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In vivo and in vitro study of resorbable magnesium wires for medical implants:Mg purity,surface quality,Zn alloying and polymer coating

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journal of Magnesium and Alloys 2024年第6期12卷 2472-2488页

作者： K.Tesar j.luňácková M.jex M.Žaloudková R.Vrbová M.Bartoš P.Klein L.Vištejnová j.Dušková E.Filová Z.Sucharda M.Steinerová S.Habr K.Balík A.Singh Department of Materials Faculty of Nuclear Sciences and Physical EngineeringCzech Technical University in PragueTrojanova 13Prague 12000Czech Republic Institute of Physics Czech Academy of SciencesNa Slovance 2Prague 18221Czech Republic Institute of Dental Medicine First Faculty of MedicineCharles University and General University Hospital in PragueKaterinská32Prague 12801Czech Republic Department of Physics Faculty of Nuclear Sciences and Physical EngineeringCzech Technical University in PragueBrehová7Prague 11519Czech Republic Department of Composites and Carbon Materials Institute of Rock Structure and MechanicsCzech Academy of SciencesV Holešovickách 41Prague 18209Czech Republic Institute of Anatomy First Faculty of MedicineCharles UniversityU Nemocnice 3Prague 12800Czech Republic Biomedical Center Faculty of Medicine in PilsenCharles UniversityAlej Svobody 76Pilsen 32300Czech Republic Department of Pathological Physiology Faculty of Medicine in PilsenCharles UniversityAlej Svobody 7632300 PilsenCzech Republic Department of Histology and Embryology Faculty of Medicine in PilsenCharles UniversityAlej Svobody 7632300 PilsenCzech Republic Institute of Pathology First Faculty of MedicineCharles University and General University Hospital in PragueStudnickova 2Prague 12800Czech Republic Department of Biomaterials and Tissue Engineering Institute of PhysiologyCzech Academy of SciencesVidenska 1083Prague 14200Czech Republic Research Center for Structural Materials National Institute for Materials Science1-2-1 SengenTsukuba 305-0047Japan

Magnesium is an excellent material in terms of biocompatibility and its corrosion products can serve as an active source for new bone ***,localized corrosion and H_(2)generation limit the potential of Mg-based *** low-alloyed Mg-Zn wires can strongly reduce problems with large H_(2)bubbles and improve the mechanical properties considerably while maintaining excellent long-term *** pickling and a polymer coating can be effectively used to lower the rate of in vivo *** this work,microstructural,mechanical,and in vitro characterization of 250μm and 300μm extruded wires made from ultra-pure Mg,commercially pure Mg,Mg-0.15Zn,Mg-0.4Zn and Mg-1Zn was ***,Mg-0.4Zn wires together with a variant coated with a copolymer of L-lactide andε-caprolactone were tested in vivo on artificially damaged Wistar rat *** on the observed Mg-induced osteogenesis,polymer-coated Mg wires with a small addition of Zn are a perspective material for bone-support applications,such as cerclage and fixation wires.

关键词： Magnesium Resorbable Mg wire Mg-Zn implant degradation Biocompatibility study Zn grain boundary segregation

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Procyanidin A_1 and its digestive products alleviate acrylamide-induced IPEC-j2 cell damage through regulating Keap1/Nrf2 pathway

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Food Science and Human Wellness 2024年第3期13卷 1475-1484页

作者： Fangfang Yan Qun lu Chengming Wang Rui Liu College of Food Science and Technology Huazhong Agricultural UniversityWuhan 430070China Key Laboratory of Environment Correlative Dietology(Huazhong Agricultural University) Ministry of EducationWuhan 430070China Key Laboratory of Urban Agriculture in Central China Ministry of Agriculture and Rural AffairsWuhan 430070China

Our previous study has revealed that procyanidin A_(1)(A_(1))and its simulated digestive product(D-A,)can alleviate acrylamide(ACR)-induced intestine cell ***,the underlying mechanism remains *** this study,we elucidated the molecular mechanism for and D-A_(1) to alleviate ACR-stimulated IPEC-j2 cell *** slightly activated nuclear factor erythroid 2-related factor 2(Nrf2)signaling and its target genes,but this activation could not reduce intestine cell damage.A_(1) and D-A_(1) could alleviate ACR-induced cell damage,but the effect was abrogated in cells transiently transfected with Nrf2 small interfering RNA(siRNA).Further investigation confirmed that A_(1) and D-A_(1) interacted with Ketch-like ECH-associated protein 1(Keapl),which boosted the stabilization of Nrf2,subsequently promoted the translocation of Nrf2 into the nucleus,and further increased the expression of antioxidant proteins,thereby inhibiting glutathione(GSH)consumption,maintaining redox balance and eventually alleviating ACR-induced cell ***,there was no difference between A_(1) and D-A_(1) treated groups,indicating that A_(1) can tolerate gastrointestinal digestion and may be a potential compound to limit the toxicity of ACR.

关键词： Procyanidin A_1 Digestive products Acrylamide Nuclear factor erythroid 2-related factor 2(Nrf2) Intestinal cell damage

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Temporal and Spectral Characteristics of Persistent Emission and Special Bursts of Magnetar SGR j1935+2154 Based on Insight-HXMT

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Research in Astronomy and Astrophysics 2024年第6期24卷 225-233页

作者： Xue-Feng lu Li-Ming Song Ming-Yu Ge Shuang-Nan Zhang jin-lu Qu Ce Cai Cong-Zhan Liu Cheng-Kui Li Yu-Cong Fu Ying-Chen Xu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China College of Physics and Hebei Key Laboratory of Photophysics Research and Application Hebei Normal UniversityShijiazhuang 050024China Department of Astronomy Beijing Normal UniversityBeijing 100875China

In October 2022,the magnetar SGR j1935+2154 entered the active outburst *** the episode,the InsightHXMT satellite carried out a long observation that lasted for 20 *** than 300 bursts were detected,and a certain amount of persistent radiation signals were also *** paper mainly introduces the results of persistent radiation profile folding and period search based on Insight-HXMT *** the same time,the burst phase distribution characteristics,spectral lag results of burst,the spectral characteristics of zero-lag bursts and the time-resolved spectral evolution characteristics of high-flux bursts are *** found that there is no significant delay feature during different energy bands for the bursts of SGR j1935+*** observed zero-lag burst does not have a unique *** time-resolved spectrum of the individual burst has consistent spectral types and spectral parameters at different time periods of the *** also find that the burst number phase distribution and the burst photon phase distribution have the same tendency to concentrate in specific regions of the persistent emission profile.

关键词： radiation mechanisms:general dense matter magnetic fields

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Potential Secretory Transporters and Biosynthetic Precursors of Biological Nitrification Inhibitor 1,9-Decanediol in Rice as Revealed by Transcriptome and Metabolome Analyses

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Rice science 2024年第1期31卷 87-102页

作者： DI Dongwei MA Mingkun ZHANG Xiaoyang lu Yufang Herbert j.KRONZUCKER SHI Weiming State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China School of Food Science and Engineering Foshan UniversityFoshan 528000China School of BioSciences The University of MelbourneParkvilleVIC 3010Australia University of Chinese Academy of Sciences Beijing 100049China

Biological nitrification inhibitors(BNIs)are released from plant roots and inhibit the nitrification activity of microorganisms in soils,reducing NO_(3)^(‒)leaching and N2O emissions,and increasing nitrogenuse efficiency(NUE).Several recent studies have focused on the identification of new BNIs,yet little is known about the genetic loci that govern their biosynthesis and *** applied a combined transcriptomic and metabolomic analysis to investigate possible biosynthetic pathways and transporters involved in the biosynthesis and release of BNI 1,9-decanediol(1,9-D),which was previously identified in rice root *** results linked four fatty acids,icosapentaenoic acid,linoleate,norlinolenic acid,and polyhydroxy-α,ω-divarboxylic acid,with 1,9-D biosynthesis and three transporter families,namely the ATP-binding cassette protein family,the multidrug and toxic compound extrusion family,and the major facilitator superfamily,with 1,9-D release from roots into the soil *** finding provided candidates for further work on the genes implicated in the biosynthesis and secretion of 1,9-D and pinpoint genetic loci for crop breeding to improve NUE by enhancing 1,9-D secretion,with the potential to reduce NO_(3)^(‒)leaching and N2O emissions from agricultural soils.

关键词： 1,9-decanediol biological nitrification inhibitor metabolomic analysis nitrogen-use efficiency transcriptomic analysis

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Spatiotemporal pattern of climate change in the China-Myanmar Economic Corridor from 1901 to 2018

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journal of Mountain Science 2024年第1期21卷 131-145页

作者： YANG Xiaoliu LI Yungang GAO lu Institute of Geography Fujian Normal UniversityFuzhou 350117China School of Geographical Sciences Fujian Normal UniversityFuzhou 350117China Institute of International Rivers and Eco-Security Yunnan UniversityKunming 650500China Fujian Provincial Engineering Research Center for Monitoring and Accessing Terrestrial Disasters Fujian Normal UniversityFuzhou 350117China Key Laboratory for Humid Subtropical Eco-geographical Processes of the Ministry of Education Fujian Normal UniversityFuzhou 350117China

The China-Myanmar Economic Corridor(CMEC) is an important part of China's Belt and Road Initiative and an important area for global ecology and biodiversity. In this study, the annual and seasonal spatiotemporal patterns of temperature and precipitation in the CMEC over the past century were investigated using linear tendency estimation, the Mann-Kendall mutation test, the T-test, and wavelet analysis based on the monthly mean climatic data from 1901 to 2018 released by the Climatic Research Unit(CRU) of the University of East Anglia, UK. The results show that the CMEC demonstrated a trend of warming and drying over the past 100 years, and the rate of change in Myanmar was stronger than that in Yunnan Province of China. The warming rate was 0.039 ℃/10a. Precipitation decreased at a rate of -6.1 mm/10a. From the perspective of spatial distribution, temperature was high in the central and southern, low in the north of the CMEC, and the high-temperature centers were mainly distributed in the southern plain and river valley. Precipitation decreased from west to east and from south to north of the CMEC. From the perspective of the rate of change, warming was stronger in central and northern CMEC than in southern and northeastern CMEC. The rate of precipitation decline was stronger in the central and western regions than in the eastern region. This study provides a scientific reference for the CMEC to address climate change and ensure sustainable social and economic development and ecological security.

关键词： China-Myanmar Economic Corridor CRU Air temperature Precipitation Spatiotemporal pattern

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Combination of Nitrogen-Rich Skeleton and Coordination Group:Synthesis of a High-Energy Primary Explosive Based on 1H-Tetrazole-5-Carbohydrazide

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Defence Technology（防务技术） 2024年第1期31卷 271-277页

作者： Tingwei Wang Zujia lu Shu Bu Baolong Kuang lu Zhang Zhenxin Yi Kun Wang Shunguan Zhu jianguo Zhang State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China School of Chemical Engineering Nanjing University of Science and Technology200 Xiaolingwei StreetXuanwuNanjing 210094China Department of Chemistry Laboratory of Structure and Functional Regulation of Hybrid MaterialsAnhui UniversityMinistry of EducationHefei 230601China

The high energy coordination compounds Cu(TZCA)_(2)(ClO_(4))_(2)(ECCs-1) was prepared by 1H-tetrazole-5-carbohydrazide(TZCA) with a high energy skeleton and a strong coordination ability *** the same time,the reaction activity of the ligand was explored,and the single crystal structure of it and intermediate were *** structures of all substances were characterized by IR and *** the structure and composition of ECCs-1 are confirmed by ESP,AC,SEM and *** and chemical properties tests show that ECCs-1 has an acceptable thermal stability(T_(d)=177℃) and extremely sensitive mechanical stimulation(IS=1 j,FS=5 N).The comprehensive performance test results show that ECCs-1 has excellent initiation *** addition,the decomposition mechanism of ECCs-1 is explored from two aspects of experiment and theoretical calculation.

关键词： 1H-tetrazole-5-carbohydrazide Primary explosive Decomposition mechanism Coordination polymers Laser

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A viscoelastic metamaterial beam for integrated vibration isolation and energy harvesting

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Applied Mathematics and Mechanics(English Edition) 2024年第7期45卷 1243-1260页

作者： Long ZHAO Zeqi lu Hu DING Liqun CHEN Shanghai Institute of Applied Mathematics and Mechanics Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai Frontier Science Center of MechanoinformaticsSchool of Mechanics and Engineering Science Shanghai University School of Microelectronics Shanghai University

Locally resonant metamaterials have low-frequency band gaps and the capability of converging vibratory energy in the band gaps at resonant cells. It has been demonstrated by several researchers that the dissipatioin of vibratory energy within the band gap can be improved by using viscoelastic materials. This paper designs an integrated viscoelastic metamaterial for energy harvesting and vibration isolation. The viscoelastic metamaterial is achieved by a viscoelastic beam periodically arrayed with spatial ball-pendulum nonlinear energy harvesters. The nonlinear resonator with an energy harvesting function is achieved by placing a free-rolling magnetic ball in a spherical cavity with an additional induction coil. The dynamic equations of viscoelastic metamaterials under transverse excitation are established, and the energy harvesting and vibration isolation characteristics within the dispersion relation of viscoelastic metamaterials are analyzed. The results show that the vibrations of the main body of the viscoelastic metamaterial beam are significantly suppressed in the frequency range of the local resonance band gap. At the same time, the elastic waves are limited in the nonlinear resonator with an energy harvesting function, which improves the energy output. Finally, an experimental platform of viscoelastic metamaterial vibration is established for validation purposes.

关键词： viscoelastic metamaterial nonlinear vibration vibration isolation energy harvesting O326 70j35

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Arginine methylation of ALKBH5 by PRMT6 promotes breast tumorigenesis via LDHA-mediated glycolysis

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Frontiers of Medicine 2024年第2期18卷 344-356页

作者： Xue Han Chune Ren Aifang jiang Yonghong Sun jiayi lu Xi Ling Chao lu Zhenhai Yu Department of Reproductive Medicine Affiliated Hospital of Weifang Medical UniversityWeifang261053China Department of Pathology Affiliated Hospital of Weifang Medical UniversityWeifang261053China

ALKBH5 is a master regulator of N6-methyladenosine(m6A)modification,which plays a crucial role in many biological ***,we show that ALKBH5 is required for breast tumor ***,PRMT6 directly methylates ALKBH5 at R283,which subsequently promotes breast tumor ***,arginine methylation of ALKBH5 by PRMT6 increases LDHA RNA stability via m6A demethylation,leading to increased aerobic ***,PRMT6-mediated ALKBH5 arginine methylation is confirmed in PRMT6-knockout ***,these findings identify a PRMT6-ALKBH5-LDHA signaling axis as a novel target for the treatment of breast cancer.

关键词： PRMT6 ALKBH5 N6-methyladenosine glycolysis tumor growth

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Palmitoleic acid on top of HFD ameliorates insulin resistance independent of diacylglycerols and alters gut microbiota in C57BL/6j mice

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Food Science and Human Wellness 2024年第2期13卷 856-868页

作者： Qijian Liang Yan Zheng Fanli Meng Xiaofan jiang Qingcai Zhen Zhongting lu Shixiu Zhang Lei Du Hao Wu Xin Guo Department of Nutrition and Food Hygiene School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China Research Center of Translational Medicine Jinan Central Hospital Affiliated to Shandong First Medical UniversityJinan 250013China Department of Hepatology Qilu Hospital of Shandong UniversityJinan 250012China Institute of Hepatology Shandong UniversityJinan 250012China

With the prevalence of obesity and obesity-related metabolic syndrome,such as insulin resistance in recent years,it is urgent to explore effective interventions to prevent the progression of obesity-related metabolic *** acid is a monounsaturated fatty acid that is available from dietary sources,mainly derived from marine products.P almitoleic acid plays a positive role in maintaining glucose homeostasis and reducing ***,it is still unknow the mechanism of palmitoleic acid in ameliorating insulin ***,we investigated the effects of palmitoleic acid on chow diet(CD)-fed and high-fat diet(HFD)-fed mice,which were fed CD or HFD for 12 weeks before *** administrated mice with BSA(control),oleic acid,or palmitoleic acid for 6 weeks on top of CD or HFD *** found that palmitoleic acid only improved glucose homeostasis in HFD-fed obese mice by increasing glucose clearance and reducing *** study explored that palmitoleic acid changed the composition of gut microbiota by decreasing Firmicutes population and increasing Bacteroidetes *** colon,palmitoleic acid increased intestinal tight junction integrity and reduced ***,palmitoleic acid decreased macrophage infiltration in liver and adipose tissue and increase glucose uptake in adipose ***(DAG)in tissue(for example,liver)is found to positively correlated with *** enhanced the levels of DAGs in liver but not in adipose tissue in this *** acid did not reverse the high DAG levels induced by HFD in ***,in HFD-fed mice,palmitoleic acid reduced insulin resistance by an independent-manner of *** might be associated with the beneficial effects of palmitoleic acid on altering the gut microbiota composition,improving of intestinal barrier function,and downregulating the inflammation in colon,liver,and adipose tissue.

关键词： Palmitoleic acid High fat diet Insulin resistance Gut microbiota

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Stability Analysis of Inverse Lax-Wendroff Procedure for a High order Compact Finite Difference Schemes

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Communications on Applied Mathematics and Computation 2024年第1期6卷 142-189页

作者： Tingting Li jianfang lu Pengde Wang School of Mathematics and Statistics Henan UniversityKaifeng475004HenanChina School of Mathematics South China University of TechnologyGuangzhou510641GuangdongChina College of Mathematics and Information Science Henan University of Economics and LawZhengzhou450046HenanChina

This paper considers the finite difference(FD)approximations of diffusion operators and the boundary treatments for different boundary *** proposed schemes have the compact form and could achieve arbitrary even order of *** main idea is to make use of the lower order compact schemes recursively,so as to obtain the high order compact schemes ***,the schemes can be implemented efficiently by solving a series of tridiagonal systems recursively or the fast Fourier transform(FFT).With mathematical induction,the eigenvalues of the proposed differencing operators are shown to be bounded away from zero,which indicates the positive definiteness of the *** obtain numerical boundary conditions for the high order schemes,the simplified inverse Lax-Wendroff(SILW)procedure is adopted and the stability analysis is performed by the Godunov-Ryabenkii method and the eigenvalue spectrum visualization *** numerical experiments are provided to demonstrate the effectiveness and robustness of our algorithms.

关键词： Compact scheme Diffusion operators Inverse Lax-Wendroff(ILW) Fourier analysis Eigenvalue analysis

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