In silico product design of pharmaceuticals

作     者：Johan Boetker Dhara Raijada Johanna Aho Milad Khorasani SФren V.SФgaard Loerke Arnfast Adam Bohr Magnus Edinger Jorrit J.Water Jukka Rantanen 

作者机构：Department of PharmacyFaculty of Health and Medical SciencesUniversity of Copenhagen 

出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)

年 卷 期：2016年第11卷第4期

页      面：492-499页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

基　　金：Natur og Univers, Det Frie Forskningsråd, FNU, DFF Lundbeckfonden, (R108-A108760) Danmarks Frie Forskningsfond, DFF, (12-126515/0602-02670B) 

主　　题：Personalized medicine Simulation Rheology Imaging Continuous manufacturing Extrusion 

摘      要：The increasing demand for personalized medicine necessitates the production of easily customizable dosage forms. As the number of possible dosage forms may scale toward infinity, their uniqueness requires a versatile production platform and numerical simulation in order to be manufactured efficiently. A mathematical description of these systems is the only feasible approach to manage such diverse properties of different products. However,experimental verification is still essential for evaluation of processability and related concomitant phenomena, such as possible solid state changes that may occur during production and storage.