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The control of Pleistocene palaeogeography on the distribution of sandy patches in a silty Holocene lagoon(central Netherlands)

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journal of Palaeogeography 2022年第4期11卷 565-583页

作者： Ai-Ping Fan A.j.(Tom)van Loon ren-Chao Yang College of Earth Science and Engineering Shandong University of Science and TechnologyQingdaoChina Laboratory for Marine Mineral Resources Qingdao National Laboratory for Marine Science and TechnologyQingdao 266071China

The brackish lagoon in the central part of The Netherlands was closed by a dike in 1932 and gradually changed into a *** of this lake were reclaimed and the surficial sediments of one of the polders(Noordoostpolder),reclaimed in 1942,has been investigated in detail by mapping of the walls of some1500 km of drainage ditches approx.1.4 m *** appeared that the sediments consist of an uncommonly large amount of silt,to different degrees mixed with reworked peat that had developed during the Holocene *** sandy deposits occur locally,at places that are at first sight distributed in a haphazard *** various sandy patches have different characteristics(grain-size distribution,rounding of the grains,mineral composition).These sands cannot have been introduced from the sea,nor can they have been supplied by the rivers that discharged into the lagoon,so they must have a local *** is found that several types of Pleistocene sandy or diamictic deposits below the Holocene peat and lagoonal sediments had an irregular topography and became eroded during the Holocene by wave *** resulted in sandy deposits around these Pleistocene highs,which consisted of glacial tills(boulder clays),river dunes(formed by aeolian activity along rivers under dry permafrost conditions)and coversand ridges,formed by aeolian activity in a belt between the ice margin and the more distal loess *** finding implies that palaegeographical interpretations of local grain-size anomalies in a specific deposit should not only consider facies changes due to changes in the sediment supply,but should also consider local erosion leading to the exposure of previously deposited material with a divergent composition.

关键词： Lagoonal palaeogeography Netherlands Noordoostpolder Wave erosion Abrasion Holocene

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Emergy evaluation of aromatics production from methanol and naphtha

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Chinese journal of Chemical Engineering 2022年第6期35卷 134-141页

作者： Siyue ren Xiao Feng School of Chemical Engineering and Technology Xi’an Jiaotong UniversityXi’an 710049China

Aromatics are traditionally produced by the catalytic reforming of ***,with the demand of aromatics increasing and the reserves of petroleum resources declining,measures should be made to reduce the dependence of aromatics production on petroleum ***-to-aromatics is proved to be an effective way to replace traditional naphtha-to-aromatics *** order to compare the economic and environmental performance of aromatics production from naphtha and methanol,this paper carries out an emergy evaluation for each system by sorting out the simulation and literature *** on the emergy data collected,the emergy indices of each system are *** results show that the sustainabilities of methanol-to-aromatics systems are higher than that of the naphtha-toaromatics system,indicating the advantages of aromatics production from *** the methanol-to-aromatics systems,the aromatics from biomass-methanol system has the highest sustainability,indicating that the biomass based methanol-to-aromatics system is worth *** sustainability indexes of methanol-to-aromatics systems based on coal and coke oven gas are less than 1,which means ***,the sustainability of natural gas based system is slightly higher than *** economic and environmental benefits of these systems can be optimized by improving resource utilization and reducing investment ***,the combination of different raw materials for methanol production should be considered.

关键词： Aromatics production Naphtha Methanol Emergy Sustainability

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Synthesis and mechanism analysis of a new oil soluble viscosity reducer for flow improvement of Chenping heavy oil

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Chinese journal of Chemical Engineering 2022年第5期35卷 58-67页

作者： Yaqi ren Shuqian Xia School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China

Oil soluble viscosity reducers have gradually attracted the attention of petrochemical research due to their cleanliness and high *** the high viscosity and non-Newtonian fluid properties of Chenping heavy oil found in China,a series of new oil soluble viscosity reducers with different proportions and molecular weights were prepared by free radical polymerization using octadecyl acrylate,2-allylphenol and N-methylolacrylamide as *** viscosity reducer was applied to different types of heavy oil and found that it exhibited a better effect on heavy oils with high asphaltene *** test of rheological behavior of heavy oil with additive was performed at wide range of shear rate(3–90 s^(-1))and temperature range(30–100°C).The apparent viscosity reduction rate was up to 70.09%,which was better than the industrially relevant ethylene–vinyl acetate copolymer under the same test *** addition,the effect of viscosity reducers on the components of heavy oil and the energy change of the system simulated by molecular dynamics simultaneously was *** consistency of the simulated and experimental results show that the effect of viscosity reduction closely related to the crystallization process of wax and the viscosity reducer can reconstruct the surface structure of asphaltene and diminish the connection of benzene ring.

关键词： Heavy oil Viscosity reduction Asphaltene Non-Newtonian fluid

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Resilient control of flexible hypersonic vehicles against unmatched distributed faults

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Chinese journal of Aeronautics 2024年第5期37卷 60-70页

作者： Dong ZHAO Wenjing ren School of Artificial Intelligence Anhui UniversityHefei 230601China Key Laboratory of System Control and Information Processing Ministry of EducationShanghai Jiao Tong UniversityShanghai 200240China School of Electrical Engineering and Automation Hefei University of TechnologyHefei 230009China

This paper studies a robust fault compensation and vibration suppression problem of flexible hypersonic *** controlled plant is represented by a cascade system composed of a nonlinear Ordinary Differential Equation(ODE)and an Euler-Bernoulli Beam Equation(EBBE),in which the vibration dynamics is coupled with the rigid dynamics and suffers from distributed faults.A state differential transformation is introduced to transfer distributed faults to an EBBE boundary and a longitudinal dynamics is refined by utilizing T-S fuzzy IF-THEN rules.A novel T-S fuzzy based fault-tolerant control algorithm is developed and related stability conditions are *** robust exponential stability and well-posedness are proved by using the modified l_(0)-semigroup based Lyapunov direct approach.A simulation study on the longitudinal dynamics of flexible hypersonic vehicles effectively verifies the validity of the developed theoretical results.

关键词： Flexible hypersonic vehicles ODE-EBBE cascade Robust exponential stability Unmatched distributed fault compensation Vibration suppression

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Cancer immunology and immunotherapy

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Cancer Biology & Medicine 2021年第4期18卷 931-933页

作者： Xiubao ren Department of Immunology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin 300060China Department of Biotherapy Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin 300060China Key Laboratory of Cancer Prevention and Therapy Tianjin’s Clinical Research Center for CancerKey Laboratory of Cancer Immunology and BiotherapyTianjin 300060China

At the beginning of the last century,*** Coley introduced“Coley’s toxin”to the scientific community after observing that a small number of patients with sarcoma with infections developed spontaneous tumor regression.“Coley’s toxin”consisted of bacteria or bacterial products and achieved a durable response in a small group of patients with cancer,most of whom had inoperable ***,this response was usually unpredictable because of the lack of understanding of the immune response at that *** then,researchers have continued to study the relationship between cancer and the host immune system,and the discovery of“Coley’s toxin”marked the beginning of cancer immunotherapy^(1).

关键词： immunotherapy sarcoma cancer

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Progress in modeling and control of probe-and-drogue autonomous aerial refueling

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Chinese journal of Aeronautics 2024年第5期37卷 6-26,I0001页

作者： jinrui ren Quan QUAN School of Automation Xi’an University of Posts&TelecommunicationsXi'an 710072China School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China

By refueling aircraft while they are in flight,aerial refueling is an efficient technique to extend their endurance and *** Aerial Refueling(AAR)is anticipated to be used to complete aerial refueling for unmanned *** are three aerial refueling methods:the Probe-and-Drogue Refueling(PDR)refueling method,the flying-boom refueling method,and the boom-drogue-adapter refueling *** paper considers the PDR approach,the most challenging of the three,because the flexible hose-drogue assembly has fast dynamics and is susceptible to various kinds of winds,which makes the probe docking with the drogue *** is divided into four phases,namely the rendezvous phase,joining phase,refueling phase,and reform phase,with the refueling phase being the most *** controller design faces the greatest challenge during the docking control of the refueling phase since it calls for a high level of safety,precision,and *** a result,the modeling and control issues encountered during the refueling phase are typical and *** fundamental idea of AAR is presented in the paper first,after which the characteristics and requirements of AAR are *** progress in modeling and control techniques for the AAR’s refueling phase is then systematically ***,potential future work for high safety,precision,and efficiency requirements is examined and suggested.

关键词： Aerial refueling Probe-and-drogue refueling Docking Flight controlsystems Unmanned Aerial Vehicles

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Designing Chaotic Mathematical Circuits for Solving Practical Problems

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International journal of Automation and computing 2014年第6期11卷 588-597页

作者： ren Lozi Laboratory j.A.Dieudonn UMR CNRS 7351 University of Nice-Sophia Antipolis Parc Valrose 06108Nice Cedex 02 France

We introduce the paradigm of chaotic mathematical circuitry which shows some similarity to the paradigm of electronic circuitry, especially in the frame of chaotic attractors for solving practical problems(generating hyperchaos; developing chaos based pseudo random number generator(CPRNG) and chaotic multistream PRNG; secure communication via synchronization). They can also be used in cryptography, generic algorithms in optimization, control, etc.

关键词： Chaotic mathematical circuit circuit modeling chaos Chua’s circuit pseudo-random number generator

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新型抗癫痫发作药物吡仑帕奈添加治疗0~18岁儿童难治性癫痫的临床观察研究

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中国全科医学 2025年第2期28卷 250-256页

作者：马湖萍任蓉侯梅苑爱云青岛大学附属妇女儿童医院神经康复科山东省青岛市266034 山东省潍坊市寿光市人民医院新生儿科 262700

背景目前儿童难治性癫痫(RE)仍是癫痫的治疗难点,国内吡仑帕奈(PER)治疗儿童RE尚属新药,缺少PER对儿童RE添加治疗的建议,且国内报道中使用PER治疗的RE患儿样本量较少。因此PER对于儿童RE,尤其低年龄RE患儿的疗效仍需大样本、进一步研究... 详细信息

背景目前儿童难治性癫痫(RE)仍是癫痫的治疗难点,国内吡仑帕奈(PER)治疗儿童RE尚属新药,缺少PER对儿童RE添加治疗的建议,且国内报道中使用PER治疗的RE患儿样本量较少。因此PER对于儿童RE,尤其低年龄RE患儿的疗效仍需大样本、进一步研究。目的探究PER添加治疗儿童RE的疗效、可能的适应证、不良反应及耐受性。方法对2022年1月—2023年1月在青岛大学附属妇女儿童医院诊治的0~18岁RE患儿进行自身对照、回顾性分析,对比PER添加治疗前后不同观察时点的癫痫发作频率的变化,评估PER的治疗效果,记录药物不良反应及药物保留率,并分析PER有效组与无效组的临床特征。结果共纳入192例研究对象,PER添加治疗后,第12、24、36周的有效率分别为56.3%(108/192)、62.1%(113/182)、69.7%(122/175),无发作率分别为19.3%(37/192)、21.4%(39/182)、24.6%(43/175)。不良反应发生率为16.1%(31/192),主要为头晕、暴躁易怒、无力嗜睡等,末次随访药物保留率为91.1%(175/192)。PER添加治疗的RE患儿连续用药12周时,治疗总有效与无效/恶化患儿起病年龄、抗癫痫治疗病程、起源类型、发作形式、添加PER前发作频率、联合其他抗癫痫发作药物(ASMs)数量、生酮饮食/外科治疗情况,差异有统计学意义(P<0.05)。此外,178例患儿进行了脑电图检查,167例患儿进行了头颅磁共振检查;治疗总有效与无效/恶化患儿脑电图检查结果、头颅磁共振检查结果比较,差异有统计学意义(P<0.05)。脑电图检查结果中以脑前部(前、中、颞前、中部)放电总有效占比较高;头颅影像学检查结果中以正常者总有效占比较高,其次为以脑白质损伤为主的患儿。结论PER添加治疗儿童RE整体有效率及保留率较高,不良反应轻微,药物耐受情况好。对于起病年龄晚、发作形式为运动性发作、局灶性起源、抗癫痫治疗病程短、联合用药数量及发作频率少的RE患儿更为有效。脑电图中以脑前部(前、中、颞前、颞中部)放电、头颅磁共振结果正常者总有效占比较高。

关键词：难治性癫痫儿童吡仑帕奈治疗结果药物不良反应

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Immunosuppressive checkpoint Siglec-15:a vital new piece of the cancer immunotherapy jigsaw puzzle

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Cancer Biology & Medicine 2019年第2期16卷 205-210页

作者： Xiubao ren Department of Biotherapy Tianjin Medical University Cancer Institute & Hospital National Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin Key Laboratory of Cancer Immunology and Biotherapy Tianjin’s Clinical Research Center for Cancer

On March 5th, a novel immunosuppressive molecule,Siglec-15, was reported in Nature Medicine by Professor Lieping Chen1. Siglec-15 was reported in a wide variety of tumors. The molecule is not a simple replica of PD-1/***, the expressions of Siglec-15 and PD-L1 are mutually exclusive1, suggesting that Siglec-15 antibodies may be effective on tumors that are not responsive to anti-PD-1/PDL1 therapy. Siglec-15 potentially serves as a complementary therapeutic target and offers alternative treatments for many anti-PD-l/PD-Ll therapy unresponsive patients. This discovery generated a huge response.

关键词： cancer immunotherapy

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Preliminary Characterization of Loop-Shaped Defect in the AlPdMn Icosahedral Quasicrystal by Conventional X-Ray Topography

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Chinese Physics Letters 2001年第1期18卷 88-90页

作者： WANG jian-Bo j.GASTALDI WANG ren-Hui Department of Physics Wuhan Univers 430072 CRMC2-CNRS Campus de Luminycase 913F-13288 Marseille Cedex 09France

Loop-shaped contrasts were observed in the as-grown Al70.3Pd2o.6Mn9.1 icosahedral quasicrystal(IQC)by means of x-ray diffraction topography(Lang's method).One possible direction of the apparent Burger vectors of loopshaped defects(LSDs)was determined to be B=[110101]by the invisibility criterion,whose physical component is parallel to the two-fold axis 1/τ1/0,1/1,0/1 of the *** from the relaxation of strain fields around the faceted dodecahedral holes and lamellar precipitates,LSDs may well originate from the growth of the quasicrystal,which shows that these defects could be a kind of intrinsic defect in the quasicrystals.

关键词： shaped visibility relaxation

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