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Solution of Liouville’s Equation for Uncertainty Characterization of the Main Problem in Satellite Theory

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Computer Modeling in Engineering & Sciences 2016年第3期111卷 269-304页

作者： Ryan weisman Manoranjan Majji Kyle T.Alfriend Research Aerospace Engineer Air Force Research LaboratoryAFRL/RVSV 3550 Aberdeen Ave.SEKirtland AFB87117 Assistant Professor Mechanical and Aerospace Engineering DepartmentUniversity at Buffalo318 Jarvis HallBuffaloNY14260 TEES Research Professor Aerospace Engineering DepartmentTexas A&M UniversityCollege StationTX77843-3141

This paper presents a closed form solution to Liouville’s equation governing the evolution of the probability density function associated with the motion of a body in a central force field and subject to *** is shown that the application of transformation of variables formula for mapping uncertainties is equivalent to the method of characteristics for computing the time evolution of the probability density function that forms the solution of the Liouville’s partial differential *** insights derived from the nature of the solution to Liouville’s equation are used to reduce the dimensionality of uncertainties in orbital element *** is demonstrated that the uncertainty propagation is fastest in the semi-major axis and the mean anomaly phase *** results obtained for uncertainty propagation for the two body problem are applied to investigate the uncertainty propagation in the presence of the j2 perturbation using a combination of osculating and mean element perturbation *** orbital uncertainty propagation calculations are validated using Monte-Carlo results for several representative orbits.

关键词： Astrodynamics Uncertainty Quantification

Studies on the cytocompatibility,mechanical and antimicrobial properties of 3D printed poly(methyl methacrylate)beads

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Bioactive Materials 2018年第2期3卷 157-166页

作者： David K.Mills Uday jammalamadaka Karthik Tappa jeffery weisman Center for Biomedical Engineering and Rehabilitation Science USA The School of Biological Sciences Louisiana Tech UniversityRustonLA 71272USA

Osteomyelitis is typically a bacterial infection(usually from Staphylococcus)or,more rarely,a fungal infection of the *** can occur in any bone in the body,but it most often affects the long bones(leg and arm),vertebral(spine),and bones of the *** success in osteomyelitis is due to their ability to form biofilms which inhibit the wound healing process and increases resistance to anti-infective ***,biofilms do not allow easy penetration of antibiotics into their matrix making clinical treatment a *** development of local antibiotic delivery systems that deliver high concentrations of antibiotics to the affected site is an emerging area of research with great *** treatment includes antibiotic therapy,either locally or systemically and refractory cases of osteomyelitis may lead to surgical intervention and a prolonged course of antibiotic treatment involving placement of antibiotic-doped beads or spacers within the wound *** are disadvantages with this treatment modality including insufficient mixing of the antibiotic,lack of uniform bead size,resulting in lower antibiotic availability,and limitations on the antibiotics ***,a method is needed to address biofilm formations in the wound and on the surface of the surgical implants to prevent *** this study,we show that all antibiotics studied were successfully doped into PMMA and antibiotic-doped 3D printed beads,disks,and filaments were easily *** growth inhibition capacity of the antibiotic-loaded PMMA 3D printed constructs was also demonstrated.

关键词： 3D printing Antibacterials Drug delivery Halloysite nanotubes Medical devices Nanotechnology

Community-Based Cardiovascular Screening: Detection of Disease in Individuals with No Self-Reported Risk Factors

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Open journal of Preventive Medicine 2015年第2期5卷 78-83页

作者： Steven M. weisman Nathalie I. Garbani Andrew j. Manganaro Innovative Science Solutions Morristown USA Life Line Screening (LLS) Independence USA

Introduction: Community-based cardiovascular screening presents an opportunity to detect the presence of cardiovascular disease in individuals who report having no traditional risk factors, and also to identify the presence of those risk factors in those who are unaware of their health status. Identification of both disease and risk factors (e.g. high cholesterol, high blood pressure, diabetes, etc.) creates an opportunity for treatment and management to reduce and prevent cardiovascular events from occurring. Methods: Over 230,000 screening records for individuals who had undergone carotid artery stenosis (CAD), abdominal aortic aneurysm (AAA), or peripheral artery disease (PAD) screening were reviewed. Participants were stratified based on self-reported risk factors as having no risk factors, one risk factor, or two or more risk factors. Self-reported risk factors were also compared with results of screening for blood pressure, blood glucose, and lipid level status. Results: Abnormal findings of CAS, AAA, and PAD were all uncovered in individuals who self-reported as having no traditional risk factors. These abnormal findings included those defined as severe. The review of self-reported risk factors for accuracy demonstrated varying levels of inaccuracies in both under and over-reporting of risk factors. Conclusions: Community-based cardiovascular screening may result in the identification of cardiovascular disease in individuals with no established risk factors. While the underreporting of risk factors has also be demonstrated, it is clear that further research is warranted to better understand the presence of disease in the absence of risk factors.

关键词： Cardiovascular Screening Risk Factors Carotid Artery Stenosis Abdominal Aortic Aneursym Peripal Artery Disease

Community-Based Screening and the Detection of Critical Carotid Artery Stenosis and Abdominal Aortic Aneurysm

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Open journal of Preventive Medicine 2015年第2期5卷 38-46页

作者： Steven M. weisman Nathalie I. Garbani Andrew j. Manganaro Innovative Science Solutions Morristown USA Life Line Screening (LLS) Independence USA

Background: Community-based cardiovascular screening has the opportunity to detect critical cardiovascular disease and positively affect public health outcomes. Disease deemed to be critical or severe at detection requires appropriate medical follow-up. This article examined the self-reported outcomes of individuals who had undergone community-based cardiovascular screening and had critical findings for abdominal aortic aneurysm (AAA) or carotid artery stenosis (CAS). Methods: Over 390,000 screening records for AAA and over 490,000 screening records for CAS were reviewed to identify individuals with critical screening findings. A critical AAA is defined as an aneurysm ≥ 5cm and critical CAS is defined as a hemodynamically significant stenosis with recorded peak systolic velocities of ≥300 cm/s, in this population. Identified individuals were then contacted via phone and surveyed about the medical care they received after their screening. Results: Review of the screening records found a prevalence of critical AAA findings of 0.037% (146 participants) and critical CAS findings of 0.12% (579 participants). 61% of participants with critical findings were reached for follow-up from both groups. Over 96% of participants with critical AAA and over 92% of participants with critical CAS had some forms of medical follow-up. Conclusions: Community-based cardiovascular screening has the ability to detect critical levels of disease. Findings of critical disease in the reviewed population are similar to the findings from previously published studies. Importantly, medical treatment received by those who seek follow-up appears to be consistent with recommended treatment guidelines. Identification and management of critical disease represent meaningful public and individual health benefits and the possibility of cost-savings.

关键词： Cardiovascular Screening Carotid Artery Stenosis Abdominal Aortic Aneursym

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内分泌眼眶病变的治疗

国外医学（内分泌学分册） 1989年第2期9卷 81-84页

作者： weisman R A Savino P j 徐航

内分泌眼眶病变的发病机理尚不清楚。甲状腺机能障碍是Graves病的主要原因,但并不是眼眶综合征的唯一原因。许多Graves眼球突出的病人,虽然其甲状腺释放激素(TRH)

关键词：眼眶病内分泌甲状腺

Simple, Reliable Isolation, Purification and Cultivation of Murine Skeletal Muscle Microvascular Endothelial Cells

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journal of Biomedical Science and Engineering 2020年第12期13卷 290-299页

作者： jianjie Wang joseph Harvey Richard Garrad Virginia Huxley Laurie Erb Gary weisman Department of Biomedical Sciences Missouri State University Springfield USA Department of Cell Biology and Physiology Washington University St. Louis USA Department of Medical Pharmacology and Physiology Dalton Cardiovascular Research Center University of Missouri Columbia USA Department of Biochemistry Life Sciences Center University of Missouri Columbia USA

Objectives: Microvascular dysfunction in skeletal muscle is involved in metabolic and vascular diseases. Microvascular endothelial cells (MEC) are poorly characterized in the progression of associated diseases in part due to lack of availability of MEC from various animal models. The objective was to provide a fast, simple, and efficient method to isolate murine MEC derived from skeletal muscle. Methods: Dissected abdominal skeletal muscles from C57BL/6j mice at 8 - 12 weeks of age were enzymatically dissociated. MEC were isolated using a modified two-step Dynabeads™-based purification method. With a combination of Dynabeads™ - Griffonia simplicifolia lectin-I and Dynabeads™ - monoclonal antibody against CD31/PECAM-1, MEC were isolated and purified twice followed by cultivation. Results: Isolated and purified cells were viable and cultured. MEC were characterized by using immunofluorescence to identify CD31/PECAM-1, an EC marker, and two specific functional assays, which include a capillary-like tube formation and the uptake of Dil-Ac-LDL. The purity of isolated cell populations from skeletal muscle microvessels, which was assessed by flow cytometry, was 88.02% ± 2.99% (n = 6). Conclusions: This method is simple, fast, and highly reproducible for isolating MEC from murine skeletal muscle. The method will enable us to obtain primary cultured MEC from various genetic or diseased murine models, contributing to insightful knowledge of diseases associated with the dysfunction of microvessels.

关键词： Microvascular Endothelial Cells Isolation Primary Cultured Skeletal Muscle Mouse