检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

聚四氟乙烯-镍化学镀的工艺管理

电镀与环保 1990年第1期10卷 31-35页

作者： David j.sugg 瞿四复美国Techmetals公司

化学镀镍层在解决耐磨、耐腐蚀问题上的优异特性是众所周知的。为了进一步提高这些性能,近年来又在复合镀工艺上进行了探索。在化学镀镍层中共沉积聚四氟乙烯粒子提高了镀层的润滑性与耐磨性。本文集中讨论了可用于控制镀液中聚四氟乙... 详细信息

化学镀镍层在解决耐磨、耐腐蚀问题上的优异特性是众所周知的。为了进一步提高这些性能,近年来又在复合镀工艺上进行了探索。在化学镀镍层中共沉积聚四氟乙烯粒子提高了镀层的润滑性与耐磨性。本文集中讨论了可用于控制镀液中聚四氟乙烯量并测定镀层中聚四氟乙烯量的各种工艺管理技术。

关键词：聚四氟乙烯化学镀镍工艺管理

在线全文

学校读者我要写书评

暂无评论

药物诱导肾性糖尿的尿路感染特征

药物诱导肾性糖尿的尿路感染特征

2型钠-葡萄糖协同转运蛋白抑制剂达格列净治疗2型糖尿病患者具有较低的致低血糖倾向

中华医学会第十一次全国内分泌学学术会议

作者： S.Parikh K.johnsson A.Ptaszynska B.Schmitz j.sugg j.F.List AstraZeneca WilmingtonDEUSA AstraZeneca MolndalSweden Bristol-Myers Squibb PrincetonNJUSA

目的:2型糖尿病(T2DM)病人易患尿路感染(UTI)。有研究报道,在体外尿中加入葡萄糖会增加大肠杆菌的生长,而流行病学数据却与此不一致,并没有显示尿糖排量增加与尿路感染之间存在关联。达格列净(Dapagliflozin)是一种随剂量增加肾葡萄糖...

目的:2型糖尿病(T2DM)病人易患尿路感染(UTI)。有研究报道,在体外尿中加入葡萄糖会增加大肠杆菌的生长,而流行病学数据却与此不一致,并没有显示尿糖排量增加与尿路感染之间存在关联。达格列净(Dapagliflozin)是一种随剂量增加肾葡萄糖排出量而改善T2DM患者血糖的2型钠-葡萄糖协同转运蛋白(SGLT2)抑制剂,从该药临床对照试验汇总的数据为检验此项假设提供了机会。方法:本研究描述的数据汇总于为期12到24周的12

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

2型钠-葡萄糖协同转运蛋白抑制剂达格列净治疗2型糖尿病患者具有...

Vigorous,but differential mononuclear cell response of cirrhotic patients to bacterial ligands

中华医学会糖尿病学分会第十六次全国学术会议

作者： K.Rohwedder V.Hruba A.Salsali L.H.Ying j.sugg j.F.List S.j.Parikh AstraZeneca WedelGermany AstraZeneca PragueCzech Republic Former Employee Bristol-Myers SquibbPrincetonNJUSA Bristol-Myers Squibb PrincetonNJUSA AstraZeneca WilmingtonDEUSA

目的2型糖尿病(T2DM)患者低血糖可反复发作,并常常成为血糖控制达标的障碍。选择性肾2型钠-葡萄糖协同转运蛋白(SGLT2)抑制剂达格列净(DAPA)通过增加尿中葡萄糖的排出来降低T2DM患者的血糖水平。此过程依赖于血浆葡萄糖水平以及肾脏滤过...

目的2型糖尿病(T2DM)患者低血糖可反复发作,并常常成为血糖控制达标的障碍。选择性肾2型钠-葡萄糖协同转运蛋白(SGLT2)抑制剂达格列净(DAPA)通过增加尿中葡萄糖的排出来降低T2DM患者的血糖水平。此过程依赖于血浆葡萄糖水平以及肾脏滤过率,而并非依赖于胰岛素,发生低血糖的风险较低。

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

World journal of Gastroenterology 2011年第10期17卷 1317-1325页

作者： Varenka j Barbero-Becerra María Concepción Gutiérrez-Ruiz Carmen Maldonado-Bernal Félix I Téllez-Avila Roberto Alfaro-Lara Florencia Vargas-Vorácková Department of Gastroenterology Instituto Nacional de Ciencias Médicasy Nutrición Salvador Zubirán Laboratorio de Fisiología Celular División de Ciencias de la Salud Universidad Autónoma Metropolitana-Iztapalapa Unidad de Investigación Médica en Enfermedades Infecciosasy Parasitarias Hospital de Pediatría Unidad de Investigación en Enfermedades Oncológicas Hospital Infantil de México Federico Gómez

AIM： To study the role of gram-positive and gram-negative bacteria in the pathogenesis of liver injury, specifically the activation of inflammatory mediators. METHODS： Peripheral blood mononuclear cells of 20 out-patients were studied, 10 of them with cirrhosis,Peripheral blood mononuclear cells were isolated and exposed to lipopolysaccharide or lipoteichoic acid. CD14, Toll-like receptor 2 and 4 expression was determined by flow cytometry, and tumor necrosis factor （TNF） α, interleukin （1L）-1β, IL-6, IL-12 and IL-10 secretion in su- pernatants was determined by ELISA. RESULTS： Higher CD14, Toll-like receptor 2 and 4 expression was observed in peripheral blood mononudear cells from cirrhotic patients, （P 〈 0.01, P 〈 0.006, P 〈 0.111） respectively. Lipopolysaccharide and lipoteichoic acid induced a further increase in CD14 expression （P 〈 0.111 lipopolysaccharide, P 〈 0.013 lipoteichoic acid）, and a decrease in Toll-like receptor 2 （P 〈 0.008 lipopolysaccharide, P 〈 0.008 lipoteichoic acid） and Toll-like receptor 4 （P 〈 0.008 lipopolysaccharide, P 〈 0.028 li- poteichoic acid） expression. With the exception of TNFα, absolute cytokine secretion of peripheral blood mononuclear cells was lower in cirrhotic patients under nonexposure conditions （P 〈 0.070 IL-6, P 〈 0.009 IL-1]5, P 〈 0.022 IL-12）. Once exposed to lipopolysaccharide or lipoteichoic acid, absolute cytokine secretion of peripheral blood mononuclear cells was similar in cirrhotic and non-cirrhotic patients, determining a more vigorous response in the former （P 〈 0.005 TNFα, IL-1β, IL-6, IL-2 and IL-10 lipopolysaccharide; P 〈 0.037 TNFα; P 〈 0.006 IL-113; P 〈 0.005 IL-6; P 〈 0.007 IL-12; P 〈 0.014 IL-10 lipoteichoic acid）. Response of peripheral blood mononuclear cells was more intense after lipopolysaccharide than after lipoteichoic acid exposure. CONCLUSION： Peripheral blood mononuclear cells of cirrhotic patients are able to respond to a sudden bacterial ligand exposure, particularly lipopolysaccharide, sugg

关键词： Liver cirrhosis Toll-like receptors Cytokines Lipopolysaccharide Lipoteichoic acid

蓝山眼科研究:老龄人群的开角型青光眼和甲状腺疾病

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（眼科学分册） 2005年第1期1卷 35-36页

作者：姜廷帅 Lee A.j RochtchinaE Wang j.j P.Mitchell University of Sydney Dep artment of Ophthalmolog yWestmead HospitalHawkesbury Rd.WestmeadNSW2145Australia

*** assess whether thyroid d isease is indepen-dently associated with open-angle g laucoma (OAG),using history of thyroid disease and curre nt thyroxine *** Blue Mountains Eye Stud y examined 3654persons,aged *** wers collected self-reported history of diagnosis and treatment for thyroid *** examinations included applanation tonome-try,stereoscopic optic disc photography and automated *** was diagnosed from th e presence of matching typical glaucomatous field changes and optic disc cupping,independent of intraocula r *** between thyroid disease(history and treatment )and OAG were assessed in a multivariate *** 324participants(8.9%)reporting history of thyroid disease,147(4.0%)were currently using *** we could not accurately categorize the thyroid disorder for all cases,current use of thyroxine sugg ests a prior hypothyroid *** thyroid dise ase subgroups affected women more frequently than men,P=*** was diagnosed in 108subjects(3.0%)and was more frequent in those reporting past thyroid dise ase(4.6vs2.8%).This relationship was not statistic ally significant after ad-justing for potential confounders,multivariate odds ratio(OR)1.6;95%confidence interval(95%CI 0.9-2.9).OAG was significantly more frequen t,however,in subjects reporting current thyroxine use(6.8vs2.8%),multivariate OR 2.1;95%CI 1.0-4.4,or history of thyroid surgery(6.5vs2.8%),multivariate OR 2.5;95%CI *** population-based study suggests that thyroid disease,indicated by current thyroxine use or past thyroid surgery,could be indepen-dently related to OAG.

关键词：开角型青光眼甲状腺疾病老龄人群眼科研究视野检查甲状腺病压平眼压计眼部检查甲状腺手术多变量模型

多发性硬化症患者的视网膜神经纤维层厚度与视觉功能之间的关系

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（眼科学分册） 2006年第6期2卷 55-56页

作者： Fisher j. B. jacobsD. A. Markowitz C. E. L.j. Balcer 王文军(译) 不详 3 East Gates Building 3400 Spruce Street Philadelphia PA 19104 United States

Purpose: To examine the relation of visual function to retinal nerve fiber layer (RNFL) thickness as a structural biomarker for axonal loss in multiple sclerosis (MS),and to compare RNFL thickness among MS eyes with a history of acute optic neuritis (MS ON eyes),MS eyes without an optic neuritis history (MS non-ON eyes),and disease-free control eyes. Design: Cross-sectional study. Participants: Patients with MS (n=90; 180 eyes) and disease-free controls (n =36; 72 eyes). Methods: Retinal never fiber layer thickness was measured using optical coherence tomography (OCT; fast RNFL thickness software protocol). Vision testing was performed for each eye and binocularly before OCT scanning using measures previously shown to capture dysfunction in MS patients: (1) low-contrast letter acuity (Sloan charts,2.5% and 1.25% contrast levels at 2 m) and (2) contrast sensitivity (Pelli-Robson chart at 1 m). Visual acuity (retroilluminated Early Treatment Diabetic Retinopathy charts at 3.2 m) was also measured,and protocol refractions were performed. Main Outcome Measures: Retinal nerve fiber layer thickness measured by OCT,and visual function test results. Results: Although median Snellen acuity equivalents were better than 20/20 in both groups,RNFL thickness was reduced significantly among eyes of MS patients (92 μ m) versus controls (105 μ m) (P justing for within-patient intereye correlations). Lower visual function scores were associated with reduced average overall RNFL thickness in MS eyes; for every 1-line decrease in low-contrast letter acuity or contrast sensitivity score,the mean RNFL thickness decreased by 4 μ m. Conclusions: Scores for low-contrast letter acuity and contrast sensitivity correlate well with RNFL thickness as a structural biomarker,supporting validity for these visual function tests as secondary clinical outcome measures for MS trials. These results also sugg

关键词：视网膜神经纤维层厚度多发性硬化症患者视觉功能急性视神经炎 NFL厚度 Snellen视力双眼视功能正常对照组糖尿病视网膜病变

从流行病学、急症护理和急性后期预后研究卒中的人种差异

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（神经病学分册） 2005年第7期1卷 61-62页

作者： Stansbury j.P. Williams L.S. 李一明 Department of Anthropology University of Florida1112 Turlington Hall Gainesville FL 32611- 7305 UnitedStates Dr.

Background and Purpose:Evidence for ethnic disparities in stroke incidence, s everity, and mortality has continued to mount in recent years. However, the pict ure for disparities in acute management and rehabilitation remains more ambiguou *** objective of this report is to summarize current evidence from stroke epid emiology and studies focusing on disparities in stroke care and disability, sugg esting courses for ***:A comprehensive search of current literature on ethnic/racial variation in stroke incidence, mortality, and severity,as well as acute and postacute patient care was ***:Recent evidence unamb iguously reaffirms a greater burden of disease in stroke, greater mortality, and greater severity of strokes for blacks. Evidence for disparities in acute and postacute care is less conclusive, as is the evidence for disparities among other ethnic groups. Evidence for health dis parities in stroke care across settings, regions, and the continuum of carevarie s considerably. Conclusions:Minority ethnic groups have higher rates or more se vere stroke, but variations in prognosis for clinical outcomes other than mortal ity remain less *** is considerable need for more studies that take in to account regional ethnic variations in treatment and outcomes, and for better documentation of stroke outcomes among groups in addition to blacks. Dealing wit h ethnic disparities in stroke will be served by sustained attention to quality improvement in high-impact areas in stroke care, complemented by initiatives th at promote cultural competence.

关键词：预后研究 ethnic 急性期卒中发病率卒中治疗残疾率 mortality 死亡率方面康复治疗 competence

在线全文

学校读者我要写书评

暂无评论

L-精氨酸能改善MELAS卒中样发作症状

世界核心医学期刊文摘（神经病学分册） 2005年第7期1卷 50-51页

作者： Koga Y. Akita Y. Nishioka j. 李一明 Dept.of Pediatrics and Child Health Kurume University School of Medicine 67 Asahi-Machi Kurume City Fukuoka 830 0011 Japan Dr.

Based on the hypothesis that mitochondrial myopathy, encephalopathy,lactic acidosis, and strokelike episodes (MELAS) are caused by impaired vasodilation in an intracerebral artery, the authors evaluated the effe cts of administering L-arginine, a nitricoxide precursor. Patients were adminis tered L-arginine intravenously at the acute phase or orally at the interictal p hase. L-Arginine infusions significantly improved all strokelike symptoms, sugg esting that oral administration within 30 minutes of a stroke significantly decr eased frequency and severity of strokelike episodes.

关键词： MELAS 卒中样发作 L-精氨酸线粒体肌病 acidosis myopathy 卒中发作发作间期 encephalopathy intracerebral

青春期少女边缘型人格障碍的特征:P300证实大脑成熟度的改变

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（神经病学分册） 2005年第10期1卷 14-15页

作者： Houston R.j. Ceballos N.A. Hesselbrock V.M. Bauer L.O. 郭中孟 Research Institute on Addictions State University of New York at Buffalo 1021 Main Street Buffalo NY 14203 United States

Objective: To examine brain maturation in adolescent girls with borderline p ersonality disorder (BPD) features using the P300 event- related potential. Met hods: One hundred twenty- three girls, aged 14- 19 yrs, were assigned to one o f 4 groups formed by the crossing of BPD features ( 16.5 yrs). P300 responses were measured while subjects perfo rmed a complex visual oddball task. Results: ANCOVAs of P300 amplitude- adjusti ng for variability associated with comorbid conduct disorder and depression symptoms- revealed a significant interaction . Among subjects without BPD features, aging was associated with the normal redu ction in visual P300 amplitude. Among subjects with BPD features, there were no age- related changes. Additional analyses, which tested the effects of BPD feat ures across the full age range, supported these findings. Conclusions: The prese nt findings suggest abnormal brain maturation among adolescent girls exhibiting features of BPD. Significance: These results support a hypothesis of altered bra in maturation in adolescents exhibiting BPD features at an early age. It is sugg ested that measures of brain maturation obtained during adolescence may improve our ability to predict BPD and comorbid disorders in adulthood.

关键词：边缘型人格障碍 P300 青春期少女成熟度行为障碍事件相关电位变异数分析诊断标准预测能力