检索结果-南通市图书馆

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

2019世界数据系统亚洲-大洋洲会议纪要

全球变化数据学报（中英文） 2019年第4期3卷 406-407,513-514页

作者：王卷乐 Takashi watanabe 中国科学院地理科学与资源研究所资源与环境信息系统国家重点实验室北京100101 世界数据系统国际项目办公室日本东京184-8795

2019年5月7–8日,2019世界数据系统亚大区域会议(World Data System Asia-Oceania Conference 2019)在北京中国科学院地理科学与资源研究所召开。本次会议由国际科学理事会(International Science Council,ISC)世界数据系统(World Data ... 详细信息

关键词：数据系统科学数据科学院国际科学理事会

CB_1 Cannabinoid Receptor-Dependent and-Independent Inhibition of Depolarization-Induced Calcium Influx in Oligodendrocytes

在线全文

学校读者我要写书评

暂无评论

神经损伤与功能重建 2009年第1期4卷 48-59页

作者： SUSANA MATO ELENA ALBERDI CATHERINE LEDENT MASAHIKO watanabe CARLOS MATUTE Department of Neuroscience Neurotek-University of the Basque CountryTechnological Park CIBERNED Department of NeuroscienceUniversity of the Basque Country Institut de Recherche Interdisciplinaire en Biologie Humaine et Moleculaire Free University of Brussels Department of Anatomy Hokkaido University School of Medicine

Ca2+稳态平衡的调节在少突胶质细胞功能和存活中起重要作用。大麻素CB1和CB2受体在许多细胞中调节Ca2+水平和/或K+电流。本文利用培养的少突胶质细胞中,通过增高细胞外K+浓度(50 mM诱导膜去极化,研究大麻素复合物在此过程引发钙内流中... 详细信息

Ca2+稳态平衡的调节在少突胶质细胞功能和存活中起重要作用。大麻素CB1和CB2受体在许多细胞中调节Ca2+水平和/或K+电流。本文利用培养的少突胶质细胞中,通过增高细胞外K+浓度(50 mM诱导膜去极化,研究大麻素复合物在此过程引发钙内流中的作用。CB2受体激动剂ACEA导致去极化诱导的少突胶质细胞胞浆的Ca2+瞬变表达浓度依赖性抑制,最大效应为(94±3)%,半效应浓度(EC50)为(1.3±0.03)μM。这种作用可被CB2/CB2激动剂CP55、940、内源性大麻素类AEA和2-AG所模拟,但是CB2受体选择性激动剂j WH133没有作用。CB2受体拮抗剂AM251(1μM)也可减少细胞外高K+诱导的Ca2+反应,但不能防止ACEA(3μM)诱发的抑制效应。然而,ACEA和AEA减少去极化诱导的Ca2+瞬变的能力在CB2受体敲除小鼠和经百日咳毒素预处理的少突胶质细胞中明显降低。内流性K+通道阻断剂BaCl2(300μM)和CsCl2(1 mM)降低电压诱导的Ca2+内流并部分阻断ACEA的抑制效应。本文表明,大麻素抑制少突胶质细胞中去极化诱导的Ca2+瞬变是通过包括PTX-敏感的Gi/o蛋白和阻断K+内流通道的CB2受体依赖性和非依赖性机制。

关键词：大麻素类 CB2受体少突胶质细胞离子通道钙髓鞘化

LXR, PPAR<i>γ</i>, and PPAR<i>δ</i>Agonists Are Not Sufficient to Demonstrate Therapeutic Potential against Mouse Model of Systemic Lupus Erythematosus

在线全文

学校读者我要写书评

暂无评论

Open journal of Rheumatology and Autoimmune Diseases 2017年第2期7卷 128-136页

作者： Noriko Toyota Tatebe Katsue Sunahori watanabe Sonia Zeggar Sumie Hiramatsu Minglu Yan Takayuki Katsuyama Eri Katsuyama Haruki watanabe Ken-ei Sada jun Wada Department of Nephrology Rheumatology Endocrinology and Metabolism Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama Japan

Aim: We aimed to investigate whether the agonists for liver X receptor (LXR) ameliorate lupus-like phenotypes in mice mediated by the clearance of apoptotic cells, and compare with peroxisome proliferator-activated receptor (PPAR) γ plus PPARδ agonists, which also facilitate the clearance of apoptotic cells and exert anti-inflammatory effects in systemic lupus erythematosus (SLE). Methods: We investigated the efficacy of LXR agonist (GW3965) or dual treatment of PPARγ (pioglitazone) and PPARδ (GW0742) agonists in SLE animal models, female MRL/Mpj-Fas/j mice and BALB/cAjcl mice treated with pristane. The data were analyzed with one-way analysis of variance and Tukey’s honestly significant difference tests. Results: The treatment with LXR or PPARγ/δ agonists did not significantly alter the swelling of lymph nodes, ds-DNA production, albuminuria, histological score of glomerular lesions, and mRNA expression of target genes including Abca1, C1qa, Icam1, Mertk and Tnf. Conclusion: LXR or PPARγ/δ agonists targeting the impaired clearance for apoptosis cells may not be efficient in the remission induction therapy in SLE.

关键词： Nuclear Receptors Liver X Receptor (LXR) Peroxisome Proliferator-Activated Receptor (PPAR) Systemic Lupus Erythematosus (SLE)

Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Communications 2024年第2期44卷 287-293页

作者： Kouya Shiraishi Atsushi Takahashi Yukihide Momozawa Yataro Daigo Syuzo Kaneko Takahisa Kawaguchi Hideo Kunitoh Shingo Matsumoto Hidehito Horinouchi Akiteru Goto Takayuki Honda Kimihiro Shimizu Masahiro Torasawa Daisuke Takayanagi Motonobu Saito Akira Saito Yuichiro Ohe Shun-ichi watanabe Koichi Goto Masahiro Tsuboi Katsuya Tsuchihara Sadaaki Takata Tomomi Aoi Atsushi Takano Masashi Kobayashi Yohei Miyagi Kazumi Tanaka Hiroyuki Suzuki Daichi Maeda Takumi Yamaura Maiko Matsuda Yoko Shimada Takaaki Mizuno Hiromi Sakamoto Teruhiko Yoshida Yasushi Goto Tatsuya Yoshida Taiki Yamaji Makoto Sonobe Shinichi Toyooka Kazue Yoneda Katsuhiro Masago Fumihiro Tanaka Megumi Hara Nobuo Fuse Satoshi S.Nishizuka Noriko Motoi Norie Sawada Yuichiro Nishida Kazuki Kumada Kenji Takeuchi Kozo Tanno Yasushi Yatabe Kuniko Sunami Tomoyuki Hishida Yasunari Miyazaki Hidemi Ito Mitsuhiro Amemiya Hirohiko Totsuka Haruhiko Nakayama Tomoyuki Yokose Kazuyoshi Ishigaki Toshiteru Nagashima Yoichi Ohtaki Kazuhiro Imai Ken Takasawa Yoshihiro Minamiya Kazuma Kobayashi Kenichi Okubo Kenji Wakai Atsushi Shimizu Masayuki Yamamoto Motoki Iwasaki Koichi Matsuda johji Inazawa Yuichi Shiraishi Hiroyoshi Nishikawa Yoshinori Murakami Michiaki Kubo Fumihiko Matsuda Yoichiro Kamatani Ryuji Hamamoto Keitaro Matsuo Takashi Kohno Division of Genome Biology National Cancer Center Research InstituteTokyoJapan Department of Clinical Genomics National Cancer Center Research InstituteTokyoJapan Laboratory for Statistical Analysis Center for Integrative Medical SciencesRIKENYokohamaJapan Department of Genomic Medicine Research InstituteNational Cerebral and Cardiovascular CenterOsakaJapan Laboratory for Genotyping Development Center for Integrative Medical SciencesRIKENYokohamaJapan Center for Antibody and Vaccine Therapy Research HospitalInstitute of Medical ScienceThe University of TokyoTokyoJapan Department of Medical Oncology and Cancer Center and Center for Advanced Medicine against CancerShiga University of Medical ScienceOtsuJapan Division of Medical AI Research and Development National Cancer Center Research InstituteTokyoJapan Center for Genomic Medicine Graduate School of MedicineKyoto UniversityKyotoJapan Department of Medical Oncology Japanese Red Cross Medical CenterTokyoJapan Department of Thoracic Oncology National Cancer Center Hospital EastJapan Department of Thoracic Oncology National Cancer Center HospitalTokyoJapan Department of Cellular and Organ Pathology Graduate School of MedicineAkita UniversityAkitaJapan Department of Respiratory Medicine Tokyo Medical and Dental UniversityBunkyo-kuTokyoJapan Division of General Thoracic Surgery Department of SurgeryShinshu University School of MedicineMatsumotoNaganoJapan Department of General Surgical Science Division of General Thoracic SurgeryGunma University Graduate School of MedicineIntegrative Center of General SurgeryGunma University HospitalGunmaJapan Department of Gastrointestinal Tract Surgery Fukushima Medical University School of MedicineFukushimaJapan StaGen Co. LtdTokyoJapan Division of Thoracic Surgery National Cancer Center HospitalTokyoJapan Department of Thoracic Surgery National Cancer Center Hospital EastChibaJapan Division of Translational Informatics Exploratory Oncology Research and Clinical Trial Center(EPOC

Dear editor,Lung carcinoma is responsible for the highest fatal-ity rate among cancer-related deaths globally,with lung adenocarcinoma(LADC)emerging as the prevailing sub-type.

关键词： adenocarcinoma lung Lung

Association of social distance toward schizophrenia with help-seeking among mothers of adolescents in japan

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Health 2012年第12期4卷 1346-1351页

作者： Hatsumi Yoshii Yuichiro watanabe Hideaki Kitamura Atiqul Haq Mazumder Kouhei Akazawa Department of Medical Informatics and Statistics Niigata University Graduate School of Medicine Niigata Japan Department of Psychiatry Niigata University Graduate School of Medical and Dental Sciences Niigata Japan National Institute of Mental Health Dhaka Bangladesh School of Health Sciences Faculty of Medicine Tohoku University Sendai Japan

Negative maternal attitudes toward schizophrenia may be linked with delayed treatment of their children. We investigated the relation between negative attitudes toward schizophrenia and help-seeking among mothers of junior and senior high school students in japan. The participants were 1309 japanese mothers of junior and senior high school students. Social distance was evaluated by using the Social Distance Scale-japanese version (SDS-j). In addition, mothers were asked about help-seeking for a child with sleeplessness, social withdrawal, and strange behavior. One-way analysis of variance and Student’s t-test were used to evaluate associations between social distance toward schizophrenia and help-seeking. Most (76.4%) participants were aged 40 - 49 years. Maternal demographic characteristics significantly associated with social distance were employment and participation in welfare activities for people with mental illness. In responding to a child with sleeplessness, social withdrawal, and strange behavior, the level of maternal social distance was not significantly associated with the likelyhood of seeking psychiatric help. However, mothers with greater social distance were less likely to seek help at a psychiatric clinic. Maternal social distance toward schizophrenia was not significantly associated with seeking psychiatric help;however, it did affect the type of facility selected among those would seek such help.

关键词： Social distance Schizophrenia Help-Seeking Mothers Adolescence

Stabilization of a high-order harmonic generation seeded extreme ultraviolet free electron laser by time-synchronization control with electro-optic sampling

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High Power Laser Science and Engineering 2015年第2期3卷 1-10页

作者： H.Tomizawa T.Sato K.Ogawa K.Togawa T.Tanaka T.Hara M.Yabashi H.Tanaka T.Ishikawa T.Togashi S.Matsubara Y.Okayasu T.watanabe E.j.Takahashi K.Midorikawa M.Aoyama K.Yamakawa S.Owada A.Iwasaki K.Yamanouchi RIKEN SPring-8 Center japan Synchrotron Radiation Research Institute RIKEN Center for Advanced Photonics japan Atomic Energy Agency The University of Tokyo

A fully coherent free electron laser(FEL) seeded with a higher-order harmonic(HH) pulse from high-order harmonic generation(HHG) is successfully operated for a sufficiently prolonged time in pilot user experiments by using a timing drift feedback. For HHG-seeded FELs, the seeding laser pulses have to be synchronized with electron bunches. Despite seeded FELs being non-chaotic light sources in principle, external laser-seeded FELs are often unstable in practice because of a timing jitter and a drift between the seeding laser pulses and the accelerated electron bunches. Accordingly,we constructed a relative arrival-timing monitor based on non-invasive electro-optic sampling(EOS). The EOS monitor made uninterrupted shot-to-shot monitoring possible even during the seeded FEL operation. The EOS system was then used for arrival-timing feedback with an adjustability of 100 fs for continual operation of the HHG-seeded FEL. Using the EOS-based beam drift controlling system, the HHG-seeded FEL was operated over half a day with an effective hit rate of 20%–30%. The output pulse energy was 20 μj at the 61.2 nm wavelength. Towards seeded FELs in the water window region, we investigated our upgrade plan to seed high-power FELs with HH photon energy of 30–100 e V and lase at shorter wavelengths of up to 2 nm through high-gain harmonic generation(HGHG) at the energy-upgraded SPring-8Compact SASE Source(SCSS) accelerator. We studied a benefit as well as the feasibility of the next HHG-seeded FEL machine with single-stage HGHG with tunability of a lasing wavelength.

关键词： arrival-timing monitor electro-optic sampling(EOS)

A Newly Investigated Approach for the Control of Tunnel Resistance of Nanogaps Using Field-Emission-Induced Electromigration

在线全文

学校读者我要写书评

暂无评论

A Newly Investigated Approach for the Control of Tunnel Resi...

Genetic analysis of the human hair roots as a tool for spaceflight experiments

第18届国际真空大会

作者： K. Takiya Y. Tomoda W. Kume S. Ueno T. watanabe j. Shirakashi Department of Electrical and Electronic Engineering Tokyo University of Agriculture and Technology Koganei

Recently, electromigration （EM） has been extensively known as the fabrication method of nanoscale electrodes with nanometer gaps [1]. EM procedure for the fabrication of nanogaps is particularly simple because the method consists of passing a current through a metal nanowire. However, the nanogaps fabricated by the method tend to exhibit high tunnel resistance. We have already reported that the control of tunnel resistance of the nanogaps is achieved using field-emission-induced EM （so-called "activation"） [2-4], with a voltage source. Activation process is based on moving atoms induced by a Fowler-Nordheim （FN） field emission current at the nanogaps. The motion of moving atoms is completely controlled by the field emission current. For instance, 1010～ 11 electrons are required for the motion of "a" Ni atom during the activation with the preset current of approximately 100 μA [4]. However, the process time of a voltage-source-based activation procedure is relatively long for controlling the resistance of the nanogaps. Here, we propose a newly investigated activation procedure with a current source, in order to shorten the process time of the activation.

关键词： nanogap electromigaration current source field emission current tunnel resistance

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Advances in Bioscience and Biotechnology 2013年第10期4卷 75-88页

作者： Masahiro Terada Masaya Seki Akira Higashibata Shin Yamada Rika Takahashi Hideyuki j. Majima Takashi Yamazaki Tomomi watanabe-Asaka Maki Niihori Chiaki Mukai Noriaki Ishioka Advanced Engineering Services Co. Ltd. Tsukuba City Japan Graduate School of Medical and Dental Sciences Kagoshima University Kagoshima City Japan japan Aerospace Exploration Agency Tsukuba City Japan

The use of hair roots as experimental samples has been a research focus for understanding the effects of spaceflight on astronauts, because it has many advantages, one of which is the fact that hair matrix cells actively divide in a hair follicle and sensitively reflect the physical conditions of the human body. In 2009, a research program focusing on the analysis of astronauts’ hairs was initiated to examine the effects of long-term spaceflight on the gene expression and mineral metabolism in the human body. Since the number of samples per astronaut is limited to 5 strands of hairs at each sampling point, due to the ethical viewpoint of astronauts or limited resources in space, it is important to develop an effective method for the molecular analysis of small amounts of hair roots. In this study, mRNA successfully extracted from 1, 5, and 10 hair follicles was amplified and subjected to the DNA microarray analysis to compare the gene expression within subjects. The results indicated that (1) it was possible to perform the genetic analysis on hair samples stored at -80℃, even without a fixation buffer and (2) the newly modified method of mRNA extraction and analysis was effective in detecting differential gene expression in samples containing only 5 hairs. In conclusion, RNA was efficiently extracted from 5 hair roots, which is the same number of hair roots used in the space experiment;therefore, this method can be applied to genetically analyze astronauts’ hair samples.

关键词： Hair Root Microarray Space Astronaut RNA Gene Expression

Weight loss increases skeletal muscle mitochondrial energy efficiency in obese mice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Life Metabolism 2023年第2期2卷 23-34页

作者： Patrick j.Ferrara Marisa j.Lang jordan M.johnson Shinya watanabe Kelsey L.McLaughlin john Alan Maschek Anthony R.P.Verkerke Piyarat Siripoksup Amandine Chaix james E.Cox Kelsey H.Fisher-Wellman Katsuhiko Funai Diabetes&Metabolism Research Center University of UtahSalt Lake CityUtah 84112United States Department of Nutrition&Integrative Physiology University of UtahSalt Lake CityUtah 84112United States East Carolina Diabetes&Obesity Institute East Carolina UniversityGreenvilleNorth Carolina 27834United States Department of Physiology East Carolina UniversityGreenvilleNorth Carolina 27834United States Metabolomics Core Research Facility University of UtahSalt Lake CityUtah 84112United States Molecular Medicine Program University of UtahSalt Lake CityUtah 84112United States Department of Biochemistry University of UtahSalt Lake CityUtah 84112United States

Weight loss from an overweight state is associated with a disproportionate decrease in whole-body energy expenditure that may contribute to the heightened risk for weight *** suggests that this energetic mismatch originates from lean *** this phenomenon is well documented,the mechanisms have remained *** hypothesized that increased mitochondrial energy efficiency in skeletal muscle is associated with reduced expenditure under weight ***(WT)male C57BL6/N mice were fed with high-fat diet for 10 weeks,followed by a subset of mice that were maintained on the obesogenic diet(OB)or switched to standard chow to promote weight loss(WL)for additional 6 *** energy efficiency was evaluated using high-resolution respirometry and *** spectrometric analyses were employed to describe the mitochondrial proteome and *** loss promoted~50%increase in the efficiency of oxidative phosphorylation(ATP produced per O_(2) consumed,or P/O)in skeletal ***,Weight loss did not appear to induce significant changes in mitochondrial proteome,nor any changes in respiratory supercomplex ***,it accelerated the remodeling of mitochondrial cardiolipin(CL)acyl-chains to increase tetralinoleoyl CL(TLCL)content,a species of lipids thought to be functionally critical for the respiratory *** further show that lowering TLCL by deleting the CL transacylase tafazzin was sufficient to reduce skeletal muscle P/O and protect mice from diet-induced weight *** findings implicate skeletal muscle mitochondrial efficiency as a novel mechanism by which weight loss reduces energy expenditure in obesity.

关键词： energy efficiency energy expenditure mitochondria oxidative phosphorylation phospholipids weight loss