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Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

traumatic brain injury(tBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).tBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Early developmental exposure to inorganic mercury does not alter affiliative behavior of adult prairie voles(Microtus ochrogaster)

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Integrative Zoology 2018年第6期13卷 761-768页

作者： Yue CHEN Robert lewis j.thomas CURtIS Department of Pharmacology and Physiology Oklahoma State University Center for Health SciencesTulsaOklahomaUK

Mercury chloride exposure through drinking water in adult male prairie voles(Microtus ochrogaster)has been shown to alter their social ***,we examined the potential disruption of adult social behavior in prairie voles that were exposed to 60 ppm mercury during early *** used a cross-fostering approach to test the effects of mercury exposure:(1)from conception until birth;(ii)from birth until weaning;and(iii)from conception until weaning,on adult affiliative *** and mercury-treated voles were given the option of remaining in an empty cage or affiliating with a same-sex conspecific in a 3-h choice *** found that early developmental mercury exposure had little if any effect on the reproductive success of breeder pairs or on affiliative behavior by either sex when subjects were tested as *** results suggest that,at least in the context of the behavior tested,the effects of early developmental exposure to mercury do not permanently alter adult prairie vole affiliative behavior,or do so in a way that is too subtle to be detected using the current testing paradigm.

关键词： behavioral testing metals toxicity social behavior prairie vole

transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 177-192页

作者： M.NAVEED M.IMRAN t.ASGHAR Z.ABBAS Department of Mathematics Division of Science and TechnologyUniversity of Education Department of Mathematics The Islamia University of Bahawalpur

this paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. the influence of magnetic fields is also inspected in terms of their physical characteristics. to depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(PDEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAM).the effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective lewis number.

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temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries on magnetic resonance imaging

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Neural Regeneration Research 2025年第11期20卷 3144-3150页

作者： Holly Flyger Samantha j.Holdsworth Alistair j.Gunn Laura Bennet Hamid Abbasi Mātai Medical Research Institute Tairāwhiti GisborneNew Zealand Department of Anatomy&Medical Imaging Faculty of Medical and Health SciencesThe University of AucklandAucklandNew Zealand Center for Brain Research The University of AucklandAucklandNew Zealand Auckland Bioengineering Institute The University of AucklandAucklandNew Zealand

Moderate to severe perinatal hypoxic-ischemic encephalopathy occurs in~1 to 3/1000 live births in high-income countries and is associated with a significant risk of death or neurodevelopmental *** assessment is important to help identify highrisk infants,to help families,and to support appropriate interventions.A wide range of monitoring tools is available to assess changes over time,including urine and blood biomarkers,neurological examination,and *** present,magnetic resonance imaging is unique as although it is expensive and not suited to monitoring the early evolution of hypoxic-ischemic encephalopathy by a week of life it can provide direct insight into the anatomical changes in the brain after hypoxic-ischemic encephalopathy and so offers strong prognostic information on the long-term outcome after hypoxic-ischemic *** review investigated the temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries,with a particular emphasis on exploring the correlation between the prognostic implications of magnetic resonance imaging scans in the first week of life and their relationship to long-term outcome prediction,particularly for infants treated with therapeutic hypothermia.A comprehensive literature search,from 2016 to 2024,identified 20 pertinent *** review highlights that while the optimal timing of magnetic resonance imaging scans is not clear,overall,it suggests that magnetic resonance imaging within the first week of life provides strong prognostic *** challenges limit the timing consistency,particularly the need for intensive care and clinical ***,although most reports examined the prognostic value of scans taken between 4 and 10 days after birth,there is evidence from small numbers of cases that,at times,brain injury may continue to evolve for weeks after *** suggests that in the future it will be important to explore a wider range of times after hypo

关键词： magnetic resonance imaging neonatal hypoxic-ischemic encephalopathy neurodevelopmental outcomes prognostic biomarkers in neuroimaging scan timing therapeutic hypothermia

Mediation of flowering by a calmodulin-dependent protein kinase

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Science China(Life Sciences) 2001年第5期44卷 506-512页

作者：梁述平汪杏芬吕应堂 lewis j.Feldman Key Laboratory of MOE for Plant Developmental Biology Wuhan University Wuhan 430072 China

A calmodulin-dependent protein kinase (MCK1) appeared important in regulating flowering in tobacco. the expression of modified MCK1 that lacks the C-terminal including calmodulin-binding domain upsets the flowering developmental program, leading to the abortion of flower primordia initiated on the main axis of the plant and, as well, caused the prolongation of the vegetative phase in axillary buds. the abortion process of flowers began first in the developing anthers and subsequently the entire flower senesces. In axillary buds the prolonged vegetative phase was characterized by atypical elongated, narrow, twisted leaves. these results suggested a role for calmodulin-dependent protein kinase homologs in mediating flowering.

关键词： calmodulin-dependent protein kinase transgenic tobacco flower.

Optimal and interactive keyframe selection for motion capture

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Computational Visual Media 2019年第2期5卷 171-191页

作者： Richard Roberts j.P.lewis Ken Anjyo jaewoo Seo Yeongho Seol Victoria University of Wellington WellingtonNew Zealand SEED Electronic ArtsLos AngelesUnited States OLM Digital TokyoJapan Pinscreen Los AngelesUnited States Weta Digital WellingtonNew Zealand

Motion capture is increasingly used in games and movies, but often requires editing before it can be used, for many reasons. the motion may need to be adjusted to correctly interact with virtual objects or to fix problems that result from mapping the motion to a character of a different size or, beyond such technical requirements, directors can request stylistic ***, editing is laborious because of the lowlevel representation of the data. While existing motion editing methods accomplish modest changes, larger edits can require the artist to "re-animate" the motion by manually selecting a subset of the frames as *** this paper, we automatically find sets of frames to serve as keyframes for editing the motion. We formulate the problem of selecting an optimal set of keyframes as a shortest-path problem, and solve it efficiently using dynamic programming. We create a new simplified animation by interpolating the found keyframes using a naive curve fitting technique. Our algorithm can simplify motion capture to around 10% of the original number of frames while retaining most of its detail. By simplifying animation with our algorithm, we realize a new approach to motion editing and stylization founded on the timetested keyframe interface. We present results that show our algorithm outperforms both research algorithms and a leading commercial tool.

关键词： motion capture motion editing keyframe animation dynamic programming

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon j.Brown Rafael j.Yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).this,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Effects of single and dual species herbivory on the behavioral responses of three thrips species to cotton seedlings

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Insect Science 2017年第4期24卷 684-698页

作者： Rehan Silva Gimme H. Walter lewis j. Wilson Michael j. Furlong School of Biological Sciences The University of Queensland St. Lucia Queensland 4072 Australia Cotton Research Unit CSIRO Agriculture Flagship Locked Bag 59 Narrabri NSW 2390 Australia

this study investigated the olfactory responses of 3 thrips species [Frankliniella schultzei trybom, E occidentalis Pergrande and thrips tabaci Lindeman （thysanoptera： thripidae）] to cotton seedlings [Gossypium hirsutum L. （Malvales： Malvaceae）] simulta- neously damaged by different combinations of herbivores. Cotton seedlings were damaged by foliar feeding tetranychus urticae Koch （trombidiforms： tetranychidae）, Helicoverpa armigera Hibner （Lepidoptera： Noctuidae）, Aphis＇ gossypii Glover （Hemiptera： Aphidi- dae） or root feeding tenebrio molitor L. （Coleoptera： tenebrionidae）. thrips responses to plants simultaneously damaged by 2 species of herbivore were additive and equivalent to the sum of the responses of thrips to plants damaged by single herbivore species feeding alone. For example, E occidentalis was attracted to t. urticae damaged plants but more attracted to undamaged plants than to plants damaged by H. armigera. Plants simultane- ously damaged by low densities of t. urticae and H. armigera repelled E occidentalis but as t. urticae density increased relative to H. armigera density, E occidentalis attraction to coinfested plants increased proportionally. thrips tabaci did not discriminate between un- damaged plants and plants damaged by H. armigera but were attracted to plants damaged by t. urticae alone or simultaneously damaged by t. urticae and H. armigera. Olfactometer assays showed that simultaneous feeding by 2 herbivores on a plant can affect predator- prey interactions. Attraction of F. occidentalis to plants damaged by its t. urticae prey was reduced when the plant was simultaneously damaged by H. armigera, t. molitor, or A. gossypii and F. schultzei was more attracted to plants simultaneously damaged by t. urticae and H. armigera than to plants damaged by t. urticae alone. We conclude that plant responses to feeding by I species of herbivore are affected by responses to feeding by other herbivores. these plant-mediated interactions between herbivo

关键词： attraction dual-herbivory Frankliniella occidentalis Frankliniella schultzei induced responses predictability simultaneous damage thrips tabaci

Effect of the postfeeding interval on olfactory responses of thrips to herbivore-induced cotton plants

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Insect Science 2016年第6期23卷 881-892页

作者： Rehan Silva Gimme H. Walter lewis j. Wilson Michael j. Furlong School of Biological Sciences University of Queensland St. Lucia Queensland 4072 Cotton Research Unit CSIRO Agriculture Flagship Narrabri NSW 2390 Austrafia

We investigated the responses of 3 thrips species, Frankliniella schultzei tryborn, E occidentalis Pergrande, and thrips tabaci Lindeman （thysanoptera： thripidae） to herbivore-damaged and undamaged cotton seedlings （Gossypium hirsutum L. [Malvales： Malvaceae]） at a range of time intervals following damage by adult tetranychus urticae （Koch）, adult t. ludeni （Zacher）（Acari： tetranychidae） or Helicoverpa armigera （Hubner）（Lepidoptera： Noctuidae） larvae in olfactometer assays. the intensity/frequency of the response of thrips to herbivore-induced plants decreased with time and ultimately disappeared in all cases; however, the rate at which the response declined was related to the herbivore species that inflicted the damage. All 3 species of thrips were attracted to plants damaged by t. urticae for longer than they were to plants damaged by t. ludeni. the duration for which damaged plants remained attractive was also affected by the degree of damage inflicted on cotton seedlings. For example, E schultzei was attracted to plants damaged by a higher density of two-spotted spider mites （100/plant） for much longer than to plants damaged by a lower density of these mites （50/plant）. the results reinforce previous studies that demonstrate that arrangement of variables influences the responses of thrips to their herbivore-induced cotton host plants. Results also show that these responses are variable in time following herbivore damage to cotton plants, which further demonstrates how difficult it is to generalize about the functional significance of these interactions.

关键词： attraction cotton duration induced responses olfactometer thysanoptera