor Sène jean Pierre Diagne Demba Diédhiou Souleymane thiam Abdou Khadir Sow Mor Diaw Aïssatou Seck Salimata Diagne Houndjo Abdoulaye ba Abdoulaye Samb Fatou Diallo-Agne Modou Oumy Kane Laboratoire de Physiologie et d’ Explorations Fonctionnelles Physiologiques Facult&#233 de M&#233decine de Pharmacie et d&#8217OdontoStomatologie (FMPOS) Universit&#233 Cheikh Anta Diop (UCAD) Dakar S&#233n&#233gal IRL3189 &#8220Environnement Sant&#233 Soci&#233t&#233&#8221 CNRS CNRST Bamako-UCAD Facult&#233 de M&#233decine de Pharmacie et d&#8217OdontoStomatologie (FMPOS) Universit&#233 Cheikh Anta Diop (UCAD) Dakar S&#233n&#233gal Laboratoire Privé de Biologie General Kaolack S&#233n&#233gal Centre Hospitalier Universitaire (CHU) Abasse Ndao Universit&#233 Cheikh Anta Diop (UCAD) Dakar S&#233n&#233gal Laboratoire de Biochimie et de Biologie molé culaire Facult&#233 de M&#233decine de Pharmacie et d&#8217OdontoStomatologie (FMPOS) Universit&#233 Cheikh Anta Diop (UCAD) Dakar S&#233n&#233gal Laboratoire de Physiologie Pharmaceutique Facult&#233 de M&#233decine de Pharmacie et d'OdontoStomatologie (FMPOS) Universit&#233 Cheikh Anta Diop (UCAD) Dakar S&#233n&#233gal

background: type 2 diabetes is a metabolic disease characterized by chronic hyperglycemia. the latter plays an essential role in inflammation by stimulating the production of pro-inflammatory cytokines or by increasing their secretion by an oxidative mechanism. these cytokines control the hepatic synthesis of an inflammatory protein called C-Reactive Protein (CRP). High or average values of CRP would have a predictive value of cardiovascular diseases and type 2 diabetes. the relationship between low CRP values and the risk of developing type 2 diabetes and its cardiovascular complications is not sufficiently studied. the hsCRP could serve as a predictive biomarker of risk of onset, follow-up and prognosis for type 2 diabetes and its cardiovascular complications. to answer this problem, we conducted this study, the aim of which was to study the predictive role of hsCRP in the risk of occurrence of type 2 diabetes and its cardiovascular complications. Materials and Methods: this is a prospective and cross-sectional case-control study involving 200 participants including 100 control women and 100 women with type 2 diabetes (mean age was respectively 49.89 years ± 8.26 & 51.92 years ± 7.18;p = 0.066). the interviews were conducted on the basis of a questionnaire. Physical examination collected biometric data and cardiovascular constants. the biochemical parameters such as hsCRP were analyzed by an automated Abbott device. Results: We noted that hsCRP was significantly higher in type 2 diabetic subjects compared to control subjects (p (rho = 0.40, p systolic blood pressure (rho = 0.30, p = 0.003), diastolic blood pressure (rho = 0.28, p = 0.006), total body fat (rho = 0.48, p Conclusion: hsCRP has a prognostic value in the evaluation of cardiovascular risk. It seems to play an important role in the pathogenesis of type 2 diabetes mellitus and its cardiovascular complications. It could thus be considered as a biomarker for the screening, monitoring and prognosis of type 2

关键词： hsCRP Biomarker Inflammation type 2 Diabetes

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作者： (英)j.t.布兰南(j.t. Brannan)

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On the Space bv_p(F) of Sequences of p-bounded Variation of Fuzzy Numbers

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Acta Mathematica Sinica,English Series 2008年第7期24卷 1205-1212页

作者： zer tALO Feyzi ba■AR Fatih niversitesi Fen-Edebiyat FakltesiMatematik BlmBykekmece Kamps 34500-stanbulTrkiye

Recently, the space bvp of real or complex numbers consisting of all sequences whose differences are in the space lp has been studied by basar, Altay [Ukrainian Math. j. 55（1）（2003）, 136-147], where 1 ≤ p ≤ ∞. the main purpose of the present paper is to introduce the space bvp（F） of sequences of p-bounded variation of fuzzy numbers. Moreover, it is proved that the space bvp（F） includes the space lp（F） and also shown that the spaces bvp（F） and lp（F） axe isomorphic for 1 ≤ p ≤∞. Furthermore, some inclusion relations have been given.

关键词： sequence of fuzzy numbers space of difference sequences isomorphic spaces and inclusion relations

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First-principles calculations to investigate structural,electronic,magnetic,optical and thermodynamic properties of RE_(2)Rh_(3)Ge(RE=Pr,Sm)

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journal of Rare Earths 2024年第7期42卷 1385-1393,I0007页

作者： A.Ezaier R.Masrour M.Hamedoun j.Kharbach A.Rezzouk A.Hourmatallah N.Benzakour K.Bouslykhane Laboratory of Solid Physics Faculty of Sciences Dhar El MehrazSidi Mohamed Ben Abdellah UniversityBP 1796FezMorocco Equipe de Physique du Solide LaboratoiresLIPIEcole Normale SupérieureBensoudaFèsMorocco

In this paper,we analyzed the physical characteristics of the ternary alloys RE_(2)Rh_(3)Ge(RE=Pr and Sm)using the first principles calculation based on functional density theory integrated in the Wien2k *** calculated formation energies of Pr_(2)Rh_(3)Ge and Sm_(2)Rh_(3)Ge are−5.3827 and−5.2782 eV/atom,respectively,showing that these alloys may exist *** results of the band structure and density of states indicate that all of the compounds tested are magnetic metals,and their magnetism is mostly related to the contribution of Pr and Sm *** total magnetic moments of Pr_(2)Rh_(3)Ge and Sm_(2)Rh_(3)Ge are 4.07245 and 11.16161μB/f.u,*** parameters such as heat capacity at constant pressure,entropy,Debye temperature,lattice volume,compressibility coefficients,and Grüneisen parameter alloys were calculated using the Gibbs algorithm and studied in depth over a large temperature range of 0-900 *** Debye temperature increases with increasing pressure and decreases with decreasing ***,the Debye temperatures calculated at p=0 GPa and t=300 K are equal to be 342 and 322 K for Pr_(2)Rh_(3)Ge and Sm_(2)Rh_(3)Ge,*** optical characteristics such as the real and imaginary portions of the dielectric function,the absorption coefficient,the energy-loss function,and the refractive index were investigated and discussed in more depth.

关键词： Magnetic metals Functional density theory Density of states Magnetic moment Optical and thermodynamic properties Rare earths

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Rescattering of stimulated Raman side scattering in nonuniform plasmas

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Matter and Radiation at Extremes 2024年第5期9卷 68-76页

作者： S.tan Q.Wang Y.Chen W.B.Yao C.Z.Xiao j.F.Myatt School of Physics and Electronics Hunan UniversityChangsha 410082China Institute of Applied Physics and Computational Mathematics Beijing 100094China School of Electrical and Information Engineering Anhui University of Science and TechnologyHuainanAnhui 232001China Department of Electrical and Computer Engineering University of Alberta9211116 St.NWEdmontonAlberta T6G 1H9Canada

Rescattering of stimulated Raman side scattering(SRSS)is observed for the first time via two-dimensional(2D)particle-in-cell(PIC)*** construct a theoretical model for the rescattering process,which can predict the region of occurrence of mth-order SRSS and estimate its *** rescattering process is identified by the 2D PIC simulations under typical conditions of a direct-drive inertial confinement fusion *** electrons produced by second-order SRSS propagate nearly perpendicular to the density gradient and gain nearly the same energy as in first-order SRSS,but there is no cascade acceleration to produce superhot *** studies for a wide range of ignition conditions show that SRSS and associated rescatterings are robust and important processes in inertial confinement fusion.

关键词： nonuniform acceleration scattering

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Bi_(2)te_(3)基热电材料中的声子工程

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硅酸盐学报 2024年第1期52卷 203-217页

作者：刘志愿管希成李周马妮马俊杰巴倩夏爱林晋传贵安徽工业大学材料科学与工程学院安徽马鞍山243002 安徽工业大学先进金属材料绿色制备与表面技术教育部重点实验室安徽马鞍山243002 安徽大学材料科学与工程学院合肥230601 中国科学技术大学化学与材料科学学院合肥230026

Bi_(2)te_(3)基合金因其优异的电输运性能和较低热导率在低温区热电材料中备受关注。然而由Bi_(2)te_(3)基合金制造的热电发电或制冷器件转化效率仍较低,因此进一步提升Bi_(2)te_(3)基材料的热电优值zt是关键。由于晶格热导率与电性能... 详细信息

Bi_(2)te_(3)基合金因其优异的电输运性能和较低热导率在低温区热电材料中备受关注。然而由Bi_(2)te_(3)基合金制造的热电发电或制冷器件转化效率仍较低,因此进一步提升Bi_(2)te_(3)基材料的热电优值zt是关键。由于晶格热导率与电性能参数关联较少,在热电性能参数中较为独立,因此,在不影响电性能的前提下,通过声子工程降低晶格热导率成为提升zt值的重要方法。本文主要综述了近年来通过纳米改性、超晶格结构、纳米复合、掺杂和引入位错阵列等声子工程优化Bi_(2)te_(3)基材料热电性能的主要研究进展。通过这些优化手段可以显著降低材料的比热容、声子群速度或声子平均自由程,Bi_(2)te_(3)基材料的晶格热导率显著降低,热电性能大幅提升,为热电器件的应用提供科学和技术支撑。

关键词：碲化铋基热电材料声子工程晶格热导率热电性能

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2000—2020年岷江上游干旱河谷区植被时空变化及其地形效应

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现代地质 2024年第3期38卷 589-598页

作者：周雪妮肖成志刘磊计扬曹亚廷李小红巴仁基中国地质调查局军民融合地质调查中心四川成都610036 自然资源要素耦合过程与效应重点实验室北京100055 成都理工大学环境与土木工程学院四川成都610059 中国地质大学(武汉)地球物理与空间信息学院湖北武汉430074

针对岷江上游干旱河谷区生态极其脆弱的特点,利用NDVI数据通过像元二分法反演了岷江上游干旱河谷区2000—2020年的植被覆盖度(FVC),运用线性趋势分析和F显著性检验法,定量分析了FVC的时空变化规律,结合地形数据剖析岷江上游干旱河谷区FV... 详细信息

针对岷江上游干旱河谷区生态极其脆弱的特点,利用NDVI数据通过像元二分法反演了岷江上游干旱河谷区2000—2020年的植被覆盖度(FVC),运用线性趋势分析和F显著性检验法,定量分析了FVC的时空变化规律,结合地形数据剖析岷江上游干旱河谷区FVC趋势变化与海拔、坡度、坡向之间的关系。结果表明:(1)2000—2020年,研究区植被覆盖度呈波动增加趋势,年均FVC由2000年0.62增加至2020年的0.67。(2)在空间上,植被覆盖度由低海拔至高海拔呈现增高趋势,低等级和中低等级植被覆盖度主要分布在岷江干流及岷江支流杂谷脑河两岸,中等级和中高等级植被覆盖度集中分布在河谷两岸低中山和中山区,高等级植被覆盖度则主要分布在远离河谷的高中山和中高山区。(3)高等级植被覆盖面积随海拔增加呈先减小后增加的趋势,在1100~1400 m和3200~3500 m区域达到峰值;高等级植被覆盖度面积随坡度增加呈现先增加后减少的趋势,10°~20°和30°~40°是植被覆盖度高等级和中高-高等级的峰值区;总体上阳坡植被覆盖度高于阴坡。植被覆盖状况受海拔、坡度以及坡向影响较大,对岷江上游干旱河谷区生态保护应考虑地形影响,因地制宜采取措施。

关键词：植被覆盖度时空变化地形效应岷江上游干旱河谷

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Factors Associated with Overweight among Workers of the Ministry of Labor and Public Service in Benin in 2023

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Open journal of Internal Medicine 2024年第3期14卷 299-318页

作者： Lucile t. S. Bedie toïhen Géraud Padonou Charles jérôme Sossa bayédjè Evrard Koutchoro Sègnon Eurydice Elvire Djossou Coovi Nonwanou Ignace tokpanoude badirou Aguemon Ministry of Labor and Public Service Cotonou Benin Faculty of Health Sciences (FSS) University of Abomey-Calavi (UAC) Cotonou Benin Health Promotion Department Regional Institute of Public Health Ouidah Benin

Introduction: the problem of excess weight is pandemic and affects the majority of nations, regardless of their level of development. However, the prevalence of overweight among workers in Benin is very poorly documented. to fill this gap, the present study aimed to determine the prevalence and factors associated with overweight among workers of the Ministry of Labor and Public Service (MtFP) in 2023 in Benin. Materials and Methods: this is a descriptive cross-sectional study with analytical purposes carried out from August 16 to December 17, 2023, among MINIStRY OF LABOR AND PUBLIC SERVICE staff. the variables studied were overweight, sociodemographic, occupational and dietary characteristics, lifestyle, anthropometric factors and family history of obesity. An exhaustive recruitment of workers meeting our inclusion criteria and a questionnaire survey was carried out. Data were analyzed using R 4.0.4 software. A bivariate analysis followed by a multivariable analysis made it possible to identify the factors associated with overweight at the p Results: In total, 379 workers were included in our study. the average age of the surveyed workers was 44.86 years ± 7.67 years, with 202 (53.30%) workers at least 45 years old. Men predominated with a number of 228 (60.16%). the prevalence of overweight was 63.32% (95% CI: [58.23 - 68.15]) and the associated factors after multivariate analysis were: female sex (ORa = 4.00;95% CI [2.11 - 7.76];p Conclusion: the prevalence of overweight is high among ministry of labor and public service workers. Education and awareness in the professional environment on the prevention and management of risk factors are essential for a long-term impact on a notable regression of this public health phenomenon.

关键词： Overweight Associated Factors Workers-Benin

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