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电子清洁CT结肠成像:对结肠癌高危人群的计算机辅助软件有帮助吗?

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国际医学放射学杂志 2010年第5期 505-505页

作者： j.y.wi S.H.Kim j.y.Lee S.G.Kim j.K.Han B.I. Choi 卞读军 Department of Radiology Seoul National University College of Medicine

非现场评估三维超声对甲状腺结节的诊断价值:与二维超声的比较

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国际医学放射学杂志 2016年第6期 707-707页

作者： S.C.Kim j.K S.H.Choi T.j.yun j.y.wi S.A.Kim 唐洁 Department of Radiology Gangnam CenterSeoul National University Hospital Healthcare System

摘要目的比较前瞻性收集的甲状腺结节的三维和二维超声的非现场评估的诊断价值。方法术前采集85例拟行甲状腺全切病人（年龄28;3岁,平均51岁）的三维和二维

关键词：二维超声三维超声结节诊断价值甲状腺粒子肉内分泌腺现场评估

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon j.Brown Rafael j.yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

表现为磨玻璃样结节的侵袭性肺腺癌与癌前病变的CT鉴别要点

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国际医学放射学杂志 2013年第5期 476-476页

作者： S.M.Lee C.M.Park j.M.Goo H.j.Lee j.y.wi C.H.Kang 王霁朏 Department of Radiology Seoul National University College of Medicineand Institute of Radiation MedicineSeoul National University Medical Research Center

摘要目的回顾性分析CT上的磨玻璃样结节(GGN)253例,分析侵袭性肺腺癌(IPA)与癌前病变的鉴别点。材料与方法本研究获得伦理委员会批准。自2005年1月—2011年10月,经病理证实的253例共272个GGN(其中IPA179个和癌前病变93个)CT结节纳入本研... 详细信息

摘要目的回顾性分析CT上的磨玻璃样结节(GGN)253例,分析侵袭性肺腺癌(IPA)与癌前病变的鉴别点。材料与方法本研究获得伦理委员会批准。自2005年1月—2011年10月,经病理证实的253例共272个GGN(其中IPA179个和癌前病变93个)CT结节纳入本研究,其中单纯GGN 64个,半实性GGN208个。癌前病变包括非典型腺瘤样增生21个和原位腺癌72个。采用logistic回归分析和ROC曲线分析明确IPA和癌前病变的CT鉴别要点及鉴别的准确性。结果单纯GGN,癌前病变与IPA相比,前者体积小,且常为非分叶状的(P<0.05)。多变量分析显示病灶大小是鉴别癌前病变

关键词：癌前病变 IPA 磨玻璃样肺腺癌结节鉴别要点侵袭性 CT

Effect of Eu^(3+),Bi^(3+),and Li^(+) doping on luminescent property of GdNbO_(4)

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journal of Rare Earths 2024年第1期42卷 66-75,I0003页

作者： S.W.wi y.S.Lee Department of Physics and Integrative Institute of Basic Sciences Soongsil UniversitySeoul06978Republic of Korea

We investigated the emission properties of Eu^(3+)-doped GdNbO_(4)-based oxide phosphors,aiming at improving the Eu^(3+)emission by codoping of Bi^(3+)and Li^(+).Eu^(3+)singly doped,Eu^(3+)and Bi^(3+)doubly doped,and Eu^(3+),Bi^(3+),and Li^(+)triply doped GdNbO_(4)were prepared using a high-temperature solid-state reaction *** red-orange emissions from Eu^(3+)in the singly doped samples are significantly improved by the codoping of Bi^(3+),mainly due to the energy transfer from Bi^(3+)to Eu^(3+).The additional codoping of Li^(+)is found to increase the Eu^(3+)emission *** improvement might be attributed to the increase in the photoluminescent quantum yield originating from larger grain sizes and better crystallinity.A detailed analysis of the X-ray diffraction pattern and the asymmetric ratio estimated from the photoluminescence spectra show that the local lattice environment around Eu^(3+)in GdNbO_(4)does not change significantly with the codoping of Bi^(3+)and Li^(+).Our results indicate that Li^(+)doping is a promising way to improve the emission properties of rare-earth ion-doped GdNbO_(4)phosphors.

关键词： Eu^(3+) GdNbO_(4) Codoping of Li^(+) Photoluminescence Sensitizer Rare earths

Partition method and experimental validation for impact dynamics of flexible multibody system

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Acta Mechanica Sinica 2018年第3期34卷 482-492页

作者： j.y.Wang Z.y.Liu j.Z.Hong School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong University

The impact problem of a flexible multibody system is a non-smooth, high-transient, and strong-nonlinear dynamic process with variable boundary. How to model the contact/impact process accurately and efficiently is one of the main difficulties in many engineering applications. The numerical approaches being used widely in impact analysis are mainly from two fields： multibody system dynamics （MBS） and computational solid mechanics （CSM）. Approaches based on MBS provide a more efficient yet less accurate analysis of the contact/impact problems, while approaches based on CSM are well suited for particularly high accuracy needs, yet require very high computational effort. To bridge the gap between accuracy and efficiency in the dynamic simulation of a flexible multibody system with contacts/impacts, a partition method is presented considering that the contact body is divided into two parts, an impact region and a non-impact region. The impact region is modeled using the finite element method to guarantee the local accuracy, while the non-impact region is modeled using the modal reduction approach to raise the global efficiency. A three-dimensional rod-plate impact experiment is designed and performed to validate the numerical results. The principle for how to partition the contact bodies is proposed： the maximum radius of the impact region can be estimated by an analytical method, and the modal truncation orders of the non-impact region can be estimated by the highest frequency of the signal measured. The simulation results using the presented method are in good agreement with the experimental results. It shows that this method is an effec-rive formulation considering both accuracy and efficiency. Moreover, a more complicated multibody impact problem of a crank slider mechanism is investigated to strengthen this conclusion.

关键词： Partition method Impact dynamics Experimental investigation Efficiency and accuracy Partition principle

Revealing the contribution of basilar membrane's biological activity to the mechanism of the cochlear phonosensitive amplification

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Applied Mathematics and Mechanics(English Edition) 2023年第5期44卷 823-840页

作者： j.y.LIANG Wenjuan yAO Genomic Medicine Institute Lerner Research InstituteCleveland Clinic FoundationClevelandOH 44106U.S.A. Shanghai Institute of Applied Mathematics and Mechanics Shanghai UniversityShanghai 200072China School of Mechanics and Engineering Science Shanghai UniversityShanghai 200072China

Explaining the mechanism of the cochlear active phonosensitive amplification has been a major problem in *** basilar membrane(BM)is the key *** 1960,Nobel Laureate von B′ek′esy first discovered BM's traveling wave *** that time,BM's models only have considered the traveling wave but not the biological ***,a new model considering changes of BM's stiffness in space and time is established based on the immersed boundary method to describe its biological *** not only reproduces the results of traveling wave motion but also explains the mechanization on the generation of traveling *** important discovery is that changes of BM's stiffness in space and time will cause the unstable global resonance,which will induce amplification of sounds in *** important inference is that biological activity shall be included in the application of mechanical principles to the analysis of life,which is the essential difference between biomechanics and general mechanics.

关键词： basilar membrane(BM) biological activity mechanical analysis cochlear phonosensitive amplification

Fluctuation theorem for entropy production at strong coupling

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Chinese Physics B 2020年第1期29卷 175-180页

作者： y y Xu j Liu M Feng Faculty of Science Kunming University of Science and TechnologyKunming 650500China Faculty of Mechanical and Electrical Engineering Kunming University of Science and TechnologyKunming 650500China State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsChinese Academy of SciencesWuhan 430071China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China

Fluctuation theorems have been applied successfully to any system away from thermal equilibrium,which are helpful for understanding the thermodynamic state *** investigate fluctuation theorems for strong coupling between a system and its reservoir,by path-dependent definition of work and heat satisfying the first law of *** present the fluctuation theorems for two kinds of entropy *** is the informational entropy production,which is always non-negative and can be employed in either strong or weak coupling *** other is the thermodynamic entropy production,which differs from the informational entropy production at strong coupling by the effects regarding the *** find that,it is the negative work on the reservoir,rather than the nonequilibrium of the thermal reservoir,which invalidates the thermodynamic entropy production at strong *** results indicate that the effects from the reservoir are essential to understanding thermodynamic processes at strong coupling.

关键词： fluctuation theorem entropy production strong coupling

Spin-correlation function of the fully frustrated Ising model and ±j Ising spin glass on a square lattice

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Chinese Physics B 2013年第6期22卷 549-552页

作者： M y Ali j Poulter Department of Mathematics Faculty of ScienceMahidol University

In this work we study the correlation function of the ground state of a two-dimensional fully frustrated Ising model as well as spin glass. The Pfaffian method is used to calculate free energy and entropy as well as the correlation function. We estimate the exponent of spin correlation function for the fully frustrated model and spin glass. In this paper an overview of the latest results on the spin correlation function is presented.

关键词： spin glass correlation function exponent square lattice