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Study on the Regulation of Diorganogermanium Compounds on the Maillard Reaction of Histidine and Glycine by Fluorescence Spectrum

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Chinese Chemical Letters 1998年第12期9卷 0-0页

作者： Chen, j Ma, GX Li, Xj Zhang, SG Li, DQ Chinese Acad Sci Changchun Inst Appl Chem Lab Rare Earth Chem & Phys Changchun 130022 Peoples R China

The suppression of diorganogermanium compounds on the Maillard reaction of histidine(His) and glycine (Gly) with glucose has been determined by fluorescence spectrum underphysiological conditions. The title compounds ... 详细信息

关键词： Diorganogermanium compounds maillard reaction fluorescence spectrum

Plant phosphatidylinositol-specific phospholipase C at the center of plant innate immunity

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journal of Integrative Plant Biology 2017年第3期59卷 164-179页

作者： Ahmed M.Abd-El-Haliem Matthieu H.A.j.joosten Laboratory of Phytopathology Wageningen University Droevendaalsesteeg 1 6708 PB Wageningen The Netherlands Plant Physiology Swammerdam Institute for Life Sciences University of Amsterdam Science Park 904 1098 XH Amsterdam The Netherlands

Understanding plant resistance to pathogenic microbes requires detailed information on the molecular mechanisms controlling the execution of plant innate immune responses. A growing body of evidence places phosphoinositide-specific phospholipase C （PI-PLC） en- zymes immediately downstream of activated immune receptors, well upstream of the initiation of early defense responses. An increase of the cytoplasmic levels of free Ca2＋, lowering of the intercellular pH and the oxidative burst are a few examples of such responses and these areregulated by PI-PLCs. Consequently, PI-PLC activation represents an early primary signaling switch between elicitation and response involving the controlled hydrolysis of essential signaling phospholipids, thereby simulta- neously generating lipid and non-lipid second messenger molecules required for a swift cellular defense response. Here, we elaborate on the signals generated by PI-PLCs and their respective downstream effects, while providing an inventory of different types of evidence describing the involvement of PI-PLCs in various aspects of plant immunity. We project the discussed information into a model describing the cellular events occurring after the activation of plant immune receptors. With this review we aim to provide new insights supporting future research on plant PI-PLCs and the development of plants with improved resistance.

关键词： Pradeep Kachroo University of Kentucky USA

A new series of chiral catalysts for the enantioselective borane reduction of ketones

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Chinese journal of Chemistry 1997年第5期15卷 459-463页

作者： Shen, ZX Zhang, YW Lu, j Xu, XN Lu, CR Suzhou Univ Sch Chem & Chem Engn Suzhou 215006 Jiangsu Peoples R China

A new series of 1,3,2-oxazaborolidine catalysts substituted in position 4 by the (CH3)(3)C(CH2)(n) group (n=2, 3, 4, 5) were synthesized and applied to the borane reduction of prochiral ketones. The relationship betwe... 详细信息

关键词： oxazaborolidine enantioselective borane reduction enantioselectivity

COMPUTERIZED PREDICTION OF INTERACTION PARAMETERSAND PHASE DIAGRAMS OF CONTINUOUS SOLID SOLUTION OFBINARY ALLOY SYSTEMS

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Acta Metallurgica Sinica(English Letters) 1999年第3期12卷 216-220页

作者： j. Guo (Department of Physics, Guangxi University, Nanning 530004, China) Guangxi Univ Nanning China

The artificial neural network method has been applied to the relationship between the atomic parameters and intemction packeters of binary alloy Phases, and the principle of thermodynamics in combination with artificial neural network method has been used for the computerized phase diagrams of continuous solid solution of bigamy alloy systems. The computerized phase diagrams well agree with the real phase diagmms.

关键词： antificial neural network interaction parameter computerized phase diagram

Control-based Fault Current Limiter for Minimizing Impact of Distributed Generation Units on Protection Systems

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journal of Modern Power Systems and Clean Energy 2023年第2期11卷 643-650页

作者： Pablo E.Muñoz Ricardo j.Mantz Sergio A.González Instituto LEICI UNLPCONICETLa Plata 1900La PlataArgentina Commission of Scientific Researches of the Buenos Aires Province(CICpBA) La PlataArgentina

Distributed generation units(DGUs)bring some problems to the existing protection system,such as those associated with protection blinding and sympathetic *** is known that fault current limiters(FCLs)help minimize the negative impact of DGUs on the protection *** this paper,a control-based FCL is proposed,i.e.,the FCL is integrated into the DGU control *** this end,a predictive control strategy with fault current limitation is *** this way,a DGU is controlled,not only for power exchange with the power grid but also to limit its fault current *** proposal is posed as a constrained optimization problem allowing taking into account the current limit explicitly in the design process as a closed-loop solution.A linear approximation is proposed to cope with the inherent nonlinear *** proposal does not require incorporating extra equipment or mechanisms in the control loop,making the design process *** evaluate the proposed control-based FCL,both protection blinding and sympathetic tripping scenarios are *** control confines the DGU currents within the constraints quickly,avoiding large transient ***,the impact on the protection system is reduced without the necessity that the DGU goes out of service.

关键词： Distributed generation distribution network protection power electronic converter fault current limiter model-based predictive controller

Transportation infrastructure settlement and heave distress:challenges and solutions

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journal of Zhejiang University-Science A(Applied Physics & Engineering) 2012年第11期13卷 850-857页

作者： Anand j.PUPPALA Bhaskar C.S.CHITTOORI Department of Civil Engineering The University of Texas at ArlingtonArlingtonTX 76019USA

Transportation agencies spend millions of dollars annually to repair civil transportation infrastructure including pavements,earth structures and approach slabs distressed by soft compressible soils and expansive *** research studies performed at the University of Texas at Arlington(UTA) focused on stabilizing these problematic soils so that they will provide better and more stable support to the transportation *** paper focuses on a summary of two major distresses and mechanisms,and remedial measures for addressing these distress problems.A combined lime-cement stabilization method is fully evaluated in providing better support of pavement infrastructure,and these results are described *** major transportation infrastructure problem involving bridge approach slabs requires different treatment methods,and these results are briefly *** a part of the recently completed research study assessments,both shallow and deep soil treatment methods for stabilizing soils are fully evaluated for their effectiveness in arresting the distress posed to the pavements and bridge approach *** results along with a few future research needs are presented in this paper.

关键词： Ground improvement Deep soil mixing Settlements Heaving Instrumentation Inclinometers

Organization of future training in bariatric gastroenterology

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World journal of Gastroenterology 2017年第35期23卷 6371-6378页

作者： Timothy R Koch Timothy R Shope Christopher j Gostout Center for Advanced Laparoscopic General and Bariatric Surgery Med Star Washington Hospital Center and Georgetown University School of Medicine Division of Gastroenterology and Hepatology Mayo Clinic

A world-wide rise in the prevalence of obesity continues. This rise increases the occurrence of, risks of, and costs of treating obesity-related medical conditions. Diet and activity programs are largely inadequate for the long-term treatment of medically-complicated obesity. Physicians who deliver gastrointestinal care after completing traditional training programs, including gastroenterologists and general surgeons, are not uniformly trained in or familiar with available bariatric care. It is certain that gastrointestinal physicians will incorporate new endoscopic methods into their practice for the treatment of individuals with medically-complicated obesity, although the longterm impact of these endoscopic techniques remains under investigation. It is presently unclear whether gastrointestinal physicians will be able to provide or coordinate important allied services in bariatric surgery, endocrinology, nutrition, psychological evaluation and support, and social work. Obtaining longitudinal results examining the effectiveness of this ad hoc approach will likely be difficult, based on prior experience with other endoscopic measures, such as the adenoma detection rates from screening colonoscopy. As a longterm approach, development of a specific curriculum incorporating one year of subspecialty training in bariatrics to the present training of gastrointestinal fellows needs to be reconsidered. This approach should be facilitated by gastrointestinal trainees' prior residency training in subspecialties that provide care for individuals with medical complications of obesity, including endocrinology, cardiology, nephrology, and neurology. Such training could incorporate additional rotations with collaborating providers in bariatric surgery, nutrition, and psychiatry. Since such training would be provided in accredited programs, longitudinal studies could be developed to examine the potential impact on accepted measures of care, such as complication rates, outcomes, and

关键词： Obesity Bariatrics Bariatric surgery Intragastric balloon Endoscopic sleeve gastroplasty Nutrition Endoscopy Training

Immuno-oncology combinations： raising the tail of the survival curve

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Cancer Biology & Medicine 2016年第2期13卷 171-193页

作者： Samuel j. Harris jessica Brown juanita Lopez Timothy A. Yap Drug Development Unit Royal Marsden Hospital and The Institute of Cancer Research London SM2 5PT UK Lung Unit Royal Marsden Hospital and The Institute of Cancer Research London SM2 5PT UK

There have been exponential gains in immuno-oncology in recent times through the development of immune checkpoint inhibitors. Already approved by the U.S. Food and Drug Administration for advanced melanoma and non-small cell lung cancer,immune checkpoint inhibitors also appears to have significant antitumor activity in multiple other tumor types. An exciting component of immunotherapy is the durability of antitumor responses observed, with some patients achieving disease control for many years. Nevertheless, not all patients benefit, and efforts should thus now focus on improving the efficacy of immunotherapy through the use of combination approaches and predictive biomarkers of response and resistance. There are multiple potential rational combinations using an immunotherapy backbone, including existing treatments such as radiotherapy, chemotherapy or molecularly targeted agents, as well as other immunotherapeutics. The aim of such antitumor strategies will be to raise the tail on the survival curve by increasing the number of long term survivors, while managing any additive or synergistic toxicities that may arise with immunotherapy combinations. Rational trial designs based on a clear understanding of tumor biology and drug pharmacology remain paramount. This article reviews the biology underpinning immuno-oncology, discusses existing and novel immunotherapeutic combinations currently in development, the challenges of predictive biomarkers of response and resistance and the impact of immuno-oncology on early phase clinical trial design.

关键词： Combination drug therapy oncology clinical trials PD-1 PD-L1 CTLA4 biomarkers immunotherapy

Voltage regulation in LV grids by coordinated volt-var control strategies

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journal of Modern Power Systems and Clean Energy 2014年第4期2卷 319-328页

作者： Miguel jUAMPEREZ Guangya YANG Søren Bækhøj KjÆR Center for Electric Power and Energy Department of Electrical EngineeringTechnical University of DenmarkElektrovej Building 3252800 Kgs.LyngbyDenmark Danfoss Solar Inverters A/S Ulsnæs 16300 Gra°stenDenmark

The increasing penetration level of photovoltaic(PV)power generation in low voltage(LV)networks results in voltage rise issues,particularly at the end of the *** order to mitigate this problem,several strategies,such as grid reinforcement,transformer tap change,demand-side management,active power curtailment,and reactive power optimization methods,show their contribution to voltage support,yet still *** paper proposes a coordinated volt-var control architecture between the LV distribution transformer and solar inverters to optimize the PV power penetration level in a representative LV network in Bornholm Island using a multi-objective genetic *** approach is to increase the reactive power contribution of the inverters closest to the transformer during overvoltage *** standard reactive power control concepts,cosu(P)and Q(U),are simulated and compared in terms of network power losses and voltage level along the *** a practical implementation,a reconfigurable hardware is used for developing a testing platform based on real-time measurements to regulate the reactive power *** proposed testing platform has been developed within *** project,which targets to study the approaches for large PV power integration into the network,without the need of reinforcement.

关键词： Voltage regulation Reactive power optimization Genetic algorithm