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Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Top quark pair production at complete NLO accuracy with NNLO+NNLL′corrections in QCD

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Chinese Physics C 2020年第8期44卷 40-45页

作者： MichałCzakon Andrea Ferroglia Alexander Mitov Davide Pagani Andrew S.Papanastasiou Benjamin D.Pecjak Darren j.scott Ioannis Tsinikos Xing Wang Li Lin Yang Marco Zaro Institut für Theoretische Teilchenphysik und Kosmologie RWTH Aachen UniversityD-52056 AachenGermany New York City College of Technology BrooklynNY 11201USA The Graduate School and University Center The City University of New YorkNew YorkNY 10016 USA Cavendish Laboratory University of CambridgeCB30HE CambridgeUK Technische Universität München James-Franck-Str.1D-85748 GarchingGermany Theory Group Deutsches Elektronen-Synchrotron(DESY)D-22607 HamburgGermany Institute for Particle Physics Phenomenology University of DurhamDH13LE DurhamUK Institute for Theoretical Physics University of AmsterdamScience Park 9041098 XH AmsterdamThe Netherlands Nikhef Theory GroupScience Park 1051098 XGAmsterdamThe Netherlands Theoretical Particle Physics Department of Astronomy and Theoretical PhysicsLund UniversitySölvegatan 14ASE-22362 LundSweden PRISMA+Cluster of Excellence Johannes Gutenberg UniversityD-55128 MainzGermany Zhejiang Institute of Modern Physics Department of PhysicsZhejiang UniversityHangzhou 310027China INFN Sezione di MilanoVia Celoria 1620133 MilanoItaly

We describe predictions for top quark pair differential distributions at hadron colliders,by combining the next-to-next-to-leading order quantum chromodynamics calculations and next-to-leading order electroweak corrections with double resummation at the next-to-next-to-leading logarithmic accuracy of threshold logarithms and small-mass *** the best of our knowledge,this is the first study to present such a combination,which incorporates all known perturbative *** results are presented for the invariant-mass distribution,transverse-momentum distribution,and rapidity distributions.

关键词： top quark production QCD electroweak

Shared decision-making in stroke:an evolving approach to improved patient care

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Stroke & Vascular Neurology 2017年第2期2卷 84-87页

作者： Melissa j armstrong Department of Neurology University of Florida College of MedicineGainesvilleFloridaUSA

Shared decision-making(SDM)occurs when patients,families and clinicians consider patients’values and preferences alongside the best medical evidence and partner to make the best decision for a given patient in a specific *** is increasingly promoted within Western contexts and is also being explored outside such settings,including in *** and tools to promote SDM can improve patients’knowledge/understanding,participation in the decision-making process,satisfaction and trust in the healthcare *** has also proposed long-term benefits to patients,clinicians,organisations and healthcare *** successfully perform SDM,clinicians must know their patients’values and goals and the evidence underlying different diagnostic and treatment *** is relevant for decisions throughout stroke care,from thrombolysis to goals of care,diagnostic assessments,rehabilitation strategies,and secondary stroke *** physician,patient,family,cultural and system barriers to SDM *** to overcome these barriers and facilitate SDM include clinician motivation,patient participation,adequate time and tools to support the process,such as decision *** research about SDM in stroke care is lacking,decision aids are available for select decisions,such as anticoagulation for stroke prevention in atrial *** research is needed regarding both cultural aspects of successful SDM and application of SDM to stroke-specific contexts.

关键词： prevention overcome outside

Effect of Exercise and Sham Exercise Trackers on Perceived Workout Intensity and Mood in College Students

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journal of Psychological Research 2021年第1期3卷 1-6页

作者： Elizabeth j.scott Terry F.Pettijohn II Coastal Carolina University Department of PsychologyCoastal Carolina UniversityP.O.Box 261954ConwaySouth Carolina29528-6054United States

Exercise is an essential contributor to both physical and mental health and is a significant part of a person’s overall *** the increasing popularity of exercise trackers,researchers were interested in the effects of sham exercise trackers on perceptions of workouts and *** predicted participants wearing a sham Fitbit band would report greater perceptions of workout intensity,challenge,and satisfaction compared to those without sham Fitbit *** addition,those wearing sham Fitbit bands were predicted to report greater positive affect and lower negative affect than those without *** hundred twenty student participants(60 in each group;one group with a sham Fitbit and one group with no Fitbit)were recruited from campus workout classes of Zumba,spinning,and body *** worked out and completed a PANAS survey,plus other workout perception *** using a sham Fitbit,participants believed the workout was more intense,physically challenging,and they were more satisfied with their ***,presence of a sham Fitbit band did not significantly affect *** suggest that knowledge of wearing an exercise tracker,even without any workout data feedback,has an effect on workout perceptions,but has little effect on mood.

关键词： Exercise Mood Fitbit PANAS Zumba Spinning Body sculpting

Hesitant adopters:COVID-19 vaccine hesitancy among diverse vaccinated adults in the United States

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Infectious Medicine

Infectious Medicine 2023年第2期2卷 89-95页

作者： Sharon Reece Sheena CarlLee Aaron j.scott Don E.Willis Brett Rowland Kristin Larsen Ijanae Holman-Allgood Pearl A.McElfish College of Medicine University of Arkansas for Medical Sciences NorthwestFayettevilleAR 72703USA Office of Community Health and Research University of Arkansas for Medical Sciences NorthwestSpringdaleAR 72703USA College of Medicine University of Arkansas for Medical Sciences NorthwestSpringdaleAR 72703USA

Background:Despite the United States(US)having an abundant supply of COVID-19 vaccines,vaccination rates lag behind other high-income countries,suggesting that vaccine hesitancy and attitudes play a greater role in public health measures than pure supply and *** the acknowledgment that vaccination attitudes and status may or may not be correlated,this study examined COVID-19 vaccine hesitancy among vaccinated US adults by asking:(1)What is the prevalence of COVID-19 vaccine hesitancy among the vaccinated?(2)Does COVID-19 vaccine hesitancy vary across sociodemographic characteristics?(3)Does COVID-19 vaccine hesitancy vary by healthcare access and influenza vaccination over the past 5 years?Methods:Data were collected through an online survey of 2022 US adults with a final analytic sample of 1383 vaccinated ***:Overall,48.8%of vaccinated adults reported some level of hesitancy,while a slight majority reported they were“not at all hesitant”.Younger respondents,women,and Black and American Indian or Alaska Native participants had greater adjusted odds of being more hesitant towards receiving the COVID-19 ***-dents who had a primary care physician had greater adjusted odds than those who did not have a primary care physician of being more hesitant towards receiving the COVID-19 ***:This is the first population-based national sample study examining COVID-19 vaccine hesitancy among vaccinated individuals from subgroups of distinctive backgrounds in order to inform targeted strategies for reducing vaccine *** can assist in efforts to increase vaccination rates and also decrease vaccine hesitancy at the national level.

关键词： COVID-19 vaccine Vaccine hesitancy Hesitant adopters US adults

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畅通英语（第三版）基础教程 3版

2014年

作者： H.Q.Mitchell，j.scott[]

本书包括12个单元，每单元包括3课内容，Lesson one以会话引入为主，包括情景对话、词语表达、语法结构和口语实践等；Lesson two重在以听和读为主的接受型技能训练，包括阅读、词语表达、语法、听力实践部分；Lesson three重在以说和... 详细信息

ISBN: (纸本)9787040394269

本书包括12个单元，每单元包括3课内容，Lesson one以会话引入为主，包括情景对话、词语表达、语法结构和口语实践等；Lesson two重在以听和读为主的接受型技能训练，包括阅读、词语表达、语法、听力实践部分；Lesson three重在以说和写为主的产出型技能训练，包括听、说、读、写四种技能的综合训练。

关键词：英语

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腹腔镜腹壁疝修补术SAGES指南

中国微创外科杂志 2017年第11期17卷 961-964页

作者： David Earle j.scott Roth Alan Saber 陈大伟 Ochsner Clinic 上海交通大学医学院附属新华医院崇明分院普外科上海202105

腹壁疝修补的目标是解除病人的症状和（或）治愈疝本身。近年来,越来越多的医生开展腹腔镜腹壁疝修补术,但是选择开放手术还是腹腔镜手术治疗腹壁疝仍有争议。该指南旨在为外科医生开展腹腔镜腹壁疝修补术时,在病人的选择、手术技术以... 详细信息

腹壁疝修补的目标是解除病人的症状和（或）治愈疝本身。近年来,越来越多的医生开展腹腔镜腹壁疝修补术,但是选择开放手术还是腹腔镜手术治疗腹壁疝仍有争议。该指南旨在为外科医生开展腹腔镜腹壁疝修补术时,在病人的选择、手术技术以及术后处理方面提供帮助。1方法用疝、腹壁、外科、腔镜、英语、人类等主题词,在Medline上进行文献检索。

关键词：疝修补术腹壁疝腹腔镜指南 Medline 外科医生手术治疗开放手术

Microchip Capillary Electrophoresis-ESI-MS for Rapid, Multi-level Analysis of Complex Proteins

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Microchip Capillary Electrophoresis-ESI-MS for Rapid, Multi-...

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

2018年中国质谱学术大会（CMSC2018）

作者： Liang Wang Erin Redman j.scott Mellors 908 Devices Inc.

Introduction: Mass spec characterization of proteins often requires multiple "levels" of analysis to generate a complete picture of the molecule. These levels are commonly referred to as top-down, middle-down/up, and bottomup. While LC-MS methods have been developed for each of these levels, those methods typically require completely different columns and mobile phases for the different levels;and the methods typically yield relatively poor results for middle and top down analysis. Microchip CE-ESI-MS can achieve excellent performance for all of these levels, using the same exact experimental conditions. This enables rapid, back-to-back multilevel characterization of a protein, with no down-time between samples. Method: All work was performed using a commercially available microfluidic CE-ESI system(ZipChip, 908 Devices Inc.). The microfluidic devices utilize a covalently attached, neutral polymer surface coating to prevent analyte interactions and suppress electroosmotic flow. For the work shown here, a chip with a 22 cm long separation channel was used(ZipChip HR chip). Data were collected on a Thermo Tribrid Fusion Lumos or an Exactive Plus EMR mass spectrometer. To achieve successful analysis at all three structural levels, a background electrolyte(BGE) with a relatively low pH was chosen. The ZipChip "Metabolite BGE"(908 Devices Inc.) is a low p H mixture containing water, methanol, and formic acid. While it was developed for optimizing metabolite separations, it is well suited for many peptide and intact protein analyses as well. Native analysis of a monoclonal antibody is also shown as a point of comparison. That method uses a BGE with a neutral pH and a low organic content(ZipChip Native Antibody BGE). Conclusion: This study has shown the ability of ZipChip CE-ESI MS system to run such a wide range of applications without making any changes to the system, which means that a wide variety of samples can simply and efficiently be run on the mass spec. For labs

关键词： Multi-level complex proteins CE-ESI-MS ZipChip HR chip

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon j.Brown Rafael j.Yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute