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Combinatorial therapies for spinal cord injury repair

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Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla S.sousa Andreia Monteiro António j.Salgado Nuno A.Silva Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVS/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

Spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

Evaluating the impact of auxiliary fan practices on localised subsurface ventilation

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International journal of Mining Science and Technology 2019年第6期29卷 933-941页

作者： David j.de Villiers Marc j.Mathews Philip Maré Marius Kleingeld deon Arndt Centre for Research and Continued Engineering development North-West University

Mines are continually expanding in size and depth,leading to an increased reliance on localised subsurface ventilation *** use of underground auxiliary fans is a favoured method to increase and control airflow in working ***,the effectiveness of auxiliary fans in this regard is not *** paper evaluated the performance of these underground fan systems in four different South African deeplevel gold mines.A total auxiliary fan system efficiency of 5%was found across six systems,with the average fan efficiency of 33 fans at 38%.The results showed that these fans deviate significantly from their design operating ***,there are significant shortcomings in current underground fan *** detailed investigations led to the conclusion that the assemblage of underground auxiliary fan systems results in significant energy ***,maintaining good underground fan practice such as optimal fan selection,ducting design and maintenance is crucial for the efficacy of a mine ventilation network.

关键词： Mine ventilation Underground fan assemblage Fan system performance

Differential regulation of basal expression of inflammatory genes by NF-κB family subunits

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Cellular & Molecular Immunology 2019年第8期16卷 720-723页

作者： Tristan j.de jesús joshua T.Centore Parameswaran Ramakrishnan department of Pathology School of MedicineCase Western Reserve UniversityClevelandOH 44106USA department of Biochemistry School of MedicineCase Western Reserve UniversityClevelandOH 44106USA The Case Comprehensive Cancer Center School of MedicineCase Western Reserve UniversityClevelandOH 44106USA

The nuclear factor kappaB(NF-κB)family of transcription factors regulates immune and inflammatory responses and controls cell survival,proliferation,differentiation,and apoptosis.1 The five subunits of the NF-κB family,(RelA,RelB,c-Rel,p105/p50,and p100/p52),are categorized as activating(RelA,RelB,and c-Rel),or inhibitory(p105/p50 and p100/p52),based on the presence or absence of the transactivation domain and form homo-and ***-dependent activation of NF-κB,either by the classical pathway involving the degradation of the inhibitor of NF-κB(IκB)or by the alternative pathway involving the partial degradation of p100 to p52 and formation of the p52/RelB dimer,has emerged as a central theme in the regulation of NF-κBdependent genes.2–4 However,in Sertoli cells and some neurons,lymphocytes,and malignant cells,NF-κB has been shown to be constitutively active in the nucleus5,6(***/nf-kb).Moreover,several recent studies have also identified disease-associated mutations in the NF-κB subunits that affect their expression level and transcriptional activity.2,7 Our understanding of the ways in which the changes in the basal level of NF-κB affect the subsequent basal regulation of the expression of NF-κBdependent genes remain poorly defined.

关键词： inflammatory constitutive subsequent

Corrosion resistance of pulsed laser modified AZ31 Mg alloy surfaces

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journal of Magnesium and Alloys 2022年第3期10卷 819-832页

作者： S.Fajardo L.Miguélez M.A.Arenas j.de Damborenea I.Llorente S.Feliu department of Surface Engineering Corrosion and DurabilityNational Centre for Metallurgical Research(CENIM-CSIC)Madrid 28040Spain

The effect of laser surface melting on the corrosion resistance of AZ31 Mg alloy in 0.1 M NaCl solution was investigated using different laser processing conditions(energy densities of 14 and 17 j cm^(-2)).Laser treatment induced rough surfaces primarily composed of oxidized species of *** analysis revealed that the surface concentration of Al increased significantly as a consequence of *** impedance spectroscopy showed that the laser treatment remarkably increased the polarization resistance of the AZ31 Mg alloy and induced a passive-like region of about 100 mV,as determined by potentiodynamic *** of the results obtained provide solid evidence that within the immersion times used in this study,LSM treatment increased the corrosion resistance of AZ31 Mg alloy under open circuit conditions and anodic polarization.

关键词： Mg alloys laser surface melting(LSM) Electrochemical impedance Potentiodynamic polarization corrosion resistance.

determining the IgG concentrations in bovine colostrum and calf sera with a novel enzymatic assay

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journal of Animal Science and Biotechnology 2019年第1期10卷 239-247页

作者： M.Drikic C.Windeyer S.Olsen Y.Fu L.Doepel j.de Buck department Production Animal Health Faculty of Veterinary MedicineUniversity of Calgary

Background: Immune protection in newborn calves relies on a combination of the timing,volume and quality of colostrum consumed by the calf after *** quality colostrum with inadequate immunoglobulin concentration contributes to failed transfer of passive immunity in calves,leading to higher calf morbidity and ***,estimating colostrum quality and ensuring the transfer of passive immunity on farm is of critical ***,there are no on-farm tools that directly measure immunoglobulin content in colostrum or *** aim of this study was to apply a novel molecular assay,split trehalase immunoglobulin G assay(STIGA),to directly estimate immunoglobulin content in dairy and beef colostrum and calf sera,and to examine its potential to be developed as on-farm *** STIGA is based on a split version of trehalase TreA,an enzyme that converts trehalose into glucose,enabling the use of a common glucometer for signal *** a first study,60 dairy and64 beef colostrum and 83 dairy and 84 beef calf sera samples were tested with STIGA,and the resulting glucose production was measured and compared with radial immunodiffusion,the standard method for measuring immunoglobulin ***: Pearson correlation coefficients between the methods were determined and the sensitivity,specificity,and accuracy of the test were calculated for different colostrum quality and failed transfer of passive immunity cut-off *** correlations of the STIGA measured by colorimetric enzymatic reaction compared to radial immunodiffusion for dairy and beef colostrum were 0.72 and 0.73,respectively,whereas the correlations for dairy and beef sera were 0.9 and 0.85,***,STIGA was tested in a blinded study with fresh colostrum and serum samples where the correlation coefficient was 0.93 and 0.94,***,the performance of STIGA followed by glucometer readings resulted in correlations with radial immunodiffusion of 0.7 and

关键词： Cattle Colostrum Immunoglobulins Passive immunity Radial immunodiffusion Split trehalase

Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi juan Pablo de Rivero Vaccari jennifer C.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang j.Adrian Tyndall Binu Tharakan Firas Kobeissy department of Surgery Morehouse School of MedicineAtlantaGAUSA department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA department of Neurological Surgery and the Miami Project to Cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric Critical Care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA department of Pediatrics Emory UniversityAtlantaGAUSA department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA department of Chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

Utilizing the ultrasensitive Schistosoma up-converting phosphor lateral flow circulating anodic antigen(UCP-LF CAA)assay for sample pooling-strategies

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Infectious Diseases of Poverty 2017年第1期6卷 1379-1391页

作者： Paul L.A.M.Corstjens Pytsje T.Hoekstra Claudia j.de Dood Govert j.van Dam department of Molecular Cell Biology Leiden University Medical CenterP.O.Box 96002300RCLeidenThe Netherlands department of Parasitology Leiden University Medical CenterP.O.Box 96002300RCLeidenThe Netherlands

Background:Methodological applications of the high sensitivity genus-specific Schistosoma CAA strip test,allowing detection of single worm active infections(ultimate sensitivity),are discussed for efficient utilization in sample pooling *** relevant cost reduction,pooling of samples rather than individual testing can provide valuable data for large scale mapping,surveillance,and ***:The laboratory-based CAA strip test utilizes luminescent quantitative up-converting phosphor(UCP)reporter particles and a rapid user-friendly lateral flow(LF)assay *** test includes a sample preparation step that permits virtually unlimited sample concentration with urine,reaching ultimate sensitivity(single worm detection)at 100%*** facilitates testing large urine pools from many individuals with minimal loss of sensitivity and *** test determines the average CAA level of the individuals in the pool thus indicating overall worm burden and *** requiring test results at the individual level,smaller pools need to be analysed with the pool-size based on expected prevalence or when unknown,on the average CAA level of a larger group;CAA negative pools do not require individual test results and thus reduce the number of ***:Straightforward pooling strategies indicate that at sub-population level the CAA strip test is an efficient assay for general mapping,identification of hotspots,determination of stratified infection levels,and accurate monitoring of mass drug administrations(MDA).At the individual level,the number of tests can be reduced *** low endemic settings as the pool size can be increased as opposed to prevalence ***:At the sub-population level,average CAA concentrations determined in urine pools can be an appropriate measure indicating worm *** strategies allowing this type of large scale testing are feasible with the various CAA strip test formats and do not affect sens

关键词： Schistosomiasis Diagnostics Sample pooling Mass drug administration Circulating anodic antigen Lateral flow Strip test Up-converting reporter particle UCP-LF CAA

Contributions of holography to the advancement of interferometric measurements of surface topography

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Light(Advanced Manufacturing) 2022年第2期3卷 80-99页

作者： Peter j.de Groot Leslie L.deck Rong Su Wolfgang Osten Zygo Corporation MiddlefieldCT USA Shanghai Institute of Optics and Fine Mechanics Chinese Academy of SciencesShanghaiChina University of Stuttgart StuttgartGermany

Two major fields of study in optics—holography and interferometry—have developed at times independently and at other times *** two methods share the principle of holistically recording as an intensity pattern the magnitude and phase distribution of a light wave,but they can differ significantly in how these recordings are formed and *** we review seven specific developments,ranging from data acquisition to fundamental imaging theory in three dimensions,that illustrate the synergistic developments of holography and interferometry.A clear trend emerges,of increasing reliance of these two fields on a common trajectory of enhancements and improvements.

关键词： holography topography interferometry metrology

Kalihioxepanes A-G:Seven Kalihinene Diterpenoids from Marine Sponge Acanthella cavernosa Collected off the South China Sea

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Chinese journal of Chemistry 2022年第15期40卷 1785-1792页

作者： Zhe Wang Xiao Han Guoping Liu Di Zhang Huiyue Hou Li Xiao Nicole j.de Voogd Xuli Tang Pinglin Li Key Laboratory of Marine Drugs Chinese Ministry of EducationSchool of Medicine and PharmacyOcean University of ChinaQingdaoShandong 266003China Laboratory of Marine Drugs and Biological Products National Laboratory for Marine Science and TechnologyQingdaoShandong 266235China National Museum of Natural History 2300 RA LeidenThe Netherlands College of Chemistry and Chemical Engineering Ocean Universityof ChinaQingdaoShandong 266100China

Comprehensive Summary Seven new kalihinene diterpenoids,kalihioxepanes A-G(1-7)bearing a rare oxepane ring,were isolated from sponge Acanthella cavernosa collected from the South China *** structures and absolute configurations were elucidated by comprehensive spectroscopic analysis,single crystal X-ray diffraction,and quantum chemical calculation *** A(1)displayed strong cytotoxicity against H69 and K562 tumor cells,while kalihioxepane B(2)showed moderate cytotoxicity against K562 cells.

关键词： Acanthella cavernosa Kalihinenes Configuration determination Cytotoxicity Natural products