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Cellular & Molecular Immunology 2021年第12期18卷 2673-2675页

作者： Prerna Arora Cheila Rocha Amy Kempf Inga Nehlmeier Luise Graichen Martin S.Winkler Martin Lier sebastian Schulz Hans-Martin jäck Anne Cossmann Metodi V.Stankov Georg M.N.Behrens Stefan Pöhlmann Markus Hoffmann Infection Biology Unit German Primate CenterKellnerweg 437077GöttingenGermany Faculty of Biology and Psychology Georg-August-University GöttingenWilhelmsplatz 137073GöttingenGermany Department of Anesthesiology University of Göttingen Medical CenterGeorg-August University of GöttingenRobert-Koch-Straße 4037075GöttingenGermany Division of Molecular Immunology Department of Internal Medicine 3Friedrich-Alexander University of Erlangen-NürnbergGlückstraße 691054ErlangenGermany Department for Rheumatology and Immunology Hannover Medical SchoolCarl-Neuberg-Straße 130625HannoverGermany

The COVID-19 pandemic,caused by SARS-CoV-2,continues to rage in many countries,straining health systems and *** protect against severe disease and death and are considered central to ending the ***-19 vaccines(and SARS-CoV-2 infection)elicit antibodies that are directed against the viral spike(S)protein and neutralize the ***,the emergence of SARS-CoV-2 variants with S protein mutations that confer resistance to neutralization might compromise vaccine efficacy[1].

关键词： antibodies vaccine death

Optical prediction of single muscle fiber force production using a combined biomechatronics and second harmonic generation imaging approach

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Light(Science & Applications) 2018年第1期7卷 289-302页

作者： Dominik Schneidereit Stefanie Nübler Gerhard Prölß Barbara Reischl sebastian Schürmann Oliver j Müller Oliver Friedrich Institute of Medical Biotechnology Friedrich-Alexander-University(FAU)Erlangen-NürnbergPaul-Gordan-Str.391052 ErlangenGermany Erlangen Graduate School in Advanced Optical Technologies(SAOT) FAU Erlangen-NürnbergPaul-Gordan-Str.791052 ErlangenGermany Muscle Research Center Erlangen(MURCE) Friedrich-Alexander-University Erlangen-NürnbergErlangenGermany Department of Internal Medicine III University of KielArnold-Heller-Str.324105 KielGermany DZHK(German Center for Cardiovascular Research)Partner Site Hamburg/Kiel/Lübeck KielGermany

Skeletal muscle is an archetypal organ whose structure is tuned to match *** magnitude of order in muscle fibers and myofibrils containing motor protein polymers determines the directed force output of the summed force vectors and,therefore,the muscle’s power performance on the structural *** and function can change dramatically during disease states involving chronic *** remodeling of the cytoarchitecture has been pursued using noninvasive and label-free multiphoton second harmonic generation(SHG)***,structure parameters can be extracted as a measure of myofibrillar order and thus are suggestive of the force output that a remodeled structure can still ***,to date,the parameters have only been an indirect measure,and a precise calibration of optical SHG assessment for an exerted force has been elusive as no technology in existence correlates these *** engineered a novel,automated,high-precision biomechatronics system into a multiphoton microscope allows simultaneous isometric Ca2+-graded force or passive viscoelasticity measurements and SHG *** this MechaMorph system,we studied force and SHG in single EDL muscle fibers from wt and mdx mice;the latter serves as a model for compromised force and abnormal myofibrillar *** present Ca2+-graded isometric force,pCa-force curves,passive viscoelastic parameters and 3D structure in the same fiber for the first ***,we provide a direct calibration of isometric force to morphology,which allows noninvasive prediction of the force output of single fibers from only multiphoton images,suggesting a potential application in the diagnosis of myopathies.

关键词： structure harmonic fibers

Neuron:科学家找到帮助修复损伤神经元的药物

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现代生物医学进展 2017年第4期17卷 I0003-I0004页

作者： Andrea Tedeschi sebastian Dupraz Claudia j. Laskowski jia Xue Thomas Ulas Marc Beyer joachim L. Schultze Frank Bradke Platform for Single Cell Genomics and Epigenomics German Center for Neurodegenerative Diseases 53175 Bonn Germany

由于受损的神经纤维无法再生，因此脊椎损伤会造成瘫痪和其他永久性的残疾。现在来自德国的科学家们成功解除了一种“刹车”分子的作用，这种分子能够阻止神经纤维的再生。他们利用一种作用于生长抑制机制的药物——Pregabalin治疗小鼠... 详细信息

由于受损的神经纤维无法再生，因此脊椎损伤会造成瘫痪和其他永久性的残疾。现在来自德国的科学家们成功解除了一种“刹车”分子的作用，这种分子能够阻止神经纤维的再生。他们利用一种作用于生长抑制机制的药物——Pregabalin治疗小鼠实现了受损的神经连接重新形成。相关研究结果发表在国际学术期刊Neuron上。

关键词：脊椎损伤科学家药物神经元修复国际学术期刊神经纤维神经连接

How coherence is governing diffuson heat transfer in amorphous solids

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npj Computational Materials 2022年第1期8卷 901-908页

作者： Zhongwei Zhang Yangyu Guo Marc Bescond jie Chen Masahiro Nomura sebastian Volz Institute of Industrial Science The University of TokyoTokyo153-8505Japan Laboratory for Integrated Micro and Mechatronic Systems CNRS-IIS UMI 2820The University of TokyoTokyo153-8505Japan IM2NP UMR CNRS 7334Aix-Marseille UniversitéFacultédes Sciences de Saint JérômeCase 14213397Marseille Cedex 20France Center for Phononics and Thermal Energy Science School of Physics Science and Engineering and China-EU Joint Lab for NanophononicsTongji University200092ShanghaiPeople’s Republic of China

Thermal transport in amorphous materials has remained one of the fundamental questions in solid state physics while involving a very large field of *** a heat conduction theory incorporating coherence,we demonstrate that the strong phase correlation between local and non-propagating modes,commonly named diffusons in the terminology of amorphous systems,triggers the conduction of *** treating the thermal vibrations as collective excitations,the significant contribution of diffusons,predominantly relying on coherence,further reveals interesting temperature and length dependences of thermal *** propagation length of diffuson clusters is found to reach the micron,overpassing the one of *** explored wavelike behavior of diffusons uncovers the unsolved physical picture of mode correlation in prevailing models and further provides an interpretation of their ability to transport *** work introduces a framework for understanding thermal vibrations and transport in amorphous materials,as well as an unexpected insight into the wave nature of thermal vibrations.

关键词： amorphous diffu conduction

Antioxidant potential,tannin and polyphenol contents of seed and pericarp of three Coffea species

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Asian Pacific journal of Tropical Medicine 2016年第4期9卷 356-362页

作者： va Brigitta Patay Nikolett Sali Tams Kszegi Rita Csepregi Viktória Lilla Blaz Tibor sebastian Németh Tibor Németh Nóra Papp Institute of Pharmacognosy Medical SchoolUniversity of PcsRókus 2.PcsHungary7624 Department of Laboratory Medicine Medical SchoolUniversity of PcsIfjúsg 13 PcsHungary76243 jnos Szentgothai Research Center Ifjúsg 20 PcsHungary.76244 Department of Pharmacognosy Faculty of Medicine and PharmacyUniversity of Oradea

Objective:To investigate the antioxidant activity,total phenolic and total tannin content of the pericarp and the seed of Coffea benghalensis(***) and Coffea liberica compared to Coffea arabica(***).Methods:The antioxidant potential,total tannin and polyphenol contents of the immature and mature seed and pericarp of *** and Coffea liberica were quantified and compared to *** chemiluminescence(ECL).2,2-diphenyl-1-picrylhydruzyl(DPPH).oxygen radical absorbance capacity,Folin-Ciocaltcau method and total tannin content assays were ***:Trolox equivalent(TE/g plant material) values obtained by ECL and DPPH methods showed loose correlation(r^2=0.587)while those measured by oxygen radical absorbance capacity assay were higher without correlation in each plant.A closer correlation was detected between the ECL method and the percentage antioxidant activity of the DPPH technique(r^2=0.610 7) in each species,however the immature pericarp of *** showed much higher DPPH scavenging potential than was seen in the ECL *** immature pericarp of *** expressed the highest tannin and polyphenol content,and a high polyphenol level was also detected in the immature seed of *** immature pericarp of Bengal and Liberian coffees showed the largest amount of phenolic ***:The obtained data highlight the potential role of *** as a new source of natural antioxidants and polyphenols compared to ***.

关键词： Coffee 2,2-diphcnyl-1-picrylhydrazyl Enhanced chemiluminescence Folin-Ciocalteau Oxygen radical absorbance capacity Total tannin method

Surface-Enhanced Raman Spectroscopy and Imaging with Molecularly Functionalized Noble Metal Nanoparticles: From Experimental Precision Plasmonics to i SERS Microscopy and Chemical Energy Conversion

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Surface-Enhanced Raman Spectroscopy and Imaging with Molecul...

Degradable magnesium-hydroxyapatite interpenetrating phase composites processed by current assisted metal infiltration in additive-manufactured porous preforms

第十九届全国光散射学术会议

作者： jun Hee Yoon Wei Xie Xinping Wang j?rg E.Wissler sebastian Schlücker University Duisburg-Essen Physical Chemistry I and Center for Nanointegration （CENIDE）

＜正＞Surface-enhanced Raman scattering（SERS）is nowadays widely used in the chemical,life and material sciences.[1]In this contribution,our most recent results on experimental precision plasmonics for applications

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journal of Magnesium and Alloys 2022年第12期10卷 3641-3656页

作者： Mariano Casas-Luna Edgar B.Montufar Norbert Hort sebastian Díaz-de-la-Torre joséClaudio Méndez-García Lucie Vištejnová Adam Brínek AlešDanhel Karel Dvorak jozef Kaiser Ladislav Celko Central European Institute of Technology Brno University of TechnologyPurkynova 123Brno 61200Czech Republic Institute of Metallic Biomaterials Helmholtz-Zentrum HereonMax-Planck-Straße 1Geesthacht 21502Germany Institute of Product and Process Innovation Leuphana University LüneburgUniversitätsallee 1Lüneburg 21335Germany Centro de Investigación e Innovación Tecnológica Instituto Politécnico NacionalCerrada de Cecati s/nMexico City 02250Mexico Biomedical Center Faculty of Medicine in PilsenCharles UniversityAlej Svobody 1655/76Plzen 32300Czech Republic Institute of Biophysics of the Czech Academy of Sciences Královopolská135Brno 61265Czech Republic Faculty of Civil Engineering Brno University of TechnologyPurkynova 139Brno 61200Czech Republic

This work explores ceramic additive manufacturing in combination with liquid metal infiltration for the production of degradable interpenetrating phase magnesium/hydroxyapatite(Mg/HA) composites. Material extrusion additive manufacturing was used to produce stoichiometric,and calcium deficient HA preforms with a well-controlled open pore network, allowing the customization of the topological relationship of the composite. Pure Mg and two different Mg alloys were used to infiltrate the preforms by means of an advanced liquid infiltration method inspired by spark plasma sintering, using a novel die design to avoid the structural collapse of the preform. Complete infiltration was achieved in 8 min, including the time for the Mg melting. The short processing time enabled to restrict the decomposition of HA due to the reducing capacity of liquid Mg. The pure Mg-base composites showed compressive yield strength above pure Mg in cast state. Mg alloy-based composites did not show higher strength than the bare alloys due to grain coarsening, but showed similar mechanical properties than other Mg/HA composites that have significantly higher fraction of metallic phase. The composites showed faster degradation rate under simulated body conditions than the bare metallic component due to the formation of galvanic pairs at microstructural level. Mg dissolved preferentially over HA leaving behind a scaffold after a prolonged degradation period. In turn, the fast production of soluble degradation products caused cell metabolic changes after 24 h of culture with not-diluted material extracts. The topological optimization and reduction of the degradation rate are the topics for future research.

关键词： Interpenetrating phase composite Biodegradable metal Topological relationship Direct ink writing Metal infiltration Computed aided design

Evaluation of Multiparametric MRI of the Prostate: Impact of Standardized Examination Protocols and the Endorectal Coil

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Open journal of Medical Imaging 2020年第1期10卷 30-41页

作者： Finn Rampoldt Frank Huebner Stephan Zangos Andreas Bucher jan-Erik Scholtz Moritz Kaup sebastian Fischer Thomas j. Vogl Boris Bodelle Department of Diagnostic and Interventional Radiology Goethe University of Frankfurt Frankfurt Germany

Purpose: The aim of the present study was to evaluate the patient population, different MRI examination protocols and the patient’s acceptance of the endorectal coil in the diagnosis of prostate cancer regarding the current discussion in PI-RADS v2.1. Material and Methods: In our institute, 256 patients were examined with different protocols and separated into six groups. The value of the different MRI protocols was identified by analyzing sensitivity, specificity, negative predictive value and positive predictive value. The patient population was tested for statistically significant differences in their characteristics to detect a distortion of the results. The patients’ acceptance of endorectal coil was evaluated by a query. Results: In total 4.7% of the patients would not recommend a MRI examination because of subjective physical strain and 65.6% of all patients subjectively saw a benefit in the examination in regard to an optimal diagnostic process. The protocol groups reached a sensitivity from 66.7% - 100%, a specificity from 40% - 75%, a positive predictive value from 33.3% - 80% and a negative predictive value from 66.7% - 100%. Conclusion: MRI of the prostate is a safe and comfortable tool with high sensitivity and negative predictive value and the potential of ruling out a clinically significant prostate cancer. However, a general recommendation for the use of biparametric MRI could not be given, considering a higher sensitivity could be performed when using dynamic contrast-enhanced MRI or spectroscopy.

关键词： Prostate Imaging Prostate Cancer Multiparametricmri

Subcellular spatial resolution achieved for deep-brain imaging in vivo using a minimally invasive multimode fiber

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Light(Science & Applications) 2018年第1期7卷 1-6页

作者： sebastian A.Vasquez-Lopez Raphaël Turcotte Vadim Koren Martin Plöschner Zahid Padamsey Martin j.Booth TomášČižmár Nigel j.Emptage Department of Pharmacology University of OxfordMansfield RoadOxford OX13QTUK Department of Engineering Science University of OxfordParks RoadOxford OX13PJUK School of Engineering Physics and MathematicsCollege of ArtScience&EngineeringUniversity of DundeeNethergateDundee DD14HN ScotlandUK. Institute of Scientific Instruments of the CAS Královopolská14761264 BrnoCzech Republic

Achieving intravital optical imaging with diffraction-limited spatial resolution of deep-brain structures represents an important step toward the goal of understanding the mammalian central nervous system1–*** in wavefrontshaping methods and computational power have recently allowed for a novel approach to high-resolution imaging,utilizing deterministic light propagation through optically complex media and,of particular importance for this work,multimode optical fibers(MMFs)5–*** report a compact and highly optimized approach for minimally invasive in vivo brain imaging *** volume of tissue lesion was reduced by more than 100-fold,while preserving diffraction-limited imaging performance utilizing wavefront control of light propagation through a single 50-μm-core ***,we demonstrated high-resolution fluorescence imaging of subcellular neuronal structures,dendrites and synaptic specializations,in deep-brain regions of living mice,as well as monitored stimulus-driven functional Ca2+*** results represent a major breakthrough in the compromise between high-resolution imaging and tissue damage,heralding new possibilities for deep-brain imaging in vivo.

关键词： multimode fiber resolution

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美国威斯康辛州叠屋

设计家 2013年第2期 110-113页

作者： Brian johnsen sebastian Schmaling john j. Macaulay johnsen Schmaling Architects

这个880平方英尺的现代小屋,安静地坐落于威斯康星州的森林中。整个小屋的建筑取材非常精细,从外部设计看,露石混凝土、雪松、阳极氧化金属和凝胶石膏与周围森林的色调互相融合。墙体、天花板和内部的小陈列间刷成白色,为冬日里的单调... 详细信息

这个880平方英尺的现代小屋,安静地坐落于威斯康星州的森林中。整个小屋的建筑取材非常精细,从外部设计看,露石混凝土、雪松、阳极氧化金属和凝胶石膏与周围森林的色调互相融合。墙体、天花板和内部的小陈列间刷成白色,为冬日里的单调阴霾平添了一分色彩。《设计家》：业主方面的要求是怎样的？johnsen Schmaling：这个项目的业主是一个来自芝加哥的家庭,

关键词：美国外部设计威斯康星州露石混凝土阳极氧化业主方天花板芝加哥