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In silico product design of pharmaceuticals

Asian journal of Pharmaceutical sciences 2016年第4期11卷 492-499页

作者： johan Boetker Dhara Raijada johanna Aho Milad Khorasani sФren V.sФgaard Loerke Arnfast Adam Bohr Magnus Edinger jorrit j.Water jukka Rantanen Department of Pharmacy Faculty of Health and Medical SciencesUniversity of Copenhagen

The increasing demand for personalized medicine necessitates the production of easily customizable dosage forms. As the number of possible dosage forms may scale toward infinity, their uniqueness requires a versatile production platform and numerical simulation in order to be manufactured efficiently. A mathematical description of these systems is the only feasible approach to manage such diverse properties of different products. However,experimental verification is still essential for evaluation of processability and related concomitant phenomena, such as possible solid state changes that may occur during production and storage.

关键词： Personalized medicine simulation Rheology Imaging Continuous manufacturing Extrusion

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Periprocedural complications and one-year outcomes after catheter ablation for treatment of atrial fibrillation in elderly patients:a nationwide Danish cohort study

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journal of Geriatric Cardiology 2021年第11期18卷 897-907页

作者： jesper Nielsen Kristian Hay Kragholm sofie Brix Christensen Arne johannessen Christian Torp-Pedersen steen Buus Kristiansen Peter Karl jacobsen Peter steen Hansen Mogens stig Djurhus Christoffer Polcwiartek Peter søgaard Anna Margrethe Thøgersen Uffe jakob Ortved Gang Ole Dan jørgensen Filip Lyng Lindgren sam Riahi Department of Cardiology Aalborg University HospitalDenmark Department of Cardiology Gentofte HospitalCopenhagen University HospitalDenmark Department of Clinical Research and Cardiology Nordsjaellands HospitalHillerødDenmark Department of Cardiology Skejby University HospitalDenmark Department of Cardiology RigshospitaletCopenhagen University HospitalDenmark Mølholm Clinic VejleDenmark Department of Cardiology Odense University hospitalDenmark Department of Cardiology Roskilde University HospitalDenmark Department of Thoracic surgery Odense University HospitalDenmark AF-study group Aalborg University Hospital Denmark Clinical Institute Aalborg UniversityDenmark

OBjECTIVEs To investigate complications within 30-days following first-time ablation for atrial fibrillation(AF),including a composite of cardiac tamponade,hematoma requiring intervention,stroke or death,in patients≥75 years of age,compared to pa-tients aged 65−74 *** addition,one-year all-cause mortality and AF relapse were ***&REsULTs All patients receiving their first catheter ablation for AF between 2012 and 2016 were identified us-ing Danish nationwide *** aged 65−74 years served as the reference group for patients≥75 *** of AF within one year was defined as cardioversion following a three-month blanking period,re-ablation or confirmed relapse within *** composite complication outcome did not differ between the two age groups,with 39/1554(2.8%)in patients 65−74 years of age,versus 5/199(2.5%)in older patients(adjusted HR=0.94),95%CI:0.37−2.39,P=0.896).Patients≥75 years or older had no increased hazard of death within 30 days after the procedure,with an incidence of 3/1554(0.2%)in younger pa-tients and 2/199(1.0%)in patients≥75 years of age(adjusted HR=4.71,95%CI:0.78−28.40,P=0.091).There was no difference in relapse of AF after one year between age groups(≥75 years adjusted HR=1.00,95%CI:0.78-1.26,P=0.969).CONCLUsION In patients≥75 years of age selected for catheter ablation for AF,the incidence of periprocedural complica-tions,as well as one-year freedom from AF showed no statistical difference,when compared to patients 65−74 years of age.

关键词： patients fibrillation atrial

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转院行直接经皮冠状动脉介入治疗的患者中自发性及介入治疗相关sT段改变的潜在意义:急性心肌梗死sT段监测研究(MONAMI研究)

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世界核心医学期刊文摘（心脏病学分册） 2006年第5期2卷 31-32页

作者： Terkelsen C.j NΦgaard B.L Lassen j.F. 王海玲 Department of Cardiology B Skejby University Hospital Brendstrupgaardsvej 100 DK- 8200 Aarhus N Denmark

Aims: In patients with sT-elevation myocardial infarction(sTEMI) scheduled for primary percutaneous coronary intervention(primary PCI), acute risk-assessment may be valuable for tailoring of adjunctive therapy at the time of coronary intervention. The present study was designed to quantify pre-, per-, and post-interventional sT-changes, to evaluate whether a pre-specified continuous sT-monitoring classification provides potential prognostic information in the pre- and per-interventional phase, and to compare post-interventional sT-resolution parameters derived from continuous sT-monitoring and snapshot ECGs, respectively. Methods and results: In 92 sTEMI patients, continuous sT-monitoring was initiated in the prehospital phase and continued during and 90 min following PCI. Patients were divided into three groups:(A) patients achieving spontaneous sT-resolution before PCI;(B) patients with preserved sT-elevation immediately before PCI and with no increase in sT-elevation during PCI; and(C) patients with preserved sT-elevation immediately before PCI and with increase in sT-elevation during PCI. Groups A(n=22), B(n=43), and C(n=27) differed in peak level of troponin-T(1.4, 4.7, and 7.2 μ g/L, P se MB isoenzyme(35, 150, and 325 μ g/L, P ssion, and left ventricular ejection fraction evaluated within 2 h of PCI(0.53, 0.48, and 0.45, P=0.047) and after 3 months(0.58, 0.54, and 0.45, P s B and C also differed in time from first balloon inflation to ≥ 70% resolution of sT-elevation(14 vs. 42 min, P=0.002), whereas no differences were observed in traditional 90 min sT-resolution analysis or angiographically assessed parameters. Conclusion: sTEMI patients transferred for primary PCI are heterogeneous with respect to pre- and per-interventional sT-changes, and a pre-specified sT-monitoring classification seems useful for strati

关键词：直接经皮冠状动脉介入治疗急性心肌梗死 sT段改变治疗相关自发性患者监测研究潜在 sT段监测 sT段恢复

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塞维利亚1992世界博览会,西班牙

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世界建筑 1992年第5期 40-41页

作者： j.jaaskelainen P.Rouhiainen. j.Tirkkonen j.P.Viguier. j.F.jodry N.Grimshaw j.s.nde.gaard. H.Rasmussen I.Makovecz 安藤忠雄 H.MuhIberger

1 芬兰馆设计 j. jaaskelainen, P. Rouhiainen, j. Tirkkonen 2 法国馆设计 j. P. Viguier, j. F. jodry 3 英国馆设计 N. Grimshaw 4 丹麦馆设计 j. sonder gaard, H. Rasmussen 5 匈牙利馆设计 I. Makovecz 6.7 日本馆设计安藤忠雄 8... 详细信息

1 芬兰馆设计 j. jaaskelainen, P. Rouhiainen, j. Tirkkonen 2 法国馆设计 j. P. Viguier, j. F. jodry 3 英国馆设计 N. Grimshaw 4 丹麦馆设计 j. sonder gaard, H. Rasmussen 5 匈牙利馆设计 I. Makovecz 6.7 日本馆设计安藤忠雄 8 步行道上,凉雾袭人

关键词：世界博览会日本馆塞维利亚安藤忠雄步行道

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